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P04344

- CRGB_MOUSE

UniProt

P04344 - CRGB_MOUSE

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Protein

Gamma-crystallin B

Gene

Crygb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

  1. structural constituent of eye lens Source: MGI

GO - Biological processi

  1. eye development Source: MGI
  2. lens development in camera-type eye Source: MGI
  3. lens fiber cell development Source: MGI
  4. lens fiber cell morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin B
Alternative name(s):
Gamma-B-crystallin
Gamma-crystallin 3
Gene namesi
Name:Crygb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:88522. Crygb.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 175174Gamma-crystallin BPRO_0000057596Add
BLAST

Proteomic databases

PRIDEiP04344.

PTM databases

PhosphoSiteiP04344.

Expressioni

Gene expression databases

CleanExiMM_CRYGB.
GenevestigatoriP04344.

Structurei

3D structure databases

ProteinModelPortaliP04344.
SMRiP04344. Positions 2-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 4039Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini41 – 8343Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini89 – 12941Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 17243Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 885Connecting peptide

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG309484.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP04344.
OMAiFRGQMSE.
OrthoDBiEOG70CR7Z.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04344-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKITFFEDR SFQGRCYECS SDCPNLQTYF SRCNSVRVDS GCWMLYERPN
60 70 80 90 100
YQGHQYFLRR GEYPDYQQWM GFSDSIRSCC LIPQHSGTYR MRIYEKDDFR
110 120 130 140 150
GQMSEITDDC LSLQDRFHFS EIHSLNVMEG CWVLYEMPSY RGRQYLLRPG
160 170
EYRRYLDWGA ANAKVGSFRR VMDFY
Length:175
Mass (Da):21,086
Last modified:October 3, 2012 - v4
Checksum:i1E39B15A0AAB175D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801C → R in CAA80296. (PubMed:8293998)Curated
Sequence conflicti80 – 801C → R in AAA37474. (PubMed:6096855)Curated
Sequence conflicti151 – 1511E → M in AAA37474. (PubMed:6096855)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22573 Genomic DNA. Translation: CAA80296.1.
EF426303 mRNA. Translation: ABO14688.1.
AK143110 mRNA. Translation: BAE25271.1.
AC101869 Genomic DNA. No translation available.
AC158958 Genomic DNA. No translation available.
BC056455 mRNA. Translation: AAH56455.1.
K02585 mRNA. Translation: AAA37474.1.
CCDSiCCDS15013.1.
PIRiI48359. CYMSG3.
RefSeqiNP_658906.1. NM_144761.2.
UniGeneiMm.440053.

Genome annotation databases

EnsembliENSMUST00000027090; ENSMUSP00000027090; ENSMUSG00000073658.
GeneIDi12965.
KEGGimmu:12965.
UCSCiuc007bhj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22573 Genomic DNA. Translation: CAA80296.1 .
EF426303 mRNA. Translation: ABO14688.1 .
AK143110 mRNA. Translation: BAE25271.1 .
AC101869 Genomic DNA. No translation available.
AC158958 Genomic DNA. No translation available.
BC056455 mRNA. Translation: AAH56455.1 .
K02585 mRNA. Translation: AAA37474.1 .
CCDSi CCDS15013.1.
PIRi I48359. CYMSG3.
RefSeqi NP_658906.1. NM_144761.2.
UniGenei Mm.440053.

3D structure databases

ProteinModelPortali P04344.
SMRi P04344. Positions 2-175.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P04344.

Proteomic databases

PRIDEi P04344.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027090 ; ENSMUSP00000027090 ; ENSMUSG00000073658 .
GeneIDi 12965.
KEGGi mmu:12965.
UCSCi uc007bhj.1. mouse.

Organism-specific databases

CTDi 1419.
MGIi MGI:88522. Crygb.

Phylogenomic databases

eggNOGi NOG309484.
GeneTreei ENSGT00760000118812.
HOGENOMi HOG000234389.
HOVERGENi HBG003364.
InParanoidi P04344.
OMAi FRGQMSE.
OrthoDBi EOG70CR7Z.

Miscellaneous databases

ChiTaRSi Crygb. mouse.
NextBioi 282706.
PROi P04344.
SOURCEi Search...

Gene expression databases

CleanExi MM_CRYGB.
Genevestigatori P04344.

Family and domain databases

InterProi IPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view ]
Pfami PF00030. Crystall. 2 hits.
[Graphical view ]
PRINTSi PR01367. BGCRYSTALLIN.
SMARTi SM00247. XTALbg. 2 hits.
[Graphical view ]
SUPFAMi SSF49695. SSF49695. 1 hit.
PROSITEi PS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic sequences of murine gamma B- and gamma C-crystallin-encoding genes: promoter analysis and complete evolutionary pattern of mouse, rat and human gamma-crystallins."
    Graw J., Liebstein A., Pietrowski D., Schmitt-John T., Werner T.
    Gene 136:145-156(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 102 X C3H.
    Tissue: Liver.
  2. "Mouse gammaB-crystallin."
    Wistow G.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Lens.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Gamma-crystallin family of the mouse lens: structural and evolutionary relationships."
    Breitman M.L., Lok S., Wistow G., Piatigorsky J., Treton J.A., Gold R.J.M., Tsui L.-C.
    Proc. Natl. Acad. Sci. U.S.A. 81:7762-7766(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-175.

Entry informationi

Entry nameiCRGB_MOUSE
AccessioniPrimary (citable) accession number: P04344
Secondary accession number(s): Q61593, Q6PHP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 108 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are six different gamma crystallins identified in mouse lens.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3