ID   GM_HHV11                Reviewed;         473 AA.
AC   P04288; B9VQD7; Q09IC3;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   RecName: Full=Envelope glycoprotein M {ECO:0000255|HAMAP-Rule:MF_04035};
DE            Short=gM {ECO:0000255|HAMAP-Rule:MF_04035};
GN   Name=gM {ECO:0000255|HAMAP-Rule:MF_04035}; ORFNames=UL10;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC   Simplexvirus humanalpha1; Human herpesvirus 1.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3010237; DOI=10.1093/nar/14.8.3435;
RA   McGeoch D.J., Dolan A., Frame M.C.;
RT   "DNA sequence of the region in the genome of herpes simplex virus type 1
RT   containing the exonuclease gene and neighbouring genes.";
RL   Nucleic Acids Res. 14:3435-3448(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA   Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nonneuroinvasive mutant HF10;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated herpes
RT   simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL   Microbes Infect. 9:142-149(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17 syn+;
RA   Cunningham C., Davison A.J.;
RT   "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98.
RX   PubMed=2826807; DOI=10.1128/jvi.62.2.444-453.1988;
RA   McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P.,
RA   Challberg M.D.;
RT   "Structures of herpes simplex virus type 1 genes required for replication
RT   of virus DNA.";
RL   J. Virol. 62:444-453(1988).
RN   [6]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=F;
RX   PubMed=17079321; DOI=10.1128/jvi.01756-06;
RA   Baines J.D., Wills E., Jacob R.J., Pennington J., Roizman B.;
RT   "Glycoprotein M of herpes simplex virus 1 is incorporated into virions
RT   during budding at the inner nuclear membrane.";
RL   J. Virol. 81:800-812(2007).
RN   [7]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=F;
RX   PubMed=18596102; DOI=10.1128/jvi.00904-08;
RA   Loret S., Guay G., Lippe R.;
RT   "Comprehensive characterization of extracellular herpes simplex virus type
RT   1 virions.";
RL   J. Virol. 82:8605-8618(2008).
RN   [8]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=F;
RX   PubMed=19279119; DOI=10.1128/jvi.02431-08;
RA   Wills E., Mou F., Baines J.D.;
RT   "The U(L)31 and U(L)34 gene products of herpes simplex virus 1 are required
RT   for optimal localization of viral glycoproteins D and M to the inner
RT   nuclear membranes of infected cells.";
RL   J. Virol. 83:4800-4809(2009).
RN   [9]
RP   INTERACTION WITH GN, SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=26999189; DOI=10.3390/v8030083;
RA   Striebinger H., Funk C., Raschbichler V., Bailer S.M.;
RT   "Subcellular trafficking and functional relationship of the HSV-1
RT   glycoproteins N and M.";
RL   Viruses 8:83-83(2016).
CC   -!- FUNCTION: Envelope glycoprotein important for virion assembly and
CC       egress. Plays a role in the correct incorporation of gH-gL into virion
CC       membrane. Directs the glycoprotein N (gN) to the host trans-Golgi
CC       network. {ECO:0000255|HAMAP-Rule:MF_04035,
CC       ECO:0000269|PubMed:26999189}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with gN (via N-terminus). The gM-gN
CC       heterodimer forms the gCII complex. {ECO:0000255|HAMAP-Rule:MF_04035,
CC       ECO:0000269|PubMed:26999189}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04035}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04035}. Host Golgi apparatus, host trans-Golgi network
CC       {ECO:0000255|HAMAP-Rule:MF_04035, ECO:0000269|PubMed:26999189}. Host
CC       endosome membrane {ECO:0000255|HAMAP-Rule:MF_04035}; Multi-pass
CC       membrane protein {ECO:0000255|HAMAP-Rule:MF_04035}. Host nucleus inner
CC       membrane {ECO:0000255|HAMAP-Rule:MF_04035,
CC       ECO:0000269|PubMed:17079321}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_04035}. Note=During virion morphogenesis,
CC       this protein accumulates in the trans-Golgi network where secondary
CC       envelopment occurs. {ECO:0000255|HAMAP-Rule:MF_04035,
CC       ECO:0000269|PubMed:17079321}.
