P04437 (TVA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-cell receptor alpha chain V region CTL-L17

Gene names

Name:

TCRA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Miscellaneous

This sequence was derived from a human cytotoxic T-lymphocyte that is T3+, T4+, T8-.

Ontologies

Keywords
Domain	Immunoglobulin domain Signal
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell costimulation Traceable author statement. Source: Reactome T cell receptor signaling pathway Traceable author statement. Source: Reactome immune response Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	MHC protein binding Non-traceable author statement Ref.1. Source: UniProtKB peptide antigen binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27
	Chain	28 – 139	112	T-cell receptor alpha chain V region CTL-L17		PRO_0000033593
Regions
	Region	28 – 120	93	V segment
	Region	121 – 125	5	D segment
	Region	126 – 139	14	J segment
Amino acid modifications
	Glycosylation	93	1	N-linked (GlcNAc...) Potential
	Disulfide bond	49 ↔ 116		By similarity
Experimental info
	Non-terminal residue	139	1

Sequences

	Sequence		Length	Mass (Da)
	P04437 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 5F9AEE21500A88D8	FASTA	139	15,441
	10 20 30 40 50 60 MAMLLGASVL ILWLQPDWVN SQQKNDDQQV KQNSPSLSVQ EGRISILNCD YTNSMFDYFL 70 80 90 100 110 120 WYKKYPAEGP TFLISISSIK DKNEDGRFTV FLNKSAKHLS LHIVPSQPGD SAVYFCAAKG 130 AGTASKLTFG TGTRLQVTL

References

[1]	"The complete primary structure of the T-cell receptor genes from an alloreactive cytotoxic human T-lymphocyte clone." Leiden J.M., Fraser J.D., Strominger J.L. Immunogenetics 24:17-23(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M15565 mRNA. Translation: AAA60627.1.
IPI	IPI00024141.
PIR	RWHU7A. A02016.
3D structure databases
ProteinModelPortal	P04437.
ModBase	Search...
Polymorphism databases
DMDM	136488.
Proteomic databases
PRIDE	P04437.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG137092.
HOVERGEN	HBG105972.
InParanoid	P04437.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Genevestigator	P04437.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TRA@. human.
NextBio	35537731.

Entry information

Entry name

TVA2_HUMAN

Accession

Primary (citable) accession number: P04437

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.