Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P04351

- IL2_MOUSE

UniProt

P04351 - IL2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Interleukin-2

Gene

Il2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Molecular functioni

  1. carbohydrate binding Source: Ensembl
  2. cytokine activity Source: MGI
  3. glycosphingolipid binding Source: Ensembl
  4. interleukin-2 receptor binding Source: MGI

GO - Biological processi

  1. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  2. immune response Source: InterPro
  3. negative regulation of B cell apoptotic process Source: MGI
  4. negative regulation of heart contraction Source: Ensembl
  5. negative regulation of inflammatory response Source: MGI
  6. negative regulation of lymphocyte proliferation Source: MGI
  7. negative regulation of protein phosphorylation Source: Ensembl
  8. positive regulation of activated T cell proliferation Source: MGI
  9. positive regulation of B cell proliferation Source: MGI
  10. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  11. positive regulation of dendritic spine development Source: Ensembl
  12. positive regulation of immunoglobulin secretion Source: MGI
  13. positive regulation of interferon-gamma production Source: MGI
  14. positive regulation of interleukin-17 production Source: Ensembl
  15. positive regulation of isotype switching to IgG isotypes Source: MGI
  16. positive regulation of regulatory T cell differentiation Source: Ensembl
  17. positive regulation of T cell proliferation Source: MGI
  18. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  19. positive regulation of tyrosine phosphorylation of Stat5 protein Source: MGI
  20. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  21. regulation of T cell homeostatic proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiREACT_210793. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:Il2
Synonyms:Il-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:96548. Il2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 169149Interleukin-2PRO_0000015493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231O-linked (GalNAc...)By similarity
Disulfide bondi92 ↔ 140By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP04351.

PTM databases

PhosphoSiteiP04351.

Expressioni

Gene expression databases

BgeeiP04351.
CleanExiMM_IL2.
ExpressionAtlasiP04351. differential.
GenevestigatoriP04351.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Il2rgP349021EBI-80538,EBI-80548

Protein-protein interaction databases

IntActiP04351. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP04351.
SMRiP04351. Positions 21-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi35 – 4612Poly-GlnAdd
BLAST

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41211.
GeneTreeiENSGT00390000003555.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
InParanoidiP04351.
KOiK05429.
OMAiKWITFCQ.
OrthoDBiEOG72RN13.
PhylomeDBiP04351.
TreeFamiTF338200.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view]
PANTHERiPTHR11443. PTHR11443. 1 hit.
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04351-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYSMQLASCV TLTLVLLVNS APTSSSTSSS TAEAQQQQQQ QQQQQQHLEQ
60 70 80 90 100
LLMDLQELLS RMENYRNLKL PRMLTFKFYL PKQATELKDL QCLEDELGPL
110 120 130 140 150
RHVLDLTQSK SFQLEDAENF ISNIRVTVVK LKGSDNTFEC QFDDESATVV
160
DFLRRWIAFC QSIISTSPQ
Length:169
Mass (Da):19,400
Last modified:March 20, 1987 - v1
Checksum:iB3B17644F6EF83CA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081Q → E in AAA39281. (PubMed:3003564)Curated

Polymorphismi

The poly-Gln region is highly polymorphic.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261S → P in strain: RF/J and CAST/Ei.
Natural varianti30 – 301S → P in strain: RF/J.
Natural varianti32 – 398AEAQQQQQ → SSSTAEA in strain: CAST/Ei.
Natural varianti32 – 387AEAQQQQ → SSSTAEA in strain: RF/J.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01663 Genomic DNA. Translation: CAA25823.1.
X01664 Genomic DNA. Translation: CAA25824.1.
X01665 Genomic DNA. Translation: CAA25825.1.
X01772 mRNA. Translation: CAA25909.1.
K02292 mRNA. Translation: AAA39289.1.
M16762, M16760, M16761 Genomic DNA. Translation: AAA39281.1.
AF195956 Genomic DNA. Translation: AAF32272.1.
AF065914 mRNA. Translation: AAD25890.1.
AL662823 Genomic DNA. Translation: CAM18418.1.
X66058 mRNA. Translation: CAA46854.1.
L07574 Genomic DNA. Translation: AAA39326.1.
L07576 Genomic DNA. Translation: AAA39328.1.
CCDSiCCDS17316.1.
PIRiA93550. ICMS2.
I54512.
I68871.
RefSeqiNP_032392.1. NM_008366.3.
UniGeneiMm.14190.

