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P04363

- KITH_MONPV

UniProt

P04363 - KITH_MONPV

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Protein

Thymidine kinase

Gene

TK

Organism
Monkeypox virus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831Proton acceptorSequence Analysis
Binding sitei113 – 1131Substrate; via amide nitrogenBy similarity
Metal bindingi138 – 1381ZincBy similarity
Metal bindingi141 – 1411ZincBy similarity
Metal bindingi170 – 1701ZincBy similarity
Metal bindingi173 – 1731ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
ORF Names:L2R
OrganismiMonkeypox virus
Taxonomic identifieri10244 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiCynomys gunnisoni (Gunnison's prairie dog) [TaxID: 45479]
Cynomys leucurus (White-tailed prairie dog) [TaxID: 99825]
Cynomys ludovicianus (Black-tailed prairie dog) [TaxID: 45480]
Cynomys mexicanus (Mexican prairie dog) [TaxID: 99826]
Cynomys parvidens (Utah prairie dog) [TaxID: 99827]
Gliridae (dormice) [TaxID: 30650]
Heliosciurus ruwenzorii (Ruwenzori sun squirrel) [TaxID: 226685]
Homo sapiens (Human) [TaxID: 9606]
Mus musculus (Mouse) [TaxID: 10090]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Thymidine kinasePRO_0000174931Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP04363.
SMRiP04363. Positions 4-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni157 – 1615Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04363-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNGGHIQLII GPMLSGKSTE LIRRVRRYQI AQYKCVTIKY SNDNRYGTGL
60 70 80 90 100
WTHDKNNFAA LEVTKLCDVL EAITDFSVIG IDEGQFFPDI VEFCERMANE
110 120 130 140 150
GKIVIVAALD GTFQRRPFNN ILNLIPLSEM VVKLTAVCMK CFKEASFSKR
160 170
LGAETEIEII GGNDMYQSVC RKCYIDS
Length:177
Mass (Da):19,990
Last modified:August 2, 2002 - v2
Checksum:i8A7BAAB3238C91D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141L → F in AAA80529. (PubMed:6330986)Curated
Sequence conflicti90 – 901I → V in AAA80529. (PubMed:6330986)Curated
Sequence conflicti153 – 1531A → T in AAA80529. (PubMed:6330986)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02025 Genomic DNA. Translation: AAA80529.1.
AF380138 Genomic DNA. Translation: AAL40544.1.
PIRiA00610. KIVZMV.
RefSeqiNP_536513.1. NC_003310.1.

Genome annotation databases

GeneIDi928935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02025 Genomic DNA. Translation: AAA80529.1 .
AF380138 Genomic DNA. Translation: AAL40544.1 .
PIRi A00610. KIVZMV.
RefSeqi NP_536513.1. NC_003310.1.

3D structure databases

ProteinModelPortali P04363.
SMRi P04363. Positions 4-175.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 928935.

Family and domain databases

InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the thymidine kinase gene region of monkeypox and variola viruses."
    Esposito J.J., Knight J.C.
    Virology 135:561-567(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Isolate Zaire-96-I-16.

Entry informationi

Entry nameiKITH_MONPV
AccessioniPrimary (citable) accession number: P04363
Secondary accession number(s): Q8V4Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: August 2, 2002
Last modified: October 1, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3