ID   CRGB_MOUSE              Reviewed;         175 AA.
AC   P04344; Q61593; Q6PHP7;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 4.
DT   27-MAR-2024, entry version 151.
DE   RecName: Full=Gamma-crystallin B;
DE   AltName: Full=Gamma-B-crystallin;
DE   AltName: Full=Gamma-crystallin 3;
GN   Name=Crygb;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=102 X C3H; TISSUE=Liver;
RX   PubMed=8293998; DOI=10.1016/0378-1119(93)90458-f;
RA   Graw J., Liebstein A., Pietrowski D., Schmitt-John T., Werner T.;
RT   "Genomic sequences of murine gamma B- and gamma C-crystallin-encoding
RT   genes: promoter analysis and complete evolutionary pattern of mouse, rat
RT   and human gamma-crystallins.";
RL   Gene 136:145-156(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Lens;
RA   Wistow G.;
RT   "Mouse gammaB-crystallin.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Eye;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 38-175.
RX   PubMed=6096855; DOI=10.1073/pnas.81.24.7762;
RA   Breitman M.L., Lok S., Wistow G., Piatigorsky J., Treton J.A., Gold R.J.M.,
RA   Tsui L.-C.;
RT   "Gamma-crystallin family of the mouse lens: structural and evolutionary
RT   relationships.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:7762-7766(1984).
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens.
CC   -!- DOMAIN: Has a two-domain beta-structure, folded into four very similar
CC       Greek key motifs.
CC   -!- MISCELLANEOUS: There are six different gamma crystallins identified in
CC       mouse lens.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family. {ECO:0000305}.
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DR   EMBL; Z22573; CAA80296.1; -; Genomic_DNA.
DR   EMBL; EF426303; ABO14688.1; -; mRNA.
DR   EMBL; AK143110; BAE25271.1; -; mRNA.
DR   EMBL; AC101869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC158958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC056455; AAH56455.1; -; mRNA.
DR   EMBL; K02585; AAA37474.1; -; mRNA.
DR   CCDS; CCDS15013.1; -.
DR   PIR; I48359; CYMSG3.
DR   RefSeq; NP_658906.1; NM_144761.2.
DR   AlphaFoldDB; P04344; -.
DR   SMR; P04344; -.
DR   BioGRID; 198917; 1.
DR   STRING; 10090.ENSMUSP00000027090; -.
DR   iPTMnet; P04344; -.
DR   PhosphoSitePlus; P04344; -.
DR   PaxDb; 10090-ENSMUSP00000027090; -.
DR   ProteomicsDB; 284012; -.
DR   Antibodypedia; 34195; 82 antibodies from 16 providers.
DR   DNASU; 12965; -.
DR   Ensembl; ENSMUST00000027090.9; ENSMUSP00000027090.8; ENSMUSG00000073658.5.
DR   GeneID; 12965; -.
DR   KEGG; mmu:12965; -.
DR   UCSC; uc007bhj.2; mouse.
DR   AGR; MGI:88522; -.
DR   CTD; 1419; -.
DR   MGI; MGI:88522; Crygb.
DR   VEuPathDB; HostDB:ENSMUSG00000073658; -.
DR   eggNOG; ENOG502RXJY; Eukaryota.
DR   GeneTree; ENSGT00940000159232; -.
DR   HOGENOM; CLU_081883_1_1_1; -.
DR   InParanoid; P04344; -.
DR   OMA; AYRMKIY; -.
DR   OrthoDB; 3998747at2759; -.
DR   PhylomeDB; P04344; -.
DR   BioGRID-ORCS; 12965; 0 hits in 78 CRISPR screens.
DR   ChiTaRS; Crygb; mouse.
DR   PRO; PR:P04344; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; P04344; Protein.
DR   Bgee; ENSMUSG00000073658; Expressed in lens of camera-type eye and 38 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005212; F:structural constituent of eye lens; IDA:MGI.
DR   GO; GO:0001654; P:eye development; IMP:MGI.
DR   GO; GO:0002088; P:lens development in camera-type eye; IMP:MGI.
DR   GO; GO:0070307; P:lens fiber cell development; IMP:MGI.
DR   GO; GO:0070309; P:lens fiber cell morphogenesis; IMP:MGI.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   Gene3D; 2.60.20.10; Crystallins; 2.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   PANTHER; PTHR11818; BETA/GAMMA CRYSTALLIN; 1.
DR   PANTHER; PTHR11818:SF123; GAMMA-CRYSTALLIN B; 1.
DR   Pfam; PF00030; Crystall; 2.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 2.
DR   SUPFAM; SSF49695; gamma-Crystallin-like; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 4.
DR   Genevisible; P04344; MM.
PE   2: Evidence at transcript level;
KW   Eye lens protein; Reference proteome; Repeat.
FT   CHAIN           1..175
FT                   /note="Gamma-crystallin B"
FT                   /id="PRO_0000057596"
FT   DOMAIN          2..40
FT                   /note="Beta/gamma crystallin 'Greek key' 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          41..83
FT                   /note="Beta/gamma crystallin 'Greek key' 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          89..129
FT                   /note="Beta/gamma crystallin 'Greek key' 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   DOMAIN          130..172
FT                   /note="Beta/gamma crystallin 'Greek key' 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00028"
FT   REGION          84..88
FT                   /note="Connecting peptide"
FT   CONFLICT        80
FT                   /note="C -> R (in Ref. 1; CAA80296 and 6; AAA37474)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        151
FT                   /note="E -> M (in Ref. 6; AAA37474)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   175 AA;  21086 MW;  1E39B15A0AAB175D CRC64;
     MGKITFFEDR SFQGRCYECS SDCPNLQTYF SRCNSVRVDS GCWMLYERPN YQGHQYFLRR
     GEYPDYQQWM GFSDSIRSCC LIPQHSGTYR MRIYEKDDFR GQMSEITDDC LSLQDRFHFS
     EIHSLNVMEG CWVLYEMPSY RGRQYLLRPG EYRRYLDWGA ANAKVGSFRR VMDFY
//