ID GM_HHV11 Reviewed; 473 AA. AC P04288; B9VQD7; Q09IC3; DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot. DT 20-MAR-1987, sequence version 1. DT 03-NOV-2009, entry version 58. DE RecName: Full=Envelope glycoprotein M; DE Short=gM; GN Name=gM; ORFNames=UL10; OS Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus OS 1). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Alphaherpesvirinae; Simplexvirus. OX NCBI_TaxID=10299; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=86205244; PubMed=3010237; DOI=10.1093/nar/14.8.3435; RA McGeoch D.J., Dolan A., Frame M.C.; RT "DNA sequence of the region in the genome of herpes simplex virus type RT 1 containing the exonuclease gene and neighbouring genes."; RL Nucleic Acids Res. 14:3435-3448(1986). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=88274327; PubMed=2839594; RA McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., RA McNab D., Perry L.J., Scott J.E., Taylor P.; RT "The complete DNA sequence of the long unique region in the genome of RT herpes simplex virus type 1."; RL J. Gen. Virol. 69:1531-1574(1988). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nonneuroinvasive mutant HF10; RX PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019; RA Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.; RT "Determination and analysis of the DNA sequence of highly attenuated RT herpes simplex virus type 1 mutant HF10, a potential oncolytic RT virus."; RL Microbes Infect. 9:142-149(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17 syn+; RA Cunningham C., Davison A.J.; RT "Herpes simplex virus type 1 bacterial artificial chromosome."; RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98. RX MEDLINE=88091053; PubMed=2826807; RA McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., RA Taylor P., Challberg M.D.; RT "Structures of herpes simplex virus type 1 genes required for RT replication of virus DNA."; RL J. Virol. 62:444-453(1988). RN [6] RP SUBCELLULAR LOCATION. RC STRAIN=F; RX PubMed=17079321; DOI=10.1128/JVI.01756-06; RA Baines J.D., Wills E., Jacob R.J., Pennington J., Roizman B.; RT "Glycoprotein M of herpes simplex virus 1 is incorporated into virions RT during budding at the inner nuclear membrane."; RL J. Virol. 81:800-812(2007). RN [7] RP SUBCELLULAR LOCATION. RC STRAIN=F; RX PubMed=18596102; DOI=10.1128/JVI.00904-08; RA Loret S., Guay G., Lippe R.; RT "Comprehensive characterization of extracellular herpes simplex virus RT type 1 virions."; RL J. Virol. 82:8605-8618(2008). CC -!- FUNCTION: Envelope glycoprotein important for cell-to-cell spread CC (By similarity). Might also be involved in fusion and/or entry CC into the host cell. CC -!- SUBUNIT: Interacts with gN (By similarity). The gM-gN heterodimer CC forms the gCII complex (By similarity). CC -!- SUBCELLULAR LOCATION: Virion membrane; Multi-pass membrane protein CC (Potential). Host Golgi apparatus membrane; Multi-pass membrane CC protein (Probable). Host endosome membrane (By similarity). CC Note=During virion morphogenesis, this protein probably CC accumulates in the endosomes and trans-Golgi where secondary CC envelopment occurs. CC -!- SIMILARITY: Belongs to the herpesviridae glycoprotein M family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X14112; CAA32346.1; -; Genomic_DNA. DR EMBL; X03839; CAA27451.1; -; Genomic_DNA. DR EMBL; DQ889502; ABI63472.1; -; Genomic_DNA. DR EMBL; FJ593289; ACM62232.1; -; Genomic_DNA. DR EMBL; M19120; AAA45821.2; -; Genomic_DNA. DR PIR; A03736; WMBE51. DR RefSeq; NP_044611.1; -. DR GeneID; 2703379; -. DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR InterPro; IPR000785; Herpes_glycop. DR Pfam; PF01528; Herpes_glycop; 1. DR PRINTS; PR00333; HSVINTEGRLMP. PE 3: Inferred from homology; KW Complete proteome; Envelope protein; Glycoprotein; Host endosome; KW Host Golgi apparatus; Host membrane; Membrane; Transmembrane; Virion; KW Virus reference strain. FT CHAIN 1 473 Envelope glycoprotein M. FT /FTId=PRO_0000115775. FT TOPO_DOM 1 32 Cytoplasmic (Potential). FT TRANSMEM 33 53 Potential. FT TOPO_DOM 54 90 Extracellular (Potential). FT TRANSMEM 91 111 Potential. FT TOPO_DOM 112 137 Cytoplasmic (Potential). FT TRANSMEM 138 158 Potential. FT TOPO_DOM 159 163 Extracellular (Potential). FT TRANSMEM 164 184 Potential. FT TOPO_DOM 185 216 Cytoplasmic (Potential). FT TRANSMEM 217 237 Potential. FT TOPO_DOM 238 250 Extracellular (Potential). FT TRANSMEM 251 271 Potential. FT TOPO_DOM 272 280 Cytoplasmic (Potential). FT TRANSMEM 281 301 Potential. FT TOPO_DOM 302 318 Extracellular (Potential). FT TRANSMEM 319 339 Potential. FT TOPO_DOM 340 473 Cytoplasmic (Potential). FT CARBOHYD 71 71 N-linked (GlcNAc...); by host FT (Potential). FT CARBOHYD 246 246 N-linked (GlcNAc...); by host FT (Potential). FT VARIANT 77 77 R -> C (in strain: Nonneuroinvasive FT mutant HF10). FT VARIANT 105 105 V -> A (in strain: Nonneuroinvasive FT mutant HF10). FT VARIANT 279 279 V -> M (in STRAIN: 17 syn+). FT VARIANT 448 448 D -> E (in strain: Nonneuroinvasive FT mutant HF10). FT VARIANT 462 462 A -> T (in strain: Nonneuroinvasive FT mutant HF10). SQ SEQUENCE 473 AA; 51393 MW; E08FD792409A81E6 CRC64; MGRPAPRGSP DSAPPTKGMT GARTAWWVWC VQVATFVVSA VCVTGLLVLA SVFRARFPCF YATASSYAGV NSTAEVRGGV AVPLRLDTQS LVGTYVITAV LLLAVAVYAV VGAVTSRYDR ALDAGRRLAA ARMAMPHATL IAGNVCSWLL QITVLLLAHR ISQLAHLVYV LHFACLVYFA AHFCTRGVLS GTYLRQVHGL MELAPTHHRV VGPARAVLTN ALLLGVFLCT ADAAVSLNTI AAFNFNFSAP GMLICLTVLF AILVVSLLLV VEGVLCHYVR VLVGPHLGAV AATGIVGLAC EHYYTNGYYV VETQWPGAQT GVRVALALVA AFALGMAVLR CTRAYLYHRR HHTKFFMRMR DTRHRAHSAL KRVRSSMRGS RDGRHRPAPG SPPGIPEYAE DPYAISYGGQ LDRYGDSDGE PIYDEVADDQ TDVLYAKIQH PRHLPDDDPI YDTVGGYDPE PAEDPVYSTV RRW //