Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P04344 (CRGB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-crystallin B
Alternative name(s):
Gamma-B-crystallin
Gamma-crystallin 3
Gene names
Name:Crygb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length175 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Crystallins are the dominant structural components of the vertebrate eye lens.

Domain

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Miscellaneous

There are six different gamma crystallins identified in mouse lens.

Sequence similarities

Belongs to the beta/gamma-crystallin family.

Contains 4 beta/gamma crystallin 'Greek key' domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 175174Gamma-crystallin B
PRO_0000057596

Regions

Domain2 – 4039Beta/gamma crystallin 'Greek key' 1
Domain41 – 8343Beta/gamma crystallin 'Greek key' 2
Domain89 – 12941Beta/gamma crystallin 'Greek key' 3
Domain130 – 17243Beta/gamma crystallin 'Greek key' 4
Region84 – 885Connecting peptide

Sites

Site691Susceptible to oxidation By similarity
Site701Susceptible to oxidation By similarity

Experimental info

Sequence conflict801C → R in CAA80296. Ref.1
Sequence conflict801C → R in AAA37474. Ref.6
Sequence conflict1511E → M in AAA37474. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P04344 [UniParc].

Last modified October 3, 2012. Version 4.
Checksum: 1E39B15A0AAB175D

FASTA17521,086
        10         20         30         40         50         60 
MGKITFFEDR SFQGRCYECS SDCPNLQTYF SRCNSVRVDS GCWMLYERPN YQGHQYFLRR 

        70         80         90        100        110        120 
GEYPDYQQWM GFSDSIRSCC LIPQHSGTYR MRIYEKDDFR GQMSEITDDC LSLQDRFHFS 

       130        140        150        160        170 
EIHSLNVMEG CWVLYEMPSY RGRQYLLRPG EYRRYLDWGA ANAKVGSFRR VMDFY 

« Hide

References

« Hide 'large scale' references
[1]"Genomic sequences of murine gamma B- and gamma C-crystallin-encoding genes: promoter analysis and complete evolutionary pattern of mouse, rat and human gamma-crystallins."
Graw J., Liebstein A., Pietrowski D., Schmitt-John T., Werner T.
Gene 136:145-156(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 102 X C3H.
Tissue: Liver.
[2]"Mouse gammaB-crystallin."
Wistow G.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Lens.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Eye.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[6]"Gamma-crystallin family of the mouse lens: structural and evolutionary relationships."
Breitman M.L., Lok S., Wistow G., Piatigorsky J., Treton J.A., Gold R.J.M., Tsui L.-C.
Proc. Natl. Acad. Sci. U.S.A. 81:7762-7766(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-175.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z22573 Genomic DNA. Translation: CAA80296.1.
EF426303 mRNA. Translation: ABO14688.1.
AK143110 mRNA. Translation: BAE25271.1.
AC101869 Genomic DNA. No translation available.
AC158958 Genomic DNA. No translation available.
BC056455 mRNA. Translation: AAH56455.1.
K02585 mRNA. Translation: AAA37474.1.
PIRCYMSG3. I48359.
RefSeqNP_658906.1. NM_144761.2.
UniGeneMm.440053.

3D structure databases

ProteinModelPortalP04344.
SMRP04344. Positions 2-175.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP04344.

Proteomic databases

PRIDEP04344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027090; ENSMUSP00000027090; ENSMUSG00000073658.
GeneID12965.
KEGGmmu:12965.
UCSCuc007bhj.1. mouse.

Organism-specific databases

CTD1419.
MGIMGI:88522. Crygb.

Phylogenomic databases

eggNOGNOG309484.
GeneTreeENSGT00680000099801.
HOGENOMHOG000234389.
HOVERGENHBG003364.
InParanoidP04344.
OMAFRGQMSE.
OrthoDBEOG70CR7Z.

Gene expression databases

CleanExMM_CRYGB.
GenevestigatorP04344.

Family and domain databases

InterProIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSPR01367. BGCRYSTALLIN.
SMARTSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMSSF49695. SSF49695. 1 hit.
PROSITEPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCRYGB. mouse.
NextBio282706.
PROP04344.
SOURCESearch...

Entry information

Entry nameCRGB_MOUSE
AccessionPrimary (citable) accession number: P04344
Secondary accession number(s): Q61593, Q6PHP7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 104 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot