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P04288 (GM_HHV11) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein M

Short name=gM
Gene names
Name:gM
ORF Names:UL10
OrganismHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) [Reference proteome]
Taxonomic identifier10299 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Envelope glycoprotein important for virion assembly and egress. May be involved in capsid budding through the inner nuclear membrane during egress. Also seems to be important for cell-to-cell spread and/or virus entry By similarity.

Subunit structure

Interacts with gN By similarity. The gM-gN heterodimer forms the gCII complex By similarity.

Subcellular location

Virion membrane; Multi-pass membrane protein By similarity. Host Golgi apparatus membrane; Multi-pass membrane protein Probable. Host endosome membrane; Multi-pass membrane protein By similarity. Host nucleus inner membrane; Multi-pass membrane protein. Note: gM recruitment to the nucleus inner membrane requires UL31 and UL34. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. Ref.6 Ref.7 Ref.8

Sequence similarities

Belongs to the herpesviridae glycoprotein M family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473Envelope glycoprotein M
PRO_0000115775

Regions

Topological domain1 – 3232Intravirion Potential
Transmembrane33 – 5321Helical; Potential
Topological domain54 – 9037Virion surface Potential
Transmembrane91 – 11121Helical; Potential
Topological domain112 – 13726Intravirion Potential
Transmembrane138 – 15821Helical; Potential
Topological domain159 – 1635Virion surface Potential
Transmembrane164 – 18421Helical; Potential
Topological domain185 – 21632Intravirion Potential
Transmembrane217 – 23721Helical; Potential
Topological domain238 – 25013Virion surface Potential
Transmembrane251 – 27121Helical; Potential
Topological domain272 – 2809Intravirion Potential
Transmembrane281 – 30121Helical; Potential
Topological domain302 – 31817Virion surface Potential
Transmembrane319 – 33921Helical; Potential
Topological domain340 – 473134Intravirion Potential

Amino acid modifications

Glycosylation711N-linked (GlcNAc...); by host Potential
Glycosylation2461N-linked (GlcNAc...); by host Potential

Natural variations

Natural variant771R → C in strain: Nonneuroinvasive mutant HF10.
Natural variant1051V → A in strain: Nonneuroinvasive mutant HF10.
Natural variant2791V → M in STRAIN: 17 syn+.
Natural variant4481D → E in strain: Nonneuroinvasive mutant HF10.
Natural variant4621A → T in strain: Nonneuroinvasive mutant HF10.

Sequences

Sequence LengthMass (Da)Tools
P04288 [UniParc].

Last modified March 20, 1987. Version 1.
Checksum: E08FD792409A81E6

FASTA47351,393
        10         20         30         40         50         60 
MGRPAPRGSP DSAPPTKGMT GARTAWWVWC VQVATFVVSA VCVTGLLVLA SVFRARFPCF 

        70         80         90        100        110        120 
YATASSYAGV NSTAEVRGGV AVPLRLDTQS LVGTYVITAV LLLAVAVYAV VGAVTSRYDR 

       130        140        150        160        170        180 
ALDAGRRLAA ARMAMPHATL IAGNVCSWLL QITVLLLAHR ISQLAHLVYV LHFACLVYFA 

       190        200        210        220        230        240 
AHFCTRGVLS GTYLRQVHGL MELAPTHHRV VGPARAVLTN ALLLGVFLCT ADAAVSLNTI 

       250        260        270        280        290        300 
AAFNFNFSAP GMLICLTVLF AILVVSLLLV VEGVLCHYVR VLVGPHLGAV AATGIVGLAC 

       310        320        330        340        350        360 
EHYYTNGYYV VETQWPGAQT GVRVALALVA AFALGMAVLR CTRAYLYHRR HHTKFFMRMR 

       370        380        390        400        410        420 
DTRHRAHSAL KRVRSSMRGS RDGRHRPAPG SPPGIPEYAE DPYAISYGGQ LDRYGDSDGE 

       430        440        450        460        470 
PIYDEVADDQ TDVLYAKIQH PRHLPDDDPI YDTVGGYDPE PAEDPVYSTV RRW 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."
McGeoch D.J., Dolan A., Frame M.C.
Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nonneuroinvasive mutant HF10.
[4]"Herpes simplex virus type 1 bacterial artificial chromosome."
Cunningham C., Davison A.J.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 17 syn+.
[5]"Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98.
[6]"Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane."
Baines J.D., Wills E., Jacob R.J., Pennington J., Roizman B.
J. Virol. 81:800-812(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.
[7]"Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
Loret S., Guay G., Lippe R.
J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.
[8]"The U(L)31 and U(L)34 gene products of herpes simplex virus 1 are required for optimal localization of viral glycoproteins D and M to the inner nuclear membranes of infected cells."
Wills E., Mou F., Baines J.D.
J. Virol. 83:4800-4809(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
Strain: F.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14112 Genomic DNA. Translation: CAA32346.1.
X03839 Genomic DNA. Translation: CAA27451.1.
DQ889502 Genomic DNA. Translation: ABI63472.1.
FJ593289 Genomic DNA. Translation: ACM62232.1.
M19120 Genomic DNA. Translation: AAA45821.2.
PIRWMBE51. A03736.
RefSeqNP_044611.1. NC_001806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2364696.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2703379.

Family and domain databases

InterProIPR000785. Herpes_glycop.
[Graphical view]
PfamPF01528. Herpes_glycop. 1 hit.
[Graphical view]
PRINTSPR00333. HSVINTEGRLMP.
ProtoNetSearch...

Entry information

Entry nameGM_HHV11
AccessionPrimary (citable) accession number: P04288
Secondary accession number(s): B9VQD7, Q09IC3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families