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Protein

Calbindin

Gene

CALB1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi25 – 361Add BLAST12
Calcium bindingi112 – 1232Add BLAST12
Calcium bindingi156 – 1673Add BLAST12
Calcium bindingi200 – 2114Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Calbindin
Alternative name(s):
Calbindin D28
D-28K
Vitamin D-dependent calcium-binding protein, avian-type
Gene namesi
Name:CALB1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cytosol Source: GO_Central
  • dendrite Source: Ensembl
  • extracellular exosome Source: Ensembl
  • neuronal cell body Source: Ensembl
  • neuron projection Source: GO_Central
  • nucleus Source: GO_Central
  • postsynaptic membrane Source: UniProtKB
  • vesicle membrane Source: UniProtKB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000734762 – 262CalbindinAdd BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP04354.

Expressioni

Tissue specificityi

Highly abundant in supporting cells. Also present in hair cells.1 Publication

Gene expression databases

BgeeiENSGALG00000015914.

Interactioni

Protein-protein interaction databases

BioGridi676764. 1 interactor.
IntActiP04354. 1 interactor.
STRINGi9031.ENSGALP00000026395.

Structurei

3D structure databases

ProteinModelPortaliP04354.
SMRiP04354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini54 – 89EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini99 – 134EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini143 – 178EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini187 – 222EF-hand 5PROSITE-ProRule annotationAdd BLAST36

Domaini

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Sequence similaritiesi

Belongs to the calbindin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiP04354.
KOiK14757.
OMAiMQTWRKY.
OrthoDBiEOG091G0GNH.
PhylomeDBiP04354.
TreeFamiTF325083.

Family and domain databases

CDDicd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR029634. Calbindin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PANTHERiPTHR19972:SF11. PTHR19972:SF11. 1 hit.
PfamiView protein in Pfam
PF13405. EF-hand_6. 2 hits.
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 5 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04354-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAETHLQGV EISAAQFFEI WHHYDSDGNG YMDGKELQNF IQELQQARKK
60 70 80 90 100
AGLDLTPEMK AFVDQYGKAT DGKIGIVELA QVLPTEENFL LFFRCQQLKS
110 120 130 140 150
SEDFMQTWRK YDSDHSGFID SEELKSFLKD LLQKANKQIE DSKLTEYTEI
160 170 180 190 200
MLRMFDANND GKLELTELAR LLPVQENFLI KFQGVKMCAK EFNKAFEMYD
210 220 230 240 250
QDGNGYIDEN ELDALLKDLC EKNKKELDIN NLATYKKSIM ALSDGGKLYR
260
AELALILCAE EN
Length:262
Mass (Da):30,167
Last modified:January 23, 2007 - v3
Checksum:i52081141364F08A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03343 mRNA. Translation: CAA27049.1.
M14230 mRNA. Translation: AAA48659.1.
M31143
, M31139, M31140, M31141, M31142 Genomic DNA. Translation: AAA83832.1.
X06629
, X06630, X06631, X06632, X06633 Genomic DNA. Translation: CAA29843.1.
PIRiA40926. KLCHI.
RefSeqiNP_990844.1. NM_205513.1.
UniGeneiGga.3286.

Genome annotation databases

EnsembliENSGALT00000074265; ENSGALP00000056213; ENSGALG00000032282.
GeneIDi396519.
KEGGigga:396519.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCALB1_CHICK
AccessioniPrimary (citable) accession number: P04354
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families