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Protein

HLA class II histocompatibility antigen, DP beta 1 chain

Gene

HLA-DPB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functioni

  • peptide antigen binding Source: UniProtKB

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
  • interferon-gamma-mediated signaling pathway Source: Reactome
  • positive regulation of interferon-gamma production Source: UniProtKB
  • positive regulation of T cell activation Source: UniProtKB
  • positive regulation of T cell proliferation Source: UniProtKB
  • T cell costimulation Source: Reactome
  • T cell receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DP beta 1 chain
Alternative name(s):
HLA class II histocompatibility antigen, DP(W4) beta chain
MHC class II antigen DPB1
Gene namesi
Name:HLA-DPB1
Synonyms:HLA-DP1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4940. HLA-DPB1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 225196ExtracellularSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Topological domaini247 – 25812CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-DPB1.
Orphaneti133. Chronic berylliosis.
900. Granulomatosis with polyangiitis.
PharmGKBiPA35064.

Polymorphism and mutation databases

BioMutaiHLA-DPB1.
DMDMi122263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Add
BLAST
Chaini30 – 258229HLA class II histocompatibility antigen, DP beta 1 chainPRO_0000018984Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 106PROSITE-ProRule annotation
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 200PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04440.
PeptideAtlasiP04440.
PRIDEiP04440.

PTM databases

iPTMnetiP04440.
PhosphoSiteiP04440.
SwissPalmiP04440.

Expressioni

Gene expression databases

BgeeiENSG00000215048.
CleanExiHS_HLA-DPB1.
ExpressionAtlasiP04440. baseline and differential.
GenevisibleiP04440. HS.

Organism-specific databases

HPAiHPA011078.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Protein-protein interaction databases

BioGridi109360. 37 interactions.
IntActiP04440. 9 interactions.
STRINGi9606.ENSP00000408146.

Structurei

Secondary structure

1
258
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 4711Combined sources
Beta strandi50 – 5910Combined sources
Beta strandi62 – 687Combined sources
Turni69 – 713Combined sources
Beta strandi73 – 786Combined sources
Helixi79 – 813Combined sources
Helixi82 – 898Combined sources
Helixi92 – 998Combined sources
Turni100 – 1045Combined sources
Helixi105 – 1128Combined sources
Helixi114 – 1185Combined sources
Beta strandi125 – 1306Combined sources
Helixi134 – 1374Combined sources
Beta strandi141 – 15212Combined sources
Beta strandi155 – 1606Combined sources
Beta strandi163 – 1653Combined sources
Beta strandi167 – 1715Combined sources
Beta strandi178 – 1803Combined sources
Beta strandi182 – 1898Combined sources
Beta strandi197 – 2037Combined sources
Beta strandi211 – 2166Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LQZX-ray3.25B33-218[»]
4P4KX-ray2.80B/F32-218[»]
4P4RX-ray3.00B/D32-218[»]
4P57X-ray2.60B/D33-218[»]
4P5KX-ray2.59B/E33-218[»]
4P5MX-ray1.70B/D/F/H33-218[»]
ProteinModelPortaliP04440.
SMRiP04440. Positions 33-218.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04440.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 21289Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 12192Beta-1Add
BLAST
Regioni122 – 21594Beta-2Add
BLAST
Regioni216 – 22510Connecting peptide

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
GeneTreeiENSGT00760000118970.
HOVERGENiHBG012730.
InParanoidiP04440.
KOiK06752.
OMAiIGAENAN.
OrthoDBiEOG091G0W5S.
PhylomeDBiP04440.
TreeFamiTF336626.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT
60 70 80 90 100
QRFLERYIYN REEFARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA
110 120 130 140 150
VPDRMCRHNY ELGGPMTLQR RVQPRVNVSP SKKGPLQHHN LLVCHVTDFY
160 170 180 190 200
PGSIQVRWFL NGQEETAGVV STNLIRNGDW TFQILVMLEM TPQQGDVYTC
210 220 230 240 250
QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFVLGLIIC GVGIFMHRRS

KKVQRGSA
Length:258
Mass (Da):29,159
Last modified:August 13, 1987 - v1
Checksum:iE74777D438DE9C41
GO

Sequence cautioni

The sequence AAQ12564 differs from that shown. Reason: Frameshift at position 39. Curated

