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P04344

- CRGB_MOUSE

UniProt

P04344 - CRGB_MOUSE

Protein

Gamma-crystallin B

Gene

Crygb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Crystallins are the dominant structural components of the vertebrate eye lens.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei69 – 691Susceptible to oxidationBy similarity
    Sitei70 – 701Susceptible to oxidationBy similarity

    GO - Molecular functioni

    1. structural constituent of eye lens Source: MGI

    GO - Biological processi

    1. eye development Source: MGI
    2. lens development in camera-type eye Source: MGI
    3. lens fiber cell development Source: MGI
    4. lens fiber cell morphogenesis Source: MGI

    Keywords - Molecular functioni

    Eye lens protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-crystallin B
    Alternative name(s):
    Gamma-B-crystallin
    Gamma-crystallin 3
    Gene namesi
    Name:Crygb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:88522. Crygb.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 175174Gamma-crystallin BPRO_0000057596Add
    BLAST

    Keywords - PTMi

    Oxidation

    Proteomic databases

    PRIDEiP04344.

    PTM databases

    PhosphoSiteiP04344.

    Expressioni

    Gene expression databases

    CleanExiMM_CRYGB.
    GenevestigatoriP04344.

    Structurei

    3D structure databases

    ProteinModelPortaliP04344.
    SMRiP04344. Positions 2-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 4039Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini41 – 8343Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini89 – 12941Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini130 – 17243Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni84 – 885Connecting peptide

    Domaini

    Has a two-domain beta-structure, folded into four very similar Greek key motifs.

    Sequence similaritiesi

    Belongs to the beta/gamma-crystallin family.Curated
    Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG309484.
    GeneTreeiENSGT00680000099801.
    HOGENOMiHOG000234389.
    HOVERGENiHBG003364.
    InParanoidiP04344.
    OMAiFRGQMSE.
    OrthoDBiEOG70CR7Z.

    Family and domain databases

    InterProiIPR001064. Beta/gamma_crystallin.
    IPR011024. G_crystallin-rel.
    [Graphical view]
    PfamiPF00030. Crystall. 2 hits.
    [Graphical view]
    PRINTSiPR01367. BGCRYSTALLIN.
    SMARTiSM00247. XTALbg. 2 hits.
    [Graphical view]
    SUPFAMiSSF49695. SSF49695. 1 hit.
    PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04344-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKITFFEDR SFQGRCYECS SDCPNLQTYF SRCNSVRVDS GCWMLYERPN    50
    YQGHQYFLRR GEYPDYQQWM GFSDSIRSCC LIPQHSGTYR MRIYEKDDFR 100
    GQMSEITDDC LSLQDRFHFS EIHSLNVMEG CWVLYEMPSY RGRQYLLRPG 150
    EYRRYLDWGA ANAKVGSFRR VMDFY 175
    Length:175
    Mass (Da):21,086
    Last modified:October 3, 2012 - v4
    Checksum:i1E39B15A0AAB175D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti80 – 801C → R in CAA80296. (PubMed:8293998)Curated
    Sequence conflicti80 – 801C → R in AAA37474. (PubMed:6096855)Curated
    Sequence conflicti151 – 1511E → M in AAA37474. (PubMed:6096855)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22573 Genomic DNA. Translation: CAA80296.1.
    EF426303 mRNA. Translation: ABO14688.1.
    AK143110 mRNA. Translation: BAE25271.1.
    AC101869 Genomic DNA. No translation available.
    AC158958 Genomic DNA. No translation available.
    BC056455 mRNA. Translation: AAH56455.1.
    K02585 mRNA. Translation: AAA37474.1.
    CCDSiCCDS15013.1.
    PIRiI48359. CYMSG3.
    RefSeqiNP_658906.1. NM_144761.2.
    UniGeneiMm.440053.

    Genome annotation databases

    EnsembliENSMUST00000027090; ENSMUSP00000027090; ENSMUSG00000073658.
    GeneIDi12965.
    KEGGimmu:12965.
    UCSCiuc007bhj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22573 Genomic DNA. Translation: CAA80296.1 .
    EF426303 mRNA. Translation: ABO14688.1 .
    AK143110 mRNA. Translation: BAE25271.1 .
    AC101869 Genomic DNA. No translation available.
    AC158958 Genomic DNA. No translation available.
    BC056455 mRNA. Translation: AAH56455.1 .
    K02585 mRNA. Translation: AAA37474.1 .
    CCDSi CCDS15013.1.
    PIRi I48359. CYMSG3.
    RefSeqi NP_658906.1. NM_144761.2.
    UniGenei Mm.440053.

    3D structure databases

    ProteinModelPortali P04344.
    SMRi P04344. Positions 2-175.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P04344.

    Proteomic databases

    PRIDEi P04344.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027090 ; ENSMUSP00000027090 ; ENSMUSG00000073658 .
    GeneIDi 12965.
    KEGGi mmu:12965.
    UCSCi uc007bhj.1. mouse.

    Organism-specific databases

    CTDi 1419.
    MGIi MGI:88522. Crygb.

    Phylogenomic databases

    eggNOGi NOG309484.
    GeneTreei ENSGT00680000099801.
    HOGENOMi HOG000234389.
    HOVERGENi HBG003364.
    InParanoidi P04344.
    OMAi FRGQMSE.
    OrthoDBi EOG70CR7Z.

    Miscellaneous databases

    ChiTaRSi CRYGB. mouse.
    NextBioi 282706.
    PROi P04344.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_CRYGB.
    Genevestigatori P04344.

    Family and domain databases

    InterProi IPR001064. Beta/gamma_crystallin.
    IPR011024. G_crystallin-rel.
    [Graphical view ]
    Pfami PF00030. Crystall. 2 hits.
    [Graphical view ]
    PRINTSi PR01367. BGCRYSTALLIN.
    SMARTi SM00247. XTALbg. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49695. SSF49695. 1 hit.
    PROSITEi PS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequences of murine gamma B- and gamma C-crystallin-encoding genes: promoter analysis and complete evolutionary pattern of mouse, rat and human gamma-crystallins."
      Graw J., Liebstein A., Pietrowski D., Schmitt-John T., Werner T.
      Gene 136:145-156(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 102 X C3H.
      Tissue: Liver.
    2. "Mouse gammaB-crystallin."
      Wistow G.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Lens.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Eye.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    6. "Gamma-crystallin family of the mouse lens: structural and evolutionary relationships."
      Breitman M.L., Lok S., Wistow G., Piatigorsky J., Treton J.A., Gold R.J.M., Tsui L.-C.
      Proc. Natl. Acad. Sci. U.S.A. 81:7762-7766(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-175.

    Entry informationi

    Entry nameiCRGB_MOUSE
    AccessioniPrimary (citable) accession number: P04344
    Secondary accession number(s): Q61593, Q6PHP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 106 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are six different gamma crystallins identified in mouse lens.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3