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P04449

- RL24A_YEAST

UniProt

P04449 - RL24A_YEAST

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Protein

60S ribosomal protein L24-A

Gene

RPL24A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: SGD
  2. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30547-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L24-A
Alternative name(s):
L30
RP29
YL21
Gene namesi
Name:RPL24A
Synonyms:RP29, RPL30A
Ordered Locus Names:YGL031C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL031c.
SGDiS000002999. RPL24A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15515560S ribosomal protein L24-APRO_0000136894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP04449.
PeptideAtlasiP04449.
PRIDEiP04449.

Expressioni

Gene expression databases

GenevestigatoriP04449.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi33215. 124 interactions.
IntActiP04449. 19 interactions.
MINTiMINT-1325572.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-S4-56[»]
1S1Ielectron microscopy11.70S1-56[»]
1VW8electron microscopy6.10X1-155[»]
1VWUelectron microscopy6.10X1-155[»]
1VXVelectron microscopy6.20X1-155[»]
1VXYelectron microscopy6.30X1-155[»]
2X7Nelectron microscopy11.80D1-56[»]
3IZSelectron microscopy-Z1-155[»]
3O58X-ray4.00V1-155[»]
3O5HX-ray4.00V1-155[»]
3U5EX-ray3.00W1-155[»]
3U5IX-ray3.00W1-155[»]
4B6Aelectron microscopy8.10W1-155[»]
4BYNelectron microscopy4.30W1-155[»]
4BYUelectron microscopy6.60W1-155[»]
4CUWelectron microscopy3.70W1-155[»]
ProteinModelPortaliP04449.
SMRiP04449. Positions 1-135.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04449.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24e family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074809.
HOGENOMiHOG000184343.
InParanoidiP04449.
KOiK02896.
OMAiENIMAKR.
OrthoDBiEOG718KQP.

Family and domain databases

Gene3Di2.30.170.20. 1 hit.
InterProiIPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR000988. Ribosomal_L24e_rel.
[Graphical view]
PANTHERiPTHR10792. PTHR10792. 1 hit.
PfamiPF01246. Ribosomal_L24e. 1 hit.
[Graphical view]
PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04449-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVEIDSFSG AKIYPGRGTL FVRGDSKIFR FQNSKSASLF KQRKNPRRIA
60 70 80 90 100
WTVLFRKHHK KGITEEVAKK RSRKTVKAQR PITGASLDLI KERRSLKPEV
110 120 130 140 150
RKANREEKLK ANKEKKKAEK AARKAEKAKS AGTQSSKFSK QQAKGAFQKV

AATSR
Length:155
Mass (Da):17,614
Last modified:August 13, 1987 - v1
Checksum:i9A79C4E409515716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02650 Genomic DNA. Translation: AAA35004.1.
Z72553 Genomic DNA. Translation: CAA96732.1.
EF123140 mRNA. Translation: ABM97484.1.
BK006941 Genomic DNA. Translation: DAA08068.1.
PIRiA02783. R6BYT9.
RefSeqiNP_011484.1. NM_001180896.1.

Genome annotation databases

EnsemblFungiiYGL031C; YGL031C; YGL031C.
GeneIDi852852.
KEGGisce:YGL031C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02650 Genomic DNA. Translation: AAA35004.1 .
Z72553 Genomic DNA. Translation: CAA96732.1 .
EF123140 mRNA. Translation: ABM97484.1 .
BK006941 Genomic DNA. Translation: DAA08068.1 .
PIRi A02783. R6BYT9.
RefSeqi NP_011484.1. NM_001180896.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K5Y model - S 4-56 [» ]
1S1I electron microscopy 11.70 S 1-56 [» ]
1VW8 electron microscopy 6.10 X 1-155 [» ]
1VWU electron microscopy 6.10 X 1-155 [» ]
1VXV electron microscopy 6.20 X 1-155 [» ]
1VXY electron microscopy 6.30 X 1-155 [» ]
2X7N electron microscopy 11.80 D 1-56 [» ]
3IZS electron microscopy - Z 1-155 [» ]
3O58 X-ray 4.00 V 1-155 [» ]
3O5H X-ray 4.00 V 1-155 [» ]
3U5E X-ray 3.00 W 1-155 [» ]
3U5I X-ray 3.00 W 1-155 [» ]
4B6A electron microscopy 8.10 W 1-155 [» ]
4BYN electron microscopy 4.30 W 1-155 [» ]
4BYU electron microscopy 6.60 W 1-155 [» ]
4CUW electron microscopy 3.70 W 1-155 [» ]
ProteinModelPortali P04449.
SMRi P04449. Positions 1-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33215. 124 interactions.
IntActi P04449. 19 interactions.
MINTi MINT-1325572.

Proteomic databases

MaxQBi P04449.
PeptideAtlasi P04449.
PRIDEi P04449.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL031C ; YGL031C ; YGL031C .
GeneIDi 852852.
KEGGi sce:YGL031C.

Organism-specific databases

CYGDi YGL031c.
SGDi S000002999. RPL24A.

Phylogenomic databases

GeneTreei ENSGT00550000074809.
HOGENOMi HOG000184343.
InParanoidi P04449.
KOi K02896.
OMAi ENIMAKR.
OrthoDBi EOG718KQP.

Enzyme and pathway databases

BioCyci YEAST:G3O-30547-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Miscellaneous databases

EvolutionaryTracei P04449.
NextBioi 972446.

Gene expression databases

Genevestigatori P04449.

Family and domain databases

Gene3Di 2.30.170.20. 1 hit.
InterProi IPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR000988. Ribosomal_L24e_rel.
[Graphical view ]
PANTHERi PTHR10792. PTHR10792. 1 hit.
Pfami PF01246. Ribosomal_L24e. 1 hit.
[Graphical view ]
PROSITEi PS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A yeast ribosomal protein gene whose intron is in the 5' leader."
    Mitra G., Warner J.R.
    J. Biol. Chem. 259:9218-9224(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing."
    Juneau K., Palm C., Miranda M., Davis R.W.
    Proc. Natl. Acad. Sci. U.S.A. 104:1522-1527(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.
    Strain: ATCC 201390 / BY4743.
  5. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 4-56, ELECTRON MICROSCOPY.
  10. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 1-56, ELECTRON MICROSCOPY.
  11. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  12. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL24A_YEAST
AccessioniPrimary (citable) accession number: P04449
Secondary accession number(s): A2TBN7, D6VUA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 26, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 247000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L24 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3