P04370 (MBP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myelin basic protein
Short name=MBP

Alternative name(s):
Myelin A1 protein

Gene names

Name:	Mbp
Synonyms:	Shi

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Ref.17
Subunit structure	Homodimer By similarity.
Subcellular location	Isoform 13: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 12: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 11: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 10: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 9: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 8: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 7: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 6: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 5: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 4: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Isoform 3: Cytoplasm. Nucleus. Isoform 2: Cytoplasm. Nucleus. Isoform 1: Cytoplasm. Nucleus.
Tissue specificity	In the embryo, isoform 1-isoform 3 are found in neurons within the central nervous system (primarily in pioneer neurons important in the formation of the cortex) and the peripheral nervous system. They are also expressed in the thymus, gut, lung and kidney. In the adult, isoform 1-isoform 3 are highly expressed in the brain (mainly in brain regions rich in oligodendrocytes) and spleen. Lower levels are seen in the heart, kidney and lung. Isoform 2 is also found in cells of the immune system. The isoforms missing the 134 first amino acids (isoform 4-isoform 13) are almost exclusively produced in the myelin-forming cells, the mature oligodendrocytes.
Developmental stage	The differential expression of MBP isoforms is developmentally regulated. Isoform 2 and isoform 3 are first expressed during embryonic stages (as early as at embryonic day 11.5), expression of isoform 1 is turned on shortly after birth. Expression of the isoforms missing the 134 first amino acids occurs later, presumably as the oligodendrocytes approach their terminally differentiated state. Ref.16
Post-translational modification	As in other animals, several charge isomers may be produced as a result of optional post-translatonial modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues. Methylated on arginine residues; decreases with the age of the animal, making MBP more cationic. Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1 By similarity. Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24
Involvement in disease	Note=Defects in Mbp are a cause of dysmyelinating diseases such as the shiverer (SHI) and myelin deficient (MLD) diseases characterized by decreased myelination in the CNS, tremors, and convulsions of progressively increasing severity leading to early death. The shiverer mice only express isoform 2, the MLD mice have a reduced amount of Mbp.
Sequence similarities	Belongs to the myelin basic protein family.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane Nucleus
Coding sequence diversity	Alternative splicing
Disease	Autoimmune encephalomyelitis
PTM	Acetylation Citrullination Methylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	myelination Inferred from direct assay PubMed 14614079. Source: MGI response to toxin Inferred from direct assay PubMed 20578039. Source: MGI
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell internode region of axon Inferred from direct assay PubMed 16421295. Source: MGI neuronal cell body Inferred from direct assay PubMed 16421295. Source: MGI nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protease binding Inferred from physical interaction PubMed 12372841. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 13 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: P04370-1)

Also known as: Golli-MBP1; J37;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P04370-2)

Also known as: Golli-MBP2; BG21; HMBPR;

The sequence of this isoform differs from the canonical sequence as follows:
     191-250: DSHTRTTHYGSLPQKSQHGRTQDENPVVHFFKNIVTPRTPPPSQGKGGRDSRSGSPMARR → VSSEP

Isoform 3 (identifier: P04370-3)

Also known as: Golli-MBP3; TP8;

The sequence of this isoform differs from the canonical sequence as follows:
     48-250: EADAIQNNGT...SRSGSPMARR → LTHENYPLWLPAPEVAARPDPR

Isoform 4 (identifier: P04370-4)

Also known as: 21.5-kDa;

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     190-190: K → KVPWLKQSRSPLPSHARSRPGLCHMYK
     236-236: K → KGRGLSLSRFSWGAEGQKPGFGYGGRASDYKSAHKGFKGAYDAQGTLSKIFKL

Note: Met-1 is removed. Contains N-acetylalanine at position 2.

Isoform 5 (identifier: P04370-5)

Also known as: 18.5-kDa;

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     236-236: K → KGRGLSLSRFSWGAEGQKPGFGYGGRASDYKSAHKGFKGAYDAQGTLSKIFKL

Note: Met-1 is removed. Contains N-acetylalanine at position 2.

Isoform 6 (identifier: P04370-6)

Also known as: 17-kDa-a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     190-190: K → KVPWLKQSRSPLPSHARSRPGLCHMYK
     236-236: K → KGRGLSLSRFSW

Note: Met-1 is removed. Contains N-acetylalanine at position 2.

Isoform 7 (identifier: P04370-7)

Also known as: 17-kDa-b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     236-236: K → KGAEGQKPGFGYGGRASDYKSAHKGFKGAYDAQGTLSKIFKL

Note: Met-1 is removed. Contains N-acetylalanine at position 2.

