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P04372

- COX2_TRYBB

UniProt

P04372 - COX2_TRYBB

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Protein

Cytochrome c oxidase subunit 2

Gene
COXII
Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571Copper A Inferred
Metal bindingi192 – 1921Copper A Inferred
Metal bindingi196 – 1961Copper A Inferred
Metal bindingi200 – 2001Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COXII
Encoded oniMitochondrion
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei16 – 3621Helical; Reviewed predictionAdd
BLAST
Topological domaini37 – 6327Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei64 – 8421Helical; Reviewed predictionAdd
BLAST
Topological domaini85 – 210126Mitochondrial intermembrane Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Cytochrome c oxidase subunit 2PRO_0000183707Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP04372.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04372-1 [UniParc]FASTAAdd to Basket

« Hide

MSFILTFWMI FLMDSIIVLI SFSIFLSVWI CALIIATVLT VTKINNIYCT    50
WDFISSKFID TYWFVLGMMF ILCLLLRLCL LLYFSCINFV SFDLCKVIGF 100
QWYWVYFLFG ETTIFSNLIL ESDYLIGDLR ILQCNHVLTL LSLVIYKLWV 150
SAVDVIHSFT ISSLGIKVDC IPGRCNEIIL FATNNATLYG QCSELCGVLH 200
GFMPIVINFI 210
Length:210
Mass (Da):24,220
Last modified:November 1, 1997 - v2
Checksum:iFE1A34EB3FE3B6F6
GO

RNA editingi

Some positions are modified by RNA editing via nucleotide insertion.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01094 Genomic DNA. No translation available.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01094 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali P04372.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Major transcript of the frameshifted coxII gene from trypanosome mitochondria contains four nucleotides that are not encoded in the DNA."
    Benne R., van den Burg J., Brakenhoff J.P.J., Sloof P., van Boom J.H., Tromp M.C.
    Cell 46:819-826(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING.
  2. "The sequence of the gene for cytochrome c oxidase subunit I, a frameshift containing gene for cytochrome c oxidase subunit II and seven unassigned reading frames in Trypanosoma brucei mitochrondrial maxi-circle DNA."
    Hensgens L.A.M., Brakenhoff J., de Vries B.F., Sloof P., Tromp M.C., van Boom J.H., Benne R.
    Nucleic Acids Res. 12:7327-7344(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_TRYBB
AccessioniPrimary (citable) accession number: P04372
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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