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P04440 (DPB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
HLA class II histocompatibility antigen, DP beta 1 chain
Alternative name(s):
HLA class II histocompatibility antigen, DP(W4) beta chain
MHC class II antigen DPB1
Gene names
Name:HLA-DPB1
Synonyms:HLA-DP1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Subunit structure

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Polymorphism

The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02, DPB1*02:03, DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01, DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02, DPB1*13:01, DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01, DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02, DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02, DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01, DPB1*36:01, DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01, DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01, DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01, DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01, DPB1*76:01, DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01, DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01, DPB1*94:01, DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of DPB1*04:01.

Sequence similarities

Belongs to the MHC class II family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence caution

The sequence AAQ12564.1 differs from that shown. Reason: Frameshift at position 39.

Ontologies

Keywords
   Biological processImmunity
   Cellular componentCell membrane
Endoplasmic reticulum
Endosome
Golgi apparatus
Lysosome
Membrane
MHC II
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell costimulation

Traceable author statement. Source: Reactome

T cell receptor signaling pathway

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class II

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi membrane

Traceable author statement. Source: Reactome

MHC class II protein complex

Inferred from electronic annotation. Source: UniProtKB-KW

clathrin-coated endocytic vesicle membrane

Traceable author statement. Source: Reactome

endocytic vesicle membrane

Traceable author statement. Source: Reactome

endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

lysosomal membrane

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

trans-Golgi network membrane

Traceable author statement. Source: Reactome

transport vesicle membrane

Traceable author statement. Source: Reactome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929
Chain30 – 258229HLA class II histocompatibility antigen, DP beta 1 chain
PRO_0000018984

Regions

Topological domain30 – 225196Extracellular Potential
Transmembrane226 – 24621Helical; Potential
Topological domain247 – 25812Cytoplasmic Potential
Domain124 – 21289Ig-like C1-type
Region30 – 12192Beta-1
Region122 – 21594Beta-2
Region216 – 22510Connecting peptide

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Disulfide bond44 ↔ 106 By similarity
Disulfide bond144 ↔ 200 By similarity