Polymorphismi

The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02, DPB1*02:03, DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01, DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02, DPB1*13:01, DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01, DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02, DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02, DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01, DPB1*36:01, DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01, DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01, DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01, DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01, DPB1*76:01, DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01, DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01, DPB1*94:01, DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of DPB1*04:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161T → M in allele DPB1*09:02.
Corresponds to variant rs41558014 [ dbSNP | Ensembl ].
VAR_060627
Natural varianti24 – 241T → I.
Corresponds to variant rs11551416 [ dbSNP | Ensembl ].
VAR_060628
Natural varianti30 – 301R → P in allele DPB1*75:01.
VAR_060629
Natural varianti31 – 311A → L in allele DPB1*75:01; requires 2 nucleotide substitutions.
VAR_060630
Natural varianti32 – 321T → P in allele DPB1*75:01.
VAR_060631
Natural varianti33 – 331P → A in allele DPB1*75:01.
VAR_060632
Natural varianti37 – 371L → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01 and allele DPB1*98:01.
Corresponds to variant rs1126504 [ dbSNP | Ensembl ].
VAR_060633
Natural varianti38 – 381F → D in allele DPB1*70:01; requires 2 nucleotide substitutions.
VAR_060635
Natural varianti38 – 381F → H in allele DPB1*09:01, allele DPB1*10:01, allele DPB1*14:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*22:02, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*45:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*76:01, allele DPB1*86:01, allele DPB1*91:01 and allele DPB1*98:01; requires 2 nucleotide substitutions.
VAR_060634
Natural varianti38 – 381F → L.
Corresponds to variant rs12722013 [ dbSNP | Ensembl ].
VAR_060636
Natural varianti38 – 381F → Y in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:02, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*56:01, allele DPB1*69:01, allele DPB1*74:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*92:01 and allele DPB1*93:01.
Corresponds to variant rs1126509 [ dbSNP | Ensembl ].
VAR_033433
Natural varianti40 – 401G → L in allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01 and allele DPB1*98:01; requires 2 nucleotide substitutions.
VAR_060637
Natural varianti40 – 401G → V.
Corresponds to variant rs1126513 [ dbSNP | Ensembl ].
VAR_033434
Natural varianti41 – 411R → L in allele DPB1*77:01.
Corresponds to variant rs41540313 [ dbSNP | Ensembl ].
VAR_060638
Natural varianti44 – 441C → G in allele DPB1*26:02.
VAR_060639
Natural varianti46 – 461A → P in allele DPB1*38:01.
Corresponds to variant rs41555313 [ dbSNP | Ensembl ].
VAR_060640
Natural varianti46 – 461A → T in allele DPB1*18:02.
Corresponds to variant rs41555313 [ dbSNP | Ensembl ].
VAR_060641
Natural varianti57 – 571Y → D in allele DPB1*99:01.
Corresponds to variant rs41553416 [ dbSNP | Ensembl ].
VAR_060642
Natural varianti61 – 611R → P in allele DPB1*14:02 and allele DPB1*21:02.
Corresponds to variant rs41561114 [ dbSNP | Ensembl ].
VAR_060643
Natural varianti62 – 621E → Q Ind allele DPB1*11:01, allele DPB1*15:01 and allele DPB1*74:01.
Corresponds to variant rs12722018 [ dbSNP | Ensembl ].
VAR_033435
Natural varianti64 – 641F → L in allele DPB1*02:02, allele DPB1*02:03, allele DPB1*05:01, allele DPB1*15:02, allele DPB1*17:02, allele DPB1*19:02, allele DPB1*21:01, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*34:01, allele DPB1*36:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*48:01, allele DPB1*58:01, allele DPB1*62:01, allele DPB1*63:01, allele DPB1*95:01 and allele DPB1*97:01.
Corresponds to variant rs9277348 [ dbSNP | Ensembl ].
VAR_060644
Natural varianti64 – 641F → Y in allele DPB1*01:01, allele DPB1*01:02, allele DPB1*09:02, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*15:01, allele DPB1*20:02, allele DPB1*21:02, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*39:01, allele DPB1*40:01, allele DPB1*49:01, allele DPB1*53:01, allele DPB1*65:01, allele DPB1*74:01, allele DPB1*85:01, allele DPB1*89:01 and allele DPB1*96:01.
Corresponds to variant rs1042117 [ dbSNP | Ensembl ].
VAR_033436
Natural varianti65 – 651A → V in allele DPB1*01:02, allele DPB1*02:01, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:01, allele DPB1*19:02, allele DPB1*21:01, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*23:01, allele DPB1*25:01, allele DPB1*26:02, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*32:01, allele DPB1*34:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*47:01, allele DPB1*48:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*62:01, allele DPB1*63:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*71:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*84:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*93:01, allele DPB1*94:01, allele DPB1*95:01, allele DPB1*97:01 and allele DPB1*98:01.
Corresponds to variant rs1042121 [ dbSNP | Ensembl ].
VAR_033437
Natural varianti68 – 681D → Y in allele DPB1*24:02.
VAR_060645
Natural varianti72 – 721G → W in allele DPB1*97:01.
Corresponds to variant rs41552915 [ dbSNP | Ensembl ].
VAR_060646
Natural varianti84 – 841A → D in allele DPB1*02:01, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:01, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:02, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*32:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*48:01, allele DPB1*49:01, allele DPB1*50:01, allele DPB1*51:01, allele DPB1*53:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*81:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*94:01 and allele DPB1*98:01.
Corresponds to variant rs707958 [ dbSNP | Ensembl ].
VAR_054662
Natural varianti84 – 841A → E in allele DPB1*01:02, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*05:01, allele DPB1*08:02, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*24:01, allele DPB1*30:01, allele DPB1*36:01, allele DPB1*38:01, allele DPB1*47:01, allele DPB1*54:01, allele DPB1*84:01 and allele DPB1*97:01.