Isoform 8 (identifier: P04370-8)

Also known as: 14-kDa;

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     236-236: K → KGRGLSLSRFSW

Note: Met-1 is removed. Contains N-acetylalanine at position 2.

Isoform 9 (identifier: P04370-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     190-190: K → KVPWLKQSRSPLPSHARSRPGLCHMYK
     236-236: K → KGAEGQKPGFGYGGRASDYKSAHKGFKGAYDAQGTLSKIFKL

Note: Met-1 is removed. Contains N-acetylalanine at position 2.

Isoform 10 (identifier: P04370-10)

Also known as: 21-kDa;

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     236-236: K → KDFVPGDHHV...QGTLSKIFKL

Isoform 11 (identifier: P04370-11)

Also known as: 19.7-kDa;

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     190-190: K → KVPWLKQSRSPLPSHARSRPGLCHMYK
     236-236: K → KDFVPGDHHVNVSVVTVSFSSSQGRGLSLSRFSW

Isoform 12 (identifier: P04370-13)

Also known as: 15.6-kDa;

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     190-190: K → KVPWLKQSRSPLPSHARSRPGLCHMYK

Isoform 13 (identifier: P04370-14)

Also known as: 13-kDa;

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	Myelin basic protein		PRO_0000158991
Amino acid modifications
	Modified residue	96	1	Phosphoserine Ref.24
	Modified residue	141	1	Phosphoserine By similarity
	Modified residue	144	1	Phosphoserine Ref.18
	Modified residue	157	1	Citrulline By similarity
	Modified residue	163	1	Citrulline By similarity
	Modified residue	167	1	Phosphothreonine Ref.22
	Modified residue	172	1	Phosphoserine Ref.19
	Modified residue	178	1	Phosphoserine Ref.19
	Modified residue	188	1	Phosphoserine By similarity
	Modified residue	199	1	Phosphotyrosine Ref.21
	Modified residue	201	1	Phosphoserine Ref.18 Ref.23
	Modified residue	226	1	Phosphothreonine By similarity
	Modified residue	229	1	Phosphothreonine Ref.18
	Modified residue	234	1	Deamidated glutamine By similarity
	Modified residue	239	1	Citrulline By similarity
	Modified residue	241	1	Phosphoserine By similarity
	Modified residue	245	1	Phosphoserine Ref.20
	Modified residue	250	1	Citrulline By similarity
Natural variations
	Alternative sequence	1 – 133	133	Missing in isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10, isoform 11, isoform 12 and isoform 13.		VSP_003312
	Alternative sequence	48 – 250	203	EADAI…PMARR → LTHENYPLWLPAPEVAARPD PR in isoform 3.		VSP_003313
	Alternative sequence	190	1	K → KVPWLKQSRSPLPSHARSRP GLCHMYK in isoform 4, isoform 6, isoform 9, isoform 11 and isoform 12.		VSP_003315
	Alternative sequence	191 – 250	60	DSHTR…PMARR → VSSEP in isoform 2.		VSP_003314
	Alternative sequence	236	1	K → KDFVPGDHHVNVSVVTVSFS SSQGRGLSLSRFSWGAEGQK PGFGYGGRASDYKSAHKGFK GAYDAQGTLSKIFKL in isoform 10.		VSP_003317
	Alternative sequence	236	1	K → KDFVPGDHHVNVSVVTVSFS SSQGRGLSLSRFSW in isoform 11.		VSP_003316
	Alternative sequence	236	1	K → KGRGLSLSRFSWGAEGQKPG FGYGGRASDYKSAHKGFKGA YDAQGTLSKIFKL in isoform 4 and isoform 5.		VSP_003319
	Alternative sequence	236	1	K → KGRGLSLSRFSW in isoform 6 and isoform 8.		VSP_003318
	Alternative sequence	236	1	K → KGAEGQKPGFGYGGRASDYK SAHKGFKGAYDAQGTLSKIF KL in isoform 7 and isoform 9.		VSP_003320
Experimental info
	Sequence conflict	204 – 205	2	QK → HN Ref.15

