Cytochrome c oxidase subunit 2 - Oryza sativa subsp. japonica (Rice)

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P04373 (COX2_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	COX2
Synonyms:	COII

Encoded on

Mitochondrion

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza ›

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chloroplast Inferred from electronic annotation. Source: EnsemblPlants/Gramene integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from sequence or structural similarity Ref.1. Source: Gramene respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 260

260

Cytochrome c oxidase subunit 2

PRO_0000183646

Regions

Topological domain

1 – 35

Mitochondrial intermembrane Potential

Transmembrane

36 – 56

Helical; Potential

Topological domain

57 – 88

Mitochondrial matrix Potential

Transmembrane

89 – 109

Helical; Potential

Topological domain

110 – 260

151

Mitochondrial intermembrane Potential

Sites

Metal binding

189

Copper A Probable

Metal binding

224

Copper A Probable

Metal binding

228

Copper A Probable

Metal binding

232

Copper A Probable

Sequences

Sequence

Length

Mass (Da)

Tools

P04373 [UniParc].

Last modified August 1, 1992. Version 4.
Checksum: B30C3109F2681355
Show »

FASTA

260

29,243

        10         20         30         40         50         60 
MILRSLECRF LTIALCDAAE PWQLGSQDAA TPMMQGIIDL HHDIFFFLIL ILVFVSRMLV 

        70         80         90        100        110        120 
RALWHFNEQT NPIPQRIVHG TTIEIIRTIF PSVIPLFIAI PSFALLYSMD GVLVDPAITI 

       130        140        150        160        170        180 
KAIGHQWYRS YEYSDYNSSD EQSLTFDSYT IPEDDPELGQ SRLLEVDNRV VVPAKTHLRM 

       190        200        210        220        230        240 
IVTPADVLHS WAVPSSGVKC DAVPGRSNLT SISVQREGVY YGQCSEICGT NHAFTPIVVE 

       250        260 
AVTLKDYADW VSNQLILQTN

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References

[1]	"Cytochrome oxidase subunit II gene of rice has an insertion sequence within the intron." Kao T.-H., Moon E., Wu R. Nucleic Acids Res. 12:7305-7315(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. Labelle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X01088 Genomic DNA. Translation: CAA25566.1.
PIR	OBRZ2. A93536.
3D structure databases
ProteinModelPortal	P04373.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Gramene	P04373.
Phylogenomic databases
eggNOG	COG1622.
HOGENOM	HOG000264988.
Gene expression databases
ArrayExpress	P04373.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. False negative. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_ORYSJ

Accession

Primary (citable) accession number: P04373

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	August 1, 1992
Last modified:	May 1, 2013
This is version 97 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents