Reviewed, UniProtKB/Swiss-Prot P04435 (TVB2_HUMAN)

Names and origin

Protein names

Recommended name:
    T-cell receptor beta chain V region CTL-L17

Gene names

Name:

TCRB

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Miscellaneous

This sequence was derived from a human cytotoxic T-lymphocyte that is T3+, T4+, T8-.

Ontologies

Keywords
Domain	Immunoglobulin domain Signal
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	immune response Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	plasma membrane Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	MHC protein binding Ref.1 Non-traceable author statement. Source: UniProtKB peptide antigen binding Ref.1 Non-traceable author statement. Source: UniProtKB receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21
	Chain	22 – 133	112	T-cell receptor beta chain V region CTL-L17		PRO_0000033599
Regions
	Region	22 – 114	93	V segment
	Region	115 – 118	4	D segment
	Region	119 – 133	15	J segment
Amino acid modifications
	Glycosylation	30	1	N-linked (GlcNAc...) Potential
	Glycosylation	37	1	N-linked (GlcNAc...) Potential
	Disulfide bond	42 ↔ 111		By similarity
Experimental info
	Non-terminal residue	133	1

Sequences

	Sequence		Length	Mass (Da)
	P04435-1 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 21030818D18D341F	FASTA	133	14,999
	10 20 30 40 50 60 MGTSLLCWMA LCLLGADHAD TGVSQNPRHN ITKRGQNVTF RCDPISEHNR LYWYRQTLGQ 70 80 90 100 110 120 GPEFLTYFQN EAQLEKSRLL SDRFSAERPK GSFSTLEIQR TEQGDSAMYL CASSLAGLNQ 130 PQHFGDGTRL SIL

References

[1]	"The complete primary structure of the T-cell receptor genes from an alloreactive cytotoxic human T-lymphocyte clone." Leiden J.M., Fraser J.D., Strominger J.L. Immunogenetics 24:17-23(1986) [PubMed: 2426193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M15564 mRNA. Translation: AAA61027.1.
IPI	IPI00024139.
PIR	RWHU7B. A02001. H32537. S30440.
3D structure databases
HSSP	HSSP built from PDB template 1BEC based on UniProtKB Q8K1Z5.
ModBase	Search...
Proteomic databases
PRIDE	P04435.
Genome annotation databases
Ensembl	ENSG00000211735. Homo sapiens. [Contig view]
Organism-specific databases
GeneCards	GC07P141917.
H-InvDB	HIX0058291.
HGNC	HGNC:12155. TRB@.
PharmGKB	PA74.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P04435.
HOVERGEN	P04435.
Enzyme and pathway databases
Reactome	REACT_6900. Signaling in Immune system.
Gene expression databases
Bgee	P04435.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TVB2_HUMAN

Accession

Primary (citable) accession number: P04435

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	August 13, 1987
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)