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P04401 (IL5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-5

Short name=IL-5
Alternative name(s):
B-cell growth factor II
Short name=BCGF-II
Cytotoxic T-lymphocyte inducer
Eosinophil differentiation factor
T-cell replacing factor
Short name=TRF
Gene names
Name:Il5
Synonyms:Il-5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length133 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

Subunit structure

Homodimer; disulfide-linked.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-5 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Growth factor
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: Ensembl

positive regulation of B cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of JAK-STAT cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of eosinophil differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of immunoglobulin secretion

Inferred from genetic interaction PubMed 18268038. Source: BHF-UCL

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 10872802. Source: MGI

positive regulation of podosome assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 7749983. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 7749983. Source: BHF-UCL

   Cellular_componentextracellular space

Inferred from direct assay PubMed 11057672PubMed 15240714PubMed 16275384PubMed 16769892PubMed 18997793PubMed 21460847. Source: MGI

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 10872802. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 133113Interleukin-5
PRO_0000015564

Amino acid modifications

Glycosylation461N-linked (GlcNAc...) Ref.4
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation891N-linked (GlcNAc...) Potential
Disulfide bond62Interchain (with C-104) By similarity
Disulfide bond104Interchain (with C-62) By similarity

Secondary structure

.................. 133
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P04401 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: C6DC091682452AF4

FASTA13315,410
        10         20         30         40         50         60 
MRRMLLHLSV LTLSCVWATA MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ 

        70         80         90        100        110        120 
LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE 

       130 
FLGVMSTEWA MEG 

« Hide

References

[1]"Isolation, structure and expression of cDNA and genomic clones for murine eosinophil differentiation factor. Comparison with other eosinophilopoietic lymphokines and identity with interleukin-5."
Campbell H.D., Sanderson C.J., Wang Y., Hort Y., Martinson M.E., Tucker W.Q.J., Stellwagen A., Strath M., Young I.G.
Eur. J. Biochem. 174:345-352(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II."
Kinashi T., Harada N., Severinson E., Tanabe T., Sideras P., Konishi M., Azuma C., Tominaga A., Bergstedt-Lindqvist S., Takahashi M., Matsuda F., Yaoita Y., Takatsu K., Honjo T.
Nature 324:70-73(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[3]"Molecular cloning and structure of the mouse interleukin-5 gene."
Mizuta T.R., Tanabe T., Nakakubo H., Noma T., Honjo T.
Growth Factors 1:51-57(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[4]"Structural comparison of murine T-cell (B151K12)-derived T-cell-replacing factor (IL-5) with rIL-5: dimer formation is essential for the expression of biological activity."
Takahashi T., Yamaguchi N., Mita S., Yamaguchi Y., Suda T., Tominaga A., Kikuchi Y., Miura Y., Takatsu K.
Mol. Immunol. 27:911-920(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-46.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X06270 mRNA. Translation: CAA29606.1.
X06271 Genomic DNA. Translation: CAA29607.1.
X04601 mRNA. Translation: CAA28266.1.
CCDSCCDS24685.1.
PIRICMS5. S00807.
RefSeqNP_034688.1. NM_010558.1.
UniGeneMm.4461.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3B5KX-ray2.50A/B21-133[»]
ProteinModelPortalP04401.
SMRP04401. Positions 26-129.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP04401.
ChEMBLCHEMBL1163111.

Proteomic databases

PRIDEP04401.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048605; ENSMUSP00000043369; ENSMUSG00000036117.
GeneID16191.
KEGGmmu:16191.
UCSCuc007iwv.1. mouse.

Organism-specific databases

CTD3567.
MGIMGI:96557. Il5.

Phylogenomic databases

eggNOGNOG41650.
HOGENOMHOG000074049.
HOVERGENHBG003865.
InParanoidP04401.
KOK05428.
OMAEERETNG.
OrthoDBEOG70PC0S.
PhylomeDBP04401.
TreeFamTF338422.

Gene expression databases

BgeeP04401.
CleanExMM_IL5.
GenevestigatorP04401.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. IL-5.
[Graphical view]
PANTHERPTHR10525. PTHR10525. 1 hit.
PfamPF02025. IL5. 1 hit.
[Graphical view]
PRINTSPR00432. INTERLEUKIN5.
ProDomPD006721. Interleukin_5. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP04401.
NextBio289101.
PROP04401.
SOURCESearch...

Entry information

Entry nameIL5_MOUSE
AccessionPrimary (citable) accession number: P04401
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: November 1, 1988
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot