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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi189Copper ACurated1
Metal bindingi224Copper ACurated1
Metal bindingi228Copper ACurated1
Metal bindingi232Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COII
Encoded oniMitochondrion
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35Mitochondrial intermembraneSequence analysisAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 88Mitochondrial matrixSequence analysisAdd BLAST32
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 260Mitochondrial intermembraneSequence analysisAdd BLAST151

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836461 – 260Cytochrome c oxidase subunit 2Add BLAST260

Proteomic databases

PaxDbiP04373

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Osm1g00330.1

Structurei

3D structure databases

ProteinModelPortaliP04373
SMRiP04373
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4767 Eukaryota
COG1622 LUCA
HOGENOMiHOG000264988
InParanoidiP04373

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P04373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILRSLECRF LTIALCDAAE PWQLGSQDAA TPMMQGIIDL HHDIFFFLIL
60 70 80 90 100
ILVFVSRMLV RALWHFNEQT NPIPQRIVHG TTIEIIRTIF PSVIPLFIAI
110 120 130 140 150
PSFALLYSMD GVLVDPAITI KAIGHQWYRS YEYSDYNSSD EQSLTFDSYT
160 170 180 190 200
IPEDDPELGQ SRLLEVDNRV VVPAKTHLRM IVTPADVLHS WAVPSSGVKC
210 220 230 240 250
DAVPGRSNLT SISVQREGVY YGQCSEICGT NHAFTPIVVE AVTLKDYADW
260
VSNQLILQTN
Length:260
Mass (Da):29,243
Last modified:August 1, 1992 - v4
Checksum:iB30C3109F2681355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01088 Genomic DNA Translation: CAA25566.1
BA000029 Genomic DNA No translation available.
PIRiA93536 OBRZ2

Similar proteinsi

Entry informationi

Entry nameiCOX2_ORYSJ
AccessioniPrimary (citable) accession number: P04373
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 121 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

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