Reviewed, UniProtKB/Swiss-Prot P04289 (UL11_HHV11)

Names and origin

Protein names

Recommended name:
    Tegument protein UL11

Gene names

Name:

UL11

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Complete proteome]

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	96 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in the virus budding process at the trans-Golgi network during nucleocapsid envelopment Potential.
Subunit structure	Interacts with UL16. Ref.4 Ref.5
Subcellular location	Virion tegument. Virion membrane; Lipid-anchor By similarity. Host cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Host Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side Potential. Host nucleus membrane By similarity. Note: Host membrane-associated tegument protein (about 700 copies per virion). Associates with host membrane lipids rafts By similarity.
Domain	The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with UL16 By similarity.
Post-translational modification	Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging By similarity. Phosphorylated. Packaging is selective for underphosphorylated forms By similarity.
Sequence similarities	Belongs to the herpesviridae HHV-1 UL11 family.

Ontologies

Keywords
Cellular component	Cell membrane Golgi apparatus Membrane Nucleus Virion Virion tegument
PTM	Lipoprotein Myristate Palmitate Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW viral tegument Inferred from electronic annotation. Source: UniProtKB-SubCell virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed; by host
	Chain	2 – 96	95	Tegument protein UL11		PRO_0000115925
Regions
	Compositional bias	37 – 43	7	Asp/Glu-rich (acidic)
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine; by host

Sequences

	Sequence		Length	Mass (Da)
	P04289-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 5D09A5B1F2034B09	FASTA	96	10,487
	10 20 30 40 50 60 MGLSFSGARP CCCRNNVLIT DDGEVVSLTA HDFDVVDIES EEEGNFYVPP DMRGVTRAPG 70 80 90 RQRLRSSDPP SRHTHRRTPG GACPATQFPP PMSDSE

References

[1]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed: 2839594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes." McGeoch D.J., Dolan A., Frame M.C. Nucleic Acids Res. 14:3435-3448(1986) [PubMed: 3010237] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The myristylated virion proteins of herpes simplex virus type 1: investigation of their role in the virus life cycle." MacLean C.A., Dolan A., Jamieson F.E., McGeoch D.J. J. Gen. Virol. 73:539-547(1992) [PubMed: 1312117] [Abstract] Cited for: MYRISTOYLATION AT GLY-2, SUBCELLULAR LOCATION.
[4]	"Binding partners for the UL11 tegument protein of herpes simplex virus type 1." Loomis J.S., Courtney R.J., Wills J.W. J. Virol. 77:11417-11424(2003) [PubMed: 14557627] [Abstract] Cited for: INTERACTION WITH UL16. Strain: KOS.
[5]	"Analysis of the interaction between the UL11 and UL16 tegument proteins of herpes simplex virus." Yeh P.-C., Meckes D.G. Jr., Wills J.W. J. Virol. 82:10693-10700(2008) [PubMed: 18715918] [Abstract] Cited for: INTERACTION WITH UL16. Strain: KOS.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X14112 Genomic DNA. Translation: CAA32347.1. X03839 Genomic DNA. Translation: CAA27452.1.
PIR	WMBE11. A03737.
RefSeq	NP_044612.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2703380.
Family and domain databases
InterPro	IPR016395. Myristoylated_tegument_UL11. [Graphical view]
PIRSF	PIRSF003496. Myristoylat_tegument_UL11. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UL11_HHV11

Accession

Primary (citable) accession number: P04289

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 59 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)