Natural variations

Natural variant161T → M in allele DPB1*09:02.
Corresponds to variant rs41558014 [ dbSNP | Ensembl ].
VAR_060627
Natural variant241T → I.
Corresponds to variant rs11551416 [ dbSNP | Ensembl ].
VAR_060628
Natural variant301R → P in allele DPB1*75:01.
VAR_060629
Natural variant311A → L in allele DPB1*75:01; requires 2 nucleotide substitutions.
VAR_060630
Natural variant321T → P in allele DPB1*75:01.
VAR_060631
Natural variant331P → A in allele DPB1*75:01.
VAR_060632
Natural variant371L → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01 and allele DPB1*98:01.
Corresponds to variant rs1126504 [ dbSNP | Ensembl ].
VAR_060633
Natural variant381F → D in allele DPB1*70:01; requires 2 nucleotide substitutions.
VAR_060635
Natural variant381F → H in allele DPB1*09:01, allele DPB1*10:01, allele DPB1*14:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*22:02, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*45:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*76:01, allele DPB1*86:01, allele DPB1*91:01 and allele DPB1*98:01; requires 2 nucleotide substitutions.
VAR_060634
Natural variant381F → L.
Corresponds to variant rs12722013 [ dbSNP | Ensembl ].
VAR_060636
Natural variant381F → Y in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:02, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*56:01, allele DPB1*69:01, allele DPB1*74:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*92:01 and allele DPB1*93:01.
Corresponds to variant rs1126509 [ dbSNP | Ensembl ].
VAR_033433
Natural variant401G → L in allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*66:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*85:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01 and allele DPB1*98:01; requires 2 nucleotide substitutions.
VAR_060637
Natural variant401G → V.
Corresponds to variant rs1126513 [ dbSNP | Ensembl ].
VAR_033434
Natural variant411R → L in allele DPB1*77:01.
Corresponds to variant rs41540313 [ dbSNP | Ensembl ].
VAR_060638
Natural variant441C → G in allele DPB1*26:02.
VAR_060639
Natural variant461A → P in allele DPB1*38:01.
Corresponds to variant rs41555313 [ dbSNP | Ensembl ].
VAR_060640
Natural variant461A → T in allele DPB1*18:02.
Corresponds to variant rs41555313 [ dbSNP | Ensembl ].
VAR_060641
Natural variant571Y → D in allele DPB1*99:01.
Corresponds to variant rs41553416 [ dbSNP | Ensembl ].
VAR_060642
Natural variant611R → P in allele DPB1*14:02 and allele DPB1*21:02.
Corresponds to variant rs41561114 [ dbSNP | Ensembl ].
VAR_060643
Natural variant621E → Q Ind allele DPB1*11:01, allele DPB1*15:01 and allele DPB1*74:01.
Corresponds to variant rs12722018 [ dbSNP | Ensembl ].
VAR_033435
Natural variant641F → L in allele DPB1*02:02, allele DPB1*02:03, allele DPB1*05:01, allele DPB1*15:02, allele DPB1*17:02, allele DPB1*19:02, allele DPB1*21:01, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*34:01, allele DPB1*36:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*48:01, allele DPB1*58:01, allele DPB1*62:01, allele DPB1*63:01, allele DPB1*95:01 and allele DPB1*97:01.
Corresponds to variant rs9277348 [ dbSNP | Ensembl ].
VAR_060644
Natural variant641F → Y in allele DPB1*01:01, allele DPB1*01:02, allele DPB1*09:02, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*15:01, allele DPB1*20:02, allele DPB1*21:02, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*39:01, allele DPB1*40:01, allele DPB1*49:01, allele DPB1*53:01, allele DPB1*65:01, allele DPB1*74:01, allele DPB1*85:01, allele DPB1*89:01 and allele DPB1*96:01.
Corresponds to variant rs1042117 [ dbSNP | Ensembl ].
VAR_033436
Natural variant651A → V in allele DPB1*01:02, allele DPB1*02:01, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:01, allele DPB1*19:02, allele DPB1*21:01, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*23:01, allele DPB1*25:01, allele DPB1*26:02, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*32:01, allele DPB1*34:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*47:01, allele DPB1*48:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*62:01, allele DPB1*63:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*71:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*84:01, allele DPB1*86:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*93:01, allele DPB1*94:01, allele DPB1*95:01, allele DPB1*97:01 and allele DPB1*98:01.
Corresponds to variant rs1042121 [ dbSNP | Ensembl ].
VAR_033437
Natural variant681D → Y in allele DPB1*24:02.
VAR_060645
Natural variant721G → W in allele DPB1*97:01.
Corresponds to variant rs41552915 [ dbSNP | Ensembl ].
VAR_060646
Natural variant841A → D in allele DPB1*02:01, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:01, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:02, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*32:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*48:01, allele DPB1*49:01, allele DPB1*50:01, allele DPB1*51:01, allele DPB1*53:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*81:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*94:01 and allele DPB1*98:01.
Corresponds to variant rs707958 [ dbSNP | Ensembl ].
VAR_054662
Natural variant841A → E in allele DPB1*01:02, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*05:01, allele DPB1*08:02, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*24:01, allele DPB1*30:01, allele DPB1*36:01, allele DPB1*38:01, allele DPB1*47:01, allele DPB1*54:01, allele DPB1*84:01 and allele DPB1*97:01.
VAR_060647
Natural variant841A → V.
Corresponds to variant rs707958 [ dbSNP | Ensembl ].
VAR_059511
Natural variant851A → E in allele DPB1*02:01, allele DPB1*03:01, allele DPB1*04:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*06:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*10:02, allele DPB1*11:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:01, allele DPB1*18:02, allele DPB1*19:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:02, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*32:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*46:01, allele DPB1*48:01, allele DPB1*49:01, allele DPB1*50:01, allele DPB1*51:01, allele DPB1*53:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*60:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*77:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*80:01, allele DPB1*81:01, allele DPB1*82:01, allele DPB1*83:01, allele DPB1*84:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*94:01 and allele DPB1*98:01.
Corresponds to variant rs1042131 [ dbSNP | Ensembl ].
VAR_033438
Natural variant861E → D in allele DPB1*03:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*10:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*17:01, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*29:01, allele DPB1*35:01, allele DPB1*44:01, allele DPB1*46:01, allele DPB1*50:01, allele DPB1*57:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*80:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*91:01, allele DPB1*92:01 and allele DPB1*98:01.
