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P04431 (KV123_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig kappa chain V-I region Walker
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222
Chain23 – 129107Ig kappa chain V-I region Walker
PRO_0000015170

Regions

Region23 – 4523Framework-1
Region46 – 5611Complementarity-determining-1
Region57 – 7115Framework-2
Region72 – 787Complementarity-determining-2
Region79 – 11032Framework-3
Region111 – 1199Complementarity-determining-3
Region120 – 12910Framework-4

Amino acid modifications

Disulfide bond45 ↔ 110 By similarity

Experimental info

Non-terminal residue1291

Secondary structure

........................ 129
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P04431 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: F941FA07D4AFC2F9

FASTA12914,069
        10         20         30         40         50         60 
MDMRVPAQLL GLLLLWLRGA RCDIQMTQSP SSLSASVGDR VTITCRASQS ISNYLNWYQQ 

        70         80         90        100        110        120 
KPGKAPKLLI YAASSLQSGV TSRFSGSGSG TDFTLTISSL QPEDSATYYC QQSYSTLITF 


GQGTRLEIK 

« Hide

References

[1]"Immunoglobulin genes of the kappa light chain type from two human lymphoid cell lines are closely related."
Klobeck H.G., Combriato G., Zachau H.G.
Nucleic Acids Res. 12:6995-7006(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X00965 Genomic DNA. Translation: CAA25477.1. Different termination.
PIRK1HUWK. A01883.
A27594.
UniGeneHs.449609.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3UPAX-ray1.80A/B23-129[»]
ProteinModelPortalP04431.
SMRP04431. Positions 23-128.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000394422.

Protein family/group databases

IMGTSearch...

Polymorphism databases

DMDM125779.

Proteomic databases

PaxDbP04431.
PRIDEP04431.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG28757.
HOVERGENHBG018013.
InParanoidP04431.
PhylomeDBP04431.

Enzyme and pathway databases

ReactomeREACT_160300. Binding and Uptake of Ligands by Scavenger Receptors.
REACT_6900. Immune System.

Gene expression databases

GenevestigatorP04431.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKV123_HUMAN
AccessionPrimary (citable) accession number: P04431
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references