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P04371

- COX1_TRYBB

UniProt

P04371 - COX1_TRYBB

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Protein

Cytochrome c oxidase subunit 1

Gene

COXI

Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme A axial ligand)Curated
Metal bindingi243 – 2431Copper BCurated
Metal bindingi247 – 2471Copper BCurated
Metal bindingi292 – 2921Copper BCurated
Metal bindingi293 – 2931Copper BCurated
Metal bindingi378 – 3781Iron (heme A3 axial ligand)Curated
Metal bindingi380 – 3801Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COXI
Synonyms:COI
Encoded oniMitochondrion
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 20121HelicalSequence AnalysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence AnalysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence AnalysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence AnalysisAdd
BLAST
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST
Transmembranei527 – 54721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Cytochrome c oxidase subunit 1PRO_0000183428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP04371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04371-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFFLCLVCLS VSHKMIGICY LLVAILCGFI GYIYSLFIRL ELSLIGCGVL
60 70 80 90 100
FGDYQFYNVL ITSHGLIMVF AFIMPITMGG FTNYFAPVMV GFPDMVFPRI
110 120 130 140 150
NNMSFWMFIG GFGCLVSGFL TEEGMGVGWT LYPTLICIDF HSSLACDFII
160 170 180 190 200
FSVHFLGISS ILNSINVVGT IFCCRRKYFS FLIWTLFIWG ALLTSILLII
210 220 230 240 250
TLPVLAGGVT LLLCDRNFNT SFYDVVGGGD LVLFQHLFWF FGHPEVYIII
260 270 280 290 300
LPVFGLVSTI IEVTSFRCVF SSVAMIYSML LISVLGMFVW AHHMFVVGMD
310 320 330 340 350
VDSRAYFGSI TVLIGLPTCI KLFNWIYSFL FTDMCICFEI YFIYMFILMF
360 370 380 390 400
LAGGLTGLFL SNVGIDILMH DTYFVVAHFH YVLSLGAVVG VFGGFFHFLM
410 420 430 440 450
KWIPIELHTF WLFFFISTLW FGSNMVFFPL HSLGMFAFPR RISDYPISFL
460 470 480 490 500
FWSAFTLYGM LLLTFLVIFC CCLFNVILFW DYCLFFINLF TYSLSIFFYF
510 520 530 540
YTWVPVCMAI YLLVIDFAHI ILDYLLIILC FCFVFYIFFW QAFLLFFYI
Length:549
Mass (Da):63,348
Last modified:March 20, 1987 - v1
Checksum:i966050DDB7FFC2F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01094 Genomic DNA. Translation: CAB57806.1.
M14820 Genomic DNA. Translation: AAB59223.1.
PIRiA00471. ODUTMB.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01094 Genomic DNA. Translation: CAB57806.1 .
M14820 Genomic DNA. Translation: AAB59223.1 .
PIRi A00471. ODUTMB.

3D structure databases

ProteinModelPortali P04371.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of the gene for cytochrome c oxidase subunit I, a frameshift containing gene for cytochrome c oxidase subunit II and seven unassigned reading frames in Trypanosoma brucei mitochrondrial maxi-circle DNA."
    Hensgens L.A.M., Brakenhoff J., de Vries B.F., Sloof P., Tromp M.C., van Boom J.H., Benne R.
    Nucleic Acids Res. 12:7327-7344(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification of mitochondrial genes in Trypanosoma brucei and homology to cytochrome c oxidase II in two different reading frames."
    Payne M., Rothwell V., Jasmer D.P., Feagin J.E., Stuart K.
    Mol. Biochem. Parasitol. 15:159-170(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-402.
    Strain: EATRO 164.

Entry informationi

Entry nameiCOX1_TRYBB
AccessioniPrimary (citable) accession number: P04371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3