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P04439

- 1A03_HUMAN

UniProt

P04439 - 1A03_HUMAN

Protein

HLA class I histocompatibility antigen, A-3 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 2 (22 Aug 2003)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.

    GO - Molecular functioni

    1. beta-2-microglobulin binding Source: UniProt
    2. peptide antigen binding Source: UniProt
    3. TAP binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. cytokine-mediated signaling pathway Source: Reactome
    6. immune response Source: UniProtKB
    7. interferon-gamma-mediated signaling pathway Source: Reactome
    8. positive regulation of T cell mediated cytotoxicity Source: InterPro
    9. regulation of immune response Source: Reactome
    10. type I interferon signaling pathway Source: Reactome
    11. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class I histocompatibility antigen, A-3 alpha chain
    Alternative name(s):
    MHC class I antigen A*3
    Gene namesi
    Name:HLA-A
    Synonyms:HLAA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4931. HLA-A.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. early endosome membrane Source: Reactome
    3. endoplasmic reticulum Source: UniProt
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. Golgi apparatus Source: UniProt
    6. Golgi membrane Source: Reactome
    7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    8. integral component of plasma membrane Source: UniProtKB
    9. membrane Source: UniProtKB
    10. MHC class I protein complex Source: UniProt
    11. phagocytic vesicle membrane Source: Reactome
    12. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35055.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 365341HLA class I histocompatibility antigen, A-3 alpha chainPRO_0000018815Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
    Disulfide bondi125 ↔ 1881 PublicationPROSITE-ProRule annotation
    Disulfide bondi227 ↔ 2831 PublicationPROSITE-ProRule annotation
    Modified residuei356 – 3561PhosphoserineBy similarity

    Post-translational modificationi

    Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP04439.
    PaxDbiP04439.
    PRIDEiP04439.

    Miscellaneous databases

    PMAP-CutDBP04439.

    Expressioni

    Gene expression databases

    ArrayExpressiP04439.
    BgeeiP04439.
    CleanExiHS_HLA-A.
    GenevestigatoriP04439.

    Interactioni

    Subunit structurei

    Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109350. 35 interactions.
    IntActiP04439. 4 interactions.

    Structurei

    Secondary structure

    1
    365
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 3610
    Beta strandi41 – 433
    Beta strandi45 – 528
    Beta strandi55 – 617
    Beta strandi64 – 663
    Helixi74 – 763
    Helixi81 – 10828
    Beta strandi113 – 1153
    Beta strandi118 – 12710
    Beta strandi133 – 14210
    Beta strandi145 – 1506
    Beta strandi157 – 1615
    Helixi162 – 17312
    Helixi176 – 1849
    Helixi187 – 19812
    Helixi200 – 2034
    Beta strandi210 – 2178
    Beta strandi219 – 23517
    Beta strandi238 – 2436
    Beta strandi251 – 2544
    Beta strandi261 – 2633
    Beta strandi265 – 27410
    Helixi278 – 2803
    Beta strandi281 – 2866
    Beta strandi290 – 2923
    Beta strandi294 – 2974

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XPGX-ray2.60A25-298[»]
    3RL1X-ray2.00A25-298[»]
    3RL2X-ray2.39A25-298[»]
    ProteinModelPortaliP04439.
    SMRiP04439. Positions 25-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 36533CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei309 – 33224HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 29587Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 11490Alpha-1Add
    BLAST
    Regioni115 – 20692Alpha-2Add
    BLAST
    Regioni207 – 29892Alpha-3Add
    BLAST
    Regioni299 – 30810Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42056.
    HOVERGENiHBG016709.
    KOiK06751.
    OrthoDBiEOG7JT6WQ.
    PhylomeDBiP04439.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04439-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG    50
    YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV 100
    DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL 150
    NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK 200
    ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL 300
    SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS 350
    DSAQGSDVSL TACKV 365
    Length:365
    Mass (Da):40,841
    Last modified:August 22, 2003 - v2
    Checksum:iDEDFCEC4450E0580
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti319 – 3191G → A in AAB66582. (PubMed:10079303)Curated

