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Protein

Cytoplasmic envelopment protein 3

Gene

UL11

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.UniRule annotation4 Publications

GO - Biological processi

  • anatomical structure morphogenesis Source: InterPro
  • viral budding from Golgi membrane Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic envelopment protein 3UniRule annotation
Gene namesi
ORF Names:UL11
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • Virion tegument UniRule annotation2 Publications
  • Virion membrane UniRule annotation; Lipid-anchor UniRule annotation
  • Host cell membrane UniRule annotation1 Publication; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation1 Publication
  • Host Golgi apparatus membrane UniRule annotation2 Publications; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation1 Publication

  • Note: Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by hostUniRule annotation
ChainiPRO_00001159252 – 96Cytoplasmic envelopment protein 3UniRule annotationAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine; by hostUniRule annotation1 Publication1
Modified residuei40PhosphoserineUniRule annotation1 Publication1

Post-translational modificationi

Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.UniRule annotation2 Publications
Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.UniRule annotation1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

PTM databases

iPTMnetiP04289.

Interactioni

Subunit structurei

Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus (By similarity). Interacts with gE (via C-terminus). Interacts with gD (via C-terminus). Interacts with UL56.UniRule annotationBy similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL16P102003EBI-7044930,EBI-7044955

Protein-protein interaction databases

IntActiP04289. 1 interactor.
MINTiMINT-6732677.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 43Asp/Glu-rich (acidic)UniRule annotation7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi18 – 19Di-leucine-like internalization motifUniRule annotation2

Domaini

The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with the capsid-binding protein UL16.1 Publication

Sequence similaritiesi

Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.UniRule annotation

Family and domain databases

HAMAPiMF_04040. HSV_CEP3_alphahv. 1 hit.
InterProiIPR024351. Tegument_UL11_Herpesvir.
IPR016395. UL11_simplexvir-type.
[Graphical view]
PfamiPF11094. UL11. 1 hit.
[Graphical view]
PIRSFiPIRSF003496. Myristoylat_tegument_UL11. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSFSGARP CCCRNNVLIT DDGEVVSLTA HDFDVVDIES EEEGNFYVPP
60 70 80 90
DMRGVTRAPG RQRLRSSDPP SRHTHRRTPG GACPATQFPP PMSDSE
Length:96
Mass (Da):10,487
Last modified:January 23, 2007 - v3
Checksum:i5D09A5B1F2034B09
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti39E → K in strain: 17 syn+. 1
Natural varianti54G → V in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti65R → C in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32347.1.
X03839 Genomic DNA. Translation: CAA27452.1.
DQ889502 Genomic DNA. Translation: ABI63473.1.
FJ593289 Genomic DNA. Translation: ACM62233.1.
PIRiA03737. WMBE11.
RefSeqiYP_009137085.1. NC_001806.2.

Genome annotation databases

GeneIDi24271464.
KEGGivg:24271464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32347.1.
X03839 Genomic DNA. Translation: CAA27452.1.
DQ889502 Genomic DNA. Translation: ABI63473.1.
FJ593289 Genomic DNA. Translation: ACM62233.1.
PIRiA03737. WMBE11.
RefSeqiYP_009137085.1. NC_001806.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04289. 1 interactor.
MINTiMINT-6732677.

PTM databases

iPTMnetiP04289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24271464.
KEGGivg:24271464.

Family and domain databases

HAMAPiMF_04040. HSV_CEP3_alphahv. 1 hit.
InterProiIPR024351. Tegument_UL11_Herpesvir.
IPR016395. UL11_simplexvir-type.
[Graphical view]
PfamiPF11094. UL11. 1 hit.
[Graphical view]
PIRSFiPIRSF003496. Myristoylat_tegument_UL11. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCEP3_HHV11
AccessioniPrimary (citable) accession number: P04289
Secondary accession number(s): B9VQD8, Q09IC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.