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P04439

- 1A03_HUMAN

UniProt

P04439 - 1A03_HUMAN

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Protein

HLA class I histocompatibility antigen, A-3 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. beta-2-microglobulin binding Source: UniProt
  2. peptide antigen binding Source: UniProt
  3. TAP binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. immune response Source: UniProtKB
  7. interferon-gamma-mediated signaling pathway Source: Reactome
  8. positive regulation of T cell mediated cytotoxicity Source: InterPro
  9. regulation of immune response Source: Reactome
  10. type I interferon signaling pathway Source: Reactome
  11. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-3 alpha chain
Alternative name(s):
MHC class I antigen A*3
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931. HLA-A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence AnalysisAdd
BLAST
Topological domaini333 – 36533CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi apparatus Source: UniProt
  6. Golgi membrane Source: Reactome
  7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  8. integral component of plasma membrane Source: UniProtKB
  9. membrane Source: UniProtKB
  10. MHC class I protein complex Source: UniProt
  11. phagocytic vesicle membrane Source: Reactome
  12. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 365341HLA class I histocompatibility antigen, A-3 alpha chainPRO_0000018815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 1881 PublicationPROSITE-ProRule annotation
Disulfide bondi227 ↔ 2831 PublicationPROSITE-ProRule annotation
Modified residuei356 – 3561PhosphoserineBy similarity

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP04439.
PaxDbiP04439.
PRIDEiP04439.

Miscellaneous databases

PMAP-CutDBP04439.

Expressioni

Gene expression databases

BgeeiP04439.
CleanExiHS_HLA-A.
ExpressionAtlasiP04439. baseline and differential.
GenevestigatoriP04439.

Interactioni

Subunit structurei

Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

BioGridi109350. 99 interactions.
IntActiP04439. 4 interactions.

Structurei

Secondary structure

1
365
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3610Combined sources
Beta strandi41 – 433Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Beta strandi64 – 663Combined sources
Helixi74 – 763Combined sources
Helixi81 – 10828Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi118 – 12710Combined sources
Beta strandi133 – 14210Combined sources
Beta strandi145 – 1506Combined sources
Beta strandi157 – 1615Combined sources
Helixi162 – 17312Combined sources
Helixi176 – 1849Combined sources
Helixi187 – 19812Combined sources
Helixi200 – 2034Combined sources
Beta strandi210 – 2178Combined sources
Beta strandi219 – 23517Combined sources
Beta strandi238 – 2436Combined sources
Beta strandi251 – 2544Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi265 – 27410Combined sources
Helixi278 – 2803Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi290 – 2923Combined sources
Beta strandi294 – 2974Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XPGX-ray2.60A25-298[»]
3RL1X-ray2.00A25-298[»]
3RL2X-ray2.39A25-298[»]
ProteinModelPortaliP04439.
SMRiP04439. Positions 25-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42056.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.
OrthoDBiEOG7JT6WQ.
PhylomeDBiP04439.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04439-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,841
Last modified:August 22, 2003 - v2
Checksum:iDEDFCEC4450E0580
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti319 – 3191G → A in AAB66582. (PubMed:10079303)Curated