Corresponds to variant rs1042133 [ dbSNP | Ensembl ].
VAR_033439
Natural variant861E → V in allele DPB1*32:01.
Corresponds to variant rs41545212 [ dbSNP | Ensembl ].
VAR_060648
Natural variant891N → H in allele DPB1*02:03.
Corresponds to variant rs41550319 [ dbSNP | Ensembl ].
VAR_060649
Natural variant931D → H in allele DPB1*96:01.
Corresponds to variant rs41560812 [ dbSNP | Ensembl ].
VAR_060650
Natural variant941I → F Allele DPB1*41:01 and allele DPB1*83:01.
Corresponds to variant rs1042136 [ dbSNP | Ensembl ].
VAR_059512
Natural variant941I → L in allele DPB1*03:01, allele DPB1*03:02, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*10:02, allele DPB1*11:01, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*15:01, allele DPB1*17:02, allele DPB1*20:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*28:01, allele DPB1*29:01, allele DPB1*31:01, allele DPB1*34:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*59:01, allele DPB1*67:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*72:01, allele DPB1*73:01, allele DPB1*74:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*87:01, allele DPB1*91:01, allele DPB1*92:01 and allele DPB1*95:01. Ref.28
Corresponds to variant rs1042136 [ dbSNP | Ensembl ].
VAR_059513
Natural variant941I → N in allele DPB1*60:01.
Corresponds to variant rs41547212 [ dbSNP | Ensembl ].
VAR_060651
Natural variant981K → E in allele DPB1*02:01, allele DPB1*02:02, allele DPB1*02:03, allele DPB1*04:03, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:02, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*16:01, allele DPB1*16:02, allele DPB1*17:01, allele DPB1*18:02, allele DPB1*19:01, allele DPB1*20:02, allele DPB1*21:01, allele DPB1*22:01, allele DPB1*26:02, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*32:01, allele DPB1*33:01, allele DPB1*37:01, allele DPB1*41:01, allele DPB1*44:01, allele DPB1*46:01, allele DPB1*47:01, allele DPB1*48:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*58:01, allele DPB1*71:01, allele DPB1*81:01, allele DPB1*86:01, allele DPB1*88:01, allele DPB1*93:01 and allele DPB1*95:01.
Corresponds to variant rs1042140 [ dbSNP | Ensembl ].
VAR_033440
Natural variant981K → R in allele DPB1*11:01, allele DPB1*15:01, allele DPB1*69:01 and allele DPB1*74:01.
Corresponds to variant rs12722027 [ dbSNP | Ensembl ].
VAR_033441
Natural variant991R → W in allele DPB1*94:01.
Corresponds to variant rs41554314 [ dbSNP | Ensembl ].
VAR_060652
Natural variant1011V → L in allele DPB1*31:01 and allele DPB1*34:01.
Corresponds to variant rs41546618 [ dbSNP | Ensembl ].
VAR_060653
Natural variant1021P → L in allele DPB1*78:01.
Corresponds to variant rs41551920 [ dbSNP | Ensembl ].
VAR_060654
Natural variant1051M → I in allele DPB1*08:02, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*13:02 and allele DPB1*19:01.
Corresponds to variant rs1042153 [ dbSNP | Ensembl ].
VAR_033443
Natural variant1051M → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:02, allele DPB1*08:01, allele DPB1*09:01, allele DPB1*10:01, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*17:02, allele DPB1*21:02, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*29:01, allele DPB1*35:01, allele DPB1*37:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*70:01, allele DPB1*73:01, allele DPB1*75:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*88:01, allele DPB1*90:01 and allele DPB1*92:01. Ref.28
Corresponds to variant rs1042151 [ dbSNP | Ensembl ].
VAR_033442
Natural variant1131G → D in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. Ref.28
Corresponds to variant rs1042169 [ dbSNP | Ensembl ].
VAR_060657
Natural variant1131G → N in allele DPB1*22:02; requires 2 nucleotide substitutions.
VAR_060655
Natural variant1131G → V in allele DPB1*15:01, allele DPB1*18:01, allele DPB1*28:01, allele DPB1*34:01, allele DPB1*40:01, allele DPB1*53:01, allele DPB1*62:01 and allele DPB1*74:01.
Corresponds to variant rs1042169 [ dbSNP | Ensembl ].
VAR_060656
Natural variant1141G → E in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. Ref.28
Corresponds to variant rs9277354 [ dbSNP | Ensembl ].
VAR_033444
Natural variant1151P → A in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*57:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. Ref.28
Corresponds to variant rs9277355 [ dbSNP | Ensembl ].
VAR_033445
Natural variant1161M → V in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*03:02, allele DPB1*04:03, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*08:01, allele DPB1*08:02, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*10:01, allele DPB1*11:01, allele DPB1*13:01, allele DPB1*13:02, allele DPB1*14:01, allele DPB1*14:02, allele DPB1*16:01, allele DPB1*17:01, allele DPB1*17:02, allele DPB1*19:01, allele DPB1*21:01, allele DPB1*21:02, allele DPB1*20:01, allele DPB1*22:01, allele DPB1*22:02, allele DPB1*25:01, allele DPB1*25:02, allele DPB1*26:01, allele DPB1*27:01, allele DPB1*29:01, allele DPB1*30:01, allele DPB1*31:01, allele DPB1*35:01, allele DPB1*36:01, allele DPB1*37:01, allele DPB1*38:01, allele DPB1*44:01, allele DPB1*45:01, allele DPB1*50:01, allele DPB1*52:01, allele DPB1*54:01, allele DPB1*55:01, allele DPB1*56:01, allele DPB1*58:01, allele DPB1*63:01, allele DPB1*65:01, allele DPB1*67:01, allele DPB1*68:01, allele DPB1*69:01, allele DPB1*70:01, allele DPB1*76:01, allele DPB1*78:01, allele DPB1*79:01, allele DPB1*84:01, allele DPB1*85:01, allele DPB1*87:01, allele DPB1*88:01, allele DPB1*89:01, allele DPB1*90:01, allele DPB1*91:01, allele DPB1*92:01, allele DPB1*93:01, allele DPB1*97:01 and allele DPB1*98:01. Ref.28
Corresponds to variant rs9277356 [ dbSNP | Ensembl ].
VAR_033446
Natural variant1201R → H in allele DPB1*82:01 and allele DPB1*85:01.
Corresponds to variant rs41541915 [ dbSNP | Ensembl ].
VAR_060658
Natural variant1251R → K in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*14:01, allele DPB1*15:01, allele DPB1*18:01, allele DPB1*19:01, allele DPB1*20:01, allele DPB1*26:01, allele DPB1*45:01 and allele DPB1*85:01. Ref.28
Corresponds to variant rs1126537 [ dbSNP | Ensembl ].
VAR_060659
Natural variant1991T → I in allele DPB1*01:01, allele DPB1*03:01, allele DPB1*05:01, allele DPB1*05:02, allele DPB1*06:01, allele DPB1*09:01, allele DPB1*09:02, allele DPB1*13:01, allele DPB1*14:01, allele DPB1*15:01, allele DPB1*18:01, allele DPB1*19:01, allele DPB1*20:01, allele DPB1*26:01, allele DPB1*45:01 and allele DPB1*85:01. Ref.28
Corresponds to variant rs1042335 [ dbSNP | Ensembl ].
VAR_060660
Natural variant2071L → M in allele DPB1*04:02.
Corresponds to variant rs14362 [ dbSNP | Ensembl ].
VAR_033447
Natural variant2231R → Q in allele DPB1*01:01.
Corresponds to variant rs9276 [ dbSNP | Ensembl ].
VAR_050393
Natural variant2341V → M in allele DPB1*05:01 and allele DPB1*19:01.
Corresponds to variant rs11551421 [ dbSNP | Ensembl ].
VAR_050394
Natural variant2441I → T in allele DPB1*15:01.
Corresponds to variant rs3097675 [ dbSNP | Ensembl ].
VAR_033448

Sequences

Sequence LengthMass (Da)Tools
P04440 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: E74777D438DE9C41

FASTA25829,159
        10         20         30         40         50         60 
MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT QRFLERYIYN 

        70         80         90        100        110        120 
REEFARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA VPDRMCRHNY ELGGPMTLQR 

       130        140        150        160        170        180 
RVQPRVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW 

       190        200        210        220        230        240 
TFQILVMLEM TPQQGDVYTC QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFVLGLIIC 

       250 
GVGIFMHRRS KKVQRGSA 

« Hide

References

« Hide 'large scale' references
[1]"Structure and polymorphism of the HLA class II SB light chain genes."
Kappes D.J., Arnot D., Okada K., Strominger J.L.
EMBO J. 3:2985-2993(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*02:01), NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DPB1*03:01 AND DPB1*04:01).
[2]"DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression."
Tonnelle C., Demars R., Long E.O.
EMBO J. 4:2839-2847(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*02:01).
[3]"Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes."
Kelly A., Trowsdale J.
Nucleic Acids Res. 13:1607-1621(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPB1*04:01).
[4]"Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes."
Gustafsson K., Widmark E., Jonsson A.-K., Servenius B., Sachs D.H., Larhammar D., Rask L., Peterson P.A.
J. Biol. Chem. 262:8778-8786(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DPB1*04:01).
[5]"The beta-chains of DP4 molecules from different haplotypes are encoded by the same gene."
Compagnone-Post P., Turco E., Robinson C., Trucco M.
Genomics 2:8-13(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*04:01).
[6]"A new HLA-DPB1 allele from a patient with systemic lupus erythematosus."
Korioth F., Hartung K., Deicher H., Frey J.
Tissue Antigens 39:216-219(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DPB1*01:01).
[7]"Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing."
Reinders J., Rozemuller E.H., van Gent R., Arts-Hilkes Y.H., van den Tweel J.G., Tilanus M.G.J.
Immunogenetics 57:790-794(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DPB1*01:01; DPB1*02:02; DPB1*04:01; DPB1*04:02; DPB1*05:01; DPB1*05:02; DPB1*06:02; DPB1*08:02; DPB1*09:01; DPB1*09:02; DPB1*13:01; DPB1*15:01 AND DPB1*19:01).
[8]Lee E., Kim E., Kwack K.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DPB1*02:02; DPB1*05:01 AND DPB1*13:01).
[9]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DPB1*04:01).
Tissue: Spleen.
[10]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DPB1*01:01).
[11]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DPB1*02:02; DPB1*03:01; DPB1*04:01 AND DPB1*04:02).
[12]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DPB1*04:01).
[13]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELES DPB1*01:01 AND DPB1*04:01).
Tissue: B-cell and Lymph.
[14]"Sequence polymorphism of HLA-DP beta chains."
Lee J.S., Sartoris S., Briata P., Choi E., Cullen C., Lepaslier D., Yunis I.
Immunogenetics 29:346-349(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-258 (ALLELE DPB1*04:01).
[15]"HLA and mtDNA variation among the Baganda in Uganda."
Louie L., Ginther C., Francisco A.M., van der Zwan A.W., Katongole-Mbidde E., Tilanus M.G.J., Klitz W.
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-114 (ALLELE DPB1*75:01).
[16]"HLA-DPB1 alleles in a population from north India and description of a new variant (DPB1*5601)."
Rani R., Fernandez-Vina M.A., Zhang S., Stastny P.
Tissue Antigens 45:264-269(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-122 (ALLELE DPB1*56:01).
[17]"Characterization of novel HLA-DPB1 alleles by oligotyping and nucleotide sequencing."
Hessner M.J., Baxter-Lowe L.A.
Tissue Antigens 40:261-263(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*39:01).
[18]"DPB1*TF, a novel HLA class II DPB1 allele (DPB1*6701) identified in a Turkish family."
Meyer C.G., May J., Simon C., Bohm B.O., Loeliger C.C.
Tissue Antigens 48:231-232(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*67:01).
[19]"Identification of two new DPB1 alleles, DPB1*7701 and *7801, by sequence-based typing."
Voorter C., Richeldi L., Gervais T., van den Berg-Loonen E.
Tissue Antigens 52:190-192(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (DPB1*77:01 AND DPB1*78:01).
[20]"Identification of a new DPB1 allele (DPB1*7901) by sequence-based typing."
Voorter C., Chatelain B., Sintnicolaas K., Tilanus M.G.J., Hidajat M., van den Berg-Loonen E.
Tissue Antigens 52:193-195(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*79:01).
[21]"DNA-sequence determination of exon 2 of a novel HLA-DPB1 allele, HLA-DPB1*0403."
Weston A., Ensey J.S., Frye B.L.
DNA Seq. 16:235-236(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*04:03).
[22]"Two new HLA DP alleles."
Cox S.T., Wallis-Jones S.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*98:01).
Tissue: Blood.
[23]"Sequence of DPB1*0301 allele, and sequence of HLA-DPB1*66new."
Cox S.T.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*20:02), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*14:02).
[24]"Sequence of DPB1*0101 variant."
Casanova A.A.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-121 (ALLELE DPB1*21:02).
[25]"Genetic diversity within the HLA class II region: ten new DPB1 alleles and their population distribution."
Moonsamy P.V., Suraj V.C., Bugawan T.L., Saiki R.K., Stoneking M., Roudier J., Magzoub M.M., Hill A.V., Begovich A.B.
Tissue Antigens 40:153-157(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-119 (ALLELES DPB1*30:01; DPB1*32:01; DPB1*33:01; DPB1*34:01 AND DPB1*35:01), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*27:01).
[26]"Identification of the novel HLA-DPB1*5801 allele detected by sequenced based typing."
Versluis L.F., van der Zwan A.W., Tilanus M.G.J., Daly L.N., Degli-Eposti M.A., Dawkins R.L.
Immunogenetics 41:173-173(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-119 (ALLELE DPB1*58:01).
[27]"Three new DPB1 alleles identified in a Bantu-speaking population from central Cameroon."
Zimmerman P.A., Steiner L.L., Titanji V.P., Nde P.N., Bradley J.E., Pogonka T., Begovich A.B.
Tissue Antigens 47:293-299(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-119 (ALLELES DPB1*60:01 AND DPB1*62:01).
[28]"Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes."
Gorski J., Rollini P., Long E., Mach B.
Proc. Natl. Acad. Sci. U.S.A. 81:3934-3938(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-258, VARIANTS LEU-94; VAL-105; ASP-113; GLU-114; ALA-115; VAL-116; LYS-125 AND ILE-199.
