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P04401

- IL5_MOUSE

UniProt

P04401 - IL5_MOUSE

Protein

Interleukin-5

Gene

Il5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: Ensembl
    2. immune response Source: InterPro
    3. inflammatory response Source: Ensembl
    4. positive regulation of B cell proliferation Source: Ensembl
    5. positive regulation of eosinophil differentiation Source: Ensembl
    6. positive regulation of immunoglobulin secretion Source: BHF-UCL
    7. positive regulation of JAK-STAT cascade Source: Ensembl
    8. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
    9. positive regulation of podosome assembly Source: Ensembl
    10. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    11. positive regulation of transcription, DNA-templated Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_210793. Interleukin receptor SHC signaling.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-5
    Short name:
    IL-5
    Alternative name(s):
    B-cell growth factor II
    Short name:
    BCGF-II
    Cytotoxic T-lymphocyte inducer
    Eosinophil differentiation factor
    T-cell replacing factor
    Short name:
    TRF
    Gene namesi
    Name:Il5
    Synonyms:Il-5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96557. Il5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 133113Interleukin-5PRO_0000015564Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)1 Publication
    Disulfide bondi62 – 62Interchain (with C-104)By similarity
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 – 104Interchain (with C-62)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP04401.

    Expressioni

    Gene expression databases

    BgeeiP04401.
    CleanExiMM_IL5.
    GenevestigatoriP04401.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.

    Structurei

    Secondary structure

    1
    133
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi28 – 3811
    Helixi40 – 434
    Beta strandi50 – 523
    Beta strandi55 – 573
    Helixi59 – 624
    Helixi63 – 7412
    Helixi83 – 10220
    Turni103 – 1053
    Beta strandi108 – 1103
    Helixi111 – 12515

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3B5KX-ray2.50A/B21-133[»]
    ProteinModelPortaliP04401.
    SMRiP04401. Positions 26-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP04401.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-5 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41650.
    HOGENOMiHOG000074049.
    HOVERGENiHBG003865.
    InParanoidiP04401.
    KOiK05428.
    OMAiEERETNG.
    OrthoDBiEOG70PC0S.
    PhylomeDBiP04401.
    TreeFamiTF338422.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000186. IL-5.
    [Graphical view]
    PANTHERiPTHR10525. PTHR10525. 1 hit.
    PfamiPF02025. IL5. 1 hit.
    [Graphical view]
    PRINTSiPR00432. INTERLEUKIN5.
    ProDomiPD006721. Interleukin_5. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04401-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRMLLHLSV LTLSCVWATA MEIPMSTVVK ETLTQLSAHR ALLTSNETMR    50
    LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ 100
    KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG 133
    Length:133
    Mass (Da):15,410
    Last modified:November 1, 1988 - v1
    Checksum:iC6DC091682452AF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06270 mRNA. Translation: CAA29606.1.
    X06271 Genomic DNA. Translation: CAA29607.1.
    X04601 mRNA. Translation: CAA28266.1.
    CCDSiCCDS24685.1.
    PIRiS00807. ICMS5.
    RefSeqiNP_034688.1. NM_010558.1.
    UniGeneiMm.4461.

    Genome annotation databases

    EnsembliENSMUST00000048605; ENSMUSP00000043369; ENSMUSG00000036117.
    GeneIDi16191.
    KEGGimmu:16191.
    UCSCiuc007iwv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06270 mRNA. Translation: CAA29606.1 .
    X06271 Genomic DNA. Translation: CAA29607.1 .
    X04601 mRNA. Translation: CAA28266.1 .
    CCDSi CCDS24685.1.
    PIRi S00807. ICMS5.
    RefSeqi NP_034688.1. NM_010558.1.
    UniGenei Mm.4461.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3B5K X-ray 2.50 A/B 21-133 [» ]
    ProteinModelPortali P04401.
    SMRi P04401. Positions 26-129.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P04401.
    ChEMBLi CHEMBL1163111.

    Proteomic databases

    PRIDEi P04401.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048605 ; ENSMUSP00000043369 ; ENSMUSG00000036117 .
    GeneIDi 16191.
    KEGGi mmu:16191.
    UCSCi uc007iwv.1. mouse.

    Organism-specific databases

    CTDi 3567.
    MGIi MGI:96557. Il5.

    Phylogenomic databases

    eggNOGi NOG41650.
    HOGENOMi HOG000074049.
    HOVERGENi HBG003865.
    InParanoidi P04401.
    KOi K05428.
    OMAi EERETNG.
    OrthoDBi EOG70PC0S.
    PhylomeDBi P04401.
    TreeFami TF338422.

    Enzyme and pathway databases

    Reactomei REACT_210793. Interleukin receptor SHC signaling.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

    Miscellaneous databases

    EvolutionaryTracei P04401.
    NextBioi 289101.
    PROi P04401.
    SOURCEi Search...

    Gene expression databases

    Bgeei P04401.
    CleanExi MM_IL5.
    Genevestigatori P04401.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000186. IL-5.
    [Graphical view ]
    PANTHERi PTHR10525. PTHR10525. 1 hit.
    Pfami PF02025. IL5. 1 hit.
    [Graphical view ]
    PRINTSi PR00432. INTERLEUKIN5.
    ProDomi PD006721. Interleukin_5. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, structure and expression of cDNA and genomic clones for murine eosinophil differentiation factor. Comparison with other eosinophilopoietic lymphokines and identity with interleukin-5."
      Campbell H.D., Sanderson C.J., Wang Y., Hort Y., Martinson M.E., Tucker W.Q.J., Stellwagen A., Strath M., Young I.G.
      Eur. J. Biochem. 174:345-352(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II."
      Kinashi T., Harada N., Severinson E., Tanabe T., Sideras P., Konishi M., Azuma C., Tominaga A., Bergstedt-Lindqvist S., Takahashi M., Matsuda F., Yaoita Y., Takatsu K., Honjo T.
      Nature 324:70-73(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "Molecular cloning and structure of the mouse interleukin-5 gene."
      Mizuta T.R., Tanabe T., Nakakubo H., Noma T., Honjo T.
      Growth Factors 1:51-57(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "Structural comparison of murine T-cell (B151K12)-derived T-cell-replacing factor (IL-5) with rIL-5: dimer formation is essential for the expression of biological activity."
      Takahashi T., Yamaguchi N., Mita S., Yamaguchi Y., Suda T., Tominaga A., Kikuchi Y., Miura Y., Takatsu K.
      Mol. Immunol. 27:911-920(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-46.

    Entry informationi

    Entry nameiIL5_MOUSE
    AccessioniPrimary (citable) accession number: P04401
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: November 1, 1988
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3