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Protein

Gamma-crystallin D

Gene

Crygd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

Miscellaneous

There are six different gamma crystallins identified in mouse lens.

GO - Molecular functioni

  • structural constituent of eye lens Source: MGI

GO - Biological processi

  • cellular response to reactive oxygen species Source: MGI
  • eye development Source: MGI
  • lens development in camera-type eye Source: MGI
  • lens fiber cell differentiation Source: MGI
  • response to peptide hormone Source: Ensembl
  • visual perception Source: MGI

Keywordsi

Molecular functionEye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin D
Alternative name(s):
Gamma-D-crystallin
Gamma-crystallin 1
Gene namesi
Name:Crygd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88524. Crygd.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000575981 – 174Gamma-crystallin DAdd BLAST174

Proteomic databases

PaxDbiP04342.
PRIDEiP04342.

PTM databases

PhosphoSitePlusiP04342.

Expressioni

Gene expression databases

BgeeiENSMUSG00000067299.
CleanExiMM_CRYGD.
ExpressionAtlasiP04342. differential.
GenevisibleiP04342. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045327.

Structurei

3D structure databases

ProteinModelPortaliP04342.
SMRiP04342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini88 – 128Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini129 – 171Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 87Connecting peptide4

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP04342.
OMAiQMIEITE.
OrthoDBiEOG091G0L2P.

Family and domain databases

InterProiView protein in InterPro
IPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-like.
PfamiView protein in Pfam
PF00030. Crystall. 2 hits.
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiView protein in SMART
SM00247. XTALbg. 2 hits.
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiView protein in PROSITE
PS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.

Sequencei

Sequence statusi: Complete.

P04342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITFYEDR GFQGRHYECS TDHSNLQPYF SRCNSVRVDS GCWMLYEQPN
60 70 80 90 100
FTGCQYFLRR GDYPDYQQWM GFSDSVRSCR LIPHAGSHRI RLYEREEYRG
110 120 130 140 150
QMIEFTEDCP SLQDRFHFNE IYSLNVLEGC WVLYDMTNYR GRQYLLRPGE
160 170
YRRYHDWGAM NARVGSLRRV MDFY
Length:174
Mass (Da):21,118
Last modified:October 3, 2012 - v3
Checksum:i1AFC29C0269B35A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32R → H in AAA37475 (PubMed:6096855).Curated1
Sequence conflicti52T → A in AAA37475 (PubMed:6096855).Curated1
Sequence conflicti52T → A in CAA11908 (PubMed:9782080).Curated1
Sequence conflicti102M → V in AAA37475 (PubMed:6096855).Curated1
Sequence conflicti102M → V in CAA11908 (PubMed:9782080).Curated1
Sequence conflicti163R → K in AAA37475 (PubMed:6096855).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02583 mRNA. Translation: AAA37475.1.
AK136286 mRNA. Translation: BAE22915.1.
AC158958 Genomic DNA. No translation available.
BC057013 mRNA. Translation: AAH57013.1.
BC132116 mRNA. Translation: AAI32117.1.
BC132118 mRNA. Translation: AAI32119.1.
AJ224342 Genomic DNA. Translation: CAA11908.1.
CCDSiCCDS35599.1.
PIRiA02932. CYMSG1.
RefSeqiNP_031802.2. NM_007776.2.
UniGeneiMm.425031.

Genome annotation databases

EnsembliENSMUST00000045028; ENSMUSP00000045327; ENSMUSG00000067299.
GeneIDi12967.
KEGGimmu:12967.
UCSCiuc007bhg.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCRGD_MOUSE
AccessioniPrimary (citable) accession number: P04342
Secondary accession number(s): O89027, Q6PGI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: October 3, 2012
Last modified: November 22, 2017
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families