##gff-version 3
P04418	UniProtKB	Chain	1	138	.	.	.	ID=PRO_0000164934;Note=Endonuclease V	
P04418	UniProtKB	Active site	2	2	.	.	.	Note=Nucleophile%3B via amide nitrogen;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:8347626,ECO:0007744|PDB:1VAS;Dbxref=PMID:8347626	
P04418	UniProtKB	Active site	23	23	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:8347626,ECO:0007744|PDB:1VAS;Dbxref=PMID:8347626	
P04418	UniProtKB	Site	3	3	.	.	.	Note=Substrate binding;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1409651,ECO:0000269|PubMed:7783199;Dbxref=PMID:1409651,PMID:7783199	
P04418	UniProtKB	Site	22	22	.	.	.	Note=Substrate binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Site	26	26	.	.	.	Note=Transition state stabilizer;Ontology_term=ECO:0007744;evidence=ECO:0007744|PDB:1VAS	
P04418	UniProtKB	Site	117	117	.	.	.	Note=Substrate binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Site	121	121	.	.	.	Note=Substrate binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	3	3	.	.	.	Note=Complete loss of DNA glycosylase activity. R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	11	11	.	.	.	Note=24%25 decrease in DNA glycosylase activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	16	16	.	.	.	Note=30%25 decrease in enzymatic activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14610082;Dbxref=PMID:14610082	
P04418	UniProtKB	Mutagenesis	16	16	.	.	.	Note=40%25 decrease in enzymatic activity. H->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14610082;Dbxref=PMID:14610082	
P04418	UniProtKB	Mutagenesis	16	16	.	.	.	Note=60%25 decrease in enzymatic activity. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14610082;Dbxref=PMID:14610082	
P04418	UniProtKB	Mutagenesis	16	16	.	.	.	Note=50%25 decrease in enzymatic activity. H->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14610082;Dbxref=PMID:14610082	
P04418	UniProtKB	Mutagenesis	16	16	.	.	.	Note=75%25 decrease in enzymatic activity. H->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14610082;Dbxref=PMID:14610082	
P04418	UniProtKB	Mutagenesis	16	16	.	.	.	Note=60%25 decrease in enzymatic activity. H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	16	16	.	.	.	Note=70%25 decrease in enzymatic activity. H->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14610082;Dbxref=PMID:14610082	
P04418	UniProtKB	Mutagenesis	21	21	.	.	.	Note=No effect on DNA glycosylase activity. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	22	22	.	.	.	Note=Almost complete loss of DNA glycosylase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	23	23	.	.	.	Note=Complete loss of DNA glycosylase activity. No effect on AP lyase activity. E->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1357629,ECO:0000269|PubMed:1409651;Dbxref=PMID:1357629,PMID:1409651	
P04418	UniProtKB	Mutagenesis	23	23	.	.	.	Note=Complete loss of DNA glycosylase activity. Complete loss of AP lyase activity. E->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1357629,ECO:0000269|PubMed:1409651;Dbxref=PMID:1357629,PMID:1409651	
P04418	UniProtKB	Mutagenesis	26	26	.	.	.	Note=Almost complete loss of DNA glycosylase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	32	32	.	.	.	Note=10%25 decrease in DNA glycosylase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	40	40	.	.	.	Note=20%25 decrease in DNA glycosylase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	42	42	.	.	.	Note=25%25 decrease in DNA glycosylase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	68	68	.	.	.	Note=35%25 decrease in DNA glycosylase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	86	86	.	.	.	Note=No effect on DNA glycosylase activity. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	87	87	.	.	.	Note=No effect on DNA glycosylase activity. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	87	87	.	.	.	Note=20%25 decrease in DNA glycosylase activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	117	117	.	.	.	Note=60%25 decrease in DNA glycosylase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	119	119	.	.	.	Note=5%25 decrease in DNA glycosylase activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	120	120	.	.	.	Note=10%25 decrease in DNA glycosylase activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	121	121	.	.	.	Note=90%25 decrease in DNA glycosylase activity. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	125	125	.	.	.	Note=10%25 decrease in DNA glycosylase activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	129	129	.	.	.	Note=65%25 decrease in DNA glycosylase activity. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	132	132	.	.	.	Note=10%25 decrease in DNA glycosylase activity. Y->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Mutagenesis	134	134	.	.	.	Note=20%25 decrease in DNA glycosylase activity. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1409651;Dbxref=PMID:1409651	
P04418	UniProtKB	Helix	9	11	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2END	
P04418	UniProtKB	Helix	14	23	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2END	
P04418	UniProtKB	Helix	26	36	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2END	
P04418	UniProtKB	Helix	41	43	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2END	
P04418	UniProtKB	Turn	54	57	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2END	
P04418	UniProtKB	Helix	58	60	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2END	
P04418	UniProtKB	Helix	64	80	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2END	
P04418	UniProtKB	Helix	98	100	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2END	
P04418	UniProtKB	Helix	108	124	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2END	
P04418	UniProtKB	Helix	126	128	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2END	
P04418	UniProtKB	Beta strand	131	133	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1ENJ