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P04371

- COX1_TRYBB

UniProt

P04371 - COX1_TRYBB

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Protein
Cytochrome c oxidase subunit 1
Gene
COXI, COI
Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme A axial ligand) Inferred
Metal bindingi243 – 2431Copper B Inferred
Metal bindingi247 – 2471Copper B Inferred
Metal bindingi292 – 2921Copper B Inferred
Metal bindingi293 – 2931Copper B Inferred
Metal bindingi378 – 3781Iron (heme A3 axial ligand) Inferred
Metal bindingi380 – 3801Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COXI
Synonyms:COI
Encoded oniMitochondrion
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Reviewed prediction
Add
BLAST
Transmembranei59 – 7921Helical; Reviewed prediction
Add
BLAST
Transmembranei100 – 12021Helical; Reviewed prediction
Add
BLAST
Transmembranei148 – 16821Helical; Reviewed prediction
Add
BLAST
Transmembranei181 – 20121Helical; Reviewed prediction
Add
BLAST
Transmembranei237 – 25721Helical; Reviewed prediction
Add
BLAST
Transmembranei279 – 29921Helical; Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Transmembranei340 – 36021Helical; Reviewed prediction
Add
BLAST
Transmembranei379 – 39921Helical; Reviewed prediction
Add
BLAST
Transmembranei410 – 43021Helical; Reviewed prediction
Add
BLAST
Transmembranei460 – 48021Helical; Reviewed prediction
Add
BLAST
Transmembranei495 – 51521Helical; Reviewed prediction
Add
BLAST
Transmembranei527 – 54721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Cytochrome c oxidase subunit 1
PRO_0000183428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP04371.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04371-1 [UniParc]FASTAAdd to Basket

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MFFLCLVCLS VSHKMIGICY LLVAILCGFI GYIYSLFIRL ELSLIGCGVL    50
FGDYQFYNVL ITSHGLIMVF AFIMPITMGG FTNYFAPVMV GFPDMVFPRI 100
NNMSFWMFIG GFGCLVSGFL TEEGMGVGWT LYPTLICIDF HSSLACDFII 150
FSVHFLGISS ILNSINVVGT IFCCRRKYFS FLIWTLFIWG ALLTSILLII 200
TLPVLAGGVT LLLCDRNFNT SFYDVVGGGD LVLFQHLFWF FGHPEVYIII 250
LPVFGLVSTI IEVTSFRCVF SSVAMIYSML LISVLGMFVW AHHMFVVGMD 300
VDSRAYFGSI TVLIGLPTCI KLFNWIYSFL FTDMCICFEI YFIYMFILMF 350
LAGGLTGLFL SNVGIDILMH DTYFVVAHFH YVLSLGAVVG VFGGFFHFLM 400
KWIPIELHTF WLFFFISTLW FGSNMVFFPL HSLGMFAFPR RISDYPISFL 450
FWSAFTLYGM LLLTFLVIFC CCLFNVILFW DYCLFFINLF TYSLSIFFYF 500
YTWVPVCMAI YLLVIDFAHI ILDYLLIILC FCFVFYIFFW QAFLLFFYI 549
Length:549
Mass (Da):63,348
Last modified:March 20, 1987 - v1
Checksum:i966050DDB7FFC2F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01094 Genomic DNA. Translation: CAB57806.1.
M14820 Genomic DNA. Translation: AAB59223.1.
PIRiA00471. ODUTMB.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01094 Genomic DNA. Translation: CAB57806.1 .
M14820 Genomic DNA. Translation: AAB59223.1 .
PIRi A00471. ODUTMB.

3D structure databases

ProteinModelPortali P04371.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of the gene for cytochrome c oxidase subunit I, a frameshift containing gene for cytochrome c oxidase subunit II and seven unassigned reading frames in Trypanosoma brucei mitochrondrial maxi-circle DNA."
    Hensgens L.A.M., Brakenhoff J., de Vries B.F., Sloof P., Tromp M.C., van Boom J.H., Benne R.
    Nucleic Acids Res. 12:7327-7344(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification of mitochondrial genes in Trypanosoma brucei and homology to cytochrome c oxidase II in two different reading frames."
    Payne M., Rothwell V., Jasmer D.P., Feagin J.E., Stuart K.
    Mol. Biochem. Parasitol. 15:159-170(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-402.
    Strain: EATRO 164.

Entry informationi

Entry nameiCOX1_TRYBB
AccessioniPrimary (citable) accession number: P04371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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