Genome annotation databases

EnsembliENSMUST00000029275; ENSMUSP00000029275; ENSMUSG00000027720.
GeneIDi16183.
KEGGimmu:16183.
UCSCiuc008pai.3. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01663 Genomic DNA. Translation: CAA25823.1 .
X01664 Genomic DNA. Translation: CAA25824.1 .
X01665 Genomic DNA. Translation: CAA25825.1 .
X01772 mRNA. Translation: CAA25909.1 .
K02292 mRNA. Translation: AAA39289.1 .
M16762 , M16760 , M16761 Genomic DNA. Translation: AAA39281.1 .
AF195956 Genomic DNA. Translation: AAF32272.1 .
AF065914 mRNA. Translation: AAD25890.1 .
AL662823 Genomic DNA. Translation: CAM18418.1 .
X66058 mRNA. Translation: CAA46854.1 .
L07574 Genomic DNA. Translation: AAA39326.1 .
L07576 Genomic DNA. Translation: AAA39328.1 .
CCDSi CCDS17316.1.
PIRi A93550. ICMS2.
I54512.
I68871.
RefSeqi NP_032392.1. NM_008366.3.
UniGenei Mm.14190.

3D structure databases

ProteinModelPortali P04351.
SMRi P04351. Positions 21-166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P04351. 1 interaction.

Chemistry

BindingDBi P04351.
ChEMBLi CHEMBL2466.

PTM databases

PhosphoSitei P04351.

Proteomic databases

PRIDEi P04351.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029275 ; ENSMUSP00000029275 ; ENSMUSG00000027720 .
GeneIDi 16183.
KEGGi mmu:16183.
UCSCi uc008pai.3. mouse.

Organism-specific databases

CTDi 3558.
MGIi MGI:96548. Il2.

Phylogenomic databases

eggNOGi NOG41211.
GeneTreei ENSGT00390000003555.
HOGENOMi HOG000048727.
HOVERGENi HBG007496.
InParanoidi P04351.
KOi K05429.
OMAi KWITFCQ.
OrthoDBi EOG72RN13.
PhylomeDBi P04351.
TreeFami TF338200.

Enzyme and pathway databases

Reactomei REACT_210793. Interleukin receptor SHC signaling.

Miscellaneous databases

NextBioi 289069.
PROi P04351.
SOURCEi Search...

Gene expression databases

Bgeei P04351.
CleanExi MM_IL2.
ExpressionAtlasi P04351. differential.
Genevestigatori P04351.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
[Graphical view ]
PANTHERi PTHR11443. PTHR11443. 1 hit.
Pfami PF00715. IL2. 1 hit.
[Graphical view ]
PRINTSi PR00265. INTERLEUKIN2.
ProDomi PD003649. Interleukin-2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00189. IL2. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00424. INTERLEUKIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  2. "Unique structure of murine interleukin-2 as deduced from cloned cDNAs."
    Kashima N., Nishi-Takaoka C., Fujita T., Taki S., Yamada G., Hamuro J., Taniguchi T.
    Nature 313:402-404(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B10BR.
  3. "Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells."
    Yokota T., Arai N., Lee F., Rennick D., Mosmann T., Arai K.
    Proc. Natl. Acad. Sci. U.S.A. 82:68-72(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  4. "Cloning and structure of a mouse interleukin-2 chromosomal gene."
    Degrave W., Simons G., Devos R., Plaetinck G., Remaut E., Tavernier J., Fiers W.
    Mol. Biol. Rep. 11:57-61(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping."
    Lyons P.A., Armitage N., Argentina F., Denny P., Hill N.J., Lord C.J., Wilusz M.B., Peterson L.B., Wicker L.S., Todd J.A.
    Genome Res. 10:446-453(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
  6. Ma R.Z., Teuscher C.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  8. "A new cDNA sequence for the murine interleukin-2 gene."
    Matesanz F., Alcina A., Pellicer A.
    Biochim. Biophys. Acta 1132:335-336(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-63.
    Strain: RF.
    Tissue: Spleen.
  9. "Existence of at least five interleukin-2 molecules in different mouse strains."
    Matesanz F., Alcina A., Pellicer A.
    Immunogenetics 38:300-303(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63.
    Strain: CAST/Ei and RF/J.
    Tissue: Spleen.
  10. "Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor."
    Zurawski S., Vega F. Jr., Doyel E.L., Huyghe B., Flaherty K., McKay D.B., Zurawski G.
    EMBO J. 12:5113-5119(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiIL2_MOUSE
AccessioniPrimary (citable) accession number: P04351
Secondary accession number(s): P97945, Q791T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3