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Cytoplasmic envelopment protein 3



Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli


Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.UniRule annotation4 Publications

GO - Biological processi

  • anatomical structure morphogenesis Source: InterPro
  • viral budding from Golgi membrane Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic envelopment protein 3UniRule annotation
Gene namesi
ORF Names:UL11
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

  • Virion tegument UniRule annotation2 Publications
  • Virion membrane UniRule annotation; Lipid-anchor UniRule annotation
  • Host cell membrane UniRule annotation1 Publication; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation1 Publication
  • Host Golgi apparatus membrane UniRule annotation2 Publications; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation1 Publication

  • Note: Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by hostUniRule annotation
ChainiPRO_00001159252 – 96Cytoplasmic envelopment protein 3UniRule annotationAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine; by hostUniRule annotation1 Publication1
Modified residuei40PhosphoserineUniRule annotation1 Publication1

Post-translational modificationi

Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.UniRule annotation2 Publications
Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.UniRule annotation1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

PTM databases



Subunit structurei

Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus (By similarity). Interacts with gE (via C-terminus). Interacts with gD (via C-terminus). Interacts with UL56.UniRule annotationBy similarity2 Publications

Binary interactionsi


Protein-protein interaction databases

IntActiP04289. 1 interactor.

Family & Domainsi


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 43Asp/Glu-rich (acidic)UniRule annotation7


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi18 – 19Di-leucine-like internalization motifUniRule annotation2


The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with the capsid-binding protein UL16.1 Publication

Sequence similaritiesi

Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.UniRule annotation

Phylogenomic databases


Family and domain databases

HAMAPiMF_04040. HSV_CEP3_alphahv. 1 hit.
InterProiView protein in InterPro
IPR024351. Tegument_UL11_Herpesvir.
IPR016395. UL11_simplexvir-type.
PfamiView protein in Pfam
PF11094. UL11. 1 hit.
PIRSFiPIRSF003496. Myristoylat_tegument_UL11. 1 hit.


Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04289-1 [UniParc]FASTAAdd to basket

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60 70 80 90
Mass (Da):10,487
Last modified:January 23, 2007 - v3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti39E → K in strain: 17 syn+. 1
Natural varianti54G → V in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti65R → C in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
Links Updated
X14112 Genomic DNA. Translation: CAA32347.1.
X03839 Genomic DNA. Translation: CAA27452.1.
DQ889502 Genomic DNA. Translation: ABI63473.1.
FJ593289 Genomic DNA. Translation: ACM62233.1.
PIRiA03737. WMBE11.
RefSeqiYP_009137085.1. NC_001806.2.

Genome annotation databases


Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCEP3_HHV11
AccessioniPrimary (citable) accession number: P04289
Secondary accession number(s): B9VQD8, Q09IC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program


Keywords - Technical termi

Complete proteome, Reference proteome


  1. SIMILARITY comments
    Index of protein domains and families