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Protein

60S ribosomal protein L24-A

Gene

RPL24A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30547-MONOMER.
ReactomeiREACT_290856. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_302067. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_307259. Formation of a pool of free 40S subunits.
REACT_314339. SRP-dependent cotranslational protein targeting to membrane.
REACT_332565. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_343353. Peptide chain elongation.
REACT_346847. GTP hydrolysis and joining of the 60S ribosomal subunit.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L24-A
Alternative name(s):
L30
RP29
YL21
Gene namesi
Name:RPL24A
Synonyms:RP29, RPL30A
Ordered Locus Names:YGL031C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VII

Organism-specific databases

CYGDiYGL031c.
EuPathDBiFungiDB:YGL031C.
SGDiS000002999. RPL24A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15515560S ribosomal protein L24-APRO_0000136894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP04449.
PeptideAtlasiP04449.
PRIDEiP04449.

Expressioni

Gene expression databases

GenevestigatoriP04449.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi33215. 126 interactions.
IntActiP04449. 19 interactions.
MINTiMINT-1325572.

Structurei

Secondary structure

1
155
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni7 – 93Combined sources
Beta strandi18 – 225Combined sources
Beta strandi24 – 263Combined sources
Beta strandi28 – 336Combined sources
Helixi34 – 418Combined sources
Helixi46 – 483Combined sources
Helixi53 – 586Combined sources
Turni59 – 624Combined sources
Helixi64 – 663Combined sources
Beta strandi83 – 853Combined sources
Turni87 – 904Combined sources
Beta strandi91 – 933Combined sources
Helixi98 – 11114Combined sources
Helixi113 – 12816Combined sources
Turni130 – 1323Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-S4-56[»]
2X7Nelectron microscopy11.80D1-56[»]
3J6Xelectron microscopy6.10641-155[»]
3J6Yelectron microscopy6.10641-155[»]
3J77electron microscopy6.20741-155[»]
3J78electron microscopy6.30741-155[»]
4U3MX-ray3.00N4/n41-155[»]
4U3NX-ray3.20N4/n41-155[»]
4U3UX-ray2.90N4/n41-155[»]
4U4NX-ray3.10N4/n41-155[»]
4U4OX-ray3.60N4/n41-155[»]
4U4QX-ray3.00N4/n41-155[»]
4U4RX-ray2.80N4/n41-155[»]
4U4UX-ray3.00N4/n41-155[»]
4U4YX-ray3.20N4/n41-155[»]
4U4ZX-ray3.10N4/n41-155[»]
4U50X-ray3.20N4/n41-155[»]
4U51X-ray3.20N4/n41-155[»]
4U52X-ray3.00N4/n41-155[»]
4U53X-ray3.30N4/n41-155[»]
4U55X-ray3.20N4/n41-155[»]
4U56X-ray3.45N4/n41-155[»]
4U6FX-ray3.10N4/n41-155[»]
4V4Belectron microscopy11.70BS1-56[»]
4V6Ielectron microscopy8.80BZ1-155[»]
4V7RX-ray4.00BV/DV1-155[»]
4V88X-ray3.00BW/DW1-155[»]
4V8Telectron microscopy8.10W1-155[»]
4V8Yelectron microscopy4.30BW1-155[»]
4V8Zelectron microscopy6.60BW1-155[»]
4V91electron microscopy3.70W1-155[»]
ProteinModelPortaliP04449.
SMRiP04449. Positions 1-56.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04449.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24e family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074809.
HOGENOMiHOG000184343.
InParanoidiP04449.
KOiK02896.
OMAiVERWSFR.
OrthoDBiEOG718KQP.

Family and domain databases

Gene3Di2.30.170.20. 1 hit.
InterProiIPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR000988. Ribosomal_L24e_rel.
[Graphical view]
PANTHERiPTHR10792. PTHR10792. 1 hit.
PfamiPF01246. Ribosomal_L24e. 1 hit.
[Graphical view]
PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVEIDSFSG AKIYPGRGTL FVRGDSKIFR FQNSKSASLF KQRKNPRRIA
60 70 80 90 100
WTVLFRKHHK KGITEEVAKK RSRKTVKAQR PITGASLDLI KERRSLKPEV
110 120 130 140 150
RKANREEKLK ANKEKKKAEK AARKAEKAKS AGTQSSKFSK QQAKGAFQKV

AATSR
Length:155
Mass (Da):17,614
Last modified:August 13, 1987 - v1
Checksum:i9A79C4E409515716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02650 Genomic DNA. Translation: AAA35004.1.
Z72553 Genomic DNA. Translation: CAA96732.1.
EF123140 mRNA. Translation: ABM97484.1.
BK006941 Genomic DNA. Translation: DAA08068.1.
PIRiA02783. R6BYT9.
RefSeqiNP_011484.1. NM_001180896.1.