VAR_060647
Natural varianti84 – 841A → V.
Corresponds to variant rs707958 [ dbSNP | Ensembl ].
VAR_059511
Natural varianti85 – 851A → E in allele DPB1*02:01, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:02, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*32:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*48:01, allele DPB1*49:01, allele DPB1*50:01, allele DPB1*51:01, allele DPB1*53:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*81:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*84:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*94:01 and allele DPB1*98:01.
Corresponds to variant rs1042131 [ dbSNP | Ensembl ].
VAR_033438
Natural varianti86 – 861E → D in allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*10:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*17:01, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*29:01, allele DPB1*35:01, allele DPB1*44:01, allele DPB1*46:01, allele DPB1*50:01, allele DPB1*57:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*80:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01 and allele DPB1*98:01.
Corresponds to variant rs1042133 [ dbSNP | Ensembl ].
VAR_033439
Natural varianti86 – 861E → V in allele DPB1*32:01.
Corresponds to variant rs41545212 [ dbSNP | Ensembl ].
VAR_060648
Natural varianti89 – 891N → H in allele DPB1*02:03.
Corresponds to variant rs41550319 [ dbSNP | Ensembl ].
VAR_060649
Natural varianti93 – 931D → H in allele DPB1*96:01.
Corresponds to variant rs41560812 [ dbSNP | Ensembl ].
VAR_060650
Natural varianti94 – 941I → F Allele DPB1*41:01 and allele DPB1*83:01.
Corresponds to variant rs1042136 [ dbSNP | Ensembl ].
VAR_059512
Natural varianti94 – 941I → L in allele DPB1*03:01, allele DPB1*03:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*10:02, allele DPB1*11:01, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*17:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*31:01, allele DPB1*34:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*72:01, allele DPB1*73:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*87:01, allele DPB1*91:01, allele DPB1*92:01 and allele DPB1*95:01. 1 Publication
Corresponds to variant rs1042136 [ dbSNP | Ensembl ].
VAR_059513
Natural varianti94 – 941I → N in allele DPB1*60:01.
Corresponds to variant rs41547212 [ dbSNP | Ensembl ].
VAR_060651
Natural varianti98 – 981K → E in allele DPB1*02:01, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*04:03, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:02, allele DPB1*19:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*26:02, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*32:01, allele DPB1*33:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*46:01, allele DPB1*47:01, allele DPB1*48:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*58:01, allele DPB1*71:01, allele DPB1*81:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*93:01 and allele DPB1*95:01.
Corresponds to variant rs1042140 [ dbSNP | Ensembl ].
VAR_033440
Natural varianti98 – 981K → R in allele DPB1*11:01, allele DPB1*15:01, allele DPB1*69:01 and allele DPB1*74:01.
Corresponds to variant rs12722027 [ dbSNP | Ensembl ].
VAR_033441
Natural varianti99 – 991R → W in allele DPB1*94:01.
Corresponds to variant rs41554314 [ dbSNP | Ensembl ].
VAR_060652
Natural varianti101 – 1011V → L in allele DPB1*31:01 and allele DPB1*34:01.
Corresponds to variant rs41546618 [ dbSNP | Ensembl ].
VAR_060653
Natural varianti102 – 1021P → L in allele DPB1*78:01.
Corresponds to variant rs41551920 [ dbSNP | Ensembl ].
VAR_060654
Natural varianti105 – 1051M → I in allele DPB1*08:02, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*13:02 and allele DPB1*19:01.
Corresponds to variant rs1042153 [ dbSNP | Ensembl ].
VAR_033443
Natural varianti105 – 1051M → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*17:02, allele DPB1*21:02, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*29:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*88:01, allele DPB1*90:01 and allele DPB1*92:01. 1 Publication
Corresponds to variant rs1042151 [ dbSNP | Ensembl ].
VAR_033442
Natural varianti113 – 1131G → D in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 Publication
Corresponds to variant rs1042169 [ dbSNP | Ensembl ].
VAR_060657
Natural varianti113 – 1131G → N in allele DPB1*22:02; requires 2 nucleotide substitutions.
VAR_060655
Natural varianti113 – 1131G → V in allele DPB1*15:01, allele DPB1*18:01, allele DPB1*28:01, allele DPB1*34:01, allele DPB1*40:01, allele DPB1*53:01, allele DPB1*62:01 and allele DPB1*74:01.
Corresponds to variant rs1042169 [ dbSNP | Ensembl ].
VAR_060656
Natural varianti114 – 1141G → E in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 Publication
Corresponds to variant rs9277354 [ dbSNP | Ensembl ].
VAR_033444
Natural varianti115 – 1151P → A in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 Publication
Corresponds to variant rs9277355 [ dbSNP | Ensembl ].
VAR_033445
Natural varianti116 – 1161M → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. 1 Publication
Corresponds to variant rs9277356 [ dbSNP | Ensembl ].
VAR_033446
Natural varianti120 – 1201R → H in allele DPB1*82:01 and allele DPB1*85:01.
Corresponds to variant rs41541915 [ dbSNP | Ensembl ].
VAR_060658
Natural varianti125 – 1251R → K in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*14:01, allele DPB1*15:01, allele DPB1*18:01, allele DPB1*19:01, allele DPB1*20:01, allele DPB1*26:01, allele DPB1*45:01 and allele DPB1*85:01. 1 Publication
Corresponds to variant rs1126537 [ dbSNP | Ensembl ].
VAR_060659
Natural varianti199 – 1991T → I in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*14:01, allele DPB1*15:01, allele DPB1*18:01, allele DPB1*19:01, allele DPB1*20:01, allele DPB1*26:01, allele DPB1*45:01 and allele DPB1*85:01. 1 Publication
Corresponds to variant rs1042335 [ dbSNP | Ensembl ].
VAR_060660
Natural varianti207 – 2071L → M in allele DPB1*04:02.
Corresponds to variant rs14362 [ dbSNP | Ensembl ].
VAR_033447
Natural varianti223 – 2231R → Q in allele DPB1*01:01.
Corresponds to variant rs9276 [ dbSNP | Ensembl ].
VAR_050393
Natural varianti234 – 2341V → M in allele DPB1*05:01 and allele DPB1*19:01.
Corresponds to variant rs11551421 [ dbSNP | Ensembl ].
VAR_050394
Natural varianti244 – 2441I → T in allele DPB1*15:01.
Corresponds to variant rs3097675 [ dbSNP | Ensembl ].
VAR_033448

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01426 mRNA. Translation: CAA25672.1.
X02964 Genomic DNA. No translation available.
X03023 Genomic DNA. Translation: CAE82008.1.
X03024 Genomic DNA. Translation: CAE82007.1.
X03022 Genomic DNA. Translation: CAA26823.1.
X03025 Genomic DNA. Translation: CAE82037.1.
X03026 Genomic DNA. Translation: CAE82042.1.
X03028 Genomic DNA. Translation: CAE82073.1.
X03027 Genomic DNA. Translation: CAE82043.1.
X03067 mRNA. Translation: CAA26871.1.
X02228 Genomic DNA. Translation: CAA26147.1.
J03041 mRNA. Translation: AAA35993.1.
M83664 mRNA. Translation: AAA59837.1.
AY804132 mRNA. Translation: AAW78737.1.
AY804133 mRNA. Translation: AAW78738.1.
AY804135 mRNA. Translation: AAW78740.1.
AY804136 mRNA. Translation: AAW78741.1.
AY804137 mRNA. Translation: AAW78742.1.
AY804138 mRNA. Translation: AAW78743.1.
AY804139 mRNA. Translation: AAW78744.1.
AY804141 mRNA. Translation: AAW78746.1.
AY804142 mRNA. Translation: AAW78747.1.
AY804143 mRNA. Translation: AAW78748.1.
AY831401 mRNA. Translation: AAW80919.1.
AY831402 mRNA. Translation: AAW80920.1.
AY831403 mRNA. Translation: AAW80921.1.
AY831404 mRNA. Translation: AAW80922.1.
AY656678 mRNA. Translation: AAV71025.1.
AY656679 mRNA. Translation: AAV71026.1.
AY656680 mRNA. Translation: AAV71027.1.
AK313305 mRNA. Translation: BAG36110.1.
BT019780 mRNA. Translation: AAV38583.1.
AL645931 Genomic DNA. Translation: CAI18042.1.
AL662824 Genomic DNA. Translation: CAI17602.1.
AL805913, AL845446 Genomic DNA. Translation: CAI18551.1.
AL845446, AL805913 Genomic DNA. Translation: CAI95555.1.
BX120009 Genomic DNA. Translation: CAM25984.1.
CR759795 Genomic DNA. Translation: CAQ07437.1.
CR759904 Genomic DNA. Translation: CAQ09869.1.
CR762479 Genomic DNA. Translation: CAQ10348.1.
CH471081 Genomic DNA. Translation: EAX03674.1.
BC007963 mRNA. Translation: AAH07963.1.
BC013184 mRNA. Translation: AAH13184.1.
M28202 mRNA. Translation: AAA53197.1.
Y09327 Genomic DNA. Translation: CAA70507.1.
L31816 Genomic DNA. No translation available.
M97686 Genomic DNA. No translation available.
X96985 Genomic DNA. No translation available.
Y13900 Genomic DNA. Translation: CAA74199.1.
Y14230 Genomic DNA. Translation: CAA74608.1.
Y16095 Genomic DNA. Translation: CAA76060.1.
AY823995 Genomic DNA. Translation: AAW79272.1.
AJ563603 Genomic DNA. Translation: CAD91639.1.
AM039828 Genomic DNA. Translation: CAJ01690.1.
AM408787 Genomic DNA. Translation: CAL64063.1.
AM698036 Genomic DNA. Translation: CAM91695.1.
M84619 Genomic DNA. No translation available.
M84620 Genomic DNA. No translation available.
M84622 Genomic DNA. No translation available.
M84623 Genomic DNA. No translation available.
M84624 Genomic DNA. No translation available.
M84626 Genomic DNA. No translation available.
X82123 Genomic DNA. Translation: CAA57635.1.
U22311 Genomic DNA. Translation: AAB60413.1.
U22313 Genomic DNA. Translation: AAB17108.1.
K01615 mRNA. Translation: AAA36313.1.
FM883600 Genomic DNA. Translation: CAT04585.2.
FM882212 Genomic DNA. Translation: CAT03206.1.
FM956650 Genomic DNA. Translation: CAX11690.1.
FM991729 Genomic DNA. Translation: CAX20314.1.
FM992080 Genomic DNA. Translation: CAX21583.2.
FM992366 Genomic DNA. Translation: CAX30407.1.
FM992364 Genomic DNA. Translation: CAX30405.1.
FN252853 Genomic DNA. Translation: CAX53275.1.
FN256250 Genomic DNA. Translation: CAX53717.1.
FN256251 Genomic DNA. Translation: CAX53721.1.
FN256254 Genomic DNA. Translation: CAX53718.1.
FN256253 Genomic DNA. Translation: CAX53726.1.
FN256255 Genomic DNA. Translation: CAX53722.1.
