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Protein

Epidermal growth factor receptor

Gene

Egfr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle. Required for embryonic epithelial tissue repair.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei971ATPPROSITE-ProRule annotation1
Active sitei1063Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi944 – 952ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • epidermal growth factor-activated receptor activity Source: FlyBase
  • protein tyrosine kinase activity Source: FlyBase
  • transmembrane signaling receptor activity Source: FlyBase

GO - Biological processi

  • antennal development Source: FlyBase
  • anterior/posterior pattern specification Source: FlyBase
  • behavioral response to ethanol Source: FlyBase
  • blastoderm segmentation Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • brain development Source: FlyBase
  • branched duct epithelial cell fate determination, open tracheal system Source: FlyBase
  • cell fate commitment Source: FlyBase
  • cell fate determination Source: FlyBase
  • cell projection assembly Source: FlyBase
  • chorion-containing eggshell pattern formation Source: FlyBase
  • compound eye cone cell fate commitment Source: FlyBase
  • compound eye development Source: FlyBase
  • compound eye morphogenesis Source: FlyBase
  • compound eye photoreceptor cell differentiation Source: FlyBase
  • compound eye photoreceptor fate commitment Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • determination of genital disc primordium Source: FlyBase
  • digestive tract morphogenesis Source: FlyBase
  • dorsal/ventral pattern formation Source: FlyBase
  • dorsal appendage formation Source: FlyBase
  • dorsal closure Source: FlyBase
  • embryo development ending in birth or egg hatching Source: CACAO
  • embryonic axis specification Source: FlyBase
  • embryonic pattern specification Source: FlyBase
  • epidermal growth factor receptor signaling pathway Source: FlyBase
  • epithelial cell proliferation involved in Malpighian tubule morphogenesis Source: FlyBase
  • establishment or maintenance of apical/basal cell polarity Source: FlyBase
  • eye-antennal disc morphogenesis Source: FlyBase
  • eye development Source: FlyBase
  • female germ-line cyst encapsulation Source: FlyBase
  • G2/M transition of mitotic cell cycle Source: FlyBase
  • gastrulation Source: FlyBase
  • germ-band shortening Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • gonad development Source: FlyBase
  • haltere development Source: FlyBase
  • heart process Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein morphogenesis Source: FlyBase
  • imaginal disc-derived wing vein specification Source: FlyBase
  • imaginal disc development Source: FlyBase
  • imaginal disc pattern formation Source: FlyBase
  • leg disc proximal/distal pattern formation Source: FlyBase
  • maintenance of epithelial integrity, open tracheal system Source: FlyBase
  • male germ-line cyst encapsulation Source: FlyBase
  • Malpighian tubule morphogenesis Source: FlyBase
  • maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded Source: FlyBase
  • morphogenesis of an epithelium Source: FlyBase
  • morphogenesis of follicular epithelium Source: FlyBase
  • muscle attachment Source: FlyBase
  • muscle cell fate specification Source: FlyBase
  • negative regulation of apoptotic process Source: FlyBase
  • negative regulation of apoptotic signaling pathway Source: FlyBase
  • negative regulation of compound eye retinal cell programmed cell death Source: FlyBase
  • negative regulation of G1/S transition of mitotic cell cycle Source: FlyBase
  • neurogenesis Source: FlyBase
  • notum cell fate specification Source: FlyBase
  • notum development Source: FlyBase
  • oenocyte differentiation Source: FlyBase
  • olfactory learning Source: FlyBase
  • ommatidial rotation Source: FlyBase
  • oocyte anterior/posterior axis specification Source: FlyBase
  • oocyte axis specification Source: FlyBase
  • oocyte dorsal/ventral axis specification Source: FlyBase
  • oogenesis Source: FlyBase
  • open tracheal system development Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • positive regulation of cell proliferation Source: FlyBase
  • positive regulation of wound healing Source: FlyBase
  • progression of morphogenetic furrow involved in compound eye morphogenesis Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • R7 cell differentiation Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • regulation of hemocyte differentiation Source: FlyBase
  • regulation of mitotic cell cycle Source: FlyBase
  • regulation of R8 cell spacing in compound eye Source: FlyBase
  • salivary gland development Source: FlyBase
  • second mitotic wave involved in compound eye morphogenesis Source: FlyBase
  • segment polarity determination Source: FlyBase
  • single organismal cell-cell adhesion Source: FlyBase
  • spiracle morphogenesis, open tracheal system Source: FlyBase
  • stem cell fate commitment Source: FlyBase
  • stomatogastric nervous system development Source: FlyBase
  • tracheal pit formation in open tracheal system Source: FlyBase
  • wing and notum subfield formation Source: FlyBase
  • wing disc morphogenesis Source: FlyBase
  • wing disc proximal/distal pattern formation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 1994.
ReactomeiR-DME-1251985. Nuclear signaling by ERBB4.
R-DME-1253288. Downregulation of ERBB4 signaling.
R-DME-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-DME-179812. GRB2 events in EGFR signaling.
R-DME-180292. GAB1 signalosome.
R-DME-180336. SHC1 events in EGFR signaling.
R-DME-182971. EGFR downregulation.
R-DME-2179392. EGFR Transactivation by Gastrin.
R-DME-445144. Signal transduction by L1.
R-DME-5673001. RAF/MAP kinase cascade.
R-DME-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-DME-8856828. Clathrin-mediated endocytosis.
R-DME-8863795. Downregulation of ERBB2 signaling.
SignaLinkiP04412.

