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P04373 (COX2_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Synonyms:COII
Encoded onMitochondrion
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Cytochrome c oxidase subunit 2
PRO_0000183646

Regions

Topological domain1 – 3535Mitochondrial intermembrane Potential
Transmembrane36 – 5621Helical; Potential
Topological domain57 – 8832Mitochondrial matrix Potential
Transmembrane89 – 10921Helical; Potential
Topological domain110 – 260151Mitochondrial intermembrane Potential

Sites

Metal binding1891Copper A Probable
Metal binding2241Copper A Probable
Metal binding2281Copper A Probable
Metal binding2321Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P04373 [UniParc].

Last modified August 1, 1992. Version 4.
Checksum: B30C3109F2681355

FASTA26029,243
        10         20         30         40         50         60 
MILRSLECRF LTIALCDAAE PWQLGSQDAA TPMMQGIIDL HHDIFFFLIL ILVFVSRMLV 

        70         80         90        100        110        120 
RALWHFNEQT NPIPQRIVHG TTIEIIRTIF PSVIPLFIAI PSFALLYSMD GVLVDPAITI 

       130        140        150        160        170        180 
KAIGHQWYRS YEYSDYNSSD EQSLTFDSYT IPEDDPELGQ SRLLEVDNRV VVPAKTHLRM 

       190        200        210        220        230        240 
IVTPADVLHS WAVPSSGVKC DAVPGRSNLT SISVQREGVY YGQCSEICGT NHAFTPIVVE 

       250        260 
AVTLKDYADW VSNQLILQTN 

« Hide

References

[1]"Cytochrome oxidase subunit II gene of rice has an insertion sequence within the intron."
Kao T.-H., Moon E., Wu R.
Nucleic Acids Res. 12:7305-7315(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Labelle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01088 Genomic DNA. Translation: CAA25566.1.
PIROBRZ2. A93536.

3D structure databases

ProteinModelPortalP04373.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP04373.

Phylogenomic databases

eggNOGCOG1622.
HOGENOMHOG000264988.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_ORYSJ
AccessionPrimary (citable) accession number: P04373
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 103 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations