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P04408 (KITH_SHV1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
OrganismSaimiriine herpesvirus 1 (strain MV-5-4-PSL) (SaHV-1) (Marmoset herpesvirus)
Taxonomic identifier10353 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostCallithrix [TaxID: 9481]
Saimiri (squirrel monkeys) [TaxID: 9520]

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Thymidine kinase
PRO_0000175078

Regions

Nucleotide binding17 – 248ATP By similarity
Compositional bias337 – 3426Poly-Ala

Sites

Active site461Proton acceptor Potential
Binding site641Substrate By similarity
Binding site881Substrate By similarity
Binding site1401Substrate By similarity
Binding site1841ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P04408 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: B2E322DB1D5542DB

FASTA36139,458
        10         20         30         40         50         60 
MSGTAGTSRI LRVYLDGPHG VGKSTTAEAL VARCEPRRPI RSMLQEPMAY WRSTFASDAI 

        70         80         90        100        110        120 
TEIYDTQHRL DSNEITAAEA GAFMTSLQLH MGTPYALLEE AMRPHVGREL AEPDDNGPLP 

       130        140        150        160        170        180 
QRRDFVLVVD RHAVASMVCY PLARFMMGCV SLRSVASLIS HLPPPLPGTN LVVASLDFRE 

       190        200        210        220        230        240 
HAARLRARAR PGERLDLTMM AAIRNAYAML ANTSRYLLSG GDWRRDWGSL PVFKPSAFVA 

       250        260        270        280        290        300 
RAAKTAYTLP LRDEPGLADT LFAALKVPEF LDARGYPRAA HAWTLDILAN RIRALRVYTL 

       310        320        330        340        350        360 
DLTGPPEACA AAFRRLCAGL VLTEGSHPGA LCELKRAAAA YAREMSVVGS REPTTAEVES 


A 

« Hide

References

[1]"Nucleotide sequence of the marmoset herpesvirus thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide."
Otsuka H., Kit S.
Virology 135:316-330(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Kit S.
Submitted (JUN-1989) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K02122 Genomic DNA. Translation: AAA67102.1.
PIRKIBETM. A00614.

3D structure databases

ProteinModelPortalP04408.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_SHV1
AccessionPrimary (citable) accession number: P04408
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families