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Protein

Esterase FrsA

Gene

frsA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Displays esterase activity toward pNP-butyrate.1 Publication

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: UniProtKB-KW
  • hydrolase activity Source: EcoCyc

GO - Biological processi

  • regulation of carbohydrate catabolic process Source: EcoCyc

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

BioCyciEcoCyc:EG11091-MONOMER
BRENDAi3.1.1.1 2026

Protein family/group databases

ESTHERiecoli-yafa Duf_1100-R

Names & Taxonomyi

Protein namesi
Recommended name:
Esterase FrsA (EC:3.1.-.-)
Gene namesi
Name:frsA
Synonyms:yafA
Ordered Locus Names:b0239, JW0229
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11091 frsA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971511 – 414Esterase FrsAAdd BLAST414

Proteomic databases

PaxDbiP04335
PRIDEiP04335

Interactioni

Protein-protein interaction databases

BioGridi4261742, 12 interactors
DIPiDIP-11208N
IntActiP04335, 7 interactors
STRINGi316385.ECDH10B_0221

Structurei

3D structure databases

ProteinModelPortaliP04335
SMRiP04335
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0255 family.Curated

Phylogenomic databases

eggNOGiENOG4105V1F Bacteria
COG1073 LUCA
HOGENOMiHOG000282295
InParanoidiP04335
KOiK11750
OMAiNWIYEWV

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
HAMAPiMF_01063 UPF0255, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR010520 UPF0255
PfamiView protein in Pfam
PF06500 DUF1100, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

P04335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQANLSETL FKPRFKHPET STLVRRFNHG AQPPVQSALD GKTIPHWYRM
60 70 80 90 100
INRLMWIWRG IDPREILDVQ ARIVMSDAER TDDDLYDTVI GYRGGNWIYE
110 120 130 140 150
WATQAMVWQQ KACAEDDPQL SGRHWLHAAT LYNIAAYPHL KGDDLAEQAQ
160 170 180 190 200
ALSNRAYEEA AQRLPGTMRQ MEFTVPGGAP ITGFLHMPKG DGPFPTVLMC
210 220 230 240 250
GGLDAMQTDY YSLYERYFAP RGIAMLTIDM PSVGFSSKWK LTQDSSLLHQ
260 270 280 290 300
HVLKALPNVP WVDHTRVAAF GFRFGANVAV RLAYLESPRL KAVACLGPVV
310 320 330 340 350
HTLLSDFKCQ QQVPEMYLDV LASRLGMHDA SDEALRVELN RYSLKVQGLL
360 370 380 390 400
GRRCPTPMLS GYWKNDPFSP EEDSRLITSS SADGKLLEIP FNPVYRNFDK
410
GLQEITDWIE KRLC
Length:414
Mass (Da):47,009
Last modified:December 13, 2001 - v2
Checksum:i2C154E46CFC9565E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242T → S (PubMed:6397401).Curated1
Sequence conflicti242T → S (Ref. 2) Curated1
Sequence conflicti277 – 278NV → TL (PubMed:6397401).Curated2
Sequence conflicti277 – 278NV → TL (Ref. 2) Curated2
Sequence conflicti397 – 414NFDKG…EKRLC → KILTKVFRKSPTGSKNACVK NLLNFANLVKQLHHNRR (PubMed:6397401).CuratedAdd BLAST18
Sequence conflicti397 – 414NFDKG…EKRLC → KILTKVFRKSPTGSKNACVK NLLNFANLVKQLHHNRR (Ref. 2) CuratedAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13422 Genomic DNA Translation: AAA23929.1
U00096 Genomic DNA Translation: AAC73343.1
AP009048 Genomic DNA Translation: BAA77908.2
U70214 Genomic DNA Translation: AAB08659.1
PIRiH64748 QQEC49
RefSeqiNP_414774.1, NC_000913.3
WP_000189532.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73343; AAC73343; b0239
BAA77908; BAA77908; BAA77908
GeneIDi946039
KEGGiecj:JW0229
eco:b0239
PATRICifig|1411691.4.peg.2044

Similar proteinsi

Entry informationi

Entry nameiFRSA_ECOLI
AccessioniPrimary (citable) accession number: P04335
Secondary accession number(s): P77413
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: December 13, 2001
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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