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Protein

2S sulfur-rich seed storage protein 1

Gene

BE2S1

Organism
Bertholletia excelsa (Brazil nut)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is a 2S seed storage protein.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Seed storage protein, Storage protein

Names & Taxonomyi

Protein namesi
Recommended name:
2S sulfur-rich seed storage protein 1
Alternative name(s):
Allergen: Ber e 1
Cleaved into the following 2 chains:
Alternative name(s):
2S albumin 1 small subunit
Alternative name(s):
2S albumin 1 large subunit
Gene namesi
Name:BE2S1
OrganismiBertholletia excelsa (Brazil nut)
Taxonomic identifieri3645 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridsEricalesLecythidaceaeBertholletia

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3134. Ber e 1.0101.
88. Ber e 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000003210523 – 361 PublicationAdd BLAST14
ChainiPRO_000003210637 – 642S sulfur-rich seed storage protein small chain 1Add BLAST28
PropeptideiPRO_000003210765 – 691 Publication5
ChainiPRO_000003210870 – 1422S sulfur-rich seed storage protein large chain 1BAdd BLAST73
PropeptideiPRO_0000032109143 – 1464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37Pyrrolidone carboxylic acid1
Disulfide bondi40 ↔ 92Interchain (between small and large chains)1 Publication
Disulfide bondi53 ↔ 81Interchain (between small and large chains)1 Publication
Disulfide bondi82 ↔ 1301 Publication
Disulfide bondi94 ↔ 1371 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

The mature protein consists of a small and a large chain linked by disulfide bonds.

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi37 – 46Combined sources10
Helixi49 – 62Combined sources14
Turni63 – 66Combined sources4
Beta strandi71 – 73Combined sources3
Helixi76 – 87Combined sources12
Helixi90 – 108Combined sources19
Helixi114 – 130Combined sources17
Turni138 – 141Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GYSmodel-A37-64[»]
B69-142[»]
2LVFNMR-A37-146[»]
ProteinModelPortaliP04403.
SMRiP04403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2S seed storage albumins family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.10.120.10. 1 hit.
InterProiIPR016140. Bifunc_inhib/LTP/seed_store.
IPR000617. Napin.
IPR013771. Trypsin/amylase_inhib.
[Graphical view]
PfamiPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PRINTSiPR00496. NAPIN.
SMARTiSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMiSSF47699. SSF47699. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKISVAAAA LLVLMALGHA TAFRATVTTT VVEEENQEEC REQMQRQQML
60 70 80 90 100
SHCRMYMRQQ MEESPYQTMP RRGMEPHMSE CCEQLEGMDE SCRCEGLRMM
110 120 130 140
MMRMQQEEMQ PRGEQMRRMM RLAENIPSRC NLSPMRCPMG GSIAGF
Length:146
Mass (Da):16,911
Last modified:October 1, 1989 - v2
Checksum:iA7DF778FD766410D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38 – 39EE → QQ AA sequence (PubMed:3758080).Curated2
Sequence conflicti102 – 103MR → RM in BAA96554 (Ref. 4) Curated2
Sequence conflicti107E → K in BAA96554 (Ref. 4) Curated1
Sequence conflicti122L → M AA sequence (PubMed:3758080).Curated1
Sequence conflicti126I → L AA sequence (PubMed:3758080).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti91S → E in variant 1A. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17146 mRNA. Translation: AAA33010.1.
X57027 Genomic DNA. Translation: CAA40343.1.
X57028 Genomic DNA. Translation: CAA40344.1.
X54490 Genomic DNA. Translation: CAA38362.1.
AB044391 Genomic DNA. Translation: BAA96554.1.
PIRiA25802.
S14946.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17146 mRNA. Translation: AAA33010.1.
X57027 Genomic DNA. Translation: CAA40343.1.
X57028 Genomic DNA. Translation: CAA40344.1.
X54490 Genomic DNA. Translation: CAA38362.1.
AB044391 Genomic DNA. Translation: BAA96554.1.
PIRiA25802.
S14946.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GYSmodel-A37-64[»]
B69-142[»]
2LVFNMR-A37-146[»]
ProteinModelPortaliP04403.
SMRiP04403.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3134. Ber e 1.0101.
88. Ber e 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.120.10. 1 hit.
InterProiIPR016140. Bifunc_inhib/LTP/seed_store.
IPR000617. Napin.
IPR013771. Trypsin/amylase_inhib.
[Graphical view]
PfamiPF00234. Tryp_alpha_amyl. 1 hit.
[Graphical view]
PRINTSiPR00496. NAPIN.
SMARTiSM00499. AAI. 1 hit.
[Graphical view]
SUPFAMiSSF47699. SSF47699. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei2SS1_BEREX
AccessioniPrimary (citable) accession number: P04403
Secondary accession number(s): P04402, Q9LRC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.