    Polymorphismi

    The following alleles of A-3 are known: A*03:01 (A-3.1), A*03:02, A*03:04, A*03:05 and A*03:06. The sequence shown is that of A*03:01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti89 – 891R → G.
    Corresponds to variant rs1059459 [ dbSNP | Ensembl ].
    VAR_050310
    Natural varianti94 – 941Q → H.
    Corresponds to variant rs1059463 [ dbSNP | Ensembl ].
    VAR_050311
    Natural varianti101 – 1011D → N.
    Corresponds to variant rs1136688 [ dbSNP | Ensembl ].
    VAR_050312
    Natural varianti121 – 1211I → M.
    Corresponds to variant rs1136695 [ dbSNP | Ensembl ].
    VAR_050313
    Natural varianti129 – 1291S → P.
    Corresponds to variant rs1136700 [ dbSNP | Ensembl ].
    VAR_050314
    Natural varianti131 – 1311G → W.
    Corresponds to variant rs1136702 [ dbSNP | Ensembl ].
    VAR_050315
    Natural varianti133 – 1331F → L.
    Corresponds to variant rs1059488 [ dbSNP | Ensembl ].
    VAR_050316
    Natural varianti151 – 1511N → K.
    Corresponds to variant rs1059509 [ dbSNP | Ensembl ].
    VAR_050317
    Natural varianti166 – 1661I → T.1 Publication
    Corresponds to variant rs1059516 [ dbSNP | Ensembl ].
    VAR_050318
    Natural varianti169 – 1691R → H.
    Corresponds to variant rs1059520 [ dbSNP | Ensembl ].
    VAR_050319
    Natural varianti176 – 1761E → V in allele A*03:02.
    Corresponds to variant rs9256983 [ dbSNP | Ensembl ].
    VAR_004351
    Natural varianti180 – 1801L → Q in allele A*03:02.
    VAR_004352
    Natural varianti185 – 1851D → E in allele A*03:05.
    Corresponds to variant rs1059542 [ dbSNP | Ensembl ].
    VAR_016604
    Natural varianti186 – 1861G → A in allele A*03:06.
    VAR_033149
    Natural varianti199 – 1991G → R in allele A*03:04.
    Corresponds to variant rs41559916 [ dbSNP | Ensembl ].
    VAR_016605
    Natural varianti205 – 2051R → H.
    Corresponds to variant rs17185861 [ dbSNP | Ensembl ].
    VAR_050320

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00492 Genomic DNA. Translation: CAA25162.1. Sequence problems.
    U32184 mRNA. Translation: AAB63980.1.
    BA000025 Genomic DNA. Translation: BAB63400.1.
    AF217561 mRNA. Translation: AAF28734.1.
    AF015930 mRNA. Translation: AAB66582.1.
    AH008295 Genomic DNA. Translation: AAF03243.1.
    AJ401085 Genomic DNA. Translation: CAC06086.1.
    AJ401086 Genomic DNA. Translation: CAC06087.1.
    AJ401087 Genomic DNA. Translation: CAC06088.1.
    AJ748743 Genomic DNA. Translation: CAG38621.1.
    AL671277 Genomic DNA. Translation: CAI18372.1.
    AH009116 Genomic DNA. Translation: AAF29557.1.
    CCDSiCCDS34373.1.
    PIRiA02192. HLHUA3.
    RefSeqiNP_002107.3. NM_002116.7.
    UniGeneiHs.181244.
    Hs.713441.

    Genome annotation databases

    EnsembliENST00000376809; ENSP00000366005; ENSG00000206503.
    ENST00000396634; ENSP00000379873; ENSG00000206503.
    GeneIDi3105.
    KEGGihsa:3105.
    UCSCiuc003nok.3. human.

    Polymorphism databases

    DMDMi34223717.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00492 Genomic DNA. Translation: CAA25162.1 . Sequence problems.
    U32184 mRNA. Translation: AAB63980.1 .
    BA000025 Genomic DNA. Translation: BAB63400.1 .
    AF217561 mRNA. Translation: AAF28734.1 .
    AF015930 mRNA. Translation: AAB66582.1 .
    AH008295 Genomic DNA. Translation: AAF03243.1 .
    AJ401085 Genomic DNA. Translation: CAC06086.1 .
    AJ401086 Genomic DNA. Translation: CAC06087.1 .
    AJ401087 Genomic DNA. Translation: CAC06088.1 .
    AJ748743 Genomic DNA. Translation: CAG38621.1 .
    AL671277 Genomic DNA. Translation: CAI18372.1 .
    AH009116 Genomic DNA. Translation: AAF29557.1 .
    CCDSi CCDS34373.1.
    PIRi A02192. HLHUA3.
    RefSeqi NP_002107.3. NM_002116.7.
    UniGenei Hs.181244.
    Hs.713441.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XPG X-ray 2.60 A 25-298 [» ]
    3RL1 X-ray 2.00 A 25-298 [» ]
    3RL2 X-ray 2.39 A 25-298 [» ]
    ProteinModelPortali P04439.
    SMRi P04439. Positions 25-298.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109350. 35 interactions.
    IntActi P04439. 4 interactions.

