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P04363 (KITH_MONPV) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 177177Thymidine kinase
PRO_0000174931

Regions

Nucleotide binding11 – 188ATP By similarity
Region157 – 1615Substrate binding By similarity

Sites

Active site831Proton acceptor Potential
Metal binding1381Zinc By similarity
Metal binding1411Zinc By similarity
Metal binding1701Zinc By similarity
Metal binding1731Zinc By similarity
Binding site1131Substrate; via amide nitrogen By similarity

Experimental info

Sequence conflict141L → F in AAA80529. Ref.1
Sequence conflict901I → V in AAA80529. Ref.1
Sequence conflict1531A → T in AAA80529. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P04363 [UniParc].

Last modified August 2, 2002. Version 2.
Checksum: 8A7BAAB3238C91D2

FASTA17719,990
        10         20         30         40         50         60 
MNGGHIQLII GPMLSGKSTE LIRRVRRYQI AQYKCVTIKY SNDNRYGTGL WTHDKNNFAA 

        70         80         90        100        110        120 
LEVTKLCDVL EAITDFSVIG IDEGQFFPDI VEFCERMANE GKIVIVAALD GTFQRRPFNN 

       130        140        150        160        170 
ILNLIPLSEM VVKLTAVCMK CFKEASFSKR LGAETEIEII GGNDMYQSVC RKCYIDS 

« Hide

References

[1]"Nucleotide sequence of the thymidine kinase gene region of monkeypox and variola viruses."
Esposito J.J., Knight J.C.
Virology 135:561-567(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human monkeypox and smallpox viruses: genomic comparison."
Shchelkunov S.N., Totmenin A.V., Babkin I.V., Safronov P.F., Ryazankina O.I., Petrov N.A., Gutorov V.V., Uvarova E.A., Mikheev M.V., Sisler J.R., Esposito J.J., Jahrling P.B., Moss B., Sandakhchiev L.S.
FEBS Lett. 509:66-70(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Isolate Zaire-96-I-16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K02025 Genomic DNA. Translation: AAA80529.1.
AF380138 Genomic DNA. Translation: AAL40544.1.
PIRKIVZMV. A00610.
RefSeqNP_536513.1. NC_003310.1.

3D structure databases

ProteinModelPortalP04363.
SMRP04363. Positions 4-175.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID928935.

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_MONPV
AccessionPrimary (citable) accession number: P04363
Secondary accession number(s): Q8V4Z6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: August 2, 2002
Last modified: May 14, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families