FN393829 Genomic DNA. Translation: CAY85528.1.
M23675 Genomic DNA. Translation: AAA59740.1.
M62326 Genomic DNA. Translation: AAA59719.1.
M62331 Genomic DNA. Translation: AAA59724.1.
L07768 Genomic DNA. Translation: AAA59690.1.
D13174 Genomic DNA. Translation: BAA02465.1.
D10834 Genomic DNA. Translation: BAA01614.1.
D28809 Genomic DNA. Translation: BAA05970.1.
X96986 Genomic DNA. Translation: CAA65710.2.
X91886 Genomic DNA. No translation available.
Y18498 Genomic DNA. Translation: CAC12860.1.
AJ238005 Genomic DNA. Translation: CAC12865.1.
AJ271373 Genomic DNA. Translation: CAB70605.2.
AF288354 Genomic DNA. Translation: AAG30143.1.
AJ292074 Genomic DNA. Translation: CAC27995.1.
AF536241 Genomic DNA. Translation: AAN33050.1.
AF549409 Genomic DNA. Translation: AAQ12563.1.
AF549410 Genomic DNA. Translation: AAQ12564.1. Frameshift.
AJ514871 Genomic DNA. Translation: CAD55852.1.
AY374100 Genomic DNA. Translation: AAR21105.1.
DQ206450 Genomic DNA. Translation: ABB17974.1.
M83914 Genomic DNA. Translation: AAA36264.1.
M83915 Genomic DNA. Translation: AAA36259.1.
M83916 Genomic DNA. Translation: AAA36260.1.
M83917 Genomic DNA. Translation: AAA36261.1.
M83918 Genomic DNA. Translation: AAA36262.1.
M83919 Genomic DNA. Translation: AAA36263.1.
AJ297820 Genomic DNA. Translation: CAC14048.1.
AY029777 Genomic DNA. Translation: AAK40344.1.
AF489518 Genomic DNA. Translation: AAL92172.1.
AF492640 Genomic DNA. Translation: AAO84765.1.
AY425707 Genomic DNA. Translation: AAR29060.1.
AY572830 Genomic DNA. Translation: AAS77869.1.
AY855160 Genomic DNA. Translation: AAW33682.1.
AY855161 Genomic DNA. Translation: AAW33683.1.
DQ089022 Genomic DNA. Translation: AAY98352.1.
AB247517 Genomic DNA. Translation: BAE78492.1.
DQ386161 Genomic DNA. Translation: ABD36812.1.
DQ485789 Genomic DNA. Translation: ABF47047.1.
AM887530 Genomic DNA. Translation: CAP08783.1.
FM211032 Genomic DNA. Translation: CAR66500.1.
FJ976693 Genomic DNA. Translation: ACS12738.1.
L17310 Genomic DNA. Translation: AAA53479.1.
L17311 Genomic DNA. Translation: AAA53480.1.
L17313 Genomic DNA. Translation: AAA53481.1.
L17314 Genomic DNA. Translation: AAA53482.1.
L22076 Genomic DNA. Translation: AAA53476.1.
L22077 Genomic DNA. Translation: AAA53477.1.
L23400 Genomic DNA. Translation: AAA58441.1.
U59437 Genomic DNA. Translation: AAD09481.1.
U59438 Genomic DNA. Translation: AAD09482.1.
U59439 Genomic DNA. Translation: AAD09483.1.
U59440 Genomic DNA. Translation: AAD09484.1.
U59441 Genomic DNA. Translation: AAD09485.1.
U59442 Genomic DNA. Translation: AAD09486.1.
AF074845 Genomic DNA. Translation: AAD39682.1.
AF074846 Genomic DNA. Translation: AAD39683.1.
AY033075 Genomic DNA. Translation: AAK51161.1.
U34033 Genomic DNA. Translation: AAA81335.1.
Z92523 Genomic DNA. Translation: CAB06822.1.
X78042 Genomic DNA. No translation available.
U29534 Genomic DNA. Translation: AAB52511.1.
AY618897 Genomic DNA. Translation: AAT40308.1.
X97406 Genomic DNA. Translation: CAA66059.1.
L01466 Genomic DNA. No translation available.
M87046 Genomic DNA. No translation available.
D10478 Genomic DNA. Translation: BAA01281.1.
D10882 Genomic DNA. Translation: BAA01704.1.
U94839 Genomic DNA. Translation: AAC64232.1.
X80752 Genomic DNA. Translation: CAA56728.1.
AF077015 Genomic DNA. Translation: AAC26835.1.
K00409 mRNA. Translation: AAA36312.1.
CCDSiCCDS4765.1.
PIRiA02228. HLHUS1.
A02229. HLHUPB.
D30536.
D30537.
E30536.
I37298.
I37541. S49382.
I38195. HLHUS2.
I38197.
I59621.
I59637.
I59641.
I81234.
I81235.
I81236.
I81237.
I81238.
RefSeqiNP_002112.3. NM_002121.5.
UniGeneiHs.485130.

