P04289 (TG11_HHV11) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tegument protein UL11

Gene names

ORF Names:

UL11

Organism

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)

Taxonomic identifier

10299 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	96 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tegument protein that may play a role in the nucleocapsid secondary envelopment at the trans-Golgi network during virus morphogenesis Potential.
Subunit structure	Interacts with UL16. Interacts with gE (via C-terminus). Interacts with gD (via C-terminus). Interacts with UL56 By similarity. Ref.6
Subcellular location	Virion tegument. Virion membrane; Lipid-anchor By similarity. Host cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Host Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side By similarity. Host nucleus membrane; Lipid-anchor; Cytoplasmic side. Note: Virion membrane-associated tegument protein (about 700 copies per virion). Associates with host membrane lipids rafts By similarity. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN) By similarity. Ref.5 Ref.7
Domain	The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with the capsid-binding protein UL16 By similarity.
Post-translational modification	Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging By similarity. Phosphorylated. Phosphorylation does not seem to be needed for UL11 recycling to the Golgi apparatus. Packaging is selective for underphosphorylated forms By similarity.
Sequence similarities	Belongs to the herpesviridae HHV-1 UL11 family.

Ontologies

Keywords
Cellular component	Host Golgi apparatus Host cell membrane Host membrane Host nucleus Membrane Virion Virion tegument
PTM	Lipoprotein Myristate Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anatomical structure morphogenesis Inferred from electronic annotation. Source: InterPro
Cellular component	host cell Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell host cell nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-KW viral tegument Inferred from electronic annotation. Source: UniProtKB-SubCell virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed; by host
	Chain	2 – 96	95	Tegument protein UL11		PRO_0000115925
Regions
	Region	37 – 43	7	Asp/Glu-rich (acidic)
	Motif	18 – 19	2	Di-leucine-like internalization motif Potential
Amino acid modifications
	Modified residue	40	1	Phosphoserine By similarity
	Lipidation	2	1	N-myristoyl glycine; by host Ref.5
Natural variations
	Natural variant	39	1	E → K in strain: 17 syn+.
	Natural variant	54	1	G → V in strain: Nonneuroinvasive mutant HF10.
	Natural variant	65	1	R → C in strain: Nonneuroinvasive mutant HF10.

Sequences

	Sequence		Length	Mass (Da)
	P04289 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 5D09A5B1F2034B09	FASTA	96	10,487
	10 20 30 40 50 60 MGLSFSGARP CCCRNNVLIT DDGEVVSLTA HDFDVVDIES EEEGNFYVPP DMRGVTRAPG 70 80 90 RQRLRSSDPP SRHTHRRTPG GACPATQFPP PMSDSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes." McGeoch D.J., Dolan A., Frame M.C. Nucleic Acids Res. 14:3435-3448(1986) [PubMed: 3010237] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed: 2839594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus." Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y. Microbes Infect. 9:142-149(2007) [PubMed: 17218138] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nonneuroinvasive mutant HF10.
[4]	"Herpes simplex virus type 1 bacterial artificial chromosome." Cunningham C., Davison A.J. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17 syn+.
[5]	"The myristylated virion proteins of herpes simplex virus type 1: investigation of their role in the virus life cycle." MacLean C.A., Dolan A., Jamieson F.E., McGeoch D.J. J. Gen. Virol. 73:539-547(1992) [PubMed: 1312117] [Abstract] Cited for: MYRISTOYLATION AT GLY-2, SUBCELLULAR LOCATION.
[6]	"Cytoplasmic residues of herpes simplex virus glycoprotein gE required for secondary envelopment and binding of tegument proteins VP22 and UL11 to gE and gD." Farnsworth A., Wisner T.W., Johnson D.C. J. Virol. 81:319-331(2007) [PubMed: 17035313] [Abstract] Cited for: INTERACTION WITH GLYCOPROTEIN D AND GLYCOPROTEIN E. Strain: F.
[7]	"Comprehensive characterization of extracellular herpes simplex virus type 1 virions." Loret S., Guay G., Lippe R. J. Virol. 82:8605-8618(2008) [PubMed: 18596102] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: F.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14112 Genomic DNA. Translation: CAA32347.1. X03839 Genomic DNA. Translation: CAA27452.1. DQ889502 Genomic DNA. Translation: ABI63473.1. FJ593289 Genomic DNA. Translation: ACM62233.1.
PIR	WMBE11. A03737.
RefSeq	NP_044612.1. NC_001806.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-6732677.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2703380.
Phylogenomic databases
ProtClustDB	PHA3356.
Family and domain databases
InterPro	IPR024351. Tegument_UL11_Herpesvir. IPR016395. UL11_simplexvir-type. [Graphical view]
Pfam	PF11094. UL11. 1 hit. [Graphical view]
PIRSF	PIRSF003496. Myristoylat_tegument_UL11. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TG11_HHV11

Accession

Primary (citable) accession number: P04289
Secondary accession number(s): B9VQD8, Q09IC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	January 23, 2007
Last modified:	October 19, 2011
This is version 72 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program