[29]"In a study for acne vulgaris, sequence-based HLA typing showed a novel DPB1 allele, DPB1*2402."
Witter K., Kirchner E., Borelli C., Messer G., Albert T., Zahn R., Kauke T.
Tissue Antigens 74:354-356(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-215 (ALLELE DPB1*24:02).
[30]"Confirmation of several HLA-DPB1 alleles including exon 3."
Witter K., Tran H., Sabine S.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-215 (ALLELES DPB1*06:01; DPB1*16:01; DPB1*17:01; DPB1*18:01; DPB1*20:01; DPB1*23:01; DPB1*26:01; DPB1*26:02; DPB1*28:01; DPB1*45:01; DPB1*55:01; DPB1*85:01 AND DPB1*88:01).
[31]"Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci."
Bugawan T.L., Horn G.T., Long C.M., Mickelson E., Hansen J.A., Ferrara G.B., Angelini G., Erlich H.A.
J. Immunol. 141:4024-4030(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*04:01).
[32]"Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes."
Bugawan T.L., Begovich A.B., Erlich H.A.
Immunogenetics 32:231-241(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*04:01), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DPB1*08:01).
[33]"Novel class II HLA-DRB4 and DPB1 alleles found in the Belgian population."
Buyse I., Emonds M.P., Bouillon R., Marynen P., Cassiman J.J.
Immunogenetics 38:380-380(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*46:01).
Tissue: Leukocyte.
[34]"Identification of a new HLA-DPB1 allele detected by PCR-RFLP and its nucleotide sequence determination by direct sequencing after PCR amplification."
Mizuki N., Ohno S., Sugimura K., Seki T., Ishioka M., Inoko H., Geng L.
Tissue Antigens 41:259-262(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*41:01).
[35]"A new HLA-DPB1 allele, DPB1*SUT (DPB1*4701)."
Koshizaka T., Taguchi M., Onishi H., Kobayashi S., Inoko H.
Tissue Antigens 43:50-53(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*47:01).
Tissue: Blood.
[36]"Direct sequencing of a novel DPB1 allele (DPB1*5101) of the heterozygote from the membrane of reverse dot blot analysis."
Kaneshige T., Kinoshita T., Hashimoto M., Matsumoto Y., Moribe T., Ichikawa Y., Fukunishi T., Uchida K.
Tissue Antigens 44:204-207(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*51:01).
Tissue: Blood.
[37]"DPB1*BR: an Mhc class II DPB1 allele (DPB1*6601) of negroid origin."
Schnittger L., May J., Kretschmer C., Kremsner P.G., Meyer C.G.
Immunogenetics 44:405-406(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*66:01).
Tissue: Blood.
[38]"Identification of a new HLA-DPB1*6501 allele in a Caucasian individual."
Versluis L.F., Philippe M., Van der Zwan A., Thonnard J., Tongio M.M., Tilanus M.G.J.
Immunogenetics 44:483-484(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*65:01).
[39]"Two new HLA DPB1 alleles identified by sequence-based typing: DPB1*8201 and DPB1*8301."
Voorter C., Tilanus M.G.J., van den Berg-Loonen E.
Tissue Antigens 56:560-562(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*82:01 AND DPB1*83:01).
[40]"DPB1*8601, a previously unrecognized DPB1 variant in the Caucasoid population."
Bengtsson M.
Tissue Antigens 57:536-539(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*86:01).
[41]"Three new DP alleles identified in a study of 800 unrelated bone marrow donor-recipient pairs."
Grams S.E., Wu J., Noreen H.J., Mangaccat J., Cognato M.A., Johnson S., Segall M., Williams T.M., Begovich A.B.
Tissue Antigens 58:272-275(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*87:01).
[42]"Identification of a new HLA-DPB1 allele,HLA-DPB1*9001."
Bengtsson M., Danielsson F., Jansson I.E., Johansson U.
Tissue Antigens 59:344-346(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*90:01).
[43]"Identification of a novel DPB1 allele, DPB1*9301, by sequence-based typing in a Lahu ethnic minority of China."
Liu Z.-H., Fan X., Lin J., Fu Y., Liu X., Xu A.
Tissue Antigens 61:261-262(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*93:01).
[44]"High resolution sequence-based DPB1 typing identified two novel DPB1 alleles, DPB1*9401 and DPB1*9501, from a Kenyan population."
Luo M., Ramdahin S., Iqbal S., Pan Y., Jacobson K., Narayansingh M.J., Schroeder M., Brunham R.C., Embree J., Plummer F.A.
Tissue Antigens 62:182-184(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*94:01 AND DPB1*95:01).
[45]"Sequence-based typing identifies a novel HLA-DPB1 allele, DPB1*9601."
Witter K., Gervais T., Dunn P.P., Voorter C., Muramoto J., Albert E.D.
Tissue Antigens 62:185-187(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (DPB1*96:01).
[46]"Identification of a novel HLA-DPB1 allele--DPB1*0102."
Lv F., Lin J., Liu Z.-H., Gao J., Fu Y., Xu A.
Tissue Antigens 64:512-514(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*01:02).
[47]"Identification of a novel HLA-DPB1 allele, DPB1*1702."
Li M., Nie J., Xu Y., Xu A., Yu X.
Tissue Antigens 68:187-188(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*17:02).
Tissue: Blood.
[48]Kimura A.
Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*21:01; DPB1*22:01; DPB1*24:01; DPB1*25:01; DPB1*29:01 AND DPB1*31:01).
[49]"A new HLA-DPB1* allele identical to the DPB1*0101 allele except for the polymorphic positions 226 and 228 where G and A are found respectively in place of A and G."
Dormoy A., Routoulp M., Froelich N., Tongio M.M.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*89:01).
[50]"A novel DPB1 allele."
Varney M.D., Rossi V.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*91:01 AND DPB1*92:01).
[51]"Sequence-based DPB typing fills the missing exon 2 sequences of multiple HLA-DPB1 alleles."
Luo M., Mao X., Shehzad I., Jacobson K., Kwan L., Shroeder M., Plummer F.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*10:01).
[52]"A novel DPB1 allele identified by sequence-based typing and Confirmed by SSP."
Edelshtein D., Sidebottom D., Chen D.-F., Baxter-Lowe L.A.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*99:01).
[53]"Novel human HLA-DPB1 allele identified in potential bone marrow donors."
Wu J., Williams T.M., Cognato M.A.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*02:03).
[54]Garbarino L., Chiesa A., Pastori F., Sacchi N., Cusano R., Bottero F., Bossi R.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELES DPB1*10:02 AND DPB1*11:02).
[55]"The identification of a new DPB1 allele in a type 1 diabetes genetics consortium family."
Moonsamy P.V., Bonella P.L., Sali P.J., Bentley L.G., Post J.L., Goodwin G., Erlich H.E.
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*13:02).
[56]"HLA-DPB1*8601V1."
Kashiwase K., Ichihara T., Shimizu M., Satake M.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*16:02).
[57]"Identification of a novel DPB1 allele by sequence-based typing in the GoKinD population."
