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Proto-oncogene Wnt-1



Mus musculus (Mouse)
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli


Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Proeminent role in the induction of the mesencephalon and cerebellum. May play a crucial role in the morphogenesis of the neural tube and/or the early stages of CNS development. Has a role in osteoblast function and bone development (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • frizzled binding Source: GO_Central
  • protein domain specific binding Source: UniProtKB
  • receptor binding Source: MGI
  • transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  • BMP signaling pathway Source: MGI
  • bone development Source: UniProtKB
  • branching involved in ureteric bud morphogenesis Source: MGI
  • canonical Wnt signaling pathway Source: BHF-UCL
  • canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: MGI
  • cell-cell signaling Source: BHF-UCL
  • cellular response to peptide hormone stimulus Source: Ensembl
  • central nervous system morphogenesis Source: BHF-UCL
  • cerebellum formation Source: BHF-UCL
  • diencephalon development Source: MGI
  • dopaminergic neuron differentiation Source: CACAO
  • embryonic axis specification Source: BHF-UCL
  • forebrain anterior/posterior pattern specification Source: MGI
  • hematopoietic stem cell proliferation Source: MGI
  • hepatocyte differentiation Source: Ensembl
  • inner ear morphogenesis Source: MGI
  • metencephalon development Source: MGI
  • midbrain development Source: BHF-UCL
  • midbrain-hindbrain boundary development Source: MGI
  • midbrain-hindbrain boundary maturation during brain development Source: MGI
  • myoblast fusion Source: MGI
  • myotube differentiation Source: MGI
  • negative regulation of BMP signaling pathway Source: MGI
  • negative regulation of cell aging Source: MGI
  • negative regulation of cell-cell adhesion Source: MGI
  • negative regulation of cell differentiation Source: AgBase
  • negative regulation of cell-substrate adhesion Source: MGI
  • negative regulation of fat cell differentiation Source: BHF-UCL
  • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • neuron fate commitment Source: MGI
  • neuron fate determination Source: MGI
  • organ morphogenesis Source: MGI
  • organ regeneration Source: Ensembl
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of dermatome development Source: MGI
  • positive regulation of fibroblast proliferation Source: MGI
  • positive regulation of insulin-like growth factor receptor signaling pathway Source: MGI
  • positive regulation of lamellipodium assembly Source: MGI
  • positive regulation of Notch signaling pathway Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to wounding Source: Ensembl
  • signal transduction Source: MGI
  • signal transduction in response to DNA damage Source: MGI
  • Spemann organizer formation Source: BHF-UCL
  • spinal cord association neuron differentiation Source: MGI
  • T cell differentiation in thymus Source: MGI
  • ubiquitin-dependent SMAD protein catabolic process Source: MGI
  • Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.
REACT_295052. WNT ligand biogenesis and trafficking.
REACT_309805. Transcriptional regulation of white adipocyte differentiation.
REACT_317277. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_333985. PCP/CE pathway.
REACT_335449. Class B/2 (Secretin family receptors).
REACT_335672. TCF dependent signaling in response to WNT.

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene Wnt-1
Alternative name(s):
Proto-oncogene Int-1
Gene namesi
Synonyms:Int-1, Wnt-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:98953. Wnt1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Many mouse mammary tumors induced by mouse mammary tumor virus (MMTV) contain a provirus integrated into a host cell region which has been named INT-1 (now Wnt1).

Keywords - Diseasei


PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
Chaini28 – 370343Proto-oncogene Wnt-1PRO_0000041406Add

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi93 ↔ 104By similarity
Disulfide bondi143 ↔ 151By similarity
Disulfide bondi153 ↔ 170By similarity
Disulfide bondi218 ↔ 232By similarity
Disulfide bondi220 ↔ 227By similarity
Lipidationi224 – 2241O-palmitoleyl serine; by PORCNBy similarity
Disulfide bondi315 ↔ 330By similarity
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi345 ↔ 360By similarity
Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi347 ↔ 357By similarity
Disulfide bondi352 ↔ 353By similarity