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Golli-MBP1) (J37) [UniParc]. Last modified October 18, 2001. Version 2. Checksum: B418ED11C27B0C43	FASTA	250	27,168
	10 20 30 40 50 60 MGNHSGKREL SAEKASKDGE IHRGEAGKKR SVGKLSQTAS EDSDVFGEAD AIQNNGTSAE 70 80 90 100 110 120 DTAVTDSKHT ADPKNNWQGA HPADPGNRPH LIRLFSRDAP GREDNTFKDR PSESDELQTI 130 140 150 160 170 180 QEDPTAASGG LDVMASQKRP SQRSKYLATA STMDHARHGF LPRHRDTGIL DSIGRFFSGD 190 200 210 220 230 240 RGAPKRGSGK DSHTRTTHYG SLPQKSQHGR TQDENPVVHF FKNIVTPRTP PPSQGKGGRD 250 SRSGSPMARR
	Isoform 2 (Golli-MBP2) (BG21) (HMBPR) [UniParc]. Checksum: 1C5C6AEFB561D2DA	FASTA	195	21,004
	10 20 30 40 50 60 MGNHSGKREL SAEKASKDGE IHRGEAGKKR SVGKLSQTAS EDSDVFGEAD AIQNNGTSAE 70 80 90 100 110 120 DTAVTDSKHT ADPKNNWQGA HPADPGNRPH LIRLFSRDAP GREDNTFKDR PSESDELQTI 130 140 150 160 170 180 QEDPTAASGG LDVMASQKRP SQRSKYLATA STMDHARHGF LPRHRDTGIL DSIGRFFSGD 190 RGAPKRGSGK VSSEP
	Isoform 3 (Golli-MBP3) (TP8) [UniParc]. Checksum: 067EABB28D687D99	FASTA	69	7,498
	10 20 30 40 50 60 MGNHSGKREL SAEKASKDGE IHRGEAGKKR SVGKLSQTAS EDSDVFGLTH ENYPLWLPAP EVAARPDPR
	Isoform 4 (21.5-kDa) [UniParc]. Checksum: 4B57CA6F06C4AC7D	FASTA	195	21,502
	10 20 30 40 50 60 MASQKRPSQR SKYLATASTM DHARHGFLPR HRDTGILDSI GRFFSGDRGA PKRGSGKVPW 70 80 90 100 110 120 LKQSRSPLPS HARSRPGLCH MYKDSHTRTT HYGSLPQKSQ HGRTQDENPV VHFFKNIVTP 130 140 150 160 170 180 RTPPPSQGKG RGLSLSRFSW GAEGQKPGFG YGGRASDYKS AHKGFKGAYD AQGTLSKIFK 190 LGGRDSRSGS PMARR
	Isoform 5 (18.5-kDa) [UniParc]. Checksum: E609240A863F36CD	FASTA	169	18,488
	10 20 30 40 50 60 MASQKRPSQR SKYLATASTM DHARHGFLPR HRDTGILDSI GRFFSGDRGA PKRGSGKDSH 70 80 90 100 110 120 TRTTHYGSLP QKSQHGRTQD ENPVVHFFKN IVTPRTPPPS QGKGRGLSLS RFSWGAEGQK 130 140 150 160 PGFGYGGRAS DYKSAHKGFK GAYDAQGTLS KIFKLGGRDS RSGSPMARR
	Isoform 6 (17-kDa-a) [UniParc]. Checksum: 00F1F10ECF90421B	FASTA	154	17,225
	10 20 30 40 50 60 MASQKRPSQR SKYLATASTM DHARHGFLPR HRDTGILDSI GRFFSGDRGA PKRGSGKVPW 70 80 90 100 110 120 LKQSRSPLPS HARSRPGLCH MYKDSHTRTT HYGSLPQKSQ HGRTQDENPV VHFFKNIVTP 130 140 150 RTPPPSQGKG RGLSLSRFSW GGRDSRSGSP MARR
	Isoform 7 (17-kDa-b) [UniParc]. Checksum: 7AA39D2A263A2BF3	FASTA	158	17,240
	10 20 30 40 50 60 MASQKRPSQR SKYLATASTM DHARHGFLPR HRDTGILDSI GRFFSGDRGA PKRGSGKDSH 70 80 90 100 110 120 TRTTHYGSLP QKSQHGRTQD ENPVVHFFKN IVTPRTPPPS QGKGAEGQKP GFGYGGRASD 130 140 150 YKSAHKGFKG AYDAQGTLSK IFKLGGRDSR SGSPMARR
	Isoform 8 (14-kDa) [UniParc]. Checksum: E1DB77B2010455FB	FASTA	128	14,211
	10 20 30 40 50 60 MASQKRPSQR SKYLATASTM DHARHGFLPR HRDTGILDSI GRFFSGDRGA PKRGSGKDSH 70 80 90 100 110 120 TRTTHYGSLP QKSQHGRTQD ENPVVHFFKN IVTPRTPPPS QGKGRGLSLS RFSWGGRDSR SGSPMARR
	Isoform 9 [UniParc]. Checksum: B7F672275771E3F4	FASTA	184	20,255
	10 20 30 40 50 60 MASQKRPSQR SKYLATASTM DHARHGFLPR HRDTGILDSI GRFFSGDRGA PKRGSGKVPW 70 80 90 100 110 120 LKQSRSPLPS HARSRPGLCH MYKDSHTRTT HYGSLPQKSQ HGRTQDENPV VHFFKNIVTP 130 140 150 160 170 180 RTPPPSQGKG AEGQKPGFGY GGRASDYKSA HKGFKGAYDA QGTLSKIFKL GGRDSRSGSP MARR
	Isoform 10 (21-kDa) [UniParc]. Checksum: D986AA8B506E2AE9	FASTA	191	20,814
	10 20 30 40 50 60 MASQKRPSQR SKYLATASTM DHARHGFLPR HRDTGILDSI GRFFSGDRGA PKRGSGKDSH 70 80 90 100 110 120 TRTTHYGSLP QKSQHGRTQD ENPVVHFFKN IVTPRTPPPS QGKDFVPGDH HVNVSVVTVS 130 140 150 160 170 180 FSSSQGRGLS LSRFSWGAEG QKPGFGYGGR ASDYKSAHKG FKGAYDAQGT LSKIFKLGGR 190 DSRSGSPMAR R