Cordovado S.K., Hancock L.N., Mueller P.W.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*18:02).
[58]"A New HLA-DPB1 allele."
Monos D.S.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*19:02).
[59]"Complete exon 2 sequence of the HLA-DPB1*110101 allele."
Vilches C.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*11:01).
Tissue: Peripheral blood.
[60]"Exon 2 sequence of a new HLA-DPB1 allele DPB1*XX exhibiting single nucleotide difference G337A from HLA-DPB1*1401."
McWhinnie A.J.M., Wallis-Jones S., Little A.M.
Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*22:02).
Tissue: Peripheral blood.
[61]Lazaro A.M., Xiao Y., Nehlsen-Cannarella S.L., Fagoaga O.R., Hurley C.K.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DPB1*25:02).
[62]"Seven new DPB1 alleles and their population distribution."
Moonsamy P.V., Aldrich C.L., Petersdorf E.W., Hill A.V., Begovich A.B.
Tissue Antigens 43:249-252(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELES DPB1*40:01; DPB1*48:01; DPB1*49:01; DPB1*50:01; DPB1*51:01; DPB1*52:01 AND DPB1*53:01).
[63]"Six new DPB1 alleles identified in a study of 1,302 unrelated bone marrow donor-recipient pairs."
Noreen H.J., Steiner L.L., Davidson M., Johnson S., Segall M., Begovich A.B.
Tissue Antigens 49:512-516(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELES DPB1*59:01; DPB1*68:01; DPB1*70:01; DPB1*71:01; DPB1*72:01 AND DPB1*73:01).
[64]"Four new DP alleles identified in a study of 500 unrelated bone marrow donor-recipient pairs."
Steiner L.L., Wu J., Noreen H.J., Moehlenkamp C., Cavalli A.S., Davidson M., Johnson S., Winden T., Segall M., Begovich A.B., Williams T.M.
Tissue Antigens 53:201-206(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*80:01), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DPB1*81:01).
[65]"Identification of a novel HLA-DPB1 allele, DPB1*9701, by sequence-based typing."
Lapi S., Curcio M., Fornaciari S., Mariotti M.L., Isola P., Bonci F., Pistello M., Scatena F.
Tissue Antigens 63:606-608(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*97:01).
[66]Begovich A.B., Steiner L.L.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*63:01).
[67]"A new HLA-DPB1 allele: a variant of DPB1*1401."
Rozemuller E.H.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*76:01).
[68]"Novel HLA-DPB1 alleles detected in the Ethiopian population."
Versluis L.F., Tilanus M.G.J., Verduyn W., Abdulkadir J., Giphart M.J.
Hum. Immunol. 42:181-183(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DPB1*44:01).
[69]"DPB1*5901a: a novel HLA-DPB1 allele from a Caucasian family with insulin-dependent diabetes mellitus."
Noble J.A., Cavalli A.S., Erlich H.A.
Tissue Antigens 47:159-162(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-118 (ALLELE DPB1*59:01).
[70]"Identification of a new allele in a Sicilian individual: HLA-DPB1*0302."
Sheldon M.H., Azzaro M.P., Sayer D., Bunce M., Sortino G.
Tissue Antigens 66:64-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-118 (ALLELE DPB1*03:02).
[71]"Identification of a novel DPB allele."
Varney M.D., Tait B.D.
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DPB1*69:01).
[72]"A new HLA-DPB1 alleles from Santa Cruz Island, Solomon Islands."
Easteal S., Croft L.
Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-114 (ALLELE DPB1*44:01).
Tissue: Blood.
[73]"DPB1*WA4 - an additional HLA class II allele identified in west Africa."
Meyer C.G., Schnittger L., Begovich A.B., Erlich H.A., Horstmann R.D.
Tissue Antigens 40:98-99(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DPB1*37:01).
[74]"Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two 'new' alleles."
Mitsunaga S., Kuwata S., Tokunaga K., Uchikawa C., Takahashi K., Akaza T., Mitomi Y., Juji T.
Hum. Immunol. 34:203-211(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-119 (ALLELE DPB1*38:01).
[75]"A novel HLA-DPB1 allele, DPB1*3601 (DPB1*KT)."
Ogawa K., Itho H., Nakajyo S., Kobayashi K., Sekiguchi S., Koshizaka T., Taguchi M., Onishi H., Kobayashi S., Inoko H.
Tissue Antigens 44:134-136(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-119 (ALLELE DPB1*36:01).
[76]"Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302."
Steiner L.L., Cavalli A., Zimmerman P.A., Boatin B.A., Titanji V.P., Bradley J.E., Lucius R., Nutman T.B., Begovich A.B.
Tissue Antigens 51:653-657(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-119 (ALLELE DPB1*74:01).
[77]"Characterization of a new DPB1 allele (DPB1*5701) isolated from a Caucasian individual."
Mersch G., Mytilineos J., De Canck I., Deufel A., Mijs W., Scherer S., Jannes G., Opelz G., Rossau R.
Tissue Antigens 46:208-212(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-115 (ALLELE DPB1*57:01).
Tissue: Lymphocyte.
[78]"The nucleotide sequence of two new DP alleles, DPA1*02015 and DPB1*8401, identified in a Chinese subject."
McTernan C.L., Mijovic C.H., Cockram C.S., Barnett A.H.
Tissue Antigens 56:95-98(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 39-121 (ALLELE DPB1*84:01).
[79]"Genetic mapping of a human class II antigen beta-chain cDNA clone to the SB region of the HLA complex."
Roux-Dosseto M., Auffray C., Lillie J.W., Boss J.M., Cohen D., Demars R., Mawas C., Seidman J.G., Strominger J.L.
Proc. Natl. Acad. Sci. U.S.A. 80:6036-6040(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 78-258 (ALLELE DPB1*02:01).
[80]"Invariant chain structure and MHC class II function."
Cresswell P.
Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[81]"Presentation of antigens by MHC class II molecules: getting the most out of them."
Villadangos J.A.
Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[82]"MHC class II molecules on the move for successful antigen presentation."
Rocha N., Neefjes J.
EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[83]"Autophagy in MHC class II presentation: sampling from within."
Menendez-Benito V., Neefjes J.
Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[84]"MHC class II transport at a glance."
Berger A.C., Roche P.A.
J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[85]"CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
Beswick E.J., Reyes V.E.
World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01426 mRNA. Translation: CAA25672.1.
X02964 Genomic DNA. No translation available.
X03023 Genomic DNA. Translation: CAE82008.1.
X03024 Genomic DNA. Translation: CAE82007.1.
X03022 Genomic DNA. Translation: CAA26823.1.
X03025 Genomic DNA. Translation: CAE82037.1.
X03026 Genomic DNA. Translation: CAE82042.1.
X03028 Genomic DNA. Translation: CAE82073.1.
X03027 Genomic DNA. Translation: CAE82043.1.
X03067 mRNA. Translation: CAA26871.1.
X02228 Genomic DNA. Translation: CAA26147.1.
J03041 mRNA. Translation: AAA35993.1.
