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P04421

- LYSC_BOVIN

UniProt

P04421 - LYSC_BOVIN

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Protein
Lysozyme C
Gene
LYZ1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei53 – 531 By similarity
Active sitei71 – 711 By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall macromolecule catabolic process Source: InterPro
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Keywords - Biological processi

Digestion

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme C (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Gene namesi
Name:LYZ1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 Publication
Add
BLAST
Chaini19 – 147129Lysozyme C
PRO_0000018453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 145 By similarity
Disulfide bondi48 ↔ 133 By similarity
Disulfide bondi83 ↔ 99 By similarity
Disulfide bondi95 ↔ 113 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Stomach-specific.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007924.

Structurei

3D structure databases

ProteinModelPortaliP04421.
SMRiP04421. Positions 19-147.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG052297.
InParanoidiP04421.
KOiK01185.
K13915.

Family and domain databases

InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04421-1 [UniParc]FASTAAdd to Basket

« Hide

MKALVILGFL FLSVAVQGKV FERCELARTL KKLGLDGYKG VSLANWLCLT    50
KWESSYNTKA TNYNPSSEST DYGIFQINSK WWCNDGKTPN AVDGCHVSCR 100
ELMENDIAKA VACAKHIVSE QGITAWVAWK SHCRDHDVSS YVEGCTL 147
Length:147
Mass (Da):16,373
Last modified:October 1, 1989 - v2
Checksum:iC678E7EECE1E66BF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31A → T in isozyme 2A.
Natural varianti5 – 51V → I in isozyme 1 and isozyme 3.
Natural varianti17 – 171Q → K in isozyme 2C.
Natural varianti45 – 451N → S in isozyme 2D.
Natural varianti66 – 661S → G in isozyme 1.
Natural varianti106 – 1061D → E in isozyme 1.
Natural varianti116 – 1161H → Q in isozyme 1.
Natural varianti143 – 1431E → Q in isozyme 3.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26246 mRNA. Translation: AAA30627.1.
M26245 mRNA. Translation: AAA30626.1.
M26242 mRNA. Translation: AAA30632.1.
M26241 mRNA. Translation: AAA30628.1.
M26243 mRNA. Translation: AAA30629.1.
M26244 mRNA. Translation: AAA30630.1.
M26240 mRNA. Translation: AAA30631.1.
RefSeqiNP_001073808.1. NM_001080339.1.
NP_776529.1. NM_174104.2.
NP_851342.1. NM_180999.1.
UniGeneiBt.29367.
Bt.80498.
Bt.89770.

Genome annotation databases

GeneIDi280849.
281289.
781349.
KEGGibta:280849.
bta:281289.
bta:781349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26246 mRNA. Translation: AAA30627.1 .
M26245 mRNA. Translation: AAA30626.1 .
M26242 mRNA. Translation: AAA30632.1 .
M26241 mRNA. Translation: AAA30628.1 .
M26243 mRNA. Translation: AAA30629.1 .
M26244 mRNA. Translation: AAA30630.1 .
M26240 mRNA. Translation: AAA30631.1 .
RefSeqi NP_001073808.1. NM_001080339.1.
NP_776529.1. NM_174104.2.
NP_851342.1. NM_180999.1.
UniGenei Bt.29367.
Bt.80498.
Bt.89770.

3D structure databases

ProteinModelPortali P04421.
SMRi P04421. Positions 19-147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000007924.

Protein family/group databases

CAZyi GH22. Glycoside Hydrolase Family 22.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 280849.
281289.
781349.
KEGGi bta:280849.
bta:281289.
bta:781349.

Organism-specific databases

CTDi 17105.
281289.

Phylogenomic databases

HOVERGENi HBG052297.
InParanoidi P04421.
KOi K01185.
K13915.

Miscellaneous databases

NextBioi 20804997.

Family and domain databases

InterProi IPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view ]
Pfami PF00062. Lys. 1 hit.
[Graphical view ]
PRINTSi PR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTi SM00263. LYZ1. 1 hit.
[Graphical view ]
SUPFAMi SSF53955. SSF53955. 1 hit.
PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Multiple cDNA sequences and the evolution of bovine stomach lysozyme."
    Irwin D.M., Wilson A.C.
    J. Biol. Chem. 264:11387-11393(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Stomach lysozymes of ruminants. II. Amino acid sequence of cow lysozyme 2 and immunological comparisons with other lysozymes."
    Jolles P., Schoentgen F., Jolles J., Dobson D.E., Prager E.M., Wilson A.C.
    J. Biol. Chem. 259:11617-11625(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-147 (2B).
  3. Cited for: SEQUENCE REVISION TO 116 (2B).

Entry informationi

Entry nameiLYSC_BOVIN
AccessioniPrimary (citable) accession number: P04421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: October 1, 1989
Last modified: January 22, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
The ruminant gastric lysozymes, which digest symbiotic bacteria coming with cud from the rumen, are much more resistant to inactivation by pepsin than are other lysozymes.
Three non-allelic lysozymes C are present in the gastric mucosa of cattle.
The sequence of isozyme 2B is shown.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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