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Protein

HLA class I histocompatibility antigen, A-3 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • TAP binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-3 alpha chain
Alternative name(s):
MHC class I antigen A*3
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931. HLA-A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 365CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3105.
MalaCardsiHLA-A.
OpenTargetsiENSG00000206503.
PharmGKBiPA35055.

Chemistry databases

ChEMBLiCHEMBL2632.

Polymorphism and mutation databases

BioMutaiPIKFYVE.
DMDMi34223717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001881525 – 365HLA class I histocompatibility antigen, A-3 alpha chainAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)By similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication
Modified residuei343PhosphoserineBy similarity1
Modified residuei344PhosphotyrosineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1
Modified residuei352PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP04439.
MaxQBiP04439.
PaxDbiP04439.
PeptideAtlasiP04439.
PRIDEiP04439.

PTM databases

iPTMnetiP04439.
SwissPalmiP04439.

Miscellaneous databases

PMAP-CutDBP04439.

Expressioni

Gene expression databases

BgeeiENSG00000206503.
CleanExiHS_HLA-A.
ExpressionAtlasiP04439. baseline and differential.
GenevisibleiP04439. HS.

Interactioni

Subunit structurei

Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • TAP binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109350. 102 interactors.
IntActiP04439. 7 interactors.
STRINGi9606.ENSP00000366005.

Chemistry databases

BindingDBiP04439.

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 184Combined sources9
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi219 – 235Combined sources17
Beta strandi238 – 243Combined sources6
Beta strandi251 – 254Combined sources4
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 297Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XPGX-ray2.60A25-298[»]
3RL1X-ray2.00A25-298[»]
3RL2X-ray2.39A25-298[»]
ProteinModelPortaliP04439.
SMRiP04439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
PhylomeDBiP04439.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,841
Last modified:August 22, 2003 - v2
Checksum:iDEDFCEC4450E0580
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti319G → A in AAB66582 (PubMed:10079303).Curated1

Polymorphismi

The following alleles of A-3 are known: A*03:01 (A-3.1), A*03:02, A*03:04, A*03:05 and A*03:06. The sequence shown is that of A*03:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05031089R → G.Corresponds to variant rs1059459dbSNPEnsembl.1
Natural variantiVAR_05031194Q → H.Corresponds to variant rs1059463dbSNPEnsembl.1
Natural variantiVAR_050312101D → N.Corresponds to variant rs1136688dbSNPEnsembl.1
Natural variantiVAR_050313121I → M.Corresponds to variant rs1136695dbSNPEnsembl.1
Natural variantiVAR_050314129S → P.Corresponds to variant rs1136700dbSNPEnsembl.1
Natural variantiVAR_050315131G → W.Corresponds to variant rs1136702dbSNPEnsembl.1
Natural variantiVAR_050316133F → L.Corresponds to variant rs1059488dbSNPEnsembl.1
Natural variantiVAR_050317151N → K.Corresponds to variant rs1059509dbSNPEnsembl.1
Natural variantiVAR_050318166I → T.Combined sourcesCorresponds to variant rs1059516dbSNPEnsembl.1
Natural variantiVAR_050319169R → H.Corresponds to variant rs1059520dbSNPEnsembl.1
Natural variantiVAR_004351176E → V in allele A*03:02. Corresponds to variant rs9256983dbSNPEnsembl.1
Natural variantiVAR_004352180L → Q in allele A*03:02. 1
Natural variantiVAR_016604185D → E in allele A*03:05. Corresponds to variant rs1059542dbSNPEnsembl.1
Natural variantiVAR_033149186G → A in allele A*03:06. Corresponds to variant rs41545519dbSNPEnsembl.1
Natural variantiVAR_016605199G → R in allele A*03:04. Corresponds to variant rs41559916dbSNPEnsembl.1
Natural variantiVAR_050320205R → H.Corresponds to variant rs17185861dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00492 Genomic DNA. Translation: CAA25162.1. Sequence problems.
U32184 mRNA. Translation: AAB63980.1.
BA000025 Genomic DNA. Translation: BAB63400.1.
AF217561 mRNA. Translation: AAF28734.1.
AF015930 mRNA. Translation: AAB66582.1.
AH008295 Genomic DNA. Translation: AAF03243.1.
AJ401085 Genomic DNA. Translation: CAC06086.1.
AJ401086 Genomic DNA. Translation: CAC06087.1.
AJ401087 Genomic DNA. Translation: CAC06088.1.
AJ748743 Genomic DNA. Translation: CAG38621.1.
AL671277 Genomic DNA. Translation: CAI18372.1.
AH009116 Genomic DNA. Translation: AAF29557.1.
CCDSiCCDS34373.1.
PIRiA02192. HLHUA3.
RefSeqiNP_002107.3. NM_002116.7.
UniGeneiHs.181244.
Hs.713441.

