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P04295 (TRM3_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite terminase subunit UL15
Alternative name(s):
DNA-packaging protein UL15
Terminase large subunit
Gene names
Name:UL15
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length735 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation.

Subunit structure

Interacts with UL28 and UL6. Ref.3 Ref.5 Ref.7

Subcellular location

Host nucleus Ref.4.

Sequence similarities

Belongs to the herpesviridae UL15 protein family.

Ontologies

Keywords
   Biological processViral genome packaging
Virus exit from host cell
   Cellular componentHost nucleus
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA packaging

Inferred from electronic annotation. Source: InterPro

viral release from host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 735735Tripartite terminase subunit UL15
PRO_0000115940

Regions

Motif258 – 2658Walker A motif
Motif352 – 3576Walker B motif

Sites

Active site3571For ATPase activity Potential

Secondary structure

............................... 735
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P04295 [UniParc].

Last modified July 1, 1989. Version 2.
Checksum: A7B8D69C3E6CD965

FASTA73580,923
        10         20         30         40         50         60 
MFGQQLASDV QQYLERLEKQ RQLKVGADEA SAGLTMGGDA LRVPFLDFAT ATPKRHQTVV 

        70         80         90        100        110        120 
PGVGTLHDCC EHSPLFSAVA RRLLFNSLVP AQLKGRDFGG DHTAKLEFLA PELVRAVARL 

       130        140        150        160        170        180 
RFKECAPADV VPQRNAYYSV LNTFQALHRS EAFRQLVHFV RDFAQLLKTS FRASSLTETT 

       190        200        210        220        230        240 
GPPKKRAKVD VATHGRTYGT LELFQKMILM HATYFLAAVL LGDHAEQVNT FLRLVFEIPL 

       250        260        270        280        290        300 
FSDAAVRHFR QRATVFLVPR RHGKTWFLVP LIALSLASFR GIKIGYTAHI RKATEPVFEE 

       310        320        330        340        350        360 
IDACLRGWFG SARVDHVKGE TISFSFPDGS RSTIVFASSH NTNGIRGQDF NLLFVDEANF 

       370        380        390        400        410        420 
IRPDAVQTIM GFLNQANCKI IFVSSTNTGK ASTSFLYNLR GAADELLNVV TYICDDHMPR 

       430        440        450        460        470        480 
VVTHTNATAC SCYILNKPVF ITMDGAVRRT ADLFLADSFM QEIIGGQARE TGDDRPVLTK 

       490        500        510        520        530        540 
SAGERFLLYR PSTTTNSGLM APDLYVYVDP AFTANTRASG TGVAVVGRYR DDYIIFALEH 

       550        560        570        580        590        600 
FFLRALTGSA PADIARCVVH SLTQVLALHP GAFRGVRVAV EGNSSQDSAV AIATHVHTEM 

       610        620        630        640        650        660 
HRLLASEGAD AGSGPELLFY HCEPPGSAVL YPFFLLNKQK TPAFEHFIKK FNSGGVMASQ 

       670        680        690        700        710        720 
EIVSATVRLQ TDPVEYLLEQ LNNLTETVSP NTDVRTYSGK RNGASDDLMV AVIMAIYLAA 

       730 
QAGPPHTFAP ITRVS 

« Hide

References

[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."
McGeoch D.J., Dolan A., Frame M.C.
Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-343.
[3]"Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28."
White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.
J. Virol. 77:6351-6358(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL6.
[4]"Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid."
Wills E., Scholtes L., Baines J.D.
J. Virol. 80:10894-10899(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[5]"Putative terminase subunits of herpes simplex virus 1 form a complex in the cytoplasm and interact with portal protein in the nucleus."
Yang K., Homa F., Baines J.D.
J. Virol. 81:6419-6433(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL28 AND UL6.
[6]"The bacteriophage DNA packaging motor."
Rao V.B., Feiss M.
Annu. Rev. Genet. 42:647-681(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"The putative leucine zipper of the UL6-encoded portal protein of herpes simplex virus 1 is necessary for interaction with pUL15 and pUL28 and their association with capsids."
Yang K., Wills E., Baines J.D.
J. Virol. 83:4557-4564(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UL6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32330.1.
X03839 Genomic DNA. Translation: CAA27456.1. Different termination.
PIRWMBE31. A03781.
WMBET5. F30083.
RefSeqNP_044616.1. NC_001806.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4IOXX-ray2.46A/B/C471-735[»]
ProteinModelPortalP04295.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP04295. 3 interactions.
MINTMINT-6732654.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703385.

Phylogenomic databases

ProtClustDBPHA3368.

Family and domain databases

InterProIPR003498. DNA_pack_C.
IPR003499. DNA_pack_N.
[Graphical view]
PfamPF02499. DNA_pack_C. 1 hit.
PF02500. DNA_pack_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRM3_HHV11
AccessionPrimary (citable) accession number: P04295
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: July 1, 1989
Last modified: February 19, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references