	Isoform 11 (19.7-kDa) [UniParc]. Checksum: 159154971A58A0CF	FASTA	176	19,552
	10 20 30 40 50 60 MASQKRPSQR SKYLATASTM DHARHGFLPR HRDTGILDSI GRFFSGDRGA PKRGSGKVPW 70 80 90 100 110 120 LKQSRSPLPS HARSRPGLCH MYKDSHTRTT HYGSLPQKSQ HGRTQDENPV VHFFKNIVTP 130 140 150 160 170 RTPPPSQGKD FVPGDHHVNV SVVTVSFSSS QGRGLSLSRF SWGGRDSRSG SPMARR
	Isoform 12 (15.6-kDa) [UniParc]. Checksum: 932F8612537F93E2	FASTA	143	15,978
	10 20 30 40 50 60 MASQKRPSQR SKYLATASTM DHARHGFLPR HRDTGILDSI GRFFSGDRGA PKRGSGKVPW 70 80 90 100 110 120 LKQSRSPLPS HARSRPGLCH MYKDSHTRTT HYGSLPQKSQ HGRTQDENPV VHFFKNIVTP 130 140 RTPPPSQGKG GRDSRSGSPM ARR
	Isoform 13 (13-kDa) [UniParc]. Checksum: 7FC65A7A1A8C7E53	FASTA	117	12,963
	10 20 30 40 50 60 MASQKRPSQR SKYLATASTM DHARHGFLPR HRDTGILDSI GRFFSGDRGA PKRGSGKDSH 70 80 90 100 110 TRTTHYGSLP QKSQHGRTQD ENPVVHFFKN IVTPRTPPPS QGKGGRDSRS GSPMARR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons." Takahashi N., Roach A., Teplow D.B., Prusiner S.B., Hood L.E. Cell 42:139-148(1985) [PubMed: 2410136] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Alternative splicing accounts for the four forms of myelin basic protein." de Ferra F., Engh H., Hudson L., Kamholz J., Puckett C., Molineaux S., Lazzarini R.A. Cell 43:721-727(1985) [PubMed: 2416470] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Identification of a cDNA coding for a fifth form of myelin basic protein in mouse." Newman S., Kitamura K., Campagnoni A.T. Proc. Natl. Acad. Sci. U.S.A. 84:886-890(1987) [PubMed: 2433693] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6 AND 7), NUCLEOTIDE SEQUENCE [MRNA] OF 9-194. Strain: C57BL/6J. Tissue: Brain.
[4]	"Expression of a novel transcript of the myelin basic protein gene." Kitamura K., Newman S.L., Campagnoni C.W., Verdi J.M., Mohandas T., Handley V.W., Campagnoni A.T. J. Neurochem. 54:2032-2041(1990) [PubMed: 1692584] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8).
[5]	"A novel transcript overlapping the myelin basic protein gene." Grima B., Zelenika D., Pessac B. J. Neurochem. 59:2318-2323(1992) [PubMed: 1279125] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Strain: C57BL/6. Tissue: Bone marrow.
[6]	"Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain." Campagnoni A.T., Pribyl T.M., Campagnoni C.W., Kampf K., Amur-Umarjee S., Landry C.F., Handley V.W., Newman S., Garbay B., Kitamura K. J. Biol. Chem. 268:4930-4938(1993) [PubMed: 7680345] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3). Strain: C57BL/6. Tissue: Brain.
[7]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8). Strain: C57BL/6J. Tissue: Cerebellum.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9). Tissue: Mammary tumor.
[9]	"The promoter elements of the mouse myelin basic protein gene function efficiently in NG108-15 neuronal/glial cells." Miura M., Tamura T.A., Aoyama A., Mikoshiba K. Gene 75:31-38(1989) [PubMed: 2470651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-157.
[10]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 146-157; 164-175; 196-205 AND 211-222, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[11]	"Gene organization and transcription of duplicated MBP genes of myelin deficient (shi(mld)) mutant mouse." Okano H., Tamura T., Miura M., Aoyama A., Ikenaka K., Oshimura M., Mikoshiba K. EMBO J. 7:77-83(1988) [PubMed: 2452084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-224.
