Reviewed,
UniProtKB/Swiss-Prot P04288 (GM_HHV11)
Last modified
June 16, 2009.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glycoprotein M Short name=gM | ||||
| Gene names |
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| Organism | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Complete proteome] | ||||
| Taxonomic identifier | 10299 [NCBI] | ||||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus | ||||
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 473 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Fusion and/or entry and cell-to-cell spread By similarity. |
| Subunit structure | Interacts with gN By similarity. The gM-gN heterodimer forms the gCII complex By similarity. |
| Subcellular location | Virion membrane; Multi-pass membrane protein Potential. Host nucleus inner membrane; Multi-pass membrane protein Probable. Host cytoplasmic vesicle membrane; Multi-pass membrane protein. Note: Becomes incorporated into the virion envelope upon budding through the inner nuclear membrane. |
| Domain | The proline-rich cytoplasmic tail might interact with the virion tegument. |
| Sequence similarities | Belongs to the herpesviridae glycoprotein M family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasmic vesicle Envelope protein Membrane Nucleus Virion |
| Domain | Transmembrane |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW integral to membraneInferred from electronic annotation. Source: UniProtKB-KW nucleusInferred from electronic annotation. Source: UniProtKB-KW viral envelopeInferred from electronic annotation. Source: UniProtKB-KW virion membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 473 | 473 | Glycoprotein M | PRO_0000115775 | |||||
Regions | |||||||||
| Transmembrane | 33 – 53 | 21 | Potential | ||||||
| Transmembrane | 91 – 111 | 21 | Potential | ||||||
| Transmembrane | 138 – 158 | 21 | Potential | ||||||
| Transmembrane | 164 – 184 | 21 | Potential | ||||||
| Transmembrane | 217 – 237 | 21 | Potential | ||||||
| Transmembrane | 251 – 271 | 21 | Potential | ||||||
| Transmembrane | 281 – 301 | 21 | Potential | ||||||
| Transmembrane | 319 – 339 | 21 | Potential | ||||||
| Topological domain | 340 – 473 | 134 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 71 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 246 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
Sequences
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References
| [1] | "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1." McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. J. Gen. Virol. 69:1531-1574(1988) [PubMed: 2839594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes." McGeoch D.J., Dolan A., Frame M.C. Nucleic Acids Res. 14:3435-3448(1986) [PubMed: 3010237] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Structures of herpes simplex virus type 1 genes required for replication of virus DNA." McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D. J. Virol. 62:444-453(1988) [PubMed: 2826807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98. |
| [4] | "Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane." Baines J.D., Wills E., Jacob R.J., Pennington J., Roizman B. J. Virol. 81:800-812(2007) [PubMed: 17079321] [Abstract] Cited for: SUBCELLULAR LOCATION. Strain: F. |
Cross-references
Sequence databases | |
|---|---|
| X14112 Genomic DNA. Translation: CAA32346.1. X03839 Genomic DNA. Translation: CAA27451.1. M19120 Genomic DNA. Translation: AAA45821.2. | |
| PIR | WMBE51. A03736. |
| RefSeq | NP_044611.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2703379. |
Family and domain databases | |
| InterPro | IPR000785. Herpes_glycop. [Graphical view] |
| Pfam | PF01528. Herpes_glycop. 1 hit. [Graphical view] |
| PRINTS | PR00333. HSVINTEGRLMP. |
| ProtoNet | Search... |
Entry information
| Entry name | GM_HHV11 | ||||||||
| Accession | Primary (citable) accession number: P04288 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||

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