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P04372 (COX2_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COXII
Encoded onMitochondrion
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

RNA editing

Modified position: not applicable.
Some positions are modified by RNA editing via nucleotide insertion. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Cytochrome c oxidase subunit 2
PRO_0000183707

Regions

Topological domain1 – 1515Mitochondrial intermembrane Potential
Transmembrane16 – 3621Helical; Potential
Topological domain37 – 6327Mitochondrial matrix Potential
Transmembrane64 – 8421Helical; Potential
Topological domain85 – 210126Mitochondrial intermembrane Potential

Sites

Metal binding1571Copper A Probable
Metal binding1921Copper A Probable
Metal binding1961Copper A Probable
Metal binding2001Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P04372 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: FE1A34EB3FE3B6F6

FASTA21024,220
        10         20         30         40         50         60 
MSFILTFWMI FLMDSIIVLI SFSIFLSVWI CALIIATVLT VTKINNIYCT WDFISSKFID 

        70         80         90        100        110        120 
TYWFVLGMMF ILCLLLRLCL LLYFSCINFV SFDLCKVIGF QWYWVYFLFG ETTIFSNLIL 

       130        140        150        160        170        180 
ESDYLIGDLR ILQCNHVLTL LSLVIYKLWV SAVDVIHSFT ISSLGIKVDC IPGRCNEIIL 

       190        200        210 
FATNNATLYG QCSELCGVLH GFMPIVINFI 

« Hide

References

[1]"Major transcript of the frameshifted coxII gene from trypanosome mitochondria contains four nucleotides that are not encoded in the DNA."
Benne R., van den Burg J., Brakenhoff J.P.J., Sloof P., van Boom J.H., Tromp M.C.
Cell 46:819-826(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING.
[2]"The sequence of the gene for cytochrome c oxidase subunit I, a frameshift containing gene for cytochrome c oxidase subunit II and seven unassigned reading frames in Trypanosoma brucei mitochrondrial maxi-circle DNA."
Hensgens L.A.M., Brakenhoff J., de Vries B.F., Sloof P., Tromp M.C., van Boom J.H., Benne R.
Nucleic Acids Res. 12:7327-7344(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01094 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalP04372.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_TRYBB
AccessionPrimary (citable) accession number: P04372
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families