Genome annotation databases

EnsemblFungiiYGL031C; YGL031C; YGL031C.
GeneIDi852852.
KEGGisce:YGL031C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02650 Genomic DNA. Translation: AAA35004.1.
Z72553 Genomic DNA. Translation: CAA96732.1.
EF123140 mRNA. Translation: ABM97484.1.
BK006941 Genomic DNA. Translation: DAA08068.1.
PIRiA02783. R6BYT9.
RefSeqiNP_011484.1. NM_001180896.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-S4-56[»]
2X7Nelectron microscopy11.80D1-56[»]
3J6Xelectron microscopy6.10641-155[»]
3J6Yelectron microscopy6.10641-155[»]
3J77electron microscopy6.20741-155[»]
3J78electron microscopy6.30741-155[»]
4U3MX-ray3.00N4/n41-155[»]
4U3NX-ray3.20N4/n41-155[»]
4U3UX-ray2.90N4/n41-155[»]
4U4NX-ray3.10N4/n41-155[»]
4U4OX-ray3.60N4/n41-155[»]
4U4QX-ray3.00N4/n41-155[»]
4U4RX-ray2.80N4/n41-155[»]
4U4UX-ray3.00N4/n41-155[»]
4U4YX-ray3.20N4/n41-155[»]
4U4ZX-ray3.10N4/n41-155[»]
4U50X-ray3.20N4/n41-155[»]
4U51X-ray3.20N4/n41-155[»]
4U52X-ray3.00N4/n41-155[»]
4U53X-ray3.30N4/n41-155[»]
4U55X-ray3.20N4/n41-155[»]
4U56X-ray3.45N4/n41-155[»]
4U6FX-ray3.10N4/n41-155[»]
4V4Belectron microscopy11.70BS1-56[»]
4V6Ielectron microscopy8.80BZ1-155[»]
4V7RX-ray4.00BV/DV1-155[»]
4V88X-ray3.00BW/DW1-155[»]
4V8Telectron microscopy8.10W1-155[»]
4V8Yelectron microscopy4.30BW1-155[»]
4V8Zelectron microscopy6.60BW1-155[»]
4V91electron microscopy3.70W1-155[»]
ProteinModelPortaliP04449.
SMRiP04449. Positions 1-56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33215. 126 interactions.
IntActiP04449. 19 interactions.
MINTiMINT-1325572.

Proteomic databases

MaxQBiP04449.
PeptideAtlasiP04449.
PRIDEiP04449.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL031C; YGL031C; YGL031C.
GeneIDi852852.
KEGGisce:YGL031C.

Organism-specific databases

CYGDiYGL031c.
EuPathDBiFungiDB:YGL031C.
SGDiS000002999. RPL24A.

Phylogenomic databases

GeneTreeiENSGT00550000074809.
HOGENOMiHOG000184343.
InParanoidiP04449.
KOiK02896.
OMAiVERWSFR.
OrthoDBiEOG718KQP.

Enzyme and pathway databases

BioCyciYEAST:G3O-30547-MONOMER.
ReactomeiREACT_290856. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_302067. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_307259. Formation of a pool of free 40S subunits.
REACT_314339. SRP-dependent cotranslational protein targeting to membrane.
REACT_332565. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_343353. Peptide chain elongation.
REACT_346847. GTP hydrolysis and joining of the 60S ribosomal subunit.

Miscellaneous databases

EvolutionaryTraceiP04449.
NextBioi972446.
PROiP04449.

Gene expression databases

GenevestigatoriP04449.

Family and domain databases

Gene3Di2.30.170.20. 1 hit.
InterProiIPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR000988. Ribosomal_L24e_rel.
[Graphical view]
PANTHERiPTHR10792. PTHR10792. 1 hit.
PfamiPF01246. Ribosomal_L24e. 1 hit.
[Graphical view]
PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A yeast ribosomal protein gene whose intron is in the 5' leader."
    Mitra G., Warner J.R.
    J. Biol. Chem. 259:9218-9224(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing."
    Juneau K., Palm C., Miranda M., Davis R.W.
    Proc. Natl. Acad. Sci. U.S.A. 104:1522-1527(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.
    Strain: ATCC 201390 / BY4743.
  5. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 4-56, ELECTRON MICROSCOPY.
  10. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 1-56, ELECTRON MICROSCOPY.
  11. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  12. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL24A_YEAST
AccessioniPrimary (citable) accession number: P04449
Secondary accession number(s): A2TBN7, D6VUA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 27, 2015
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 247000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L24 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.