ID   UL14_HHV11              Reviewed;         219 AA.
AC   P04291; B9VQE1; O09797; Q09IB9;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   15-AUG-2003, sequence version 2.
DT   03-NOV-2009, entry version 49.
DE   RecName: Full=Protein UL14;
GN   ORFNames=UL14;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus
OS   1).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=88274327; PubMed=2839594;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C.,
RA   McNab D., Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [2]
RP   SEQUENCE REVISION TO N-TERMINUS.
RX   MEDLINE=98139095; PubMed=9499055;
RA   Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT   "The genome sequence of herpes simplex virus type 2.";
RL   J. Virol. 72:2010-2021(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=86205244; PubMed=3010237; DOI=10.1093/nar/14.8.3435;
RA   McGeoch D.J., Dolan A., Frame M.C.;
RT   "DNA sequence of the region in the genome of herpes simplex virus type
RT   1 containing the exonuclease gene and neighbouring genes.";
RL   Nucleic Acids Res. 14:3435-3448(1986).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nonneuroinvasive mutant HF10;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated
RT   herpes simplex virus type 1 mutant HF10, a potential oncolytic
RT   virus.";
RL   Microbes Infect. 9:142-149(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17 syn+;
RA   Cunningham C., Davison A.J.;
RT   "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   PHOSPHORYLATION, AND SUBCELLULAR LOCATION.
RX   PubMed=10590088;
RA   Cunningham C., Davison A.J., MacLean A.R., Taus N.S., Baines J.D.;
RT   "Herpes simplex virus type 1 gene UL14: phenotype of a null mutant and
RT   identification of the encoded protein.";
RL   J. Virol. 74:33-41(2000).
RN   [7]
RP   FUNCTION.
RX   PubMed=18032514; DOI=10.1128/JVI.01226-07;
RA   Yamauchi Y., Kiriyama K., Kubota N., Kimura H., Usukura J.,
RA   Nishiyama Y.;
RT   "The UL14 tegument protein of herpes simplex virus type 1 is required
RT   for efficient nuclear transport of the alpha transinducing factor VP16
RT   and viral capsids.";
RL   J. Virol. 82:1094-1106(2008).
CC   -!- FUNCTION: Plays a significant role in the nuclear localization of
CC       VP16 at the immediate-early phase of infection, thus regulating
CC       immediate-early gene expression.
CC   -!- SUBCELLULAR LOCATION: Virion tegument. Host cytoplasm. Host
CC       nucleus.
CC   -!- PTM: Phosphorylated.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL14 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA27455.1; Type=Erroneous gene model prediction;
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DR   EMBL; X14112; CAA32327.1; -; Genomic_DNA.
DR   EMBL; X03839; CAA27455.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; DQ889502; ABI63476.1; -; Genomic_DNA.
DR   EMBL; FJ593289; ACM62236.1; -; Genomic_DNA.
DR   PIR; A03739; WMBE21.
DR   RefSeq; NP_044615.1; -.
DR   GeneID; 2703384; -.
DR   InterPro; IPR005207; Herpes_UL14.
DR   Pfam; PF03580; Herpes_UL14; 1.
DR   ProDom; PD008302; Herpes_UL14; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Host cytoplasm; Host nucleus; Phosphoprotein;
KW   Virion; Virion tegument; Virus reference strain.
FT   CHAIN         1    219       Protein UL14.
FT                                /FTId=PRO_0000115935.
FT   VARIANT     109    109       V -> M (in strain: Nonneuroinvasive
FT                                mutant HF10).
FT   VARIANT     178    178       T -> M (in strain: Nonneuroinvasive
FT                                mutant HF10).
FT   VARIANT     201    201       P -> A (in strain: Nonneuroinvasive
FT                                mutant HF10).
FT   CONFLICT     17     18       TH -> RP (in Ref. 3).
SQ   SEQUENCE   219 AA;  23934 MW;  58479A4B7255F3BA CRC64;
     MDRDAAHAAL RRRLAETHLR AEIYKDQTLQ LHREGVSTQD PRFVGAFMAA KAAHLELEAR
     LKSRARLEMM RQRATCVKIR VEEQAARRDF LTAHRRYLDP ALGERLDAVD DRLADQEEQL
     EEAATNASLW GDGDLAEGWM SPADSDLLVM WQLTSAPKVH ANGPSRIGSH PTYTPTPTGP
     PGAPAAPLSR TPPSPAPPTG PATDPASASG FARDYPDGE
//