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P04291

- TEG3_HHV11

UniProt

P04291 - TEG3_HHV11

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Protein

Tegument protein UL14

Gene
UL14
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Contributes to the nuclear transport of the viral transcriptional activator VP16 during the early phase of infection. Therefore, participates indirectly in the regulation of the immediate-early gene expression. Additionally, seems to be important for efficient nuclear targeting of capsids.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL14
Gene namesi
ORF Names:UL14
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion tegument. Host cytoplasm. Host nucleus 1 Publication

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. viral tegument Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Tegument protein UL14PRO_0000115935Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR005207. Herpes_UL14.
[Graphical view]
PfamiPF03580. Herpes_UL14. 1 hit.
[Graphical view]
ProDomiPD008302. Herpes_UL14. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P04291-1 [UniParc]FASTAAdd to Basket

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MDRDAAHAAL RRRLAETHLR AEIYKDQTLQ LHREGVSTQD PRFVGAFMAA    50
KAAHLELEAR LKSRARLEMM RQRATCVKIR VEEQAARRDF LTAHRRYLDP 100
ALGERLDAVD DRLADQEEQL EEAATNASLW GDGDLAEGWM SPADSDLLVM 150
WQLTSAPKVH ANGPSRIGSH PTYTPTPTGP PGAPAAPLSR TPPSPAPPTG 200
PATDPASASG FARDYPDGE 219
Length:219
Mass (Da):23,934
Last modified:August 15, 2003 - v2
Checksum:i58479A4B7255F3BA
GO

Sequence cautioni

The sequence CAA27455.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091V → M in strain: Nonneuroinvasive mutant HF10.
Natural varianti178 – 1781T → M in strain: Nonneuroinvasive mutant HF10.
Natural varianti201 – 2011P → A in strain: Nonneuroinvasive mutant HF10.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 182TH → RP1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32327.1.
X03839 Genomic DNA. Translation: CAA27455.1. Sequence problems.
DQ889502 Genomic DNA. Translation: ABI63476.1.
FJ593289 Genomic DNA. Translation: ACM62236.1.
PIRiA03739. WMBE21.
RefSeqiNP_044615.1. NC_001806.1.

Genome annotation databases

GeneIDi2703384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32327.1 .
X03839 Genomic DNA. Translation: CAA27455.1 . Sequence problems.
DQ889502 Genomic DNA. Translation: ABI63476.1 .
FJ593289 Genomic DNA. Translation: ACM62236.1 .
PIRi A03739. WMBE21.
RefSeqi NP_044615.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703384.

Family and domain databases

InterProi IPR005207. Herpes_UL14.
[Graphical view ]
Pfami PF03580. Herpes_UL14. 1 hit.
[Graphical view ]
ProDomi PD008302. Herpes_UL14. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The genome sequence of herpes simplex virus type 2."
    Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.
    J. Virol. 72:2010-2021(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO N-TERMINUS.
  3. "DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."
    McGeoch D.J., Dolan A., Frame M.C.
    Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  5. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  6. "Herpes simplex virus type 1 gene UL14: phenotype of a null mutant and identification of the encoded protein."
    Cunningham C., Davison A.J., MacLean A.R., Taus N.S., Baines J.D.
    J. Virol. 74:33-41(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
  7. "The UL14 tegument protein of herpes simplex virus type 1 is required for efficient nuclear transport of the alpha transinducing factor VP16 and viral capsids."
    Yamauchi Y., Kiriyama K., Kubota N., Kimura H., Usukura J., Nishiyama Y.
    J. Virol. 82:1094-1106(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTEG3_HHV11
AccessioniPrimary (citable) accession number: P04291
Secondary accession number(s): B9VQE1, O09797, Q09IB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: August 15, 2003
Last modified: May 14, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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