P04408 (KITH_SHV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:

TK

Organism

Saimiriine herpesvirus 1 (strain MV-5-4-PSL) (SaHV-1) (Marmoset herpesvirus)

Taxonomic identifier

10353 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus

Virus host

Callithrix [TaxID: 9481]
Saimiri (squirrel monkeys) [TaxID: 9520]

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.
Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the herpesviruses thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW TMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Thymidine kinase		PRO_0000175078
Regions
	Nucleotide binding	17 – 24	8	ATP By similarity
	Compositional bias	337 – 342	6	Poly-Ala
Sites
	Active site	46	1	Proton acceptor Potential
	Binding site	64	1	Substrate By similarity
	Binding site	88	1	Substrate By similarity
	Binding site	140	1	Substrate By similarity
	Binding site	184	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P04408 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: B2E322DB1D5542DB	FASTA	361	39,458
	10 20 30 40 50 60 MSGTAGTSRI LRVYLDGPHG VGKSTTAEAL VARCEPRRPI RSMLQEPMAY WRSTFASDAI 70 80 90 100 110 120 TEIYDTQHRL DSNEITAAEA GAFMTSLQLH MGTPYALLEE AMRPHVGREL AEPDDNGPLP 130 140 150 160 170 180 QRRDFVLVVD RHAVASMVCY PLARFMMGCV SLRSVASLIS HLPPPLPGTN LVVASLDFRE 190 200 210 220 230 240 HAARLRARAR PGERLDLTMM AAIRNAYAML ANTSRYLLSG GDWRRDWGSL PVFKPSAFVA 250 260 270 280 290 300 RAAKTAYTLP LRDEPGLADT LFAALKVPEF LDARGYPRAA HAWTLDILAN RIRALRVYTL 310 320 330 340 350 360 DLTGPPEACA AAFRRLCAGL VLTEGSHPGA LCELKRAAAA YAREMSVVGS REPTTAEVES A

References

[1]	"Nucleotide sequence of the marmoset herpesvirus thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide." Otsuka H., Kit S. Virology 135:316-330(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Kit S. Submitted (JUN-1989) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	K02122 Genomic DNA. Translation: AAA67102.1.
PIR	KIBETM. A00614.
3D structure databases
ProteinModelPortal	P04408.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001889. Herpes_TK. [Graphical view]
Pfam	PF00693. Herpes_TK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_SHV1

Accession

Primary (citable) accession number: P04408

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program