Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P04291 (TEG3_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tegument protein UL14
Gene names
ORF Names:UL14
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Contributes to the nuclear transport of the viral transcriptional activator VP16 during the early phase of infection. Therefore, participates indirectly in the regulation of the immediate-early gene expression. Additionally, seems to be important for efficient nuclear targeting of capsids. Ref.7

Subcellular location

Virion tegument. Host cytoplasm. Host nucleus Ref.6.

Post-translational modification

Phosphorylated. Ref.6

Sequence similarities

Belongs to the alphaherpesvirinae HHV-1 UL14 protein family.

Sequence caution

The sequence CAA27455.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentHost cytoplasm
Host nucleus
Virion
Virion tegument
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

viral tegument

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Tegument protein UL14
PRO_0000115935

Natural variations

Natural variant1091V → M in strain: Nonneuroinvasive mutant HF10.
Natural variant1781T → M in strain: Nonneuroinvasive mutant HF10.
Natural variant2011P → A in strain: Nonneuroinvasive mutant HF10.

Experimental info

Sequence conflict17 – 182TH → RP Ref.3

Sequences

Sequence LengthMass (Da)Tools
P04291 [UniParc].

Last modified August 15, 2003. Version 2.
Checksum: 58479A4B7255F3BA

FASTA21923,934
        10         20         30         40         50         60 
MDRDAAHAAL RRRLAETHLR AEIYKDQTLQ LHREGVSTQD PRFVGAFMAA KAAHLELEAR 

        70         80         90        100        110        120 
LKSRARLEMM RQRATCVKIR VEEQAARRDF LTAHRRYLDP ALGERLDAVD DRLADQEEQL 

       130        140        150        160        170        180 
EEAATNASLW GDGDLAEGWM SPADSDLLVM WQLTSAPKVH ANGPSRIGSH PTYTPTPTGP 

       190        200        210 
PGAPAAPLSR TPPSPAPPTG PATDPASASG FARDYPDGE 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The genome sequence of herpes simplex virus type 2."
Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.
J. Virol. 72:2010-2021(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO N-TERMINUS.
[3]"DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."
McGeoch D.J., Dolan A., Frame M.C.
Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[5]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[6]"Herpes simplex virus type 1 gene UL14: phenotype of a null mutant and identification of the encoded protein."
Cunningham C., Davison A.J., MacLean A.R., Taus N.S., Baines J.D.
J. Virol. 74:33-41(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
[7]"The UL14 tegument protein of herpes simplex virus type 1 is required for efficient nuclear transport of the alpha transinducing factor VP16 and viral capsids."
Yamauchi Y., Kiriyama K., Kubota N., Kimura H., Usukura J., Nishiyama Y.
J. Virol. 82:1094-1106(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32327.1.
X03839 Genomic DNA. Translation: CAA27455.1. Sequence problems.
DQ889502 Genomic DNA. Translation: ABI63476.1.
FJ593289 Genomic DNA. Translation: ACM62236.1.
PIRWMBE21. A03739.
RefSeqNP_044615.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703384.

Family and domain databases

InterProIPR005207. Herpes_UL14.
[Graphical view]
PfamPF03580. Herpes_UL14. 1 hit.
[Graphical view]
ProDomPD008302. Herpes_UL14. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameTEG3_HHV11
AccessionPrimary (citable) accession number: P04291
Secondary accession number(s): B9VQE1, O09797, Q09IB9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: August 15, 2003
Last modified: May 14, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families