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P04295

- TRM3_HHV11

UniProt

P04295 - TRM3_HHV11

Protein

Tripartite terminase subunit UL15

Gene

UL15

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei357 – 3571For ATPase activitySequence Analysis

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. DNA packaging Source: InterPro
    2. viral release from host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Viral genome packaging, Virus exit from host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite terminase subunit UL15
    Alternative name(s):
    DNA-packaging protein UL15
    Terminase large subunit
    Gene namesi
    Name:UL15
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Host nucleus 1 Publication

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 735735Tripartite terminase subunit UL15PRO_0000115940Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with UL28 and UL6.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UL28P102128EBI-7032965,EBI-7032948
    UL33P102176EBI-7032965,EBI-7033000

    Protein-protein interaction databases

    IntActiP04295. 3 interactions.
    MINTiMINT-6732654.

    Structurei

    Secondary structure

    1
    735
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi480 – 4889
    Helixi497 – 4993
    Beta strandi502 – 5098
    Beta strandi514 – 5163
    Beta strandi520 – 52910
    Beta strandi532 – 54211
    Helixi550 – 56819
    Beta strandi574 – 5818
    Helixi586 – 60015
    Beta strandi616 – 6194
    Helixi640 – 65213
    Beta strandi656 – 6638
    Beta strandi665 – 6717
    Helixi673 – 6819
    Helixi707 – 71913

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IOXX-ray2.46A/B/C471-735[»]
    ProteinModelPortaliP04295.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi258 – 2658Walker A motif
    Motifi352 – 3576Walker B motif

    Sequence similaritiesi

    Belongs to the herpesviridae UL15 protein family.Curated

    Family and domain databases

    InterProiIPR003498. DNA_pack_C.
    IPR003499. DNA_pack_N.
    [Graphical view]
    PfamiPF02499. DNA_pack_C. 1 hit.
    PF02500. DNA_pack_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P04295-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFGQQLASDV QQYLERLEKQ RQLKVGADEA SAGLTMGGDA LRVPFLDFAT    50
    ATPKRHQTVV PGVGTLHDCC EHSPLFSAVA RRLLFNSLVP AQLKGRDFGG 100
    DHTAKLEFLA PELVRAVARL RFKECAPADV VPQRNAYYSV LNTFQALHRS 150
    EAFRQLVHFV RDFAQLLKTS FRASSLTETT GPPKKRAKVD VATHGRTYGT 200
    LELFQKMILM HATYFLAAVL LGDHAEQVNT FLRLVFEIPL FSDAAVRHFR 250
    QRATVFLVPR RHGKTWFLVP LIALSLASFR GIKIGYTAHI RKATEPVFEE 300
    IDACLRGWFG SARVDHVKGE TISFSFPDGS RSTIVFASSH NTNGIRGQDF 350
    NLLFVDEANF IRPDAVQTIM GFLNQANCKI IFVSSTNTGK ASTSFLYNLR 400
    GAADELLNVV TYICDDHMPR VVTHTNATAC SCYILNKPVF ITMDGAVRRT 450
    ADLFLADSFM QEIIGGQARE TGDDRPVLTK SAGERFLLYR PSTTTNSGLM 500
    APDLYVYVDP AFTANTRASG TGVAVVGRYR DDYIIFALEH FFLRALTGSA 550
    PADIARCVVH SLTQVLALHP GAFRGVRVAV EGNSSQDSAV AIATHVHTEM 600
    HRLLASEGAD AGSGPELLFY HCEPPGSAVL YPFFLLNKQK TPAFEHFIKK 650
    FNSGGVMASQ EIVSATVRLQ TDPVEYLLEQ LNNLTETVSP NTDVRTYSGK 700
    RNGASDDLMV AVIMAIYLAA QAGPPHTFAP ITRVS 735
    Length:735
    Mass (Da):80,923
    Last modified:July 1, 1989 - v2
    Checksum:iA7B8D69C3E6CD965
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32330.1.
    X03839 Genomic DNA. Translation: CAA27456.1. Different termination.
    PIRiA03781. WMBE31.
    F30083. WMBET5.
    RefSeqiNP_044616.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703385.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32330.1 .
    X03839 Genomic DNA. Translation: CAA27456.1 . Different termination.
    PIRi A03781. WMBE31.
    F30083. WMBET5.
    RefSeqi NP_044616.1. NC_001806.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IOX X-ray 2.46 A/B/C 471-735 [» ]
    ProteinModelPortali P04295.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P04295. 3 interactions.
    MINTi MINT-6732654.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703385.

    Family and domain databases

    InterProi IPR003498. DNA_pack_C.
    IPR003499. DNA_pack_N.
    [Graphical view ]
    Pfami PF02499. DNA_pack_C. 1 hit.
    PF02500. DNA_pack_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."
      McGeoch D.J., Dolan A., Frame M.C.
      Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-343.
    3. "Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28."
      White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.
      J. Virol. 77:6351-6358(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL6.
    4. "Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid."
      Wills E., Scholtes L., Baines J.D.
      J. Virol. 80:10894-10899(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    5. "Putative terminase subunits of herpes simplex virus 1 form a complex in the cytoplasm and interact with portal protein in the nucleus."
      Yang K., Homa F., Baines J.D.
      J. Virol. 81:6419-6433(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL28 AND UL6.
    6. "The bacteriophage DNA packaging motor."
      Rao V.B., Feiss M.
      Annu. Rev. Genet. 42:647-681(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. "The putative leucine zipper of the UL6-encoded portal protein of herpes simplex virus 1 is necessary for interaction with pUL15 and pUL28 and their association with capsids."
      Yang K., Wills E., Baines J.D.
      J. Virol. 83:4557-4564(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UL6.

    Entry informationi

    Entry nameiTRM3_HHV11
    AccessioniPrimary (citable) accession number: P04295
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3