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Protein

Interleukin-2

Gene

Il2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Molecular functioni

  • carbohydrate binding Source: Ensembl
  • cytokine activity Source: MGI
  • glycosphingolipid binding Source: Ensembl
  • interleukin-2 receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-451927. Interleukin-2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:Il2
Synonyms:Il-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96548. Il2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2466.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001549321 – 169Interleukin-2Add BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23O-linked (GalNAc...)By similarity1
Disulfide bondi92 ↔ 140By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP04351.
PRIDEiP04351.

PTM databases

PhosphoSitePlusiP04351.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027720.
CleanExiMM_IL2.
GenevisibleiP04351. MM.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • interleukin-2 receptor binding Source: MGI

Protein-protein interaction databases

IntActiP04351. 1 interactor.
STRINGi10090.ENSMUSP00000029275.

Chemistry databases

BindingDBiP04351.

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 60Combined sources14
Helixi70 – 73Combined sources4
Beta strandi75 – 79Combined sources5
Helixi87 – 90Combined sources4
Helixi91 – 94Combined sources4
Helixi97 – 103Combined sources7
Helixi118 – 132Combined sources15
Beta strandi134 – 136Combined sources3
Beta strandi144 – 148Combined sources5
Helixi149 – 164Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YQXX-ray2.83A/M47-169[»]
4YUEX-ray2.19C47-169[»]
ProteinModelPortaliP04351.
SMRiP04351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 46Poly-GlnAdd BLAST12

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
GeneTreeiENSGT00390000003555.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
InParanoidiP04351.
KOiK05429.
OMAiLMSNINV.
OrthoDBiEOG091G0VTZ.
PhylomeDBiP04351.
TreeFamiTF338200.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSMQLASCV TLTLVLLVNS APTSSSTSSS TAEAQQQQQQ QQQQQQHLEQ
60 70 80 90 100
LLMDLQELLS RMENYRNLKL PRMLTFKFYL PKQATELKDL QCLEDELGPL
110 120 130 140 150
RHVLDLTQSK SFQLEDAENF ISNIRVTVVK LKGSDNTFEC QFDDESATVV
160
DFLRRWIAFC QSIISTSPQ
Length:169
Mass (Da):19,400
Last modified:March 20, 1987 - v1
Checksum:iB3B17644F6EF83CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108Q → E in AAA39281 (PubMed:3003564).Curated1

Polymorphismi

The poly-Gln region is highly polymorphic.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti26S → P in strain: RF/J and CAST/Ei. 1
Natural varianti30S → P in strain: RF/J. 1
Natural varianti32 – 39AEAQQQQQ → SSSTAEA in strain: CAST/Ei. 8
Natural varianti32 – 38AEAQQQQ → SSSTAEA in strain: RF/J. 7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01663 Genomic DNA. Translation: CAA25823.1.
X01664 Genomic DNA. Translation: CAA25824.1.
X01665 Genomic DNA. Translation: CAA25825.1.
X01772 mRNA. Translation: CAA25909.1.
K02292 mRNA. Translation: AAA39289.1.
M16762, M16760, M16761 Genomic DNA. Translation: AAA39281.1.
AF195956 Genomic DNA. Translation: AAF32272.1.
AF065914 mRNA. Translation: AAD25890.1.
AL662823 Genomic DNA. Translation: CAM18418.1.
X66058 mRNA. Translation: CAA46854.1.
L07574 Genomic DNA. Translation: AAA39326.1.
L07576 Genomic DNA. Translation: AAA39328.1.
CCDSiCCDS17316.1.
PIRiA93550. ICMS2.
I54512.
I68871.
RefSeqiNP_032392.1. NM_008366.3.
UniGeneiMm.14190.

Genome annotation databases

EnsembliENSMUST00000029275; ENSMUSP00000029275; ENSMUSG00000027720.
GeneIDi16183.
KEGGimmu:16183.
UCSCiuc008pai.3. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01663 Genomic DNA. Translation: CAA25823.1.
X01664 Genomic DNA. Translation: CAA25824.1.
X01665 Genomic DNA. Translation: CAA25825.1.
X01772 mRNA. Translation: CAA25909.1.
K02292 mRNA. Translation: AAA39289.1.
M16762, M16760, M16761 Genomic DNA. Translation: AAA39281.1.
AF195956 Genomic DNA. Translation: AAF32272.1.
AF065914 mRNA. Translation: AAD25890.1.
AL662823 Genomic DNA. Translation: CAM18418.1.
X66058 mRNA. Translation: CAA46854.1.
L07574 Genomic DNA. Translation: AAA39326.1.
L07576 Genomic DNA. Translation: AAA39328.1.
CCDSiCCDS17316.1.
PIRiA93550. ICMS2.
I54512.
I68871.
RefSeqiNP_032392.1. NM_008366.3.
UniGeneiMm.14190.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YQXX-ray2.83A/M47-169[»]
4YUEX-ray2.19C47-169[»]
ProteinModelPortaliP04351.
SMRiP04351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04351. 1 interactor.
STRINGi10090.ENSMUSP00000029275.

Chemistry databases

BindingDBiP04351.
ChEMBLiCHEMBL2466.

PTM databases

PhosphoSitePlusiP04351.

Proteomic databases

PaxDbiP04351.
PRIDEiP04351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029275; ENSMUSP00000029275; ENSMUSG00000027720.
GeneIDi16183.
KEGGimmu:16183.
UCSCiuc008pai.3. mouse.

Organism-specific databases

CTDi3558.
MGIiMGI:96548. Il2.

Phylogenomic databases

eggNOGiENOG410J049. Eukaryota.
ENOG41119SF. LUCA.
GeneTreeiENSGT00390000003555.
HOGENOMiHOG000048727.
HOVERGENiHBG007496.
InParanoidiP04351.
KOiK05429.
OMAiLMSNINV.
OrthoDBiEOG091G0VTZ.
PhylomeDBiP04351.
TreeFamiTF338200.

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-451927. Interleukin-2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-912526. Interleukin receptor SHC signaling.

Miscellaneous databases

PROiP04351.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027720.
CleanExiMM_IL2.
GenevisibleiP04351. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000779. IL-2.
IPR030477. IL-2_CS.
[Graphical view]
PfamiPF00715. IL2. 1 hit.
[Graphical view]
PRINTSiPR00265. INTERLEUKIN2.
ProDomiPD003649. Interleukin-2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00189. IL2. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00424. INTERLEUKIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL2_MOUSE
AccessioniPrimary (citable) accession number: P04351
Secondary accession number(s): P97945, Q791T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.