P04291 (TG14_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tegument protein UL14

Gene names

ORF Names:

UL14

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Contributes to the nuclear transport of the viral transcriptional activator VP16 during the early phase of infection. Therefore, participates indirectly in the regulation of the immediate-early gene expression. Additionally, seems to be important for efficient nuclear targeting of capsids. Ref.7
Subcellular location	Virion tegument. Host cytoplasm. Host nucleus Ref.6.
Post-translational modification	Phosphorylated. Ref.6
Sequence similarities	Belongs to the alphaherpesvirinae HHV-1 UL14 protein family.
Sequence caution	The sequence CAA27455.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Host cytoplasm Host nucleus Virion Virion tegument
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell viral tegument Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Tegument protein UL14		PRO_0000115935
Natural variations
	Natural variant	109	1	V → M in strain: Nonneuroinvasive mutant HF10.
	Natural variant	178	1	T → M in strain: Nonneuroinvasive mutant HF10.
	Natural variant	201	1	P → A in strain: Nonneuroinvasive mutant HF10.
Experimental info
	Sequence conflict	17 – 18	2	TH → RP Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P04291 [UniParc]. Last modified August 15, 2003. Version 2. Checksum: 58479A4B7255F3BA	FASTA	219	23,934
	10 20 30 40 50 60 MDRDAAHAAL RRRLAETHLR AEIYKDQTLQ LHREGVSTQD PRFVGAFMAA KAAHLELEAR 70 80 90 100 110 120 LKSRARLEMM RQRATCVKIR VEEQAARRDF LTAHRRYLDP ALGERLDAVD DRLADQEEQL 130 140 150 160 170 180 EEAATNASLW GDGDLAEGWM SPADSDLLVM WQLTSAPKVH ANGPSRIGSH PTYTPTPTGP 190 200 210 PGAPAAPLSR TPPSPAPPTG PATDPASASG FARDYPDGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The genome sequence of herpes simplex virus type 2." Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J. J. Virol. 72:2010-2021(1998) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO N-TERMINUS.
[3]	"DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes." McGeoch D.J., Dolan A., Frame M.C. Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[5]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[6]	"Herpes simplex virus type 1 gene UL14: phenotype of a null mutant and identification of the encoded protein." Cunningham C., Davison A.J., MacLean A.R., Taus N.S., Baines J.D. J. Virol. 74:33-41(2000) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
[7]	"The UL14 tegument protein of herpes simplex virus type 1 is required for efficient nuclear transport of the alpha transinducing factor VP16 and viral capsids." Yamauchi Y., Kiriyama K., Kubota N., Kimura H., Usukura J., Nishiyama Y. J. Virol. 82:1094-1106(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32327.1. X03839 Genomic DNA. Translation: CAA27455.1. Sequence problems. DQ889502 Genomic DNA. Translation: ABI63476.1. FJ593289 Genomic DNA. Translation: ACM62236.1.
PIR	WMBE21. A03739.
RefSeq	NP_044615.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703384.
Phylogenomic databases
ProtClustDB	PHA3185.
Family and domain databases
InterPro	IPR005207. Herpes_UL14. [Graphical view]
Pfam	PF03580. Herpes_UL14. 1 hit. [Graphical view]
ProDom	PD008302. Herpes_UL14. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

TG14_HHV11

Accession

Primary (citable) accession number: P04291
Secondary accession number(s): B9VQE1, O09797, Q09IB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	August 15, 2003
Last modified:	April 3, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program