Polymorphismi

The following alleles of A-3 are known: A*03:01 (A-3.1), A*03:02, A*03:04, A*03:05 and A*03:06. The sequence shown is that of A*03:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891R → G.
Corresponds to variant rs1059459 [ dbSNP | Ensembl ].
VAR_050310
Natural varianti94 – 941Q → H.
Corresponds to variant rs1059463 [ dbSNP | Ensembl ].
VAR_050311
Natural varianti101 – 1011D → N.
Corresponds to variant rs1136688 [ dbSNP | Ensembl ].
VAR_050312
Natural varianti121 – 1211I → M.
Corresponds to variant rs1136695 [ dbSNP | Ensembl ].
VAR_050313
Natural varianti129 – 1291S → P.
Corresponds to variant rs1136700 [ dbSNP | Ensembl ].
VAR_050314
Natural varianti131 – 1311G → W.
Corresponds to variant rs1136702 [ dbSNP | Ensembl ].
VAR_050315
Natural varianti133 – 1331F → L.
Corresponds to variant rs1059488 [ dbSNP | Ensembl ].
VAR_050316
Natural varianti151 – 1511N → K.
Corresponds to variant rs1059509 [ dbSNP | Ensembl ].
VAR_050317
Natural varianti166 – 1661I → T.1 Publication
Corresponds to variant rs1059516 [ dbSNP | Ensembl ].
VAR_050318
Natural varianti169 – 1691R → H.
Corresponds to variant rs1059520 [ dbSNP | Ensembl ].
VAR_050319
Natural varianti176 – 1761E → V in allele A*03:02.
Corresponds to variant rs9256983 [ dbSNP | Ensembl ].
VAR_004351
Natural varianti180 – 1801L → Q in allele A*03:02.
VAR_004352
Natural varianti185 – 1851D → E in allele A*03:05.
Corresponds to variant rs1059542 [ dbSNP | Ensembl ].
VAR_016604
Natural varianti186 – 1861G → A in allele A*03:06.
VAR_033149
Natural varianti199 – 1991G → R in allele A*03:04.
Corresponds to variant rs41559916 [ dbSNP | Ensembl ].
VAR_016605
Natural varianti205 – 2051R → H.
Corresponds to variant rs17185861 [ dbSNP | Ensembl ].
VAR_050320

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00492 Genomic DNA. Translation: CAA25162.1. Sequence problems.
U32184 mRNA. Translation: AAB63980.1.
BA000025 Genomic DNA. Translation: BAB63400.1.
AF217561 mRNA. Translation: AAF28734.1.
AF015930 mRNA. Translation: AAB66582.1.
AH008295 Genomic DNA. Translation: AAF03243.1.
AJ401085 Genomic DNA. Translation: CAC06086.1.
AJ401086 Genomic DNA. Translation: CAC06087.1.
AJ401087 Genomic DNA. Translation: CAC06088.1.
AJ748743 Genomic DNA. Translation: CAG38621.1.
AL671277 Genomic DNA. Translation: CAI18372.1.
AH009116 Genomic DNA. Translation: AAF29557.1.
CCDSiCCDS34373.1.
PIRiA02192. HLHUA3.
RefSeqiNP_002107.3. NM_002116.7.
UniGeneiHs.181244.
Hs.713441.

Genome annotation databases

EnsembliENST00000376809; ENSP00000366005; ENSG00000206503.
ENST00000396634; ENSP00000379873; ENSG00000206503.
GeneIDi3105.
KEGGihsa:3105.
UCSCiuc003nok.3. human.

Polymorphism databases

DMDMi34223717.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00492 Genomic DNA. Translation: CAA25162.1 . Sequence problems.
U32184 mRNA. Translation: AAB63980.1 .
BA000025 Genomic DNA. Translation: BAB63400.1 .
AF217561 mRNA. Translation: AAF28734.1 .
AF015930 mRNA. Translation: AAB66582.1 .
AH008295 Genomic DNA. Translation: AAF03243.1 .
AJ401085 Genomic DNA. Translation: CAC06086.1 .
AJ401086 Genomic DNA. Translation: CAC06087.1 .
AJ401087 Genomic DNA. Translation: CAC06088.1 .
AJ748743 Genomic DNA. Translation: CAG38621.1 .
AL671277 Genomic DNA. Translation: CAI18372.1 .
AH009116 Genomic DNA. Translation: AAF29557.1 .
CCDSi CCDS34373.1.
PIRi A02192. HLHUA3.
RefSeqi NP_002107.3. NM_002116.7.
UniGenei Hs.181244.
Hs.713441.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XPG X-ray 2.60 A 25-298 [» ]
3RL1 X-ray 2.00 A 25-298 [» ]
3RL2 X-ray 2.39 A 25-298 [» ]
ProteinModelPortali P04439.
SMRi P04439. Positions 25-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109350. 99 interactions.
IntActi P04439. 4 interactions.