Genome annotation databases

EnsembliENST00000399500; ENSP00000382422; ENSG00000215048.
ENST00000411749; ENSP00000414196; ENSG00000236693.
ENST00000418931; ENSP00000408146; ENSG00000223865.
ENST00000425130; ENSP00000396095; ENSG00000230763.
ENST00000433800; ENSP00000407674; ENSG00000226826.
ENST00000454006; ENSP00000389288; ENSG00000237710.
GeneIDi3115.
KEGGihsa:3115.
UCSCiuc003ocu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01426 mRNA. Translation: CAA25672.1.
X02964 Genomic DNA. No translation available.
X03023 Genomic DNA. Translation: CAE82008.1.
X03024 Genomic DNA. Translation: CAE82007.1.
X03022 Genomic DNA. Translation: CAA26823.1.
X03025 Genomic DNA. Translation: CAE82037.1.
X03026 Genomic DNA. Translation: CAE82042.1.
X03028 Genomic DNA. Translation: CAE82073.1.
X03027 Genomic DNA. Translation: CAE82043.1.
X03067 mRNA. Translation: CAA26871.1.
X02228 Genomic DNA. Translation: CAA26147.1.
J03041 mRNA. Translation: AAA35993.1.
M83664 mRNA. Translation: AAA59837.1.
AY804132 mRNA. Translation: AAW78737.1.
AY804133 mRNA. Translation: AAW78738.1.
AY804135 mRNA. Translation: AAW78740.1.
AY804136 mRNA. Translation: AAW78741.1.
AY804137 mRNA. Translation: AAW78742.1.
AY804138 mRNA. Translation: AAW78743.1.
AY804139 mRNA. Translation: AAW78744.1.
AY804141 mRNA. Translation: AAW78746.1.
AY804142 mRNA. Translation: AAW78747.1.
AY804143 mRNA. Translation: AAW78748.1.
AY831401 mRNA. Translation: AAW80919.1.
AY831402 mRNA. Translation: AAW80920.1.
AY831403 mRNA. Translation: AAW80921.1.
AY831404 mRNA. Translation: AAW80922.1.
AY656678 mRNA. Translation: AAV71025.1.
AY656679 mRNA. Translation: AAV71026.1.
AY656680 mRNA. Translation: AAV71027.1.
AK313305 mRNA. Translation: BAG36110.1.
BT019780 mRNA. Translation: AAV38583.1.
AL645931 Genomic DNA. Translation: CAI18042.1.
AL662824 Genomic DNA. Translation: CAI17602.1.
AL805913, AL845446 Genomic DNA. Translation: CAI18551.1.
AL845446, AL805913 Genomic DNA. Translation: CAI95555.1.
BX120009 Genomic DNA. Translation: CAM25984.1.
CR759795 Genomic DNA. Translation: CAQ07437.1.
CR759904 Genomic DNA. Translation: CAQ09869.1.
CR762479 Genomic DNA. Translation: CAQ10348.1.
CH471081 Genomic DNA. Translation: EAX03674.1.
BC007963 mRNA. Translation: AAH07963.1.
BC013184 mRNA. Translation: AAH13184.1.
M28202 mRNA. Translation: AAA53197.1.
Y09327 Genomic DNA. Translation: CAA70507.1.
L31816 Genomic DNA. No translation available.
M97686 Genomic DNA. No translation available.
X96985 Genomic DNA. No translation available.
Y13900 Genomic DNA. Translation: CAA74199.1.
Y14230 Genomic DNA. Translation: CAA74608.1.
Y16095 Genomic DNA. Translation: CAA76060.1.
AY823995 Genomic DNA. Translation: AAW79272.1.
AJ563603 Genomic DNA. Translation: CAD91639.1.
AM039828 Genomic DNA. Translation: CAJ01690.1.
AM408787 Genomic DNA. Translation: CAL64063.1.
AM698036 Genomic DNA. Translation: CAM91695.1.
M84619 Genomic DNA. No translation available.
M84620 Genomic DNA. No translation available.
M84622 Genomic DNA. No translation available.
M84623 Genomic DNA. No translation available.
M84624 Genomic DNA. No translation available.
M84626 Genomic DNA. No translation available.
X82123 Genomic DNA. Translation: CAA57635.1.
U22311 Genomic DNA. Translation: AAB60413.1.
U22313 Genomic DNA. Translation: AAB17108.1.
K01615 mRNA. Translation: AAA36313.1.
FM883600 Genomic DNA. Translation: CAT04585.2.
FM882212 Genomic DNA. Translation: CAT03206.1.
FM956650 Genomic DNA. Translation: CAX11690.1.
FM991729 Genomic DNA. Translation: CAX20314.1.
FM992080 Genomic DNA. Translation: CAX21583.2.
FM992366 Genomic DNA. Translation: CAX30407.1.
FM992364 Genomic DNA. Translation: CAX30405.1.
FN252853 Genomic DNA. Translation: CAX53275.1.
FN256250 Genomic DNA. Translation: CAX53717.1.
FN256251 Genomic DNA. Translation: CAX53721.1.
FN256254 Genomic DNA. Translation: CAX53718.1.
FN256253 Genomic DNA. Translation: CAX53726.1.
FN256255 Genomic DNA. Translation: CAX53722.1.
