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P04295

- TRM3_HHV11

UniProt

P04295 - TRM3_HHV11

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Protein
Tripartite terminase subunit UL15
Gene
UL15
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei357 – 3571For ATPase activity Reviewed prediction

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. DNA packaging Source: InterPro
  2. viral release from host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Viral genome packaging, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite terminase subunit UL15
Alternative name(s):
DNA-packaging protein UL15
Terminase large subunit
Gene namesi
Name:UL15
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Host nucleus 1 Publication

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Tripartite terminase subunit UL15
PRO_0000115940Add
BLAST

Interactioni

Subunit structurei

Interacts with UL28 and UL6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL28P102128EBI-7032965,EBI-7032948
UL33P102176EBI-7032965,EBI-7033000

Protein-protein interaction databases

IntActiP04295. 3 interactions.
MINTiMINT-6732654.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi480 – 4889
Helixi497 – 4993
Beta strandi502 – 5098
Beta strandi514 – 5163
Beta strandi520 – 52910
Beta strandi532 – 54211
Helixi550 – 56819
Beta strandi574 – 5818
Helixi586 – 60015
Beta strandi616 – 6194
Helixi640 – 65213
Beta strandi656 – 6638
Beta strandi665 – 6717
Helixi673 – 6819
Helixi707 – 71913

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IOXX-ray2.46A/B/C471-735[»]
ProteinModelPortaliP04295.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi258 – 2658Walker A motif
Motifi352 – 3576Walker B motif

Sequence similaritiesi

Family and domain databases

InterProiIPR003498. DNA_pack_C.
IPR003499. DNA_pack_N.
[Graphical view]
PfamiPF02499. DNA_pack_C. 1 hit.
PF02500. DNA_pack_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P04295-1 [UniParc]FASTAAdd to Basket

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MFGQQLASDV QQYLERLEKQ RQLKVGADEA SAGLTMGGDA LRVPFLDFAT    50
ATPKRHQTVV PGVGTLHDCC EHSPLFSAVA RRLLFNSLVP AQLKGRDFGG 100
DHTAKLEFLA PELVRAVARL RFKECAPADV VPQRNAYYSV LNTFQALHRS 150
EAFRQLVHFV RDFAQLLKTS FRASSLTETT GPPKKRAKVD VATHGRTYGT 200
LELFQKMILM HATYFLAAVL LGDHAEQVNT FLRLVFEIPL FSDAAVRHFR 250
QRATVFLVPR RHGKTWFLVP LIALSLASFR GIKIGYTAHI RKATEPVFEE 300
IDACLRGWFG SARVDHVKGE TISFSFPDGS RSTIVFASSH NTNGIRGQDF 350
NLLFVDEANF IRPDAVQTIM GFLNQANCKI IFVSSTNTGK ASTSFLYNLR 400
GAADELLNVV TYICDDHMPR VVTHTNATAC SCYILNKPVF ITMDGAVRRT 450
ADLFLADSFM QEIIGGQARE TGDDRPVLTK SAGERFLLYR PSTTTNSGLM 500
APDLYVYVDP AFTANTRASG TGVAVVGRYR DDYIIFALEH FFLRALTGSA 550
PADIARCVVH SLTQVLALHP GAFRGVRVAV EGNSSQDSAV AIATHVHTEM 600
HRLLASEGAD AGSGPELLFY HCEPPGSAVL YPFFLLNKQK TPAFEHFIKK 650
FNSGGVMASQ EIVSATVRLQ TDPVEYLLEQ LNNLTETVSP NTDVRTYSGK 700
RNGASDDLMV AVIMAIYLAA QAGPPHTFAP ITRVS 735
Length:735
Mass (Da):80,923
Last modified:July 1, 1989 - v2
Checksum:iA7B8D69C3E6CD965
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32330.1.
X03839 Genomic DNA. Translation: CAA27456.1. Different termination.
PIRiA03781. WMBE31.
F30083. WMBET5.
RefSeqiNP_044616.1. NC_001806.1.

Genome annotation databases

GeneIDi2703385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32330.1 .
X03839 Genomic DNA. Translation: CAA27456.1 . Different termination.
PIRi A03781. WMBE31.
F30083. WMBET5.
RefSeqi NP_044616.1. NC_001806.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IOX X-ray 2.46 A/B/C 471-735 [» ]
ProteinModelPortali P04295.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P04295. 3 interactions.
MINTi MINT-6732654.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703385.

Family and domain databases

InterProi IPR003498. DNA_pack_C.
IPR003499. DNA_pack_N.
[Graphical view ]
Pfami PF02499. DNA_pack_C. 1 hit.
PF02500. DNA_pack_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."
    McGeoch D.J., Dolan A., Frame M.C.
    Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-343.
  3. "Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28."
    White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.
    J. Virol. 77:6351-6358(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL6.
  4. "Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid."
    Wills E., Scholtes L., Baines J.D.
    J. Virol. 80:10894-10899(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. "Putative terminase subunits of herpes simplex virus 1 form a complex in the cytoplasm and interact with portal protein in the nucleus."
    Yang K., Homa F., Baines J.D.
    J. Virol. 81:6419-6433(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL28 AND UL6.
  6. "The bacteriophage DNA packaging motor."
    Rao V.B., Feiss M.
    Annu. Rev. Genet. 42:647-681(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "The putative leucine zipper of the UL6-encoded portal protein of herpes simplex virus 1 is necessary for interaction with pUL15 and pUL28 and their association with capsids."
    Yang K., Wills E., Baines J.D.
    J. Virol. 83:4557-4564(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UL6.

Entry informationi

Entry nameiTRM3_HHV11
AccessioniPrimary (citable) accession number: P04295
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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