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Protein

Gamma-crystallin A

Gene

Cryga

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

GO - Biological processi

  • eye development Source: MGI
  • lens development in camera-type eye Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin A
Alternative name(s):
Gamma-A-crystallin
Gamma-crystallin 4
Gene namesi
Name:Cryga
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88521. Cryga.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000575952 – 174Gamma-crystallin AAdd BLAST173

Proteomic databases

PaxDbiP04345.
PRIDEiP04345.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044429.
CleanExiMM_CRYGA.
GenevisibleiP04345. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058548.

Structurei

3D structure databases

ProteinModelPortaliP04345.
SMRiP04345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini88 – 128Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini129 – 171Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 87Connecting peptide4

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP04345.
OMAiCRSIPYT.
OrthoDBiEOG091G0L2P.
PhylomeDBiP04345.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITFYEDR GFQGRCYECS SDCPNLQTYF SRCNSIRVDS GCWMLYERPN
60 70 80 90 100
YQGYQYFLRR GDYPDYQQWM GFSDSIRSCR SIPYTSSHRI RLYERDDYRG
110 120 130 140 150
LVSELMDDCS CIHDRFRLHE IYSMHVLEGC WVLYEMPNYR GRQYLLRPGD
160 170
YRRYHDWGAM DAKVGSLRRV MDLY
Length:174
Mass (Da):21,149
Last modified:January 23, 2007 - v2
Checksum:i169758B24919D632
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00635 Genomic DNA. Translation: CAA25266.1.
X00654 Genomic DNA. Translation: CAA25275.1.
BC056430 mRNA. Translation: AAH56430.1.
CCDSiCCDS15014.1.
PIRiA02935. CYMSG4.
I48353.
RefSeqiNP_031800.1. NM_007774.3.
UniGeneiMm.26904.

Genome annotation databases

EnsembliENSMUST00000061497; ENSMUSP00000058548; ENSMUSG00000044429.
GeneIDi12964.
KEGGimmu:12964.
UCSCiuc007bhk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00635 Genomic DNA. Translation: CAA25266.1.
X00654 Genomic DNA. Translation: CAA25275.1.
BC056430 mRNA. Translation: AAH56430.1.
CCDSiCCDS15014.1.
PIRiA02935. CYMSG4.
I48353.
RefSeqiNP_031800.1. NM_007774.3.
UniGeneiMm.26904.

3D structure databases

ProteinModelPortaliP04345.
SMRiP04345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058548.

Proteomic databases

PaxDbiP04345.
PRIDEiP04345.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061497; ENSMUSP00000058548; ENSMUSG00000044429.
GeneIDi12964.
KEGGimmu:12964.
UCSCiuc007bhk.1. mouse.

Organism-specific databases

CTDi1418.
MGIiMGI:88521. Cryga.

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP04345.
OMAiCRSIPYT.
OrthoDBiEOG091G0L2P.
PhylomeDBiP04345.

Miscellaneous databases

ChiTaRSiCryga. mouse.
PROiP04345.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044429.
CleanExiMM_CRYGA.
GenevisibleiP04345. MM.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRGA_MOUSE
AccessioniPrimary (citable) accession number: P04345
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are six different gamma crystallins identified in mouse lens.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.