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P04401

- IL5_MOUSE

UniProt

P04401 - IL5_MOUSE

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Protein
Interleukin-5
Gene
Il5, Il-5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

GO - Molecular functioni

  1. cytokine activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: Ensembl
  2. immune response Source: InterPro
  3. inflammatory response Source: Ensembl
  4. positive regulation of B cell proliferation Source: Ensembl
  5. positive regulation of JAK-STAT cascade Source: Ensembl
  6. positive regulation of eosinophil differentiation Source: Ensembl
  7. positive regulation of immunoglobulin secretion Source: BHF-UCL
  8. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  9. positive regulation of podosome assembly Source: Ensembl
  10. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  11. positive regulation of transcription, DNA-templated Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiREACT_210793. Interleukin receptor SHC signaling.
REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-5
Short name:
IL-5
Alternative name(s):
B-cell growth factor II
Short name:
BCGF-II
Cytotoxic T-lymphocyte inducer
Eosinophil differentiation factor
T-cell replacing factor
Short name:
TRF
Gene namesi
Name:Il5
Synonyms:Il-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96557. Il5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020
Add
BLAST
Chaini21 – 133113Interleukin-5
PRO_0000015564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)1 Publication
Disulfide bondi62 – 62Interchain (with C-104) By similarity
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi104 – 104Interchain (with C-62) By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP04401.

Expressioni

Gene expression databases

BgeeiP04401.
CleanExiMM_IL5.
GenevestigatoriP04401.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi28 – 3811
Helixi40 – 434
Beta strandi50 – 523
Beta strandi55 – 573
Helixi59 – 624
Helixi63 – 7412
Helixi83 – 10220
Turni103 – 1053
Beta strandi108 – 1103
Helixi111 – 12515

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3B5KX-ray2.50A/B21-133[»]
ProteinModelPortaliP04401.
SMRiP04401. Positions 26-129.

Miscellaneous databases

EvolutionaryTraceiP04401.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-5 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41650.
HOGENOMiHOG000074049.
HOVERGENiHBG003865.
InParanoidiP04401.
KOiK05428.
OMAiEERETNG.
OrthoDBiEOG70PC0S.
PhylomeDBiP04401.
TreeFamiTF338422.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. IL-5.
[Graphical view]
PANTHERiPTHR10525. PTHR10525. 1 hit.
PfamiPF02025. IL5. 1 hit.
[Graphical view]
PRINTSiPR00432. INTERLEUKIN5.
ProDomiPD006721. Interleukin_5. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04401-1 [UniParc]FASTAAdd to Basket

« Hide

MRRMLLHLSV LTLSCVWATA MEIPMSTVVK ETLTQLSAHR ALLTSNETMR    50
LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ 100
KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG 133
Length:133
Mass (Da):15,410
Last modified:November 1, 1988 - v1
Checksum:iC6DC091682452AF4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06270 mRNA. Translation: CAA29606.1.
X06271 Genomic DNA. Translation: CAA29607.1.
X04601 mRNA. Translation: CAA28266.1.
CCDSiCCDS24685.1.
PIRiS00807. ICMS5.
RefSeqiNP_034688.1. NM_010558.1.
UniGeneiMm.4461.

Genome annotation databases

EnsembliENSMUST00000048605; ENSMUSP00000043369; ENSMUSG00000036117.
GeneIDi16191.
KEGGimmu:16191.
UCSCiuc007iwv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06270 mRNA. Translation: CAA29606.1 .
X06271 Genomic DNA. Translation: CAA29607.1 .
X04601 mRNA. Translation: CAA28266.1 .
CCDSi CCDS24685.1.
PIRi S00807. ICMS5.
RefSeqi NP_034688.1. NM_010558.1.
UniGenei Mm.4461.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3B5K X-ray 2.50 A/B 21-133 [» ]
ProteinModelPortali P04401.
SMRi P04401. Positions 26-129.
ModBasei Search...

Chemistry

BindingDBi P04401.
ChEMBLi CHEMBL1163111.

Proteomic databases

PRIDEi P04401.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048605 ; ENSMUSP00000043369 ; ENSMUSG00000036117 .
GeneIDi 16191.
KEGGi mmu:16191.
UCSCi uc007iwv.1. mouse.

Organism-specific databases

CTDi 3567.
MGIi MGI:96557. Il5.

Phylogenomic databases

eggNOGi NOG41650.
HOGENOMi HOG000074049.
HOVERGENi HBG003865.
InParanoidi P04401.
KOi K05428.
OMAi EERETNG.
OrthoDBi EOG70PC0S.
PhylomeDBi P04401.
TreeFami TF338422.

Enzyme and pathway databases

Reactomei REACT_210793. Interleukin receptor SHC signaling.
REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

Miscellaneous databases

EvolutionaryTracei P04401.
NextBioi 289101.
PROi P04401.
SOURCEi Search...

Gene expression databases

Bgeei P04401.
CleanExi MM_IL5.
Genevestigatori P04401.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. IL-5.
[Graphical view ]
PANTHERi PTHR10525. PTHR10525. 1 hit.
Pfami PF02025. IL5. 1 hit.
[Graphical view ]
PRINTSi PR00432. INTERLEUKIN5.
ProDomi PD006721. Interleukin_5. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation, structure and expression of cDNA and genomic clones for murine eosinophil differentiation factor. Comparison with other eosinophilopoietic lymphokines and identity with interleukin-5."
    Campbell H.D., Sanderson C.J., Wang Y., Hort Y., Martinson M.E., Tucker W.Q.J., Stellwagen A., Strath M., Young I.G.
    Eur. J. Biochem. 174:345-352(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II."
    Kinashi T., Harada N., Severinson E., Tanabe T., Sideras P., Konishi M., Azuma C., Tominaga A., Bergstedt-Lindqvist S., Takahashi M., Matsuda F., Yaoita Y., Takatsu K., Honjo T.
    Nature 324:70-73(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "Molecular cloning and structure of the mouse interleukin-5 gene."
    Mizuta T.R., Tanabe T., Nakakubo H., Noma T., Honjo T.
    Growth Factors 1:51-57(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Structural comparison of murine T-cell (B151K12)-derived T-cell-replacing factor (IL-5) with rIL-5: dimer formation is essential for the expression of biological activity."
    Takahashi T., Yamaguchi N., Mita S., Yamaguchi Y., Suda T., Tominaga A., Kikuchi Y., Miura Y., Takatsu K.
    Mol. Immunol. 27:911-920(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-46.

Entry informationi

Entry nameiIL5_MOUSE
AccessioniPrimary (citable) accession number: P04401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: November 1, 1988
Last modified: September 3, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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