FN393829 Genomic DNA. Translation: CAY85528.1.
M23675 Genomic DNA. Translation: AAA59740.1.
M62326 Genomic DNA. Translation: AAA59719.1.
M62331 Genomic DNA. Translation: AAA59724.1.
L07768 Genomic DNA. Translation: AAA59690.1.
D13174 Genomic DNA. Translation: BAA02465.1.
D10834 Genomic DNA. Translation: BAA01614.1.
D28809 Genomic DNA. Translation: BAA05970.1.
X96986 Genomic DNA. Translation: CAA65710.2.
X91886 Genomic DNA. No translation available.
Y18498 Genomic DNA. Translation: CAC12860.1.
AJ238005 Genomic DNA. Translation: CAC12865.1.
AJ271373 Genomic DNA. Translation: CAB70605.2.
AF288354 Genomic DNA. Translation: AAG30143.1.
AJ292074 Genomic DNA. Translation: CAC27995.1.
AF536241 Genomic DNA. Translation: AAN33050.1.
AF549409 Genomic DNA. Translation: AAQ12563.1.
AF549410 Genomic DNA. Translation: AAQ12564.1. Frameshift.
AJ514871 Genomic DNA. Translation: CAD55852.1.
AY374100 Genomic DNA. Translation: AAR21105.1.
DQ206450 Genomic DNA. Translation: ABB17974.1.
M83914 Genomic DNA. Translation: AAA36264.1.
M83915 Genomic DNA. Translation: AAA36259.1.
M83916 Genomic DNA. Translation: AAA36260.1.
M83917 Genomic DNA. Translation: AAA36261.1.
M83918 Genomic DNA. Translation: AAA36262.1.
M83919 Genomic DNA. Translation: AAA36263.1.
AJ297820 Genomic DNA. Translation: CAC14048.1.
AY029777 Genomic DNA. Translation: AAK40344.1.
AF489518 Genomic DNA. Translation: AAL92172.1.
AF492640 Genomic DNA. Translation: AAO84765.1.
AY425707 Genomic DNA. Translation: AAR29060.1.
AY572830 Genomic DNA. Translation: AAS77869.1.
AY855160 Genomic DNA. Translation: AAW33682.1.
AY855161 Genomic DNA. Translation: AAW33683.1.
DQ089022 Genomic DNA. Translation: AAY98352.1.
AB247517 Genomic DNA. Translation: BAE78492.1.
DQ386161 Genomic DNA. Translation: ABD36812.1.
DQ485789 Genomic DNA. Translation: ABF47047.1.
AM887530 Genomic DNA. Translation: CAP08783.1.
FM211032 Genomic DNA. Translation: CAR66500.1.
FJ976693 Genomic DNA. Translation: ACS12738.1.
L17310 Genomic DNA. Translation: AAA53479.1.
L17311 Genomic DNA. Translation: AAA53480.1.
L17313 Genomic DNA. Translation: AAA53481.1.
L17314 Genomic DNA. Translation: AAA53482.1.
L22076 Genomic DNA. Translation: AAA53476.1.
L22077 Genomic DNA. Translation: AAA53477.1.
L23400 Genomic DNA. Translation: AAA58441.1.
U59437 Genomic DNA. Translation: AAD09481.1.
U59438 Genomic DNA. Translation: AAD09482.1.
U59439 Genomic DNA. Translation: AAD09483.1.
U59440 Genomic DNA. Translation: AAD09484.1.
U59441 Genomic DNA. Translation: AAD09485.1.
U59442 Genomic DNA. Translation: AAD09486.1.
AF074845 Genomic DNA. Translation: AAD39682.1.
AF074846 Genomic DNA. Translation: AAD39683.1.
AY033075 Genomic DNA. Translation: AAK51161.1.
U34033 Genomic DNA. Translation: AAA81335.1.
Z92523 Genomic DNA. Translation: CAB06822.1.
X78042 Genomic DNA. No translation available.
U29534 Genomic DNA. Translation: AAB52511.1.
AY618897 Genomic DNA. Translation: AAT40308.1.
X97406 Genomic DNA. Translation: CAA66059.1.
L01466 Genomic DNA. No translation available.
M87046 Genomic DNA. No translation available.
D10478 Genomic DNA. Translation: BAA01281.1.
D10882 Genomic DNA. Translation: BAA01704.1.
U94839 Genomic DNA. Translation: AAC64232.1.
X80752 Genomic DNA. Translation: CAA56728.1.
AF077015 Genomic DNA. Translation: AAC26835.1.
K00409 mRNA. Translation: AAA36312.1.
CCDSiCCDS4765.1.
PIRiA02228. HLHUS1.
A02229. HLHUPB.
D30536.
D30537.
E30536.
I37298.
I37541. S49382.
I38195. HLHUS2.
I38197.
I59621.
I59637.
I59641.
I81234.
I81235.
I81236.
I81237.
I81238.
RefSeqiNP_002112.3. NM_002121.5.
UniGeneiHs.485130.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LQZX-ray3.25B33-218[»]
4P4KX-ray2.80B/F32-218[»]
4P4RX-ray3.00B/D32-218[»]
4P57X-ray2.60B/D33-218[»]
4P5KX-ray2.59B/E33-218[»]
4P5MX-ray1.70B/D/F/H33-218[»]
ProteinModelPortaliP04440.
SMRiP04440. Positions 33-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109360. 37 interactions.
IntActiP04440. 9 interactions.
STRINGi9606.ENSP00000408146.