M83664 mRNA. Translation: AAA59837.1.
AY804132 mRNA. Translation: AAW78737.1.
AY804133 mRNA. Translation: AAW78738.1.
AY804135 mRNA. Translation: AAW78740.1.
AY804136 mRNA. Translation: AAW78741.1.
AY804137 mRNA. Translation: AAW78742.1.
AY804138 mRNA. Translation: AAW78743.1.
AY804139 mRNA. Translation: AAW78744.1.
AY804141 mRNA. Translation: AAW78746.1.
AY804142 mRNA. Translation: AAW78747.1.
AY804143 mRNA. Translation: AAW78748.1.
AY831401 mRNA. Translation: AAW80919.1.
AY831402 mRNA. Translation: AAW80920.1.
AY831403 mRNA. Translation: AAW80921.1.
AY831404 mRNA. Translation: AAW80922.1.
AY656678 mRNA. Translation: AAV71025.1.
AY656679 mRNA. Translation: AAV71026.1.
AY656680 mRNA. Translation: AAV71027.1.
AK313305 mRNA. Translation: BAG36110.1.
BT019780 mRNA. Translation: AAV38583.1.
AL645931 Genomic DNA. Translation: CAI18042.1.
AL662824 Genomic DNA. Translation: CAI17602.1.
AL805913, AL845446 Genomic DNA. Translation: CAI18551.1.
AL845446, AL805913 Genomic DNA. Translation: CAI95555.1.
BX120009 Genomic DNA. Translation: CAM25984.1.
CR759795 Genomic DNA. Translation: CAQ07437.1.
CR759904 Genomic DNA. Translation: CAQ09869.1.
CR762479 Genomic DNA. Translation: CAQ10348.1.
CH471081 Genomic DNA. Translation: EAX03674.1.
BC007963 mRNA. Translation: AAH07963.1.
BC013184 mRNA. Translation: AAH13184.1.
M28202 mRNA. Translation: AAA53197.1.
Y09327 Genomic DNA. Translation: CAA70507.1.
L31816 Genomic DNA. No translation available.
M97686 Genomic DNA. No translation available.
X96985 Genomic DNA. No translation available.
Y13900 Genomic DNA. Translation: CAA74199.1.
Y14230 Genomic DNA. Translation: CAA74608.1.
Y16095 Genomic DNA. Translation: CAA76060.1.
AY823995 Genomic DNA. Translation: AAW79272.1.
AJ563603 Genomic DNA. Translation: CAD91639.1.
AM039828 Genomic DNA. Translation: CAJ01690.1.
AM408787 Genomic DNA. Translation: CAL64063.1.
AM698036 Genomic DNA. Translation: CAM91695.1.
M84619 Genomic DNA. No translation available.
M84620 Genomic DNA. No translation available.
M84622 Genomic DNA. No translation available.
M84623 Genomic DNA. No translation available.
M84624 Genomic DNA. No translation available.
M84626 Genomic DNA. No translation available.
X82123 Genomic DNA. Translation: CAA57635.1.
U22311 Genomic DNA. Translation: AAB60413.1.
U22313 Genomic DNA. Translation: AAB17108.1.
K01615 mRNA. Translation: AAA36313.1.
FM883600 Genomic DNA. Translation: CAT04585.2.
FM882212 Genomic DNA. Translation: CAT03206.1.
FM956650 Genomic DNA. Translation: CAX11690.1.
FM991729 Genomic DNA. Translation: CAX20314.1.
FM992080 Genomic DNA. Translation: CAX21583.2.
FM992366 Genomic DNA. Translation: CAX30407.1.
FM992364 Genomic DNA. Translation: CAX30405.1.
FN252853 Genomic DNA. Translation: CAX53275.1.
FN256250 Genomic DNA. Translation: CAX53717.1.
FN256251 Genomic DNA. Translation: CAX53721.1.
FN256254 Genomic DNA. Translation: CAX53718.1.
FN256253 Genomic DNA. Translation: CAX53726.1.
FN256255 Genomic DNA. Translation: CAX53722.1.
FN393829 Genomic DNA. Translation: CAY85528.1.
M23675 Genomic DNA. Translation: AAA59740.1.
M62326 Genomic DNA. Translation: AAA59719.1.
M62331 Genomic DNA. Translation: AAA59724.1.
L07768 Genomic DNA. Translation: AAA59690.1.
D13174 Genomic DNA. Translation: BAA02465.1.
D10834 Genomic DNA. Translation: BAA01614.1.
D28809 Genomic DNA. Translation: BAA05970.1.
X96986 Genomic DNA. Translation: CAA65710.2.
X91886 Genomic DNA. No translation available.
Y18498 Genomic DNA. Translation: CAC12860.1.
AJ238005 Genomic DNA. Translation: CAC12865.1.
AJ271373 Genomic DNA. Translation: CAB70605.2.
AF288354 Genomic DNA. Translation: AAG30143.1.
AJ292074 Genomic DNA. Translation: CAC27995.1.
AF536241 Genomic DNA. Translation: AAN33050.1.
AF549409 Genomic DNA. Translation: AAQ12563.1.
AF549410 Genomic DNA. Translation: AAQ12564.1. Frameshift.
AJ514871 Genomic DNA. Translation: CAD55852.1.
AY374100 Genomic DNA. Translation: AAR21105.1.
DQ206450 Genomic DNA. Translation: ABB17974.1.
M83914 Genomic DNA. Translation: AAA36264.1.
M83915 Genomic DNA. Translation: AAA36259.1.
M83916 Genomic DNA. Translation: AAA36260.1.
M83917 Genomic DNA. Translation: AAA36261.1.
M83918 Genomic DNA. Translation: AAA36262.1.
M83919 Genomic DNA. Translation: AAA36263.1.
AJ297820 Genomic DNA. Translation: CAC14048.1.
AY029777 Genomic DNA. Translation: AAK40344.1.
AF489518 Genomic DNA. Translation: AAL92172.1.
AF492640 Genomic DNA. Translation: AAO84765.1.
AY425707 Genomic DNA. Translation: AAR29060.1.
AY572830 Genomic DNA. Translation: AAS77869.1.
AY855160 Genomic DNA. Translation: AAW33682.1.
AY855161 Genomic DNA. Translation: AAW33683.1.
DQ089022 Genomic DNA. Translation: AAY98352.1.
AB247517 Genomic DNA. Translation: BAE78492.1.
DQ386161 Genomic DNA. Translation: ABD36812.1.
DQ485789 Genomic DNA. Translation: ABF47047.1.
AM887530 Genomic DNA. Translation: CAP08783.1.
FM211032 Genomic DNA. Translation: CAR66500.1.
FJ976693 Genomic DNA. Translation: ACS12738.1.
L17310 Genomic DNA. Translation: AAA53479.1.
L17311 Genomic DNA. Translation: AAA53480.1.
L17313 Genomic DNA. Translation: AAA53481.1.
L17314 Genomic DNA. Translation: AAA53482.1.
L22076 Genomic DNA. Translation: AAA53476.1.
L22077 Genomic DNA. Translation: AAA53477.1.
L23400 Genomic DNA. Translation: AAA58441.1.
U59437 Genomic DNA. Translation: AAD09481.1.
U59438 Genomic DNA. Translation: AAD09482.1.
U59439 Genomic DNA. Translation: AAD09483.1.
U59440 Genomic DNA. Translation: AAD09484.1.
U59441 Genomic DNA. Translation: AAD09485.1.
U59442 Genomic DNA. Translation: AAD09486.1.
AF074845 Genomic DNA. Translation: AAD39682.1.
AF074846 Genomic DNA. Translation: AAD39683.1.
AY033075 Genomic DNA. Translation: AAK51161.1.
U34033 Genomic DNA. Translation: AAA81335.1.
Z92523 Genomic DNA. Translation: CAB06822.1.
X78042 Genomic DNA. No translation available.
U29534 Genomic DNA. Translation: AAB52511.1.
AY618897 Genomic DNA. Translation: AAT40308.1.
X97406 Genomic DNA. Translation: CAA66059.1.
L01466 Genomic DNA. No translation available.
M87046 Genomic DNA. No translation available.
D10478 Genomic DNA. Translation: BAA01281.1.
D10882 Genomic DNA. Translation: BAA01704.1.
U94839 Genomic DNA. Translation: AAC64232.1.
X80752 Genomic DNA. Translation: CAA56728.1.
AF077015 Genomic DNA. Translation: AAC26835.1.
K00409 mRNA. Translation: AAA36312.1.
PIRHLHUS1. A02228.
HLHUPB. A02229.
D30536.
D30537.
E30536.
I37298.
S49382. I37541.
HLHUS2. I38195.
I38197.
I59621.
I59637.
I59641.
I81234.
I81235.
I81236.
I81237.
I81238.
RefSeqNP_002112.3. NM_002121.5.
UniGeneHs.485130.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3LQZX-ray3.25B33-218[»]
ProteinModelPortalP04440.
SMRP04440. Positions 29-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109360. 3 interactions.
IntActP04440. 9 interactions.