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor receptor (EC:2.7.10.1)
Short name:
Egfr
Alternative name(s):
Drosophila relative of ERBB
Gurken receptor
Protein torpedo
Gene namesi
Name:Egfr
Synonyms:c-erbB, DER, top
ORF Names:CG10079
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003731. Egfr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 868ExtracellularSequence analysisAdd BLAST838
Transmembranei869 – 889HelicalSequence analysisAdd BLAST21
Topological domaini890 – 1426CytoplasmicSequence analysisAdd BLAST537

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Embryonic wound healing defects.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi793C → R in EGFR-ELP-1. 1
Mutagenesisi936A → T in EGFR-ELP-B1 and EGFR-ELP-B1RB1. 1
Mutagenesisi1058R → Q in EGFR-ELP-B1RB1. 1
Mutagenesisi1135T → I in EGFR-2W74. 1
Mutagenesisi1156G → S in EGFR-2C82. 1
Mutagenesisi1162P → L in EGFR-1F26. 1
Mutagenesisi1166S → L in EGFR-2L65. 1
Mutagenesisi1210 – 1216DKFTRLP → EKVHPAA in EGFR-2X51. 7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001667631 – 1426Epidermal growth factor receptorAdd BLAST1396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1
Glycosylationi443N-linked (GlcNAc...)Sequence analysis1
Glycosylationi482N-linked (GlcNAc...)Sequence analysis1
Glycosylationi569N-linked (GlcNAc...)Sequence analysis1
Glycosylationi599N-linked (GlcNAc...)Sequence analysis1
Glycosylationi617N-linked (GlcNAc...)Sequence analysis1
Glycosylationi816N-linked (GlcNAc...)Sequence analysis1
Glycosylationi823N-linked (GlcNAc...)Sequence analysis1
Glycosylationi828N-linked (GlcNAc...)Sequence analysis1
Modified residuei902Phosphothreonine; by PKCBy similarity1
Modified residuei1310Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP04412.
PRIDEiP04412.

Expressioni

Tissue specificityi

Ubiquitously expressed in embryos. In larvae, uniform expression is seen in wing disks, genital disk, anlagen of testis and ovary, and brain cortex. In eye-antenna disk, highest expression is anterior to morphogenetic furrow, levels remain high in photoreceptor precursor cells. This pattern is reversed in posterior eye disk. In adults expression is high in brain cortex and thoracic and abdominal ganglia.1 Publication

Gene expression databases

BgeeiFBgn0003731.
ExpressionAtlasiP04412. baseline.
GenevisibleiP04412. DM.

Interactioni

Subunit structurei

Interacts (when phosphorylated on tyrosine residues) with Vav (via SH2 domain).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
kek1P916432EBI-197863,EBI-6896313
spiQ010834EBI-197863,EBI-91342

Protein-protein interaction databases

BioGridi63083. 72 interactors.
DIPiDIP-17316N.
IntActiP04412. 5 interactors.
MINTiMINT-806082.
STRINGi7227.FBpp0071571.

Structurei

Secondary structure

11426
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi101 – 103Combined sources3
Helixi115 – 126Combined sources12
Beta strandi131 – 134Combined sources4
Beta strandi136 – 141Combined sources6
Helixi149 – 151Combined sources3
Beta strandi156 – 159Combined sources4
Beta strandi161 – 166Combined sources6
Beta strandi169 – 172Combined sources4
Beta strandi194 – 200Combined sources7
Beta strandi204 – 207Combined sources4
Beta strandi216 – 223Combined sources8
Turni230 – 232Combined sources3
Helixi235 – 237Combined sources3
Beta strandi239 – 241Combined sources3
Beta strandi246 – 248Combined sources3
Beta strandi269 – 273Combined sources5
Helixi274 – 276Combined sources3
Beta strandi281 – 285Combined sources5
Beta strandi287 – 289Combined sources3
Beta strandi290 – 292Combined sources3
Beta strandi295 – 300Combined sources6
Beta strandi305 – 316Combined sources12
Beta strandi319 – 327Combined sources9
Beta strandi330 – 334Combined sources5
Beta strandi338 – 342Combined sources5
Turni343 – 346Combined sources4
Beta strandi347 – 350Combined sources4
Beta strandi356 – 358Combined sources3
Beta strandi361 – 365Combined sources5
Beta strandi370 – 373Combined sources4
Beta strandi376 – 380Combined sources5
Beta strandi385 – 394Combined sources10
Beta strandi396 – 398Combined sources3
Beta strandi402 – 404Combined sources3
Turni411 – 413Combined sources3
Helixi414 – 417Combined sources4
Beta strandi421 – 425Combined sources5
Beta strandi427 – 429Combined sources3
Helixi431 – 435Combined sources5
Beta strandi438 – 440Combined sources3
Turni442 – 444Combined sources3
Beta strandi446 – 449Combined sources4
Helixi455 – 463Combined sources9
Beta strandi466 – 469Combined sources4
Beta strandi471 – 473Combined sources3
Helixi484 – 486Combined sources3
Beta strandi491 – 493Combined sources3
Turni499 – 502Combined sources4
Beta strandi503 – 509Combined sources7
Beta strandi525 – 531Combined sources7
Turni539 – 541Combined sources3
Helixi544 – 547Combined sources4
Beta strandi555 – 561Combined sources7
Helixi563 – 567Combined sources5
Turni568 – 570Combined sources3
Beta strandi575 – 577Combined sources3
Beta strandi582 – 586Combined sources5
Beta strandi590 – 598Combined sources9
Beta strandi601 – 604Combined sources4
Beta strandi608 – 610Combined sources3
Beta strandi616 – 618Combined sources3
Beta strandi628 – 630Combined sources3
Beta strandi632 – 636Combined sources5
Beta strandi638 – 640Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I2TX-ray2.70A100-644[»]
3LTFX-ray3.20A/C100-688[»]
3LTGX-ray3.40A/C100-688[»]
ProteinModelPortaliP04412.
SMRiP04412.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04412.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini938 – 1198Protein kinasePROSITE-ProRule annotationAdd BLAST261

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.
InParanoidiP04412.
KOiK04361.
OrthoDBiEOG091G00U7.
PhylomeDBiP04412.

