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Protein

Cytoplasmic envelopment protein 3

Gene

UL11

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.UniRule annotation4 Publications

GO - Biological processi

  • anatomical structure morphogenesis Source: InterPro
  • viral budding from Golgi membrane Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic envelopment protein 3UniRule annotation
Gene namesi
ORF Names:UL11
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

  • Virion tegument UniRule annotation2 Publications
  • Virion membrane UniRule annotation; Lipid-anchor UniRule annotation
  • Host cell membrane UniRule annotation1 Publication; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation1 Publication
  • Host Golgi apparatus membrane UniRule annotation2 Publications; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation1 Publication
  • Note: Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by hostUniRule annotation
ChainiPRO_00001159252 – 96Cytoplasmic envelopment protein 3UniRule annotationAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine; by hostUniRule annotation1 Publication1
Modified residuei40PhosphoserineUniRule annotation1 Publication1

Post-translational modificationi

Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.UniRule annotation2 Publications
Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.UniRule annotation1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP04289

PTM databases

iPTMnetiP04289

Interactioni

Subunit structurei

Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus (By similarity). Interacts with gE (via C-terminus). Interacts with gD (via C-terminus). Interacts with UL56.UniRule annotationBy similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL16P102003EBI-7044930,EBI-7044955

Protein-protein interaction databases

IntActiP04289, 1 interactor
MINTiP04289

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni37 – 43Asp/Glu-rich (acidic)UniRule annotation7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi18 – 19Di-leucine-like internalization motifUniRule annotation2

Domaini

The acidic region is required for efficient packaging. It is also involved in recycling the protein from the plasma membrane to the Golgi apparatus, and in the interaction with the capsid-binding protein UL16.1 Publication

Sequence similaritiesi

Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090002QO

Family and domain databases

HAMAPiMF_04040 HSV_CEP3_alphahv, 1 hit
InterProiView protein in InterPro
IPR024351 Tegument_UL11_Herpesvir
IPR016395 UL11_simplexvir-type
PfamiView protein in Pfam
PF11094 UL11, 1 hit
PIRSFiPIRSF003496 Myristoylat_tegument_UL11, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSFSGARP CCCRNNVLIT DDGEVVSLTA HDFDVVDIES EEEGNFYVPP
60 70 80 90
DMRGVTRAPG RQRLRSSDPP SRHTHRRTPG GACPATQFPP PMSDSE
Length:96
Mass (Da):10,487
Last modified:January 23, 2007 - v3
Checksum:i5D09A5B1F2034B09
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti39E → K in strain: 17 syn+. 1
Natural varianti54G → V in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti65R → C in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32347.1
X03839 Genomic DNA Translation: CAA27452.1
DQ889502 Genomic DNA Translation: ABI63473.1
FJ593289 Genomic DNA Translation: ACM62233.1
PIRiA03737 WMBE11
RefSeqiYP_009137085.1, NC_001806.2

Genome annotation databases

GeneIDi24271464
KEGGivg:24271464

Similar proteinsi

Entry informationi

Entry nameiCEP3_HHV11
AccessioniPrimary (citable) accession number: P04289
Secondary accession number(s): B9VQD8, Q09IC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 93 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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