PTM databases

PhosphoSiteP04440.

Polymorphism databases

DMDM122263.

Proteomic databases

PaxDbP04440.
PRIDEP04440.

Protocols and materials databases

DNASU3115.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000399500; ENSP00000382422; ENSG00000215048.
ENST00000411749; ENSP00000414196; ENSG00000236693.
ENST00000418931; ENSP00000408146; ENSG00000223865.
ENST00000425130; ENSP00000396095; ENSG00000230763.
ENST00000433800; ENSP00000407674; ENSG00000226826.
ENST00000454006; ENSP00000389288; ENSG00000237710.
GeneID3115.
KEGGhsa:3115.
UCSCuc003ocu.2. human.

Organism-specific databases

CTD3115.
GeneCardsGC06P033043.
GC06Pi33027.
GC06Pk33021.
GC06Pm33077.
GC06Pn32972.
GC06Po33183.
HGNCHGNC:4940. HLA-DPB1.
HPAHPA011078.
MIM142858. gene.
neXtProtNX_P04440.
Orphanet133. Chronic berylliosis.
900. Granulomatosis with polyangiitis.
PharmGKBPA35064.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG295798.
HOVERGENHBG012730.
InParanoidP13763.
KOK06752.
OMAERISCVI.
PhylomeDBP04440.
TreeFamTF336626.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressP04440.
BgeeP04440.
CleanExHS_HLA-DPB1.
GenevestigatorP04440.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-DPB1. human.
EvolutionaryTraceP04440.
GeneWikiHLA-DPB1.
GenomeRNAi3115.
NextBio12359.
PROP04440.
SOURCESearch...

Entry information

Entry nameDPB1_HUMAN
AccessionPrimary (citable) accession number: P04440
Secondary accession number(s): A0PFJ7 expand/collapse secondary AC list , A5I886, A8YPB3, B5U8B4, B7VF80, B7VF87, B8ZX68, B8ZYT0, B9W5S8, B9W6F7, B9W6F9, C0MPP5, C0MPQ2, C0MPQ3, C0MPQ5, C0MPQ6, C0MPQ7, C4R9J5, C5IZL1, O00259, O19698, O19700, O19702, O19749, O46884, O77952, O98215, O98216, O98217, O98218, O98219, O98222, O98223, P01916, P04232, P13763, P79493, P79608, Q0P0L4, Q0ZFN3, Q14279, Q27S71, Q29682, Q29684, Q29698, Q29714, Q29775, Q29776, Q29778, Q29779, Q29781, Q29827, Q29828, Q29879, Q29880, Q29898, Q29977, Q2MGW3, Q30015, Q30031, Q30032, Q30033, Q30034, Q30050, Q30051, Q30052, Q30053, Q30054, Q30055, Q30174, Q4GY31, Q4JHD8, Q5ENE0, Q5ENE1, Q5ENW3, Q5EP46, Q5EP47, Q5EP49, Q5EP51, Q5EP52, Q5EP53, Q5EP56, Q5I4H8, Q5I4H9, Q5ISH4, Q5ISH5, Q5SQ73, Q5STP2, Q5YLA6, Q6IVX1, Q6LBX2, Q6LBX3, Q6LBX4, Q6LBX5, Q6LBX6, Q6LBX7, Q6PWX6, Q6TAS4, Q714U1, Q714U2, Q7YQ10, Q860Z7, Q8HWL7, Q8HWT5, Q8SNC4, Q95HC1, Q95IT7, Q95IT8, Q9BD13, Q9GIM2, Q9GIM4, Q9GIX6, Q9GJ41, Q9MY67, Q9TNT7, Q9TQE2, Q9XS11, Q9XS12
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: April 16, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM