Reviewed,
UniProtKB/Swiss-Prot P04289 (UL11_HHV11)
Last modified
June 16, 2009.
Version 59.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tegument protein UL11 | ||
| Gene names |
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| Organism | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Complete proteome] | ||
| Taxonomic identifier | 10299 [NCBI] | ||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus | ||
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 96 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May play a role in the virus budding process at the trans-Golgi network during nucleocapsid envelopment Potential. |
| Subunit structure | |
| Subcellular location | Virion tegument. Virion membrane; Lipid-anchor By similarity. Host cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Host Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side Potential. Host nucleus membrane By similarity. Note: Host membrane-associated tegument protein (about 700 copies per virion). Associates with host membrane lipids rafts By similarity. |
| Domain | The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with UL16 By similarity. |
| Post-translational modification | Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging By similarity. Phosphorylated. Packaging is selective for underphosphorylated forms By similarity. |
| Sequence similarities | Belongs to the herpesviridae HHV-1 UL11 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Golgi apparatus Membrane Nucleus Virion Virion tegument |
| PTM | Lipoprotein Myristate Palmitate Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW host cell plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-KW viral tegumentInferred from electronic annotation. Source: UniProtKB-SubCell virion membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed: 2839594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes." McGeoch D.J., Dolan A., Frame M.C. Nucleic Acids Res. 14:3435-3448(1986) [PubMed: 3010237] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The myristylated virion proteins of herpes simplex virus type 1: investigation of their role in the virus life cycle." MacLean C.A., Dolan A., Jamieson F.E., McGeoch D.J. J. Gen. Virol. 73:539-547(1992) [PubMed: 1312117] [Abstract] Cited for: MYRISTOYLATION AT GLY-2, SUBCELLULAR LOCATION. |
| [4] | "Binding partners for the UL11 tegument protein of herpes simplex virus type 1." Loomis J.S., Courtney R.J., Wills J.W. J. Virol. 77:11417-11424(2003) [PubMed: 14557627] [Abstract] Cited for: INTERACTION WITH UL16. Strain: KOS. |
| [5] | "Analysis of the interaction between the UL11 and UL16 tegument proteins of herpes simplex virus." Yeh P.-C., Meckes D.G. Jr., Wills J.W. J. Virol. 82:10693-10700(2008) [PubMed: 18715918] [Abstract] Cited for: INTERACTION WITH UL16. Strain: KOS. |
Cross-references
Sequence databases | |
|---|---|
| X14112 Genomic DNA. Translation: CAA32347.1. X03839 Genomic DNA. Translation: CAA27452.1. | |
| PIR | WMBE11. A03737. |
| RefSeq | NP_044612.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2703380. |
Family and domain databases | |
| InterPro | IPR016395. Myristoylated_tegument_UL11. [Graphical view] |
| PIRSF | PIRSF003496. Myristoylat_tegument_UL11. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | UL11_HHV11 | ||||||||
| Accession | Primary (citable) accession number: P04289 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||

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