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Protein

HLA class I histocompatibility antigen, A-3 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • TAP binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-3 alpha chain
Alternative name(s):
MHC class I antigen A*3
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000206503.11
HGNCiHGNC:4931 HLA-A
MIMi142800 gene
neXtProtiNX_P04439

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 365CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3105
MalaCardsiHLA-A
OpenTargetsiENSG00000206503
PharmGKBiPA35055

Chemistry databases

ChEMBLiCHEMBL2632

Polymorphism and mutation databases

BioMutaiPIKFYVE
DMDMi34223717

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001881525 – 365HLA class I histocompatibility antigen, A-3 alpha chainAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication
Modified residuei343PhosphoserineBy similarity1
Modified residuei344PhosphotyrosineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP04439
PaxDbiP04439
PeptideAtlasiP04439
PRIDEiP04439

PTM databases

iPTMnetiP04439
SwissPalmiP04439

Miscellaneous databases

PMAP-CutDBiP04439

Expressioni

Gene expression databases

BgeeiENSG00000206503
CleanExiHS_HLA-A
ExpressionAtlasiP04439 baseline and differential
GenevisibleiP04439 HS

Organism-specific databases

HPAiCAB078470

Interactioni

Subunit structurei

Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • TAP binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109350, 90 interactors
IntActiP04439, 17 interactors
STRINGi9606.ENSP00000366005

Chemistry databases

BindingDBiP04439

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 184Combined sources9
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi219 – 235Combined sources17
Beta strandi238 – 243Combined sources6
Beta strandi251 – 254Combined sources4
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 297Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XPGX-ray2.60A25-298[»]
3RL1X-ray2.00A25-298[»]
3RL2X-ray2.39A25-298[»]
6ENYelectron microscopy5.80F25-365[»]
ProteinModelPortaliP04439
SMRiP04439
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00760000118960
HOVERGENiHBG016709
PhylomeDBiP04439

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,841
Last modified:August 22, 2003 - v2
Checksum:iDEDFCEC4450E0580
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319G → A in AAB66582 (PubMed:10079303).Curated1

Polymorphismi

The following alleles of A-3 are known: A*03:01 (A-3.1), A*03:02, A*03:04, A*03:05 and A*03:06. The sequence shown is that of A*03:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05031089R → G. Corresponds to variant dbSNP:rs199474430Ensembl.1
Natural variantiVAR_05031194Q → H. Corresponds to variant dbSNP:rs78306866Ensembl.1
Natural variantiVAR_050312101D → N. Corresponds to variant dbSNP:rs1136688Ensembl.1
Natural variantiVAR_050313121I → M. Corresponds to variant dbSNP:rs1136695Ensembl.1
Natural variantiVAR_050314129S → P. Corresponds to variant dbSNP:rs1136700Ensembl.1
Natural variantiVAR_050315131G → W. Corresponds to variant dbSNP:rs1136702Ensembl.1
Natural variantiVAR_050316133F → L. Corresponds to variant dbSNP:rs1059488Ensembl.1
Natural variantiVAR_050317151N → K. Corresponds to variant dbSNP:rs1059509Ensembl.1
Natural variantiVAR_050318166I → TCombined sourcesCorresponds to variant dbSNP:rs1059516Ensembl.1
Natural variantiVAR_050319169R → H. Corresponds to variant dbSNP:rs1059520Ensembl.1
Natural variantiVAR_004351176E → V in allele A*03:02. Corresponds to variant dbSNP:rs9256983Ensembl.1
Natural variantiVAR_004352180L → Q in allele A*03:02. 1
Natural variantiVAR_016604185D → E in allele A*03:05. Corresponds to variant dbSNP:rs1059542Ensembl.1
Natural variantiVAR_033149186G → A in allele A*03:06. Corresponds to variant dbSNP:rs41545519Ensembl.1
Natural variantiVAR_016605199G → R in allele A*03:04. Corresponds to variant dbSNP:rs41559916Ensembl.1
Natural variantiVAR_050320205R → H. Corresponds to variant dbSNP:rs17185861Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00492 Genomic DNA Translation: CAA25162.1 Sequence problems.
U32184 mRNA Translation: AAB63980.1
BA000025 Genomic DNA Translation: BAB63400.1
AF217561 mRNA Translation: AAF28734.1
AF015930 mRNA Translation: AAB66582.1
AH008295 Genomic DNA Translation: AAF03243.1
AJ401085 Genomic DNA Translation: CAC06086.1
AJ401086 Genomic DNA Translation: CAC06087.1
AJ401087 Genomic DNA Translation: CAC06088.1
AJ748743 Genomic DNA Translation: CAG38621.1
AL671277 Genomic DNA No translation available.
AH009116 Genomic DNA Translation: AAF29557.1
CCDSiCCDS34373.1
PIRiA02192 HLHUA3
RefSeqiNP_002107.3, NM_002116.7
UniGeneiHs.181244
Hs.713441

Genome annotation databases

EnsembliENST00000376809; ENSP00000366005; ENSG00000206503
ENST00000396634; ENSP00000379873; ENSG00000206503
GeneIDi3105

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei1A03_HUMAN
AccessioniPrimary (citable) accession number: P04439
Secondary accession number(s): O19546
, O19756, Q65A82, Q9GJE6, Q9GJE7, Q9GJE8, Q9MYE6, Q9MYG4, Q9TPR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 22, 2003
Last modified: May 23, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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