[12]	"Characterization of mouse myelin basic protein messenger RNAs with a myelin basic protein cDNA clone." Zeller N.K., Hunkeler M.J., Campagnoni A.T., Sprague J., Lazzarini R.A. Proc. Natl. Acad. Sci. U.S.A. 81:18-22(1984) [PubMed: 6198644] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 193-222.
[13]	"Identification of three forms of human myelin basic protein by cDNA cloning." Kamholz J., de Ferra F., Puckett C., Lazzarini R.A. Proc. Natl. Acad. Sci. U.S.A. 83:4962-4966(1986) [PubMed: 2425357] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 6 AND 9).
[14]	"Identification of the new isoforms of mouse myelin basic protein: the existence of exon 5a." Aruga J., Okano H., Mikoshiba K. J. Neurochem. 56:1222-1226(1991) [PubMed: 1705957] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10 AND 11). Tissue: Spinal cord.
[15]	"Novel isoforms of mouse myelin basic protein predominantly expressed in embryonic stage." Nakajima K., Ikenaka K., Kagawa T., Aruga J., Nakao J., Nakahira K., Shiota C., Kim S.U., Mikoshiba K. J. Neurochem. 60:1554-1563(1993) [PubMed: 7681106] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 12 AND 13). Tissue: Embryonic brain.
[16]	"Embryonic expression of the myelin basic protein gene: identification of a promoter region that targets transgene expression to pioneer neurons." Landry C.F., Pribyl T.M., Ellison J.A., Givogri M.I., Kampf K., Campagnoni C.W., Campagnoni A.T. J. Neurosci. 18:7315-7327(1998) [PubMed: 9736652] [Abstract] Cited for: DEVELOPMENTAL STAGE.
[17]	"The pathobiology of myelin mutants reveal novel biological functions of the MBP and PLP genes." Campagnoni A.T., Skoff R.P. Brain Pathol. 11:74-91(2001) [PubMed: 11145205] [Abstract] Cited for: FUNCTION.
[18]	"Proteomic analysis of in vivo phosphorylated synaptic proteins." Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I., Blackstock W.P., Choudhary J.S., Grant S.G. J. Biol. Chem. 280:5972-5982(2005) [PubMed: 15572359] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144; SER-201 AND THR-229, MASS SPECTROMETRY. Tissue: Forebrain.
[19]	"Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol." Vosseller K., Hansen K.C., Chalkley R.J., Trinidad J.C., Wells L., Hart G.W., Burlingame A.L. Proteomics 5:388-398(2005) [PubMed: 15648052] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172 AND SER-178, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[20]	"Comprehensive identification of phosphorylation sites in postsynaptic density preparations." Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L. Mol. Cell. Proteomics 5:914-922(2006) [PubMed: 16452087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, MASS SPECTROMETRY. Tissue: Brain.
[21]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed: 18034455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-199, MASS SPECTROMETRY. Tissue: Brain.
[22]	Lubec G., Kang S. Submitted (APR-2007) to UniProtKB Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-167, MASS SPECTROMETRY. Tissue: Brain.
[23]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 19367708] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201, MASS SPECTROMETRY. Tissue: Melanoma.
