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P04288

- GM_HHV11

UniProt

P04288 - GM_HHV11

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Protein

Envelope glycoprotein M

Gene

gM

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Envelope glycoprotein important for virion assembly and egress. May be involved in capsid budding through the inner nuclear membrane during egress. Also seems to be important for cell-to-cell spread and/or virus entry By similarity.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein M
Short name:
gM
Gene namesi
Name:gM
ORF Names:UL10
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion membrane By similarity; Multi-pass membrane protein By similarity. Host Golgi apparatus membrane Curated; Multi-pass membrane protein Curated. Host endosome membrane By similarity; Multi-pass membrane protein By similarity. Host nucleus inner membrane; Multi-pass membrane protein
Note: gM recruitment to the nucleus inner membrane requires UL31 and UL34. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs.

GO - Cellular componenti

  1. host cell endosome Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. host cell nucleus Source: UniProtKB-KW
  5. integral component of membrane Source: UniProtKB-KW
  6. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endosome, Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Envelope glycoprotein MPRO_0000115775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi246 – 2461N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with gN. The gM-gN heterodimer forms the gCII complex.By similarity

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232IntravirionSequence AnalysisAdd
BLAST
Topological domaini54 – 9037Virion surfaceSequence AnalysisAdd
BLAST
Topological domaini112 – 13726IntravirionSequence AnalysisAdd
BLAST
Topological domaini159 – 1635Virion surfaceSequence Analysis
Topological domaini185 – 21632IntravirionSequence AnalysisAdd
BLAST
Topological domaini238 – 25013Virion surfaceSequence AnalysisAdd
BLAST
Topological domaini272 – 2809IntravirionSequence Analysis
Topological domaini302 – 31817Virion surfaceSequence AnalysisAdd
BLAST
Topological domaini340 – 473134IntravirionSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence AnalysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence AnalysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence AnalysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence AnalysisAdd
BLAST
Transmembranei319 – 33921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR000785. Herpes_glycop.
[Graphical view]
PfamiPF01528. Herpes_glycop. 1 hit.
[Graphical view]
PRINTSiPR00333. HSVINTEGRLMP.

Sequencei

Sequence statusi: Complete.

P04288-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRPAPRGSP DSAPPTKGMT GARTAWWVWC VQVATFVVSA VCVTGLLVLA
60 70 80 90 100
SVFRARFPCF YATASSYAGV NSTAEVRGGV AVPLRLDTQS LVGTYVITAV
110 120 130 140 150
LLLAVAVYAV VGAVTSRYDR ALDAGRRLAA ARMAMPHATL IAGNVCSWLL
160 170 180 190 200
QITVLLLAHR ISQLAHLVYV LHFACLVYFA AHFCTRGVLS GTYLRQVHGL
210 220 230 240 250
MELAPTHHRV VGPARAVLTN ALLLGVFLCT ADAAVSLNTI AAFNFNFSAP
260 270 280 290 300
GMLICLTVLF AILVVSLLLV VEGVLCHYVR VLVGPHLGAV AATGIVGLAC
310 320 330 340 350
EHYYTNGYYV VETQWPGAQT GVRVALALVA AFALGMAVLR CTRAYLYHRR
360 370 380 390 400
HHTKFFMRMR DTRHRAHSAL KRVRSSMRGS RDGRHRPAPG SPPGIPEYAE
410 420 430 440 450
DPYAISYGGQ LDRYGDSDGE PIYDEVADDQ TDVLYAKIQH PRHLPDDDPI
460 470
YDTVGGYDPE PAEDPVYSTV RRW
Length:473
Mass (Da):51,393
Last modified:March 20, 1987 - v1
Checksum:iE08FD792409A81E6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771R → C in strain: Nonneuroinvasive mutant HF10.
Natural varianti105 – 1051V → A in strain: Nonneuroinvasive mutant HF10.
Natural varianti279 – 2791V → M in STRAIN: 17 syn+.
Natural varianti448 – 4481D → E in strain: Nonneuroinvasive mutant HF10.
Natural varianti462 – 4621A → T in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32346.1.
X03839 Genomic DNA. Translation: CAA27451.1.
DQ889502 Genomic DNA. Translation: ABI63472.1.
FJ593289 Genomic DNA. Translation: ACM62232.1.
M19120 Genomic DNA. Translation: AAA45821.2.
PIRiA03736. WMBE51.
RefSeqiNP_044611.1. NC_001806.1.

Genome annotation databases

GeneIDi2703379.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32346.1 .
X03839 Genomic DNA. Translation: CAA27451.1 .
DQ889502 Genomic DNA. Translation: ABI63472.1 .
FJ593289 Genomic DNA. Translation: ACM62232.1 .
M19120 Genomic DNA. Translation: AAA45821.2 .
PIRi A03736. WMBE51.
RefSeqi NP_044611.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2364696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703379.

Family and domain databases

InterProi IPR000785. Herpes_glycop.
[Graphical view ]
Pfami PF01528. Herpes_glycop. 1 hit.
[Graphical view ]
PRINTSi PR00333. HSVINTEGRLMP.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."
    McGeoch D.J., Dolan A., Frame M.C.
    Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  4. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  5. "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
    McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
    J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98.
  6. "Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane."
    Baines J.D., Wills E., Jacob R.J., Pennington J., Roizman B.
    J. Virol. 81:800-812(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  8. "The U(L)31 and U(L)34 gene products of herpes simplex virus 1 are required for optimal localization of viral glycoproteins D and M to the inner nuclear membranes of infected cells."
    Wills E., Mou F., Baines J.D.
    J. Virol. 83:4800-4809(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.

Entry informationi

Entry nameiGM_HHV11
AccessioniPrimary (citable) accession number: P04288
Secondary accession number(s): B9VQD7, Q09IC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3