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Protein

Tegument protein UL11

Gene

UL11

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.4 Publications

GO - Biological processi

  • anatomical structure morphogenesis Source: InterPro
  • viral budding from Golgi membrane Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL11
Gene namesi
ORF Names:UL11
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved; by host
Chaini2 – 9695Tegument protein UL11PRO_0000115925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine; by host1 Publication
Modified residuei40 – 401Phosphoserine1 Publication

Post-translational modificationi

Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.2 Publications
Phosphorylated. Phosphorylation does not seem to be needed for UL11 recycling to the Golgi apparatus. Packaging is selective for underphosphorylated forms.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

PTM databases

iPTMnetiP04289.

Interactioni

Subunit structurei

Interacts with UL16; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus. Interacts with gE (via C-terminus). Interacts with gD (via C-terminus). Interacts with UL56.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL16P102003EBI-7044930,EBI-7044955

Protein-protein interaction databases

IntActiP04289. 1 interaction.
MINTiMINT-6732677.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 437Asp/Glu-rich (acidic)

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi18 – 192Di-leucine-like internalization motifSequence analysis

Domaini

The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with the capsid-binding protein UL16.1 Publication

Sequence similaritiesi

Belongs to the herpesviridae HHV-1 UL11 family.Curated

Family and domain databases

InterProiIPR024351. Tegument_UL11_Herpesvir.
IPR016395. UL11_simplexvir-type.
[Graphical view]
PfamiPF11094. UL11. 1 hit.
[Graphical view]
PIRSFiPIRSF003496. Myristoylat_tegument_UL11. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSFSGARP CCCRNNVLIT DDGEVVSLTA HDFDVVDIES EEEGNFYVPP
60 70 80 90
DMRGVTRAPG RQRLRSSDPP SRHTHRRTPG GACPATQFPP PMSDSE
Length:96
Mass (Da):10,487
Last modified:January 23, 2007 - v3
Checksum:i5D09A5B1F2034B09
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391E → K in strain: 17 syn+.
Natural varianti54 – 541G → V in strain: Nonneuroinvasive mutant HF10.
Natural varianti65 – 651R → C in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32347.1.
X03839 Genomic DNA. Translation: CAA27452.1.
DQ889502 Genomic DNA. Translation: ABI63473.1.
FJ593289 Genomic DNA. Translation: ACM62233.1.
PIRiA03737. WMBE11.
RefSeqiYP_009137085.1. NC_001806.2.

Genome annotation databases

GeneIDi24271464.
KEGGivg:24271464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32347.1.
X03839 Genomic DNA. Translation: CAA27452.1.
DQ889502 Genomic DNA. Translation: ABI63473.1.
FJ593289 Genomic DNA. Translation: ACM62233.1.
PIRiA03737. WMBE11.
RefSeqiYP_009137085.1. NC_001806.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04289. 1 interaction.
MINTiMINT-6732677.

PTM databases

iPTMnetiP04289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24271464.
KEGGivg:24271464.

Family and domain databases

InterProiIPR024351. Tegument_UL11_Herpesvir.
IPR016395. UL11_simplexvir-type.
[Graphical view]
PfamiPF11094. UL11. 1 hit.
[Graphical view]
PIRSFiPIRSF003496. Myristoylat_tegument_UL11. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTEG2_HHV11
AccessioniPrimary (citable) accession number: P04289
Secondary accession number(s): B9VQD8, Q09IC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.