Interleukin-5 precursor - Mus musculus (Mouse)

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P04401 (IL5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 114. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Interleukin-5
Short name=IL-5

Alternative name(s):
B-cell growth factor II
Short name=BCGF-II
Cytotoxic T-lymphocyte inducer
Eosinophil differentiation factor
T-cell replacing factor
Short name=TRF

Gene names

Name:	Il5
Synonyms:	Il-5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Subunit structure	Homodimer; disulfide-linked.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-5 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of B cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of JAK-STAT cascade Inferred from electronic annotation. Source: Compara positive regulation of eosinophil differentiation Inferred from electronic annotation. Source: Compara positive regulation of immunoglobulin secretion Inferred from genetic interaction PubMed 18268038. Source: BHF-UCL positive regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay PubMed 10872802. Source: MGI positive regulation of podosome assembly Inferred from electronic annotation. Source: Compara positive regulation of sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 7749983. Source: BHF-UCL positive regulation of transcription, DNA-dependent Inferred from direct assay PubMed 7749983. Source: BHF-UCL
Cellular_component	extracellular space Inferred from direct assay PubMed 11057672 PubMed 15240714 PubMed 16275384 PubMed 16769892 PubMed 18997793 PubMed 21460847. Source: MGI
Molecular_function	cytokine activity Inferred from direct assay PubMed 10872802. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

Chain

21 – 133

113

Interleukin-5

PRO_0000015564

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Ref.4

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

Interchain (with C-104) By similarity

Disulfide bond

104

Interchain (with C-62) By similarity

Secondary structure

133

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P04401 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: C6DC091682452AF4
Show »

FASTA

133

15,410

        10         20         30         40         50         60 
MRRMLLHLSV LTLSCVWATA MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ 

        70         80         90        100        110        120 
LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE 

       130 
FLGVMSTEWA MEG

« Hide

References

[1]	"Isolation, structure and expression of cDNA and genomic clones for murine eosinophil differentiation factor. Comparison with other eosinophilopoietic lymphokines and identity with interleukin-5." Campbell H.D., Sanderson C.J., Wang Y., Hort Y., Martinson M.E., Tucker W.Q.J., Stellwagen A., Strath M., Young I.G. Eur. J. Biochem. 174:345-352(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II." Kinashi T., Harada N., Severinson E., Tanabe T., Sideras P., Konishi M., Azuma C., Tominaga A., Bergstedt-Lindqvist S., Takahashi M., Matsuda F., Yaoita Y., Takatsu K., Honjo T. Nature 324:70-73(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[3]	"Molecular cloning and structure of the mouse interleukin-5 gene." Mizuta T.R., Tanabe T., Nakakubo H., Noma T., Honjo T. Growth Factors 1:51-57(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Structural comparison of murine T-cell (B151K12)-derived T-cell-replacing factor (IL-5) with rIL-5: dimer formation is essential for the expression of biological activity." Takahashi T., Yamaguchi N., Mita S., Yamaguchi Y., Suda T., Tominaga A., Kikuchi Y., Miura Y., Takatsu K. Mol. Immunol. 27:911-920(1990) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-46.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X06270 mRNA. Translation: CAA29606.1.
X06271 Genomic DNA. Translation: CAA29607.1.
X04601 mRNA. Translation: CAA28266.1.

IPI

IPI00115757.

PIR

ICMS5. S00807.

RefSeq

NP_034688.1. NM_010558.1.

UniGene

Mm.4461.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3B5K	X-ray	2.50	A/B	22-133	[»]

ProteinModelPortal

P04401.

SMR

P04401. Positions 26-129.

ModBase

Search...

Proteomic databases

PRIDE

P04401.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000048605; ENSMUSP00000043369; ENSMUSG00000036117.

GeneID

16191.

KEGG

mmu:16191.

Organism-specific databases

CTD

3567.

MGI

MGI:96557. Il5.

Phylogenomic databases

eggNOG

NOG41650.

HOGENOM

HOG000074049.

HOVERGEN

HBG003865.

InParanoid

P04401.

K05428.

OMA

GVINTEW.

OrthoDB

EOG4FJ8B7.

Gene expression databases

ArrayExpress

P04401.

Bgee

P04401.

CleanEx

MM_IL5.

Genevestigator

P04401.

GermOnline

ENSMUSG00000036117. Mus musculus.

Family and domain databases

Gene3D

1.20.1250.10. 1 hit.

InterPro

IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. Interleukin_5.
[Graphical view]

PANTHER

PTHR10525. PTHR10525. 1 hit.

Pfam

PF02025. IL5. 1 hit.
[Graphical view]

PRINTS

PR00432. INTERLEUKIN5.

ProDom

PD006721. Interleukin_5. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF47266. 4_helix_cytokine. 1 hit.

ProtoNet

Search...

Other

BindingDB

P04401.

ChEMBL

CHEMBL1163111.

EvolutionaryTrace

P04401.

NextBio

289101.

SOURCE

Search...

Entry information

Entry name

IL5_MOUSE

Accession

Primary (citable) accession number: P04401

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	November 1, 1988
Last modified:	April 3, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents