P04372 (COX2_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:

COXII

Encoded on

Mitochondrion

Organism

Trypanosoma brucei brucei

Taxonomic identifier

5702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Trypanozoon › Trypanosoma brucei

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.
RNA editing	Modified position: not applicable. Some positions are modified by RNA editing via nucleotide insertion. Ref.1

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	RNA editing
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Cytochrome c oxidase subunit 2		PRO_0000183707
Regions
	Topological domain	1 – 15	15	Mitochondrial intermembrane Potential
	Transmembrane	16 – 36	21	Helical; Potential
	Topological domain	37 – 63	27	Mitochondrial matrix Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Topological domain	85 – 210	126	Mitochondrial intermembrane Potential
Sites
	Metal binding	157	1	Copper A Probable
	Metal binding	192	1	Copper A Probable
	Metal binding	196	1	Copper A Probable
	Metal binding	200	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	P04372 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: FE1A34EB3FE3B6F6	FASTA	210	24,220
	10 20 30 40 50 60 MSFILTFWMI FLMDSIIVLI SFSIFLSVWI CALIIATVLT VTKINNIYCT WDFISSKFID 70 80 90 100 110 120 TYWFVLGMMF ILCLLLRLCL LLYFSCINFV SFDLCKVIGF QWYWVYFLFG ETTIFSNLIL 130 140 150 160 170 180 ESDYLIGDLR ILQCNHVLTL LSLVIYKLWV SAVDVIHSFT ISSLGIKVDC IPGRCNEIIL 190 200 210 FATNNATLYG QCSELCGVLH GFMPIVINFI

References

[1]

"Major transcript of the frameshifted coxII gene from trypanosome mitochondria contains four nucleotides that are not encoded in the DNA." Benne R., van den Burg J., Brakenhoff J.P.J., Sloof P., van Boom J.H., Tromp M.C. Cell 46:819-826(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], RNA EDITING.

[2]

"The sequence of the gene for cytochrome c oxidase subunit I, a frameshift containing gene for cytochrome c oxidase subunit II and seven unassigned reading frames in Trypanosoma brucei mitochrondrial maxi-circle DNA." Hensgens L.A.M., Brakenhoff J., de Vries B.F., Sloof P., Tromp M.C., van Boom J.H., Benne R. Nucleic Acids Res. 12:7327-7344(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X01094 Genomic DNA. No translation available.
3D structure databases
ProteinModelPortal	P04372.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. [Graphical view]
Pfam	PF00116. COX2. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_TRYBB

Accession

Primary (citable) accession number: P04372

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)