ID   TERL_HHV11              Reviewed;         735 AA.
AC   P04295;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 2.
DT   03-NOV-2009, entry version 44.
DE   RecName: Full=Large terminase protein;
DE   AltName: Full=Terminase large subunit;
DE   AltName: Full=DNA-packaging protein UL15;
GN   Name=UL15;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus
OS   1).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=88274327; PubMed=2839594;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C.,
RA   McNab D., Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-343.
RX   MEDLINE=86205244; PubMed=3010237; DOI=10.1093/nar/14.8.3435;
RA   McGeoch D.J., Dolan A., Frame M.C.;
RT   "DNA sequence of the region in the genome of herpes simplex virus type
RT   1 containing the exonuclease gene and neighbouring genes.";
RL   Nucleic Acids Res. 14:3435-3448(1986).
RN   [3]
RP   INTERACTION WITH UL6.
RX   PubMed=12743292; DOI=10.1128/JVI.77.11.6351-6358.2003;
RA   White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.;
RT   "Herpes simplex virus type 1 portal protein UL6 interacts with the
RT   putative terminase subunits UL15 and UL28.";
RL   J. Virol. 77:6351-6358(2003).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=16920825; DOI=10.1128/JVI.01364-06;
RA   Wills E., Scholtes L., Baines J.D.;
RT   "Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15,
RT   UL17, UL28, and UL33 are located on the external surface of the viral
RT   capsid.";
RL   J. Virol. 80:10894-10899(2006).
RN   [5]
RP   INTERACTION WITH UL28 AND UL6.
RX   PubMed=17392365; DOI=10.1128/JVI.00047-07;
RA   Yang K., Homa F., Baines J.D.;
RT   "Putative terminase subunits of herpes simplex virus 1 form a complex
RT   in the cytoplasm and interact with portal protein in the nucleus.";
RL   J. Virol. 81:6419-6433(2007).
RN   [6]
RP   REVIEW.
RX   PubMed=18687036; DOI=10.1146/annurev.genet.42.110807.091545;
RA   Rao V.B., Feiss M.;
RT   "The bacteriophage DNA packaging motor.";
RL   Annu. Rev. Genet. 42:647-681(2008).
RN   [7]
RP   INTERACTION WITH UL6.
RX   PubMed=19224991; DOI=10.1128/JVI.00026-09;
RA   Yang K., Wills E., Baines J.D.;
RT   "The putative leucine zipper of the UL6-encoded portal protein of
RT   herpes simplex virus 1 is necessary for interaction with pUL15 and
RT   pUL28 and their association with capsids.";
RL   J. Virol. 83:4557-4564(2009).
CC   -!- FUNCTION: Component of the molecular motor that translocates
CC       genomic DNA in empty capsid during DNA packaging. Heterodimerizes
CC       with small terminase protein to be docked on capsid portal
CC       protein. The latter forms a ring in which genomic DNA in
CC       translocated into the capsid. May have or induce an endonuclease
CC       activity to cleave the genome concatemer after encapsidation.
CC   -!- SUBUNIT: Interacts with UL28 and UL6.
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the herpesviridae large terminase family.
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DR   EMBL; X14112; CAA32330.1; -; Genomic_DNA.
DR   EMBL; X03839; CAA27456.1; ALT_TERM; Genomic_DNA.
DR   PIR; A03781; WMBE31.
DR   PIR; F30083; WMBET5.
DR   RefSeq; NP_044616.1; -.
DR   GeneID; 2703385; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0006323; P:DNA packaging; IEA:UniProtKB-KW.
DR   InterPro; IPR003498; DNA_pack_C.
DR   InterPro; IPR003499; DNA_pack_N.
DR   Pfam; PF02499; DNA_pack_C; 1.
DR   Pfam; PF02500; DNA_pack_N; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; DNA packaging; Host nucleus.
FT   CHAIN         1    735       Large terminase protein.
FT                                /FTId=PRO_0000115940.
FT   MOTIF       258    265       Walker A motif.
FT   MOTIF       352    357       Walker B motif.
FT   ACT_SITE    357    357       For ATPase activity (Potential).
SQ   SEQUENCE   735 AA;  80923 MW;  A7B8D69C3E6CD965 CRC64;
     MFGQQLASDV QQYLERLEKQ RQLKVGADEA SAGLTMGGDA LRVPFLDFAT ATPKRHQTVV
     PGVGTLHDCC EHSPLFSAVA RRLLFNSLVP AQLKGRDFGG DHTAKLEFLA PELVRAVARL
     RFKECAPADV VPQRNAYYSV LNTFQALHRS EAFRQLVHFV RDFAQLLKTS FRASSLTETT
     GPPKKRAKVD VATHGRTYGT LELFQKMILM HATYFLAAVL LGDHAEQVNT FLRLVFEIPL
     FSDAAVRHFR QRATVFLVPR RHGKTWFLVP LIALSLASFR GIKIGYTAHI RKATEPVFEE
     IDACLRGWFG SARVDHVKGE TISFSFPDGS RSTIVFASSH NTNGIRGQDF NLLFVDEANF
     IRPDAVQTIM GFLNQANCKI IFVSSTNTGK ASTSFLYNLR GAADELLNVV TYICDDHMPR
     VVTHTNATAC SCYILNKPVF ITMDGAVRRT ADLFLADSFM QEIIGGQARE TGDDRPVLTK
     SAGERFLLYR PSTTTNSGLM APDLYVYVDP AFTANTRASG TGVAVVGRYR DDYIIFALEH
     FFLRALTGSA PADIARCVVH SLTQVLALHP GAFRGVRVAV EGNSSQDSAV AIATHVHTEM
     HRLLASEGAD AGSGPELLFY HCEPPGSAVL YPFFLLNKQK TPAFEHFIKK FNSGGVMASQ
     EIVSATVRLQ TDPVEYLLEQ LNNLTETVSP NTDVRTYSGK RNGASDDLMV AVIMAIYLAA
     QAGPPHTFAP ITRVS
//