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Protein

H-2 class II histocompatibility antigen gamma chain

Gene

Cd74

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: Ensembl
  • antigen processing and presentation Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
  • cell proliferation Source: UniProtKB
  • chaperone cofactor-dependent protein refolding Source: MGI
  • defense response Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • intracellular protein transport Source: MGI
  • macrophage migration inhibitory factor signaling pathway Source: BHF-UCL
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
  • negative regulation of mature B cell apoptotic process Source: BHF-UCL
  • negative regulation of peptide secretion Source: MGI
  • negative regulation of T cell differentiation Source: MGI
  • negative thymic T cell selection Source: MGI
  • positive regulation of adaptive immune response Source: BHF-UCL
  • positive regulation of B cell proliferation Source: MGI
  • positive regulation of chemokine (C-X-C motif) ligand 2 production Source: BHF-UCL
  • positive regulation of cytokine-mediated signaling pathway Source: BHF-UCL
  • positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • positive regulation of fibroblast proliferation Source: MGI
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • positive regulation of innate immune response Source: BHF-UCL
  • positive regulation of kinase activity Source: MGI
  • positive regulation of macrophage cytokine production Source: BHF-UCL
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of monocyte differentiation Source: MGI
  • positive regulation of neutrophil chemotaxis Source: BHF-UCL
  • positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of T cell differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of type 2 immune response Source: BHF-UCL
  • positive regulation of viral entry into host cell Source: MGI
  • positive thymic T cell selection Source: MGI
  • prostaglandin biosynthetic process Source: UniProtKB
  • protein-containing complex assembly Source: MGI
  • protein heterotetramerization Source: MGI
  • protein trimerization Source: InterPro
  • signal transduction Source: MGI

Keywordsi

Molecular functionChaperone
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-2132295 MHC class II antigen presentation

Protein family/group databases

MEROPSiI31.002

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen gamma chain
Alternative name(s):
Ia antigen-associated invariant chain
Short name:
Ii
MHC class II-associated invariant chain
CD_antigen: CD74
Gene namesi
Name:Cd74
Synonyms:Ii
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:96534 Cd74

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 55Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST26
Topological domaini56 – 279ExtracellularSequence analysisAdd BLAST224

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi265S → A: No addition of glycosaminoglycan; no effect on the synthesis of the protein. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000679551 – 279H-2 class II histocompatibility antigen gamma chainAdd BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi196 ↔ 215PROSITE-ProRule annotation
Disulfide bondi226 ↔ 233PROSITE-ProRule annotation
Disulfide bondi235 ↔ 254PROSITE-ProRule annotation
Glycosylationi265O-linked (Xyl...) (chondroitin sulfate) serine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiP04441
PeptideAtlasiP04441
PRIDEiP04441

PTM databases

iPTMnetiP04441
PhosphoSitePlusiP04441
SwissPalmiP04441

Expressioni

Gene expression databases

BgeeiENSMUSG00000024610
ExpressionAtlasiP04441 baseline and differential
GenevisibleiP04441 MM

Interactioni

Subunit structurei

Nonamer composed of three alpha/beta/gamma heterotrimers.By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP04441
IntActiP04441, 1 interactor
MINTiP04441
STRINGi10090.ENSMUSP00000095171

Structurei

3D structure databases

ProteinModelPortaliP04441
SMRiP04441
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini193 – 254Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY5J Eukaryota
ENOG410Z4PR LUCA
GeneTreeiENSGT00390000008961
HOGENOMiHOG000013145
HOVERGENiHBG004444
InParanoidiP04441
KOiK06505
OMAiKCSRGAL
OrthoDBiEOG091G0FT7
PhylomeDBiP04441
TreeFamiTF317779

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di1.10.870.10, 1 hit
4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR015386 MHC_II-assoc_invar/CLIP_MHC-bd
IPR022339 MHC_II-assoc_invar_chain
IPR011988 MHC_II-assoc_invariant_trimer
IPR036613 MHCII_invariant_trimer_sf
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF09307 MHC2-interact, 1 hit
PF08831 MHCassoc_trimer, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01990 CD74ANTIGEN
SMARTiView protein in SMART
SM00211 TY, 1 hit
SUPFAMiSSF48305 SSF48305, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P04441-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDQRDLISN HEQLPILGNR PREPERCSRG ALYTGVSVLV ALLLAGQATT
60 70 80 90 100
AYFLYQQQGR LDKLTITSQN LQLESLRMKL PKSAKPVSQM RMATPLLMRP
110 120 130 140 150
MSMDNMLLGP VKNVTKYGNM TQDHVMHLLT RSGPLEYPQL KGTFPENLKH
160 170 180 190 200
LKNSMDGVNW KIFESWMKQW LLFEMSKNSL EEKKPTEAPP KVLTKCQEEV
210 220 230 240 250
SHIPAVYPGA FRPKCDENGN YLPLQCHGST GYCWCVFPNG TEVPHTKSRG
260 270
RHNCSEPLDM EDLSSGLGVT RQELGQVTL
Length:279
Mass (Da):31,557
Last modified:November 1, 1991 - v3
Checksum:i300A85014F170792
GO
Isoform Short (identifier: P04441-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-255: Missing.

Show »
Length:215
Mass (Da):24,454
Checksum:i090928B6B0F4200C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10N → M (PubMed:2492095).Curated1
Sequence conflicti113N → Q (PubMed:2492095).Curated1
Sequence conflicti229 – 231STG → RHC in CAB37297 (PubMed:3038530).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005332192 – 255Missing in isoform Short. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05428 Genomic DNA Translation: CAA29010.1
X05429 Genomic DNA Translation: CAA29012.2
X05430 Genomic DNA Translation: CAB37297.1
X13414 Genomic DNA No translation available.
BC003476 mRNA Translation: AAH03476.1
X07129 mRNA Translation: CAA30141.1
M35872 Genomic DNA Translation: AAA37897.1
X00496 mRNA Translation: CAA25191.1
CCDSiCCDS37835.1 [P04441-1]
CCDS50299.1 [P04441-2]
PIRiB27866 HLHMSG
RefSeqiNP_001036070.1, NM_001042605.1 [P04441-1]
UniGeneiMm.439737

Genome annotation databases

EnsembliENSMUST00000050487; ENSMUSP00000057836; ENSMUSG00000024610 [P04441-2]
ENSMUST00000097563; ENSMUSP00000095171; ENSMUSG00000024610 [P04441-1]
ENSMUST00000167610; ENSMUSP00000126688; ENSMUSG00000024610 [P04441-1]
GeneIDi16149
KEGGimmu:16149
UCSCiuc008faz.1 mouse [P04441-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHG2A_MOUSE
AccessioniPrimary (citable) accession number: P04441
Secondary accession number(s): O19452
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 1, 1991
Last modified: May 23, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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