PTM databases

iPTMnetiP04440.
PhosphoSiteiP04440.
SwissPalmiP04440.

Polymorphism and mutation databases

BioMutaiHLA-DPB1.
DMDMi122263.

Proteomic databases

PaxDbiP04440.
PeptideAtlasiP04440.
PRIDEiP04440.

Protocols and materials databases

DNASUi3115.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399500; ENSP00000382422; ENSG00000215048.
ENST00000411749; ENSP00000414196; ENSG00000236693.
ENST00000418931; ENSP00000408146; ENSG00000223865.
ENST00000425130; ENSP00000396095; ENSG00000230763.
ENST00000433800; ENSP00000407674; ENSG00000226826.
ENST00000454006; ENSP00000389288; ENSG00000237710.
GeneIDi3115.
KEGGihsa:3115.
UCSCiuc003ocu.3. human.

Organism-specific databases

CTDi3115.
GeneCardsiHLA-DPB1.
HGNCiHGNC:4940. HLA-DPB1.
HPAiHPA011078.
MalaCardsiHLA-DPB1.
MIMi142858. gene.
neXtProtiNX_P04440.
Orphaneti133. Chronic berylliosis.
900. Granulomatosis with polyangiitis.
PharmGKBiPA35064.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
GeneTreeiENSGT00760000118970.
HOVERGENiHBG012730.
InParanoidiP04440.
KOiK06752.
OMAiIGAENAN.
OrthoDBiEOG091G0W5S.
PhylomeDBiP04440.
TreeFamiTF336626.

Enzyme and pathway databases

ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSiHLA-DPB1. human.
EvolutionaryTraceiP04440.
GeneWikiiHLA-DPB1.
GenomeRNAii3115.
PROiP04440.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215048.
CleanExiHS_HLA-DPB1.
ExpressionAtlasiP04440. baseline and differential.
GenevisibleiP04440. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPB1_HUMAN
AccessioniPrimary (citable) accession number: P04440
Secondary accession number(s): A0PFJ7
, A5I886, A8YPB3, B5U8B4, B7VF80, B7VF87, B8ZX68, B8ZYT0, B9W5S8, B9W6F7, B9W6F9, C0MPP5, C0MPQ2, C0MPQ3, C0MPQ5, C0MPQ6, C0MPQ7, C4R9J5, C5IZL1, O00259, O19698, O19700, O19702, O19749, O46884, O77952, O98215, O98216, O98217, O98218, O98219, O98222, O98223, P01916, P04232, P13763, P79493, P79608, Q0P0L4, Q0ZFN3, Q14279, Q27S71, Q29682, Q29684, Q29698, Q29714, Q29775, Q29776, Q29778, Q29779, Q29781, Q29827, Q29828, Q29879, Q29880, Q29898, Q29977, Q2MGW3, Q30015, Q30031, Q30032, Q30033, Q30034, Q30050, Q30051, Q30052, Q30053, Q30054, Q30055, Q30174, Q4GY31, Q4JHD8, Q5ENE0, Q5ENE1, Q5ENW3, Q5EP46, Q5EP47, Q5EP49, Q5EP51, Q5EP52, Q5EP53, Q5EP56, Q5I4H8, Q5I4H9, Q5ISH4, Q5ISH5, Q5SQ73, Q5STP2, Q5YLA6, Q6IVX1, Q6LBX2, Q6LBX3, Q6LBX4, Q6LBX5, Q6LBX6, Q6LBX7, Q6PWX6, Q6TAS4, Q714U1, Q714U2, Q7YQ10, Q860Z7, Q8HWL7, Q8HWT5, Q8SNC4, Q95HC1, Q95IT7, Q95IT8, Q9BD13, Q9GIM2, Q9GIM4, Q9GIX6, Q9GJ41, Q9MY67, Q9TNT7, Q9TQE2, Q9XS11, Q9XS12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.