Genome annotation databases

EnsembliENST00000376809; ENSP00000366005; ENSG00000206503.
ENST00000396634; ENSP00000379873; ENSG00000206503.
GeneIDi3105.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00492 Genomic DNA. Translation: CAA25162.1. Sequence problems.
U32184 mRNA. Translation: AAB63980.1.
BA000025 Genomic DNA. Translation: BAB63400.1.
AF217561 mRNA. Translation: AAF28734.1.
AF015930 mRNA. Translation: AAB66582.1.
AH008295 Genomic DNA. Translation: AAF03243.1.
AJ401085 Genomic DNA. Translation: CAC06086.1.
AJ401086 Genomic DNA. Translation: CAC06087.1.
AJ401087 Genomic DNA. Translation: CAC06088.1.
AJ748743 Genomic DNA. Translation: CAG38621.1.
AL671277 Genomic DNA. Translation: CAI18372.1.
AH009116 Genomic DNA. Translation: AAF29557.1.
CCDSiCCDS34373.1.
PIRiA02192. HLHUA3.
RefSeqiNP_002107.3. NM_002116.7.
UniGeneiHs.181244.
Hs.713441.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XPGX-ray2.60A25-298[»]
3RL1X-ray2.00A25-298[»]
3RL2X-ray2.39A25-298[»]
ProteinModelPortaliP04439.
SMRiP04439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109350. 102 interactors.
IntActiP04439. 7 interactors.
STRINGi9606.ENSP00000366005.

Chemistry databases

BindingDBiP04439.
ChEMBLiCHEMBL2632.

PTM databases

iPTMnetiP04439.
SwissPalmiP04439.

Polymorphism and mutation databases

BioMutaiPIKFYVE.
DMDMi34223717.

Proteomic databases

EPDiP04439.
MaxQBiP04439.
PaxDbiP04439.
PeptideAtlasiP04439.
PRIDEiP04439.

Protocols and materials databases

DNASUi3105.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376809; ENSP00000366005; ENSG00000206503.
ENST00000396634; ENSP00000379873; ENSG00000206503.
GeneIDi3105.

Organism-specific databases

CTDi3105.
DisGeNETi3105.
GeneCardsiHLA-A.
HGNCiHGNC:4931. HLA-A.
MalaCardsiHLA-A.
MIMi142800. gene.
neXtProtiNX_P04439.
OpenTargetsiENSG00000206503.
PharmGKBiPA35055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
PhylomeDBiP04439.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-A. human.
GeneWikiiHLA-A.
GenomeRNAii3105.
PMAP-CutDBP04439.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000206503.
CleanExiHS_HLA-A.
ExpressionAtlasiP04439. baseline and differential.
GenevisibleiP04439. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1A03_HUMAN
AccessioniPrimary (citable) accession number: P04439
Secondary accession number(s): O19546
, O19756, Q65A82, Q9GJE6, Q9GJE7, Q9GJE8, Q9MYE6, Q9MYG4, Q9TPR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 22, 2003
Last modified: November 2, 2016
This is version 164 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.