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Protein

Interleukin-5

Gene

Il5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-5 receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-512988. Interleukin-3, 5 and GM-CSF signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-5
Short name:
IL-5
Alternative name(s):
B-cell growth factor II
Short name:
BCGF-II
Cytotoxic T-lymphocyte inducer
Eosinophil differentiation factor
T-cell replacing factor
Short name:
TRF
Gene namesi
Name:Il5
Synonyms:Il-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96557. Il5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1163111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001556421 – 133Interleukin-5Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)1 Publication1
Disulfide bondi62Interchain (with C-104)By similarity
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104Interchain (with C-62)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04401.
PRIDEiP04401.

PTM databases

PhosphoSitePlusiP04401.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036117.
CleanExiMM_IL5.
ExpressionAtlasiP04401. baseline and differential.
GenevisibleiP04401. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-5 receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043369.

Chemistry databases

BindingDBiP04401.

Structurei

Secondary structure

1133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 38Combined sources11
Helixi40 – 43Combined sources4
Beta strandi50 – 52Combined sources3
Beta strandi55 – 57Combined sources3
Helixi59 – 62Combined sources4
Helixi63 – 74Combined sources12
Helixi83 – 102Combined sources20
Turni103 – 105Combined sources3
Beta strandi108 – 110Combined sources3
Helixi111 – 125Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B5KX-ray2.50A/B21-133[»]
ProteinModelPortaliP04401.
SMRiP04401.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04401.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-5 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYJN. Eukaryota.
ENOG41117ER. LUCA.
GeneTreeiENSGT00390000016991.
HOGENOMiHOG000074049.
HOVERGENiHBG003865.
InParanoidiP04401.
KOiK05428.
OMAiGVINTEW.
OrthoDBiEOG091G0XPD.
PhylomeDBiP04401.
TreeFamiTF338422.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. IL-5.
[Graphical view]
PANTHERiPTHR10525. PTHR10525. 1 hit.
PfamiPF02025. IL5. 1 hit.
[Graphical view]
PRINTSiPR00432. INTERLEUKIN5.
ProDomiPD006721. Interleukin_5. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRMLLHLSV LTLSCVWATA MEIPMSTVVK ETLTQLSAHR ALLTSNETMR
60 70 80 90 100
LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ
110 120 130
KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG
Length:133
Mass (Da):15,410
Last modified:November 1, 1988 - v1
Checksum:iC6DC091682452AF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06270 mRNA. Translation: CAA29606.1.
X06271 Genomic DNA. Translation: CAA29607.1.
X04601 mRNA. Translation: CAA28266.1.
CCDSiCCDS24685.1.
PIRiS00807. ICMS5.
RefSeqiNP_034688.1. NM_010558.1.
UniGeneiMm.4461.

Genome annotation databases

EnsembliENSMUST00000048605; ENSMUSP00000043369; ENSMUSG00000036117.
GeneIDi16191.
KEGGimmu:16191.
UCSCiuc007iwv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06270 mRNA. Translation: CAA29606.1.
X06271 Genomic DNA. Translation: CAA29607.1.
X04601 mRNA. Translation: CAA28266.1.
CCDSiCCDS24685.1.
PIRiS00807. ICMS5.
RefSeqiNP_034688.1. NM_010558.1.
UniGeneiMm.4461.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B5KX-ray2.50A/B21-133[»]
ProteinModelPortaliP04401.
SMRiP04401.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043369.

Chemistry databases

BindingDBiP04401.
ChEMBLiCHEMBL1163111.

PTM databases

PhosphoSitePlusiP04401.

Proteomic databases

PaxDbiP04401.
PRIDEiP04401.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048605; ENSMUSP00000043369; ENSMUSG00000036117.
GeneIDi16191.
KEGGimmu:16191.
UCSCiuc007iwv.1. mouse.

Organism-specific databases

CTDi3567.
MGIiMGI:96557. Il5.

Phylogenomic databases

eggNOGiENOG410IYJN. Eukaryota.
ENOG41117ER. LUCA.
GeneTreeiENSGT00390000016991.
HOGENOMiHOG000074049.
HOVERGENiHBG003865.
InParanoidiP04401.
KOiK05428.
OMAiGVINTEW.
OrthoDBiEOG091G0XPD.
PhylomeDBiP04401.
TreeFamiTF338422.

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-512988. Interleukin-3, 5 and GM-CSF signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-912526. Interleukin receptor SHC signaling.

Miscellaneous databases

EvolutionaryTraceiP04401.
PROiP04401.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036117.
CleanExiMM_IL5.
ExpressionAtlasiP04401. baseline and differential.
GenevisibleiP04401. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. IL-5.
[Graphical view]
PANTHERiPTHR10525. PTHR10525. 1 hit.
PfamiPF02025. IL5. 1 hit.
[Graphical view]
PRINTSiPR00432. INTERLEUKIN5.
ProDomiPD006721. Interleukin_5. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIL5_MOUSE
AccessioniPrimary (citable) accession number: P04401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: November 1, 1988
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.