true1987-03-202024-03-27196IL2_MOUSEOrganization and structure of the mouse interleukin-2 gene.Fuse A.Fujita T.Yasumitsu H.Kashima N.Hasegawa K.Taniguchi T.doi:10.1093/nar/12.24.93231984Nucleic Acids Res.129323-9331NUCLEOTIDE SEQUENCE [GENOMIC DNA]BALB/cJUnique structure of murine interleukin-2 as deduced from cloned cDNAs.Kashima N.Nishi-Takaoka C.Fujita T.Taki S.Yamada G.Hamuro J.Taniguchi T.doi:10.1038/313402a01985Nature313402-404NUCLEOTIDE SEQUENCE [MRNA]B10BRUse of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.Yokota T.Arai N.Lee F.Rennick D.Mosmann T.Arai K.doi:10.1073/pnas.82.1.681985Proc. Natl. Acad. Sci. U.S.A.8268-72NUCLEOTIDE SEQUENCE [MRNA]C57BL/6JCloning and structure of a mouse interleukin-2 chromosomal gene.Degrave W.Simons G.Devos R.Plaetinck G.Remaut E.Tavernier J.Fiers W.doi:10.1007/bf004175971986Mol. Biol. Rep.1157-61NUCLEOTIDE SEQUENCE [GENOMIC DNA]Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping.Lyons P.A.Armitage N.Argentina F.Denny P.Hill N.J.Lord C.J.Wilusz M.B.Peterson L.B.Wicker L.S.Todd J.A.doi:10.1101/gr.10.4.4462000Genome Res.10446-453NUCLEOTIDE SEQUENCE [GENOMIC DNA]Ma R.Z.Teuscher C.1998-05EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [MRNA]SpleenLineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M.Goodstadt L.Hillier L.W.Zody M.C.Goldstein S.She X.Bult C.J.Agarwala R.Cherry J.L.DiCuccio M.Hlavina W.Kapustin Y.Meric P.Maglott D.Birtle Z.Marques A.C.Graves T.Zhou S.Teague B.Potamousis K.Churas C.Place M.Herschleb J.Runnheim R.Forrest D.Amos-Landgraf J.Schwartz D.C.Cheng Z.Lindblad-Toh K.Eichler E.E.Ponting C.P.doi:10.1371/journal.pbio.10001122009PLoS Biol.7E1000112NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]A new cDNA sequence for the murine interleukin-2 gene.Matesanz F.Alcina A.Pellicer A.doi:10.1016/0167-4781(92)90174-x1992Biochim. Biophys. Acta1132335-336NUCLEOTIDE SEQUENCE [MRNA] OF 1-63RFExistence of at least five interleukin-2 molecules in different mouse strains.Matesanz F.Alcina A.Pellicer A.doi:10.1007/bf001888091993Immunogenetics38300-303NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63CAST/EiJRF/JThymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice.Reya T.Bassiri H.Biancaniello R.Carding S.R.doi:10.1155/1998/195671998Dev. Immunol.5287-302FUNCTIONDISRUPTION PHENOTYPEInducible IL-2 production by dendritic cells revealed by global gene expression analysis.Granucci F.Vizzardelli C.Pavelka N.Feau S.Persico M.Virzi E.Rescigno M.Moro G.Ricciardi-Castagnoli P.doi:10.1038/ni0901-8822001Nat. Immunol.2882-888FUNCTIONTISSUE SPECIFICITYINDUCTION BY DENDRITIC CELLSStat5 activation plays a critical role in Th2 differentiation.Zhu J.Cote-Sierra J.Guo L.Paul W.E.doi:10.1016/s1074-7613(03)00292-92003Immunity19739-748FUNCTIONEssential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling.Smith G.A.Uchida K.Weiss A.Taunton J.doi:10.1038/nchembio.20562016Nat. Chem. Biol.12373-379FUNCTIONDefinition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor.Zurawski S.Vega F. Jr.Doyel E.L.Huyghe B.Flaherty K.McKay D.B.Zurawski G.doi:10.1002/j.1460-2075.1993.tb06206.x1993EMBO J.125113-51193D-STRUCTURE MODELINGAntibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.Spangler J.B.Tomala J.Luca V.C.Jude K.M.Dong S.Ring A.M.Votavova P.Pepper M.Kovar M.Garcia K.C.doi:10.1016/j.immuni.2015.04.0152015Immunity42815-825X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 47-169DISULFIDE BONDICMS22.83A/M=47-1692.19C=47-16911 site, No reported glycans1 site2 sequenced antibodies2307 antibodies from 49 providersmouseIl2Eukaryota2 hits in 118 CRISPR screensmouseProteinExpressed in chordate pharynx and 15 other cell types or tissues4_helix_cytokine-like_coreIL-2IL-2_CSINTERLEUKIN-2INTERLEUKIN-2IL2INTERLEUKIN2IL24-helical cytokinesINTERLEUKIN_2MMInterleukin-2IL-2T-cell growth factorTCGFIl2Il-2Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:9814585, PubMed:14614860). Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 (PubMed:14614860, PubMed:27018889). This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance (PubMed:14614860). Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells (PubMed:9814585).Produced by immune cells including dendritic cells. In contrast, macrophages do not produce IL2 upon bacterial stimulation.By bacterial infection.The poly-Gln region is highly polymorphic.Mutant mice exhibit lethal autoimmunity and are impaired in regulatory T-cell production. After 4 to 5 weeks of birth, they develop a thymic disorder resulting in the disruption of thymocyte maturation.Belongs to the IL-2 family.120Interleukin-21723121169O-linked (GalNAc...) threonine2392140In strain: RF/J and CAST/Ei.P26In strain: RF/J.P30In strain: CAST/Ei.SSSTAEA3239In strain: RF/J.SSSTAEA38E10847607073757987909194971031181321341361441481491641987-03-201true19400dcc3fbb777beb714d18ea0892813ec8aMYSMQLASCVTLTLVLLVNSAPTSSSTSSSTAEAQQQQQQQQQQQQHLEQLLMDLQELLSRMENYRNLKLPRMLTFKFYLPKQATELKDLQCLEDELGPLRHVLDLTQSKSFQLEDAENFISNIRVTVVKLKGSDNTFECQFDDESATVVDFLRRWIAFCQSIISTSPQtruetruetruetruetruetruetruetruetruetruetruetrue