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P04291

- TEG3_HHV11

UniProt

P04291 - TEG3_HHV11

Protein

Tegument protein UL14

Gene

UL14

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (15 Aug 2003)
      Previous versions | rss
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    Functioni

    Contributes to the nuclear transport of the viral transcriptional activator VP16 during the early phase of infection. Therefore, participates indirectly in the regulation of the immediate-early gene expression. Additionally, seems to be important for efficient nuclear targeting of capsids.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tegument protein UL14
    Gene namesi
    ORF Names:UL14
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion tegument 1 Publication. Host cytoplasm 1 Publication. Host nucleus 1 Publication

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. host cell nucleus Source: UniProtKB-SubCell
    3. viral tegument Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Host nucleus, Virion, Virion tegument

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Tegument protein UL14PRO_0000115935Add
    BLAST

    Post-translational modificationi

    Phosphorylated.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR005207. Herpes_UL14.
    [Graphical view]
    PfamiPF03580. Herpes_UL14. 1 hit.
    [Graphical view]
    ProDomiPD008302. Herpes_UL14. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P04291-1 [UniParc]FASTAAdd to Basket

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    MDRDAAHAAL RRRLAETHLR AEIYKDQTLQ LHREGVSTQD PRFVGAFMAA    50
    KAAHLELEAR LKSRARLEMM RQRATCVKIR VEEQAARRDF LTAHRRYLDP 100
    ALGERLDAVD DRLADQEEQL EEAATNASLW GDGDLAEGWM SPADSDLLVM 150
    WQLTSAPKVH ANGPSRIGSH PTYTPTPTGP PGAPAAPLSR TPPSPAPPTG 200
    PATDPASASG FARDYPDGE 219
    Length:219
    Mass (Da):23,934
    Last modified:August 15, 2003 - v2
    Checksum:i58479A4B7255F3BA
    GO

    Sequence cautioni

    The sequence CAA27455.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 182TH → RP(PubMed:3010237)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti109 – 1091V → M in strain: Nonneuroinvasive mutant HF10.
    Natural varianti178 – 1781T → M in strain: Nonneuroinvasive mutant HF10.
    Natural varianti201 – 2011P → A in strain: Nonneuroinvasive mutant HF10.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32327.1.
    X03839 Genomic DNA. Translation: CAA27455.1. Sequence problems.
    DQ889502 Genomic DNA. Translation: ABI63476.1.
    FJ593289 Genomic DNA. Translation: ACM62236.1.
    PIRiA03739. WMBE21.
    RefSeqiNP_044615.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703384.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32327.1 .
    X03839 Genomic DNA. Translation: CAA27455.1 . Sequence problems.
    DQ889502 Genomic DNA. Translation: ABI63476.1 .
    FJ593289 Genomic DNA. Translation: ACM62236.1 .
    PIRi A03739. WMBE21.
    RefSeqi NP_044615.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703384.

    Family and domain databases

    InterProi IPR005207. Herpes_UL14.
    [Graphical view ]
    Pfami PF03580. Herpes_UL14. 1 hit.
    [Graphical view ]
    ProDomi PD008302. Herpes_UL14. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The genome sequence of herpes simplex virus type 2."
      Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.
      J. Virol. 72:2010-2021(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO N-TERMINUS.
    3. "DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."
      McGeoch D.J., Dolan A., Frame M.C.
      Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    5. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    6. "Herpes simplex virus type 1 gene UL14: phenotype of a null mutant and identification of the encoded protein."
      Cunningham C., Davison A.J., MacLean A.R., Taus N.S., Baines J.D.
      J. Virol. 74:33-41(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, SUBCELLULAR LOCATION.
    7. "The UL14 tegument protein of herpes simplex virus type 1 is required for efficient nuclear transport of the alpha transinducing factor VP16 and viral capsids."
      Yamauchi Y., Kiriyama K., Kubota N., Kimura H., Usukura J., Nishiyama Y.
      J. Virol. 82:1094-1106(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTEG3_HHV11
    AccessioniPrimary (citable) accession number: P04291
    Secondary accession number(s): B9VQE1, O09797, Q09IB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: August 15, 2003
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3