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Protein

T-cell receptor beta chain V region CTL-L17

Gene

TCRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • MHC protein binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127382-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-389948. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor beta chain V region CTL-L17
Gene namesi
Name:TCRB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.

Chemistry databases

ChEMBLiCHEMBL3580506.

Polymorphism and mutation databases

DMDMi136494.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000003359922 – 133T-cell receptor beta chain V region CTL-L17Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi42 ↔ 111PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP04435.
PRIDEiP04435.

Interactioni

GO - Molecular functioni

  • MHC protein binding Source: UniProtKB

Protein-protein interaction databases

IntActiP04435. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP04435.
SMRiP04435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 114V segmentAdd BLAST93
Regioni115 – 118D segment4
Regioni119 – 133J segmentAdd BLAST15

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

HOVERGENiHBG100543.
InParanoidiP04435.
PhylomeDBiP04435.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04435-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTSLLCWMA LCLLGADHAD TGVSQNPRHN ITKRGQNVTF RCDPISEHNR
60 70 80 90 100
LYWYRQTLGQ GPEFLTYFQN EAQLEKSRLL SDRFSAERPK GSFSTLEIQR
110 120 130
TEQGDSAMYL CASSLAGLNQ PQHFGDGTRL SIL
Length:133
Mass (Da):14,999
Last modified:August 13, 1987 - v1
Checksum:i21030818D18D341F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1331

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15564 mRNA. Translation: AAA61027.1.
PIRiA02001. RWHU7B.
H32537.
S30440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15564 mRNA. Translation: AAA61027.1.
PIRiA02001. RWHU7B.
H32537.
S30440.

3D structure databases

ProteinModelPortaliP04435.
SMRiP04435.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04435. 1 interactor.

Chemistry databases

ChEMBLiCHEMBL3580506.

Polymorphism and mutation databases

DMDMi136494.

Proteomic databases

PeptideAtlasiP04435.
PRIDEiP04435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.

Phylogenomic databases

HOVERGENiHBG100543.
InParanoidiP04435.
PhylomeDBiP04435.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127382-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-389948. PD-1 signaling.

Miscellaneous databases

PROiP04435.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTVB2_HUMAN
AccessioniPrimary (citable) accession number: P04435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This sequence was derived from a human cytotoxic T-lymphocyte that is T3+, T4+, T8-.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.