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P04289

- TEG2_HHV11

UniProt

P04289 - TEG2_HHV11

Protein

Tegument protein UL11

Gene

UL11

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Tegument protein that may play a role in the nucleocapsid secondary envelopment at the trans-Golgi network during virus morphogenesis.Curated

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. anatomical structure morphogenesis Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tegument protein UL11
    Gene namesi
    ORF Names:UL11
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion tegument. Virion membrane By similarity; Lipid-anchor By similarity. Host cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Host Golgi apparatus membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Host nucleus membrane; Lipid-anchor; Cytoplasmic side
    Note: Virion membrane-associated tegument protein (about 700 copies per virion). Associates with host membrane lipids rafts By similarity. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN) By similarity.By similarity

    GO - Cellular componenti

    1. host cell Golgi membrane Source: UniProtKB-SubCell
    2. host cell nuclear membrane Source: UniProtKB-SubCell
    3. host cell plasma membrane Source: UniProtKB-SubCell
    4. viral tegument Source: UniProtKB-SubCell
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Virion, Virion tegument

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed; by host
    Chaini2 – 9695Tegument protein UL11PRO_0000115925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycine; by host1 Publication
    Modified residuei40 – 401PhosphoserineBy similarity

    Post-translational modificationi

    Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.By similarity
    Phosphorylated. Phosphorylation does not seem to be needed for UL11 recycling to the Golgi apparatus. Packaging is selective for underphosphorylated forms By similarity.By similarity

    Keywords - PTMi

    Lipoprotein, Myristate, Palmitate, Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with UL16. Interacts with gE (via C-terminus). Interacts with gD (via C-terminus). Interacts with UL56 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UL16P102003EBI-7044930,EBI-7044955

    Protein-protein interaction databases

    IntActiP04289. 1 interaction.
    MINTiMINT-6732677.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni37 – 437Asp/Glu-rich (acidic)

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi18 – 192Di-leucine-like internalization motifSequence Analysis

    Domaini

    The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with the capsid-binding protein UL16 By similarity.By similarity

    Sequence similaritiesi

    Belongs to the herpesviridae HHV-1 UL11 family.Curated

    Family and domain databases

    InterProiIPR024351. Tegument_UL11_Herpesvir.
    IPR016395. UL11_simplexvir-type.
    [Graphical view]
    PfamiPF11094. UL11. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003496. Myristoylat_tegument_UL11. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04289-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLSFSGARP CCCRNNVLIT DDGEVVSLTA HDFDVVDIES EEEGNFYVPP   50
    DMRGVTRAPG RQRLRSSDPP SRHTHRRTPG GACPATQFPP PMSDSE 96
    Length:96
    Mass (Da):10,487
    Last modified:January 23, 2007 - v3
    Checksum:i5D09A5B1F2034B09
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti39 – 391E → K in strain: 17 syn+.
    Natural varianti54 – 541G → V in strain: Nonneuroinvasive mutant HF10.
    Natural varianti65 – 651R → C in strain: Nonneuroinvasive mutant HF10.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32347.1.
    X03839 Genomic DNA. Translation: CAA27452.1.
    DQ889502 Genomic DNA. Translation: ABI63473.1.
    FJ593289 Genomic DNA. Translation: ACM62233.1.
    PIRiA03737. WMBE11.
    RefSeqiNP_044612.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32347.1 .
    X03839 Genomic DNA. Translation: CAA27452.1 .
    DQ889502 Genomic DNA. Translation: ABI63473.1 .
    FJ593289 Genomic DNA. Translation: ACM62233.1 .
    PIRi A03737. WMBE11.
    RefSeqi NP_044612.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P04289. 1 interaction.
    MINTi MINT-6732677.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703380.

    Family and domain databases

    InterProi IPR024351. Tegument_UL11_Herpesvir.
    IPR016395. UL11_simplexvir-type.
    [Graphical view ]
    Pfami PF11094. UL11. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003496. Myristoylat_tegument_UL11. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."
      McGeoch D.J., Dolan A., Frame M.C.
      Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    4. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    5. "The myristylated virion proteins of herpes simplex virus type 1: investigation of their role in the virus life cycle."
      MacLean C.A., Dolan A., Jamieson F.E., McGeoch D.J.
      J. Gen. Virol. 73:539-547(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: MYRISTOYLATION AT GLY-2, SUBCELLULAR LOCATION.
    6. "Cytoplasmic residues of herpes simplex virus glycoprotein gE required for secondary envelopment and binding of tegument proteins VP22 and UL11 to gE and gD."
      Farnsworth A., Wisner T.W., Johnson D.C.
      J. Virol. 81:319-331(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GLYCOPROTEIN D AND GLYCOPROTEIN E.
      Strain: F.
    7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.

    Entry informationi

    Entry nameiTEG2_HHV11
    AccessioniPrimary (citable) accession number: P04289
    Secondary accession number(s): B9VQD8, Q09IC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 79 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3