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P04371

- COX1_TRYBB

UniProt

P04371 - COX1_TRYBB

Protein

Cytochrome c oxidase subunit 1

Gene

COXI

Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (20 Mar 1987)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi64 – 641Iron (heme A axial ligand)Curated
    Metal bindingi243 – 2431Copper BCurated
    Metal bindingi247 – 2471Copper BCurated
    Metal bindingi292 – 2921Copper BCurated
    Metal bindingi293 – 2931Copper BCurated
    Metal bindingi378 – 3781Iron (heme A3 axial ligand)Curated
    Metal bindingi380 – 3801Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COXI
    Synonyms:COI
    Encoded oniMitochondrion
    OrganismiTrypanosoma brucei brucei
    Taxonomic identifieri5702 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Cytochrome c oxidase subunit 1PRO_0000183428Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP04371.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei340 – 36021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei460 – 48021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei527 – 54721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P04371-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFFLCLVCLS VSHKMIGICY LLVAILCGFI GYIYSLFIRL ELSLIGCGVL    50
    FGDYQFYNVL ITSHGLIMVF AFIMPITMGG FTNYFAPVMV GFPDMVFPRI 100
    NNMSFWMFIG GFGCLVSGFL TEEGMGVGWT LYPTLICIDF HSSLACDFII 150
    FSVHFLGISS ILNSINVVGT IFCCRRKYFS FLIWTLFIWG ALLTSILLII 200
    TLPVLAGGVT LLLCDRNFNT SFYDVVGGGD LVLFQHLFWF FGHPEVYIII 250
    LPVFGLVSTI IEVTSFRCVF SSVAMIYSML LISVLGMFVW AHHMFVVGMD 300
    VDSRAYFGSI TVLIGLPTCI KLFNWIYSFL FTDMCICFEI YFIYMFILMF 350
    LAGGLTGLFL SNVGIDILMH DTYFVVAHFH YVLSLGAVVG VFGGFFHFLM 400
    KWIPIELHTF WLFFFISTLW FGSNMVFFPL HSLGMFAFPR RISDYPISFL 450
    FWSAFTLYGM LLLTFLVIFC CCLFNVILFW DYCLFFINLF TYSLSIFFYF 500
    YTWVPVCMAI YLLVIDFAHI ILDYLLIILC FCFVFYIFFW QAFLLFFYI 549
    Length:549
    Mass (Da):63,348
    Last modified:March 20, 1987 - v1
    Checksum:i966050DDB7FFC2F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01094 Genomic DNA. Translation: CAB57806.1.
    M14820 Genomic DNA. Translation: AAB59223.1.
    PIRiA00471. ODUTMB.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01094 Genomic DNA. Translation: CAB57806.1 .
    M14820 Genomic DNA. Translation: AAB59223.1 .
    PIRi A00471. ODUTMB.

    3D structure databases

    ProteinModelPortali P04371.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the gene for cytochrome c oxidase subunit I, a frameshift containing gene for cytochrome c oxidase subunit II and seven unassigned reading frames in Trypanosoma brucei mitochrondrial maxi-circle DNA."
      Hensgens L.A.M., Brakenhoff J., de Vries B.F., Sloof P., Tromp M.C., van Boom J.H., Benne R.
      Nucleic Acids Res. 12:7327-7344(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification of mitochondrial genes in Trypanosoma brucei and homology to cytochrome c oxidase II in two different reading frames."
      Payne M., Rothwell V., Jasmer D.P., Feagin J.E., Stuart K.
      Mol. Biochem. Parasitol. 15:159-170(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-402.
      Strain: EATRO 164.

    Entry informationi

    Entry nameiCOX1_TRYBB
    AccessioniPrimary (citable) accession number: P04371
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: March 20, 1987
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3