Family and domain databases

Gene3Di3.80.20.20. 4 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF14843. GF_recep_IV. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 7 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Type I (identifier: P04412-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLRRRNGPC PFPLLLLLLA HCICIWPASA ARDRYARQNN RQRHQDIDRD
60 70 80 90 100
RDRDRFLYRS SSAQNRQRGG ANFALGLGAN GVTIPTSLED KNKNEFVKGK
110 120 130 140 150
ICIGTKSRLS VPSNKEHHYR NLRDRYTNCT YVDGNLKLTW LPNENLDLSF
160 170 180 190 200
LDNIREVTGY ILISHVDVKK VVFPKLQIIR GRTLFSLSVE EEKYALFVTY
210 220 230 240 250
SKMYTLEIPD LRDVLNGQVG FHNNYNLCHM RTIQWSEIVS NGTDAYYNYD
260 270 280 290 300
FTAPERECPK CHESCTHGCW GEGPKNCQKF SKLTCSPQCA GGRCYGPKPR
310 320 330 340 350
ECCHLFCAGG CTGPTQKDCI ACKNFFDEAV SKEECPPMRK YNPTTYVLET
360 370 380 390 400
NPEGKYAYGA TCVKECPGHL LRDNGACVRS CPQDKMDKGG ECVPCNGPCP
410 420 430 440 450
KTCPGVTVLH AGNIDSFRNC TVIDGNIRIL DQTFSGFQDV YANYTMGPRY
460 470 480 490 500
IPLDPERREV FSTVKEITGY LNIEGTHPQF RNLSYFRNLE TIHGRQLMES
510 520 530 540 550
MFAALAIVKS SLYSLEMRNL KQISSGSVVI QHNRDLCYVS NIRWPAIQKE
560 570 580 590 600
PEQKVWVNEN LRADLCEKNG TICSDQCNED GCWGAGTDQC LTCKNFNFNG
610 620 630 640 650
TCIADCGYIS NAYKFDNRTC KICHPECRTC NGAGADHCQE CVHVRDGQHC
660 670 680 690 700
VSECPKNKYN DRGVCRECHA TCDGCTGPKD TIGIGACTTC NLAIINNDAT
710 720 730 740 750
VKRCLLKDDK CPDGYFWEYV HPQEQGSLKP LAGRAVCRKC HPLCELCTNY
760 770 780 790 800
GYHEQVCSKC THYKRREQCE TECPADHYTD EEQRECFQRH PECNGCTGPG
810 820 830 840 850
ADDCKSCRNF KLFDANETGP YVNSTMFNCT SKCPLEMRHV NYQYTAIGPY
860 870 880 890 900
CAASPPRSSK ITANLDVNMI FIITGAVLVP TICILCVVTY ICRQKQKAKK
910 920 930 940 950
ETVKMTMALS GCEDSEPLRP SNIGANLCKL RIVKDAELRK GGVLGMGAFG
960 970 980 990 1000
RVYKGVWVPE GENVKIPVAI KELLKSTGAE SSEEFLREAY IMASEEHVNL
1010 1020 1030 1040 1050
LKLLAVCMSS QMMLITQLMP LGCLLDYVRN NRDKIGSKAL LNWSTQIAKG
1060 1070 1080 1090 1100
MSYLEEKRLV HRDLAARNVL VQTPSLVKIT DFGLAKLLSS DSNEYKAAGG
1110 1120 1130 1140 1150
KMPIKWLALE CIRNRVFTSK SDVWAFGVTI WELLTFGQRP HENIPAKDIP
1160 1170 1180 1190 1200
DLIEVGLKLE QPEICSLDIY CTLLSCWHLD AAMRPTFKQL TTVFAEFARD
1210 1220 1230 1240 1250
PGRYLAIPGD KFTRLPAYTS QDEKDLIRKL APTTDGSEAI AKPDDYLQPK
1260 1270 1280 1290 1300
AAPGPSHRTD CTDEMPKLNR YCKDPSNKNS STGDDERDSS AREVGVGNLR
1310 1320 1330 1340 1350
LDLPVDEDDY LMPTCQPGPN NNNNMNNPNQ NNMAAVGVAA GYMDLIGVPV
1360 1370 1380 1390 1400
SVDNPEYLLN AQTLGVGESP IPTQTIGIPV MGGPGTMEVK VPMPGSEPTS
1410 1420
SDHEYYNDTQ RELQPLHRNR NTETRV
Length:1,426
Mass (Da):159,718
Last modified:December 15, 1998 - v3
Checksum:i4D424C3C99DA4AF4
GO
Isoform Type II (identifier: P04412-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: MLLRRRNGPC...NKNEFVKGKI → MMIISMWMSI...GYVDNGNMKV

