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P04408

- KITH_SHV1

UniProt

P04408 - KITH_SHV1

Protein

Thymidine kinase

Gene

TK

Organism
Saimiriine herpesvirus 1 (strain MV-5-4-PSL) (SaHV-1) (Marmoset herpesvirus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei46 – 461Proton acceptorSequence Analysis
    Binding sitei64 – 641SubstrateBy similarity
    Binding sitei88 – 881SubstrateBy similarity
    Binding sitei140 – 1401SubstrateBy similarity
    Binding sitei184 – 1841ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 248ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    OrganismiSaimiriine herpesvirus 1 (strain MV-5-4-PSL) (SaHV-1) (Marmoset herpesvirus)
    Taxonomic identifieri10353 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiCallithrix [TaxID: 9481]
    Saimiri (squirrel monkeys) [TaxID: 9520]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Thymidine kinasePRO_0000175078Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP04408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi337 – 3426Poly-Ala

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P04408-1 [UniParc]FASTAAdd to Basket

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    MSGTAGTSRI LRVYLDGPHG VGKSTTAEAL VARCEPRRPI RSMLQEPMAY    50
    WRSTFASDAI TEIYDTQHRL DSNEITAAEA GAFMTSLQLH MGTPYALLEE 100
    AMRPHVGREL AEPDDNGPLP QRRDFVLVVD RHAVASMVCY PLARFMMGCV 150
    SLRSVASLIS HLPPPLPGTN LVVASLDFRE HAARLRARAR PGERLDLTMM 200
    AAIRNAYAML ANTSRYLLSG GDWRRDWGSL PVFKPSAFVA RAAKTAYTLP 250
    LRDEPGLADT LFAALKVPEF LDARGYPRAA HAWTLDILAN RIRALRVYTL 300
    DLTGPPEACA AAFRRLCAGL VLTEGSHPGA LCELKRAAAA YAREMSVVGS 350
    REPTTAEVES A 361
    Length:361
    Mass (Da):39,458
    Last modified:November 1, 1995 - v2
    Checksum:iB2E322DB1D5542DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02122 Genomic DNA. Translation: AAA67102.1.
    PIRiA00614. KIBETM.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02122 Genomic DNA. Translation: AAA67102.1 .
    PIRi A00614. KIBETM.

    3D structure databases

    ProteinModelPortali P04408.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the marmoset herpesvirus thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide."
      Otsuka H., Kit S.
      Virology 135:316-330(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Kit S.
      Submitted (JUN-1989) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiKITH_SHV1
    AccessioniPrimary (citable) accession number: P04408
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 1987
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3