    Chemistry

    ChEMBLi CHEMBL2632.

    Polymorphism databases

    DMDMi 34223717.

    Proteomic databases

    MaxQBi P04439.
    PaxDbi P04439.
    PRIDEi P04439.

    Protocols and materials databases

    DNASUi 3105.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376809 ; ENSP00000366005 ; ENSG00000206503 .
    ENST00000396634 ; ENSP00000379873 ; ENSG00000206503 .
    GeneIDi 3105.
    KEGGi hsa:3105.
    UCSCi uc003nok.3. human.

    Organism-specific databases

    CTDi 3105.
    GeneCardsi GC06P029949.
    HGNCi HGNC:4931. HLA-A.
    MIMi 142800. gene.
    neXtProti NX_P04439.
    PharmGKBi PA35055.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42056.
    HOVERGENi HBG016709.
    KOi K06751.
    OrthoDBi EOG7JT6WQ.
    PhylomeDBi P04439.

    Enzyme and pathway databases

    Reactomei REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi HLA-A. human.
    GeneWikii HLA-A.
    GenomeRNAii 3105.
    NextBioi 12319.
    PMAP-CutDB P04439.
    PROi P04439.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P04439.
    Bgeei P04439.
    CleanExi HS_HLA-A.
    Genevestigatori P04439.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes."
      Strachan T., Sodoyer R., Damotte M., Jordan B.R.
      EMBO J. 3:887-894(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*03:01).
    2. Ellexson M.E., Hildebrand W.H.
      Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*03:01).
    3. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE A*03:01).
    4. "Molecular cloning and DNA sequence analysis of genes encoding cytotoxic T lymphocyte-defined HLA-A3 subtypes: the E1 subtype."
      Cowan E.P., Jordan B.E., Coligan J.E.
      J. Immunol. 135:2835-2841(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*03:02).
    5. "Complete coding sequence of HLA-A*0302."
      Bettinotti M.P., Hadzikadic L., Adams S., Marincola F.M.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*03:02).
    6. "Full length sequence of an HLA-A*0301 intron 2 variant."
      Mayor N.P.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "Complete cDNA coding sequence of a new HLA-A3 subtype (A*0304) with a new HLA polymorphism at exon 3."
      Santos S., Balas A., Garcia-Sanchez F., Lillo R., Merino J.L., Vicario J.L.
      Immunogenetics 49:360-361(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-341 (ALLELE A*03:04).
    9. "Novel human HLA-A alleles identified in potential bone marrow donors."
      Becher M.P., Wu J., Williams T.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*03:05).
    10. "Identification of a HLA-A*03 new variant."
      Poli F., Frison S., Crespiatico L., Longhi E.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 26-298 (ALLELE A*03:05).
      Tissue: Blood.
    11. "Novel HLA-A locus alleles including A*01012, A*0306, A*0308, A*2616, A*2617, A*3009, A*3206, A*3403, A*3602 and A*6604."
      Bradshaw D., Gans C.P., Jones P., Rizzuto G., Steiner N., Mitton W., Ng J., Koester R., Hartzman R.J., Hurley C.K.
      Tissue Antigens 59:325-327(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*03:06).
    12. "Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis."
      McMahon R.M., Friis L., Siebold C., Friese M.A., Fugger L., Jones E.Y.
      Acta Crystallogr. D 67:447-454(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 25-298 (ALLELE A*03:01) IN COMPLEX WITH PLP1 ANTIGENIC PEPTIDE, DISULFIDE BONDS.
    13. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-166, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry namei1A03_HUMAN
    AccessioniPrimary (citable) accession number: P04439
    Secondary accession number(s): O19546
    , O19756, Q65A82, Q9GJE6, Q9GJE7, Q9GJE8, Q9MYE6, Q9MYG4, Q9TPR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: August 22, 2003
    Last modified: October 1, 2014
    This is version 143 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3