Show »
Length:1,377
Mass (Da):153,700
Checksum:iAEA869BD7849A0D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137K → E (PubMed:9882502).Curated1
Sequence conflicti137K → E (PubMed:10731132).Curated1
Sequence conflicti329 – 331AVS → GVC (PubMed:9882502).Curated3
Sequence conflicti329 – 331AVS → GVC (PubMed:10731132).Curated3
Sequence conflicti458R → L (PubMed:9882502).Curated1
Sequence conflicti458R → L (PubMed:10731132).Curated1
Sequence conflicti789R → C (PubMed:9882502).Curated1
Sequence conflicti789R → C (PubMed:10731132).Curated1
Sequence conflicti959P → A in CAA26157 (PubMed:2983232).Curated1
Sequence conflicti995E → V (PubMed:9882502).Curated1
Sequence conflicti995E → V (PubMed:10731132).Curated1
Sequence conflicti1072 – 1080QTPSLVKIT → RLLAGEDH (PubMed:2982499).Curated9
Sequence conflicti1072 – 1080QTPSLVKIT → RLLAGEDH (PubMed:3093080).Curated9
Sequence conflicti1072 – 1080QTPSLVKIT → RLLAGEDH (PubMed:9731193).Curated9
Sequence conflicti1097 – 1098AA → I in CAA05747 (PubMed:9731193).Curated2
Sequence conflicti1118T → R in CAA05747 (PubMed:9731193).Curated1
Sequence conflicti1242K → E (PubMed:9882502).Curated1
Sequence conflicti1242K → E (PubMed:10731132).Curated1
Sequence conflicti1265M → I (PubMed:9882502).Curated1
Sequence conflicti1265M → I (PubMed:10731132).Curated1
Sequence conflicti1287R → T (PubMed:9882502).Curated1
Sequence conflicti1287R → T (PubMed:10731132).Curated1
Sequence conflicti1325M → I in AAF46732 (PubMed:10731132).Curated1
Sequence conflicti1383G → V (PubMed:9882502).Curated1
Sequence conflicti1383G → V (PubMed:10731132).Curated1
Sequence conflicti1412 – 1426ELQPL…TETRV → SCSHASKPQHGDEGVGSSRV GAIANEEGESCQVPLEAMRY AFAGCYLR (PubMed:2982499).CuratedAdd BLAST15
Sequence conflicti1412 – 1426ELQPL…TETRV → SCSHASKPQHGDEGVGSSRV GAIANEEGESCQVPLEAMRY AFAGCYLR (PubMed:3093080).CuratedAdd BLAST15

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0028971 – 101MLLRR…VKGKI → MMIISMWMSISRGLWDSSSI LSVLLILACMASITTSSSVS NAGYVDNGNMKV in isoform Type II. CuratedAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052754, AF052753 Genomic DNA. Translation: AAC08536.1.
AF052754, AF052752 Genomic DNA. Translation: AAC08535.1.
K03054 Genomic DNA. Translation: AAA51462.1.
K03417 mRNA. Translation: AAA51460.1.
K03416 mRNA. Translation: AAA50965.1.
AF109077 Genomic DNA. Translation: AAD26134.1.
AF109078, AF109082 Genomic DNA. Translation: AAD26132.1.
AF109078, AF109084 Genomic DNA. Translation: AAD26133.1.
AF109079, AF109081 Genomic DNA. Translation: AAD26130.1.
AF109079, AF109083 Genomic DNA. Translation: AAD26131.1.
AF109080 Genomic DNA. Translation: AAD26135.1.
AE013599 Genomic DNA. Translation: AAF46732.1.
X02293 Genomic DNA. Translation: CAA26157.1.
AJ002912 Genomic DNA. Translation: CAA05747.1.
X78920 Genomic DNA. Translation: CAA55523.1.
X78918 Genomic DNA. Translation: CAA55521.1.
X78919 Genomic DNA. Translation: CAA55522.1.
PIRiA00640. GQFFE.
RefSeqiNP_476759.1. NM_057411.4.