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein M family.
CC       {ECO:0000255|HAMAP-Rule:MF_04035}.
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DR   EMBL; X14112; CAA32346.1; -; Genomic_DNA.
DR   EMBL; X03839; CAA27451.1; -; Genomic_DNA.
DR   EMBL; DQ889502; ABI63472.1; -; Genomic_DNA.
DR   EMBL; FJ593289; ACM62232.1; -; Genomic_DNA.
DR   EMBL; AH002360; AAA45821.2; -; Genomic_DNA.
DR   PIR; A03736; WMBE51.
DR   RefSeq; YP_009137084.1; NC_001806.2.
DR   SMR; P04288; -.
DR   BioGRID; 971418; 1.
DR   ChEMBL; CHEMBL2364696; -.
DR   DrugCentral; P04288; -.
DR   TCDB; 9.B.212.1.1; the human simplex virus-1 gm protein (hsv-gm) family.
DR   DNASU; 2703379; -.
DR   GeneID; 2703379; -.
DR   KEGG; vg:2703379; -.
DR   PRO; PR:P04288; -.
DR   Proteomes; UP000009294; Genome.
DR   Proteomes; UP000180652; Genome.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0044201; C:host cell nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IDA:CAFA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04035; HSV_GM; 1.
DR   InterPro; IPR000785; Herpes_glycop_M.
DR   Pfam; PF01528; Herpes_glycop; 1.
DR   PRINTS; PR00333; HSVINTEGRLMP.
PE   1: Evidence at protein level;
KW   Disulfide bond; Glycoprotein; Host endosome; Host Golgi apparatus;
KW   Host membrane; Host nucleus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Virion.
FT   CHAIN           1..473
FT                   /note="Envelope glycoprotein M"
FT                   /id="PRO_0000115775"
FT   TOPO_DOM        1..32
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TOPO_DOM        54..90
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TOPO_DOM        112..137
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TOPO_DOM        159..163
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TOPO_DOM        185..216
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TOPO_DOM        238..250
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TOPO_DOM        272..280
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TOPO_DOM        302..318
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   TOPO_DOM        340..473
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   REGION          371..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          440..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        59
FT                   /note="Interchain (with gN)"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04035"
FT   VARIANT         77
FT                   /note="R -> C (in strain: Nonneuroinvasive mutant HF10)"
FT   VARIANT         105
FT                   /note="V -> A (in strain: Nonneuroinvasive mutant HF10)"
FT   VARIANT         279
FT                   /note="V -> M (in STRAIN: 17 syn+)"
FT   VARIANT         448
FT                   /note="D -> E (in strain: Nonneuroinvasive mutant HF10)"
FT   VARIANT         462
FT                   /note="A -> T (in strain: Nonneuroinvasive mutant HF10)"
SQ   SEQUENCE   473 AA;  51393 MW;  E08FD792409A81E6 CRC64;
     MGRPAPRGSP DSAPPTKGMT GARTAWWVWC VQVATFVVSA VCVTGLLVLA SVFRARFPCF
     YATASSYAGV NSTAEVRGGV AVPLRLDTQS LVGTYVITAV LLLAVAVYAV VGAVTSRYDR
     ALDAGRRLAA ARMAMPHATL IAGNVCSWLL QITVLLLAHR ISQLAHLVYV LHFACLVYFA
     AHFCTRGVLS GTYLRQVHGL MELAPTHHRV VGPARAVLTN ALLLGVFLCT ADAAVSLNTI
     AAFNFNFSAP GMLICLTVLF AILVVSLLLV VEGVLCHYVR VLVGPHLGAV AATGIVGLAC
     EHYYTNGYYV VETQWPGAQT GVRVALALVA AFALGMAVLR CTRAYLYHRR HHTKFFMRMR
     DTRHRAHSAL KRVRSSMRGS RDGRHRPAPG SPPGIPEYAE DPYAISYGGQ LDRYGDSDGE
     PIYDEVADDQ TDVLYAKIQH PRHLPDDDPI YDTVGGYDPE PAEDPVYSTV RRW
//