ID TEG3_HHV11 Reviewed; 219 AA. AC P04291; B9VQE1; O09797; Q09IB9; DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot. DT 15-AUG-2003, sequence version 2. DT 24-JAN-2024, entry version 84. DE RecName: Full=Tegument protein UL14; GN ORFNames=UL14; OS Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1). OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus; OC Simplexvirus humanalpha1; Human herpesvirus 1. OX NCBI_TaxID=10299; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531; RA McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., RA Perry L.J., Scott J.E., Taylor P.; RT "The complete DNA sequence of the long unique region in the genome of RT herpes simplex virus type 1."; RL J. Gen. Virol. 69:1531-1574(1988). RN [2] RP SEQUENCE REVISION TO N-TERMINUS. RX PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998; RA Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.; RT "The genome sequence of herpes simplex virus type 2."; RL J. Virol. 72:2010-2021(1998). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=3010237; DOI=10.1093/nar/14.8.3435; RA McGeoch D.J., Dolan A., Frame M.C.; RT "DNA sequence of the region in the genome of herpes simplex virus type 1 RT containing the exonuclease gene and neighbouring genes."; RL Nucleic Acids Res. 14:3435-3448(1986). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nonneuroinvasive mutant HF10; RX PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019; RA Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.; RT "Determination and analysis of the DNA sequence of highly attenuated herpes RT simplex virus type 1 mutant HF10, a potential oncolytic virus."; RL Microbes Infect. 9:142-149(2007). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17 syn+; RA Cunningham C., Davison A.J.; RT "Herpes simplex virus type 1 bacterial artificial chromosome."; RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. RN [6] RP PHOSPHORYLATION, AND SUBCELLULAR LOCATION. RX PubMed=10590088; DOI=10.1128/jvi.74.1.33-41.2000; RA Cunningham C., Davison A.J., MacLean A.R., Taus N.S., Baines J.D.; RT "Herpes simplex virus type 1 gene UL14: phenotype of a null mutant and RT identification of the encoded protein."; RL J. Virol. 74:33-41(2000). RN [7] RP FUNCTION. RX PubMed=18032514; DOI=10.1128/jvi.01226-07; RA Yamauchi Y., Kiriyama K., Kubota N., Kimura H., Usukura J., Nishiyama Y.; RT "The UL14 tegument protein of herpes simplex virus type 1 is required for RT efficient nuclear transport of the alpha transinducing factor VP16 and RT viral capsids."; RL J. Virol. 82:1094-1106(2008). RN [8] RP INTERACTION WITH UL51. RX PubMed=27440890; DOI=10.1128/jvi.01258-16; RA Oda S., Arii J., Koyanagi N., Kato A., Kawaguchi Y.; RT "The interaction between Herpes Simplex Virus 1 tegument proteins UL51 and RT UL14 and its role in virion morphogenesis."; RL J. Virol. 90:8754-8767(2016). CC -!- FUNCTION: Contributes to the nuclear transport of the viral CC transcriptional activator VP16 during the early phase of infection. CC Therefore, participates indirectly in the regulation of the immediate- CC early gene expression. Additionally, seems to be important for CC efficient nuclear targeting of capsids. The UL51-UL14 complex regulates CC final viral envelopment for efficient viral replication CC (PubMed:27440890). {ECO:0000269|PubMed:18032514, CC ECO:0000269|PubMed:27440890}. CC -!- SUBUNIT: Interacts with UL51. {ECO:0000269|PubMed:27440890}. CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000269|PubMed:10590088}. CC Host cytoplasm {ECO:0000269|PubMed:10590088}. Host nucleus CC {ECO:0000269|PubMed:10590088}. CC -!- PTM: Phosphorylated. {ECO:0000269|PubMed:10590088}. CC -!- SIMILARITY: Belongs to the alphaherpesvirinae HHV-1 UL14 protein CC family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA27455.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X14112; CAA32327.1; -; Genomic_DNA. DR EMBL; X03839; CAA27455.1; ALT_SEQ; Genomic_DNA. DR EMBL; DQ889502; ABI63476.1; -; Genomic_DNA. DR EMBL; FJ593289; ACM62236.1; -; Genomic_DNA. DR PIR; A03739; WMBE21. DR RefSeq; YP_009137088.1; NC_001806.2. DR SMR; P04291; -. DR BioGRID; 971422; 1. DR DNASU; 2703384; -. DR GeneID; 2703384; -. DR KEGG; vg:2703384; -. DR Proteomes; UP000009294; Genome. DR Proteomes; UP000180652; Genome. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell. DR InterPro; IPR005207; Herpes_UL14. DR Pfam; PF03580; Herpes_UL14; 1. PE 1: Evidence at protein level; KW Host cytoplasm; Host nucleus; Phosphoprotein; Reference proteome; Virion; KW Virion tegument. FT CHAIN 1..219 FT /note="Tegument protein UL14" FT /id="PRO_0000115935" FT REGION 161..219 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 174..202 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 109 FT /note="V -> M (in strain: Nonneuroinvasive mutant HF10)" FT VARIANT 178 FT /note="T -> M (in strain: Nonneuroinvasive mutant HF10)" FT VARIANT 201 FT /note="P -> A (in strain: Nonneuroinvasive mutant HF10)" FT CONFLICT 17..18 FT /note="TH -> RP (in Ref. 3)" FT /evidence="ECO:0000305" SQ SEQUENCE 219 AA; 23934 MW; 58479A4B7255F3BA CRC64; MDRDAAHAAL RRRLAETHLR AEIYKDQTLQ LHREGVSTQD PRFVGAFMAA KAAHLELEAR LKSRARLEMM RQRATCVKIR VEEQAARRDF LTAHRRYLDP ALGERLDAVD DRLADQEEQL EEAATNASLW GDGDLAEGWM SPADSDLLVM WQLTSAPKVH ANGPSRIGSH PTYTPTPTGP PGAPAAPLSR TPPSPAPPTG PATDPASASG FARDYPDGE //