Genome annotation databases

GeneIDi37455.
KEGGidme:Dmel_CG10079.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052754, AF052753 Genomic DNA. Translation: AAC08536.1.
AF052754, AF052752 Genomic DNA. Translation: AAC08535.1.
K03054 Genomic DNA. Translation: AAA51462.1.
K03417 mRNA. Translation: AAA51460.1.
K03416 mRNA. Translation: AAA50965.1.
AF109077 Genomic DNA. Translation: AAD26134.1.
AF109078, AF109082 Genomic DNA. Translation: AAD26132.1.
AF109078, AF109084 Genomic DNA. Translation: AAD26133.1.
AF109079, AF109081 Genomic DNA. Translation: AAD26130.1.
AF109079, AF109083 Genomic DNA. Translation: AAD26131.1.
AF109080 Genomic DNA. Translation: AAD26135.1.
AE013599 Genomic DNA. Translation: AAF46732.1.
X02293 Genomic DNA. Translation: CAA26157.1.
AJ002912 Genomic DNA. Translation: CAA05747.1.
X78920 Genomic DNA. Translation: CAA55523.1.
X78918 Genomic DNA. Translation: CAA55521.1.
X78919 Genomic DNA. Translation: CAA55522.1.
PIRiA00640. GQFFE.
RefSeqiNP_476759.1. NM_057411.4.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I2TX-ray2.70A100-644[»]
3LTFX-ray3.20A/C100-688[»]
3LTGX-ray3.40A/C100-688[»]
ProteinModelPortaliP04412.
SMRiP04412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63083. 72 interactors.
DIPiDIP-17316N.
IntActiP04412. 5 interactors.
MINTiMINT-806082.
STRINGi7227.FBpp0071571.

Proteomic databases

PaxDbiP04412.
PRIDEiP04412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi37455.
KEGGidme:Dmel_CG10079.

Organism-specific databases

CTDi1956.
FlyBaseiFBgn0003731. Egfr.

Phylogenomic databases

eggNOGiKOG1025. Eukaryota.
ENOG410XNSR. LUCA.
InParanoidiP04412.
KOiK04361.
OrthoDBiEOG091G00U7.
PhylomeDBiP04412.

Enzyme and pathway databases

BRENDAi2.7.10.1. 1994.
ReactomeiR-DME-1251985. Nuclear signaling by ERBB4.
R-DME-1253288. Downregulation of ERBB4 signaling.
R-DME-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-DME-179812. GRB2 events in EGFR signaling.
R-DME-180292. GAB1 signalosome.
R-DME-180336. SHC1 events in EGFR signaling.
R-DME-182971. EGFR downregulation.
R-DME-2179392. EGFR Transactivation by Gastrin.
R-DME-445144. Signal transduction by L1.
R-DME-5673001. RAF/MAP kinase cascade.
R-DME-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-DME-8856828. Clathrin-mediated endocytosis.
R-DME-8863795. Downregulation of ERBB2 signaling.
SignaLinkiP04412.

Miscellaneous databases

ChiTaRSiEgfr. fly.
EvolutionaryTraceiP04412.
GenomeRNAii37455.
PROiP04412.

Gene expression databases

BgeeiFBgn0003731.
ExpressionAtlasiP04412. baseline.
GenevisibleiP04412. DM.

Family and domain databases

Gene3Di3.80.20.20. 4 hits.
InterProiIPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR032778. GF_recep_IV.
IPR009030. Growth_fac_rcpt_.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF14843. GF_recep_IV. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 7 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 3 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGFR_DROME
AccessioniPrimary (citable) accession number: P04412
Secondary accession number(s): O18370
, O61601, P81868, Q9W2G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: December 15, 1998
Last modified: November 30, 2016
This is version 192 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.