Chemistry

BindingDBi P04439.
ChEMBLi CHEMBL2632.

Polymorphism databases

DMDMi 34223717.

Proteomic databases

MaxQBi P04439.
PaxDbi P04439.
PRIDEi P04439.

Protocols and materials databases

DNASUi 3105.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376809 ; ENSP00000366005 ; ENSG00000206503 .
ENST00000396634 ; ENSP00000379873 ; ENSG00000206503 .
GeneIDi 3105.
KEGGi hsa:3105.
UCSCi uc003nok.3. human.

Organism-specific databases

CTDi 3105.
GeneCardsi GC06P030186.
HGNCi HGNC:4931. HLA-A.
MIMi 142800. gene.
neXtProti NX_P04439.
PharmGKBi PA35055.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42056.
GeneTreei ENSGT00760000118960.
HOVERGENi HBG016709.
KOi K06751.
OrthoDBi EOG7JT6WQ.
PhylomeDBi P04439.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-A. human.
GeneWikii HLA-A.
GenomeRNAii 3105.
NextBioi 12319.
PMAP-CutDB P04439.
PROi P04439.
SOURCEi Search...

Gene expression databases

Bgeei P04439.
CleanExi HS_HLA-A.
ExpressionAtlasi P04439. baseline and differential.
Genevestigatori P04439.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes."
    Strachan T., Sodoyer R., Damotte M., Jordan B.R.
    EMBO J. 3:887-894(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*03:01).
  2. Ellexson M.E., Hildebrand W.H.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*03:01).
  3. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE A*03:01).
  4. "Molecular cloning and DNA sequence analysis of genes encoding cytotoxic T lymphocyte-defined HLA-A3 subtypes: the E1 subtype."
    Cowan E.P., Jordan B.E., Coligan J.E.
    J. Immunol. 135:2835-2841(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*03:02).
  5. "Complete coding sequence of HLA-A*0302."
    Bettinotti M.P., Hadzikadic L., Adams S., Marincola F.M.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*03:02).
  6. "Full length sequence of an HLA-A*0301 intron 2 variant."
    Mayor N.P.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Complete cDNA coding sequence of a new HLA-A3 subtype (A*0304) with a new HLA polymorphism at exon 3."
    Santos S., Balas A., Garcia-Sanchez F., Lillo R., Merino J.L., Vicario J.L.
    Immunogenetics 49:360-361(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-341 (ALLELE A*03:04).
  9. "Novel human HLA-A alleles identified in potential bone marrow donors."
    Becher M.P., Wu J., Williams T.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*03:05).
  10. "Identification of a HLA-A*03 new variant."
    Poli F., Frison S., Crespiatico L., Longhi E.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 26-298 (ALLELE A*03:05).
    Tissue: Blood.
  11. "Novel HLA-A locus alleles including A*01012, A*0306, A*0308, A*2616, A*2617, A*3009, A*3206, A*3403, A*3602 and A*6604."
    Bradshaw D., Gans C.P., Jones P., Rizzuto G., Steiner N., Mitton W., Ng J., Koester R., Hartzman R.J., Hurley C.K.
    Tissue Antigens 59:325-327(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*03:06).
  12. "Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis."
    McMahon R.M., Friis L., Siebold C., Friese M.A., Fugger L., Jones E.Y.
    Acta Crystallogr. D 67:447-454(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 25-298 (ALLELE A*03:01) IN COMPLEX WITH PLP1 ANTIGENIC PEPTIDE, DISULFIDE BONDS.
  13. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1A03_HUMAN
AccessioniPrimary (citable) accession number: P04439
Secondary accession number(s): O19546
, O19756, Q65A82, Q9GJE6, Q9GJE7, Q9GJE8, Q9MYE6, Q9MYG4, Q9TPR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 22, 2003
Last modified: November 26, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3