[24]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M11533 , M11291, M11529, M11530, M11531, M11532 Genomic DNA. Translation: AAA39496.1. M11533 , M11291, M11529, M11530, M11531 Genomic DNA. Translation: AAA39497.1. L00404 , L00398, L00400, L00401, L00402 Genomic DNA. Translation: AAA39499.1. L00404 , L00398, L00399, L00400, L00401, L00402 Genomic DNA. Translation: AAA39500.1. L00404 , L00398, L00400, L00401, L00402, L00403 Genomic DNA. Translation: AAA39501.1. L00404 , L00398, L00399, L00400, L00401, L00402, L00403 Genomic DNA. Translation: AAA39502.1. M15060 mRNA. Translation: AAB59711.1. M15062 mRNA. Translation: AAB59712.1. X67319 mRNA. Translation: CAA47733.1. L07507 mRNA. Translation: AAA37720.1. L07508 mRNA. Translation: AAA37721.1. L07509 mRNA. Translation: AAA37722.1. L07505, L07504 Genomic DNA. Translation: AAA37719.1. AK005129 mRNA. Translation: BAB23830.1. BC004704 mRNA. Translation: AAH04704.1. M24410 Genomic DNA. Translation: AAA39498.1. M36275 Genomic DNA. Translation: AAA39504.1. K00989 mRNA. Translation: AAA39495.1. M20010 mRNA. Translation: AAA39503.1.
IPI	IPI00115240. IPI00223375. IPI00223376. IPI00223377. IPI00223378. IPI00223379. IPI00223380. IPI00223381. IPI00223382. IPI00223593. IPI00223594. IPI00223595. IPI00223596.
PIR	MBMSB. A45421.
RefSeq	NP_001020416.1. NM_001025245.1. NP_001020422.1. NM_001025251.2. NP_001020425.1. NM_001025254.2. NP_001020426.1. NM_001025255.2. NP_001020427.1. NM_001025256.2. NP_001020429.1. NM_001025258.2. NP_001020430.1. NM_001025259.2. NP_034907.1. NM_010777.3.
UniGene	Mm.252063. Mm.392350. Mm.454459.
3D structure databases
DisProt	DP00237.
ProteinModelPortal	P04370.
ModBase	Search...
Protein-protein interaction databases
IntAct	P04370. 4 interactions.
STRING	P04370.
PTM databases
PhosphoSite	P04370.
Proteomic databases
PRIDE	P04370.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000047865; ENSMUSP00000046185; ENSMUSG00000041607. ENSMUST00000062446; ENSMUSP00000053495; ENSMUSG00000041607. ENSMUST00000075372; ENSMUSP00000074836; ENSMUSG00000041607. ENSMUST00000080658; ENSMUSP00000079488; ENSMUSG00000041607. ENSMUST00000091789; ENSMUSP00000089393; ENSMUSG00000041607. ENSMUST00000102812; ENSMUSP00000099876; ENSMUSG00000041607. ENSMUST00000114674; ENSMUSP00000110322; ENSMUSG00000041607.
GeneID	17196.
KEGG	mmu:17196.
UCSC	uc008fts.1. mouse. uc008ftu.1. mouse. uc008ftv.1. mouse. uc008ftw.1. mouse. uc008fty.1. mouse.
Organism-specific databases
CTD	4155.
MGI	MGI:96925. Mbp.
Phylogenomic databases
eggNOG	NOG75180.
GeneTree	ENSGT00390000014772.
HOVERGEN	HBG008347.
InParanoid	P04370.
OMA	DAHREGH.
OrthoDB	EOG4S1T86.
Gene expression databases
ArrayExpress	P04370.
Bgee	P04370.
CleanEx	MM_MBP.
Genevestigator	P04370.
GermOnline	ENSMUSG00000041607. Mus musculus.
Family and domain databases
InterPro	IPR000548. Myelin_BP. [Graphical view]
PANTHER	PTHR11429. Myelin_BP. 1 hit.
Pfam	PF01669. Myelin_MBP. 1 hit. [Graphical view]
PRINTS	PR00212. MYELINMBP.
PROSITE	PS00569. MYELIN_MBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	291554.
PMAP-CutDB	P04370.
SOURCE	Search...

Entry information

Entry name

MBP_MOUSE

Accession

Primary (citable) accession number: P04370
Secondary accession number(s): Q01585 , Q03139, Q03176, Q61836, Q61837, Q99KE4, Q9QWP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	October 18, 2001
Last modified:	April 18, 2012
This is version 136 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program