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P04371 (COX1_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COXI
Synonyms:COI
Encoded onMitochondrion
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Cytochrome c oxidase subunit 1
PRO_0000183428

Regions

Transmembrane18 – 3821Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane181 – 20121Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane340 – 36021Helical; Potential
Transmembrane379 – 39921Helical; Potential
Transmembrane410 – 43021Helical; Potential
Transmembrane460 – 48021Helical; Potential
Transmembrane495 – 51521Helical; Potential
Transmembrane527 – 54721Helical; Potential

Sites

Metal binding641Iron (heme A axial ligand) Probable
Metal binding2431Copper B Probable
Metal binding2471Copper B Probable
Metal binding2921Copper B Probable
Metal binding2931Copper B Probable
Metal binding3781Iron (heme A3 axial ligand) Probable
Metal binding3801Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
P04371 [UniParc].

Last modified March 20, 1987. Version 1.
Checksum: 966050DDB7FFC2F0

FASTA54963,348
        10         20         30         40         50         60 
MFFLCLVCLS VSHKMIGICY LLVAILCGFI GYIYSLFIRL ELSLIGCGVL FGDYQFYNVL 

        70         80         90        100        110        120 
ITSHGLIMVF AFIMPITMGG FTNYFAPVMV GFPDMVFPRI NNMSFWMFIG GFGCLVSGFL 

       130        140        150        160        170        180 
TEEGMGVGWT LYPTLICIDF HSSLACDFII FSVHFLGISS ILNSINVVGT IFCCRRKYFS 

       190        200        210        220        230        240 
FLIWTLFIWG ALLTSILLII TLPVLAGGVT LLLCDRNFNT SFYDVVGGGD LVLFQHLFWF 

       250        260        270        280        290        300 
FGHPEVYIII LPVFGLVSTI IEVTSFRCVF SSVAMIYSML LISVLGMFVW AHHMFVVGMD 

       310        320        330        340        350        360 
VDSRAYFGSI TVLIGLPTCI KLFNWIYSFL FTDMCICFEI YFIYMFILMF LAGGLTGLFL 

       370        380        390        400        410        420 
SNVGIDILMH DTYFVVAHFH YVLSLGAVVG VFGGFFHFLM KWIPIELHTF WLFFFISTLW 

       430        440        450        460        470        480 
FGSNMVFFPL HSLGMFAFPR RISDYPISFL FWSAFTLYGM LLLTFLVIFC CCLFNVILFW 

       490        500        510        520        530        540 
DYCLFFINLF TYSLSIFFYF YTWVPVCMAI YLLVIDFAHI ILDYLLIILC FCFVFYIFFW 


QAFLLFFYI 

« Hide

References

[1]"The sequence of the gene for cytochrome c oxidase subunit I, a frameshift containing gene for cytochrome c oxidase subunit II and seven unassigned reading frames in Trypanosoma brucei mitochrondrial maxi-circle DNA."
Hensgens L.A.M., Brakenhoff J., de Vries B.F., Sloof P., Tromp M.C., van Boom J.H., Benne R.
Nucleic Acids Res. 12:7327-7344(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Identification of mitochondrial genes in Trypanosoma brucei and homology to cytochrome c oxidase II in two different reading frames."
Payne M., Rothwell V., Jasmer D.P., Feagin J.E., Stuart K.
Mol. Biochem. Parasitol. 15:159-170(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-402.
Strain: EATRO 164.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01094 Genomic DNA. Translation: CAB57806.1.
M14820 Genomic DNA. Translation: AAB59223.1.
PIRODUTMB. A00471.

3D structure databases

ProteinModelPortalP04371.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_TRYBB
AccessionPrimary (citable) accession number: P04371
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways