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P04449

- RL24A_YEAST

UniProt

P04449 - RL24A_YEAST

Protein

60S ribosomal protein L24-A

Gene

RPL24A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (13 Aug 1987)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. RNA binding Source: SGD
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30547-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L24-A
    Alternative name(s):
    L30
    RP29
    YL21
    Gene namesi
    Name:RPL24A
    Synonyms:RP29, RPL30A
    Ordered Locus Names:YGL031C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    CYGDiYGL031c.
    SGDiS000002999. RPL24A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15515560S ribosomal protein L24-APRO_0000136894Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei7 – 71PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP04449.
    PeptideAtlasiP04449.
    PRIDEiP04449.

    Expressioni

    Gene expression databases

    GenevestigatoriP04449.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi33215. 123 interactions.
    IntActiP04449. 19 interactions.
    MINTiMINT-1325572.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Ymodel-S4-56[»]
    1S1Ielectron microscopy11.70S1-56[»]
    1VW8electron microscopy6.10X1-155[»]
    1VWUelectron microscopy6.10X1-155[»]
    2X7Nelectron microscopy11.80D1-56[»]
    3IZSelectron microscopy-Z1-155[»]
    3O58X-ray4.00V1-155[»]
    3O5HX-ray4.00V1-155[»]
    3U5EX-ray3.00W1-155[»]
    3U5IX-ray3.00W1-155[»]
    4B6Aelectron microscopy8.10W1-155[»]
    4BYNelectron microscopy4.30W1-155[»]
    4BYUelectron microscopy6.60W1-155[»]
    4CUWelectron microscopy3.70W1-155[»]
    ProteinModelPortaliP04449.
    SMRiP04449. Positions 1-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP04449.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L24e family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00550000074809.
    HOGENOMiHOG000184343.
    KOiK02896.
    OMAiENIMAKR.
    OrthoDBiEOG718KQP.

    Family and domain databases

    Gene3Di2.30.170.20. 1 hit.
    InterProiIPR023442. Ribosomal_L24e_CS.
    IPR023441. Ribosomal_L24e_dom.
    IPR000988. Ribosomal_L24e_rel.
    [Graphical view]
    PANTHERiPTHR10792. PTHR10792. 1 hit.
    PfamiPF01246. Ribosomal_L24e. 1 hit.
    [Graphical view]
    PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P04449-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVEIDSFSG AKIYPGRGTL FVRGDSKIFR FQNSKSASLF KQRKNPRRIA    50
    WTVLFRKHHK KGITEEVAKK RSRKTVKAQR PITGASLDLI KERRSLKPEV 100
    RKANREEKLK ANKEKKKAEK AARKAEKAKS AGTQSSKFSK QQAKGAFQKV 150
    AATSR 155
    Length:155
    Mass (Da):17,614
    Last modified:August 13, 1987 - v1
    Checksum:i9A79C4E409515716
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02650 Genomic DNA. Translation: AAA35004.1.
    Z72553 Genomic DNA. Translation: CAA96732.1.
    EF123140 mRNA. Translation: ABM97484.1.
    BK006941 Genomic DNA. Translation: DAA08068.1.
    PIRiA02783. R6BYT9.
    RefSeqiNP_011484.1. NM_001180896.1.

    Genome annotation databases

    EnsemblFungiiYGL031C; YGL031C; YGL031C.
    GeneIDi852852.
    KEGGisce:YGL031C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02650 Genomic DNA. Translation: AAA35004.1 .
    Z72553 Genomic DNA. Translation: CAA96732.1 .
    EF123140 mRNA. Translation: ABM97484.1 .
    BK006941 Genomic DNA. Translation: DAA08068.1 .
    PIRi A02783. R6BYT9.
    RefSeqi NP_011484.1. NM_001180896.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5Y model - S 4-56 [» ]
    1S1I electron microscopy 11.70 S 1-56 [» ]
    1VW8 electron microscopy 6.10 X 1-155 [» ]
    1VWU electron microscopy 6.10 X 1-155 [» ]
    2X7N electron microscopy 11.80 D 1-56 [» ]
    3IZS electron microscopy - Z 1-155 [» ]
    3O58 X-ray 4.00 V 1-155 [» ]
    3O5H X-ray 4.00 V 1-155 [» ]
    3U5E X-ray 3.00 W 1-155 [» ]
    3U5I X-ray 3.00 W 1-155 [» ]
    4B6A electron microscopy 8.10 W 1-155 [» ]
    4BYN electron microscopy 4.30 W 1-155 [» ]
    4BYU electron microscopy 6.60 W 1-155 [» ]
    4CUW electron microscopy 3.70 W 1-155 [» ]
    ProteinModelPortali P04449.
    SMRi P04449. Positions 1-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33215. 123 interactions.
    IntActi P04449. 19 interactions.
    MINTi MINT-1325572.

    Proteomic databases

    MaxQBi P04449.
    PeptideAtlasi P04449.
    PRIDEi P04449.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL031C ; YGL031C ; YGL031C .
    GeneIDi 852852.
    KEGGi sce:YGL031C.

    Organism-specific databases

    CYGDi YGL031c.
    SGDi S000002999. RPL24A.

    Phylogenomic databases

    GeneTreei ENSGT00550000074809.
    HOGENOMi HOG000184343.
    KOi K02896.
    OMAi ENIMAKR.
    OrthoDBi EOG718KQP.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30547-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P04449.
    NextBioi 972446.

    Gene expression databases

    Genevestigatori P04449.

    Family and domain databases

    Gene3Di 2.30.170.20. 1 hit.
    InterProi IPR023442. Ribosomal_L24e_CS.
    IPR023441. Ribosomal_L24e_dom.
    IPR000988. Ribosomal_L24e_rel.
    [Graphical view ]
    PANTHERi PTHR10792. PTHR10792. 1 hit.
    Pfami PF01246. Ribosomal_L24e. 1 hit.
    [Graphical view ]
    PROSITEi PS01073. RIBOSOMAL_L24E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A yeast ribosomal protein gene whose intron is in the 5' leader."
      Mitra G., Warner J.R.
      J. Biol. Chem. 259:9218-9224(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing."
      Juneau K., Palm C., Miranda M., Davis R.W.
      Proc. Natl. Acad. Sci. U.S.A. 104:1522-1527(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.
      Strain: ATCC 201390 / BY4743.
    5. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 4-56, ELECTRON MICROSCOPY.
    10. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 1-56, ELECTRON MICROSCOPY.
    11. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    12. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL24A_YEAST
    AccessioniPrimary (citable) accession number: P04449
    Secondary accession number(s): A2TBN7, D6VUA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 247000 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L24 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3