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Protein

Thymidine kinase

Gene

TK

Organism
Monkeypox virus (strain Zaire-96-I-16) (MPX)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83Proton acceptorSequence analysis1
Binding sitei113Substrate; via amide nitrogenBy similarity1
Metal bindingi138ZincBy similarity1
Metal bindingi141ZincBy similarity1
Metal bindingi170ZincBy similarity1
Metal bindingi173ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
ORF Names:L2R
OrganismiMonkeypox virus (strain Zaire-96-I-16) (MPX)
Taxonomic identifieri619591 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiCynomys gunnisoni (Gunnison's prairie dog) [TaxID: 45479]
Cynomys leucurus (White-tailed prairie dog) [TaxID: 99825]
Cynomys ludovicianus (Black-tailed prairie dog) [TaxID: 45480]
Cynomys mexicanus (Mexican prairie dog) [TaxID: 99826]
Cynomys parvidens (Utah prairie dog) [TaxID: 99827]
Gliridae (dormice) [TaxID: 30650]
Heliosciurus ruwenzorii (Ruwenzori sun squirrel) [TaxID: 226685]
Homo sapiens (Human) [TaxID: 9606]
Mus musculus (Mouse) [TaxID: 10090]
Proteomesi
  • UP000101269 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001749311 – 177Thymidine kinaseAdd BLAST177

Structurei

3D structure databases

ProteinModelPortaliP04363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 161Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

P04363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGGHIQLII GPMLSGKSTE LIRRVRRYQI AQYKCVTIKY SNDNRYGTGL
60 70 80 90 100
WTHDKNNFAA LEVTKLCDVL EAITDFSVIG IDEGQFFPDI VEFCERMANE
110 120 130 140 150
GKIVIVAALD GTFQRRPFNN ILNLIPLSEM VVKLTAVCMK CFKEASFSKR
160 170
LGAETEIEII GGNDMYQSVC RKCYIDS
Length:177
Mass (Da):19,990
Last modified:August 2, 2002 - v2
Checksum:i8A7BAAB3238C91D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14L → F in AAA80529 (PubMed:6330986).Curated1
Sequence conflicti90I → V in AAA80529 (PubMed:6330986).Curated1
Sequence conflicti153A → T in AAA80529 (PubMed:6330986).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02025 Genomic DNA. Translation: AAA80529.1.
AF380138 Genomic DNA. Translation: AAL40544.1.
PIRiA00610. KIVZMV.
RefSeqiNP_536513.1. NC_003310.1.

Genome annotation databases

GeneIDi928935.
KEGGivg:928935.

Similar proteinsi

Entry informationi

Entry nameiKITH_MONPZ
AccessioniPrimary (citable) accession number: P04363
Secondary accession number(s): Q8V4Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: August 2, 2002
Last modified: September 27, 2017
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families