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Protein

Metallothionein-1

Gene

MtnA

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein binds cations of several transition elements. It is thought to be involved in detoxification processes.

GO - Molecular functioni

  • metal ion binding Source: FlyBase

GO - Biological processi

  • metal ion homeostasis Source: FlyBase
  • response to metal ion Source: FlyBase

Keywordsi

LigandCadmium, Copper, Mercury, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Gene namesi
Name:MtnA
ORF Names:CG9470
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002868. MtnA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001973531 – 40Metallothionein-1Add BLAST40

Proteomic databases

PaxDbiP04357.

Expressioni

Developmental stagei

Late embryogenesis, larva and adult.

Inductioni

Strongly induced by cadmium, copper and mercury.

Gene expression databases

BgeeiFBgn0002868.
ExpressionAtlasiP04357. differential.
GenevisibleiP04357. DM.

Interactioni

Protein-protein interaction databases

BioGridi66359. 9 interactors.
DIPiDIP-19543N.
IntActiP04357. 8 interactors.
MINTiMINT-980299.
STRINGi7227.FBpp0081636.

Structurei

3D structure databases

ProteinModelPortaliP04357.
SMRiP04357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738. Eukaryota.
ENOG410Z9YK. LUCA.
InParanoidiP04357.
OrthoDBiEOG091G1A2R.
PhylomeDBiP04357.

Family and domain databases

InterProiView protein in InterPro
IPR000966. Metalthion_5.
PfamiView protein in Pfam
PF02067. Metallothio_5. 1 hit.
PRINTSiPR00872. MTDIPTERA.

Sequencei

Sequence statusi: Complete.

P04357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40
MPCPCGSGCK CASQATKGSC NCGSDCKCGG DKKSACGCSE
Length:40
Mass (Da):3,853
Last modified:March 20, 1987 - v1
Checksum:i99A2A53CCCAE634A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti40E → K in allele MtnA-3 and strain: AF6, Highgrove, Indiana, LA20, Taiwan, ZH18, ZH21, ZH27, ZS11, ZS30 and ZS56. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02314 mRNA. Translation: AAA28681.1.
M27708 Genomic DNA. Translation: AAA28684.1.
X03758 Genomic DNA. Translation: CAA27391.1.
M69015 Genomic DNA. Translation: AAB41334.1.
EU744337 Genomic DNA. Translation: ACH73302.1.
EU744338 Genomic DNA. Translation: ACH73303.1.
EU744339 Genomic DNA. Translation: ACH73304.1.
EU744340 Genomic DNA. Translation: ACH73305.1.
EU744341 Genomic DNA. Translation: ACH73306.1.
EU744342 Genomic DNA. Translation: ACH73307.1.
EU744343 Genomic DNA. Translation: ACH73308.1.
EU744344 Genomic DNA. Translation: ACH73309.1.
EU744345 Genomic DNA. Translation: ACH73310.1.
EU744346 Genomic DNA. Translation: ACH73311.1.
EU744347 Genomic DNA. Translation: ACH73312.1.
EU744348 Genomic DNA. Translation: ACH73313.1.
EU744349 Genomic DNA. Translation: ACH73314.1.
EU744350 Genomic DNA. Translation: ACH73315.1.
AE014297 Genomic DNA. Translation: AAF54452.1.
BT001431 mRNA. Translation: AAN71186.1.
PIRiA25294. SMFF.
RefSeqiNP_001262438.1. NM_001275509.1.
NP_524299.1. NM_079575.2.
UniGeneiDm.1134.

Genome annotation databases

EnsemblMetazoaiFBtr0082158; FBpp0081636; FBgn0002868.
FBtr0334686; FBpp0306744; FBgn0002868.
GeneIDi41202.
KEGGidme:Dmel_CG9470.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMT1_DROME
AccessioniPrimary (citable) accession number: P04357
Secondary accession number(s): B5T1U3, B5T1U5, Q9VH67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: September 27, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families