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P04288

- GM_HHV11

UniProt

P04288 - GM_HHV11

Protein

Envelope glycoprotein M

Gene

gM

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (20 Mar 1987)
      Previous versions | rss
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    Functioni

    Envelope glycoprotein important for virion assembly and egress. May be involved in capsid budding through the inner nuclear membrane during egress. Also seems to be important for cell-to-cell spread and/or virus entry By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein M
    Short name:
    gM
    Gene namesi
    Name:gM
    ORF Names:UL10
    OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
    Taxonomic identifieri10299 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000009294: Genome

    Subcellular locationi

    Virion membrane By similarity; Multi-pass membrane protein By similarity. Host Golgi apparatus membrane Curated; Multi-pass membrane protein Curated. Host endosome membrane By similarity; Multi-pass membrane protein By similarity. Host nucleus inner membrane; Multi-pass membrane protein
    Note: gM recruitment to the nucleus inner membrane requires UL31 and UL34. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs.

    GO - Cellular componenti

    1. host cell endosome membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. host cell nuclear inner membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. viral envelope Source: UniProtKB-KW
    6. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endosome, Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473Envelope glycoprotein MPRO_0000115775Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi246 – 2461N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with gN. The gM-gN heterodimer forms the gCII complex.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini54 – 9037Virion surfaceSequence AnalysisAdd
    BLAST
    Topological domaini112 – 13726IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini159 – 1635Virion surfaceSequence Analysis
    Topological domaini185 – 21632IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini238 – 25013Virion surfaceSequence AnalysisAdd
    BLAST
    Topological domaini272 – 2809IntravirionSequence Analysis
    Topological domaini302 – 31817Virion surfaceSequence AnalysisAdd
    BLAST
    Topological domaini340 – 473134IntravirionSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei91 – 11121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 27121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei319 – 33921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR000785. Herpes_glycop.
    [Graphical view]
    PfamiPF01528. Herpes_glycop. 1 hit.
    [Graphical view]
    PRINTSiPR00333. HSVINTEGRLMP.

    Sequencei

    Sequence statusi: Complete.

    P04288-1 [UniParc]FASTAAdd to Basket

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    MGRPAPRGSP DSAPPTKGMT GARTAWWVWC VQVATFVVSA VCVTGLLVLA    50
    SVFRARFPCF YATASSYAGV NSTAEVRGGV AVPLRLDTQS LVGTYVITAV 100
    LLLAVAVYAV VGAVTSRYDR ALDAGRRLAA ARMAMPHATL IAGNVCSWLL 150
    QITVLLLAHR ISQLAHLVYV LHFACLVYFA AHFCTRGVLS GTYLRQVHGL 200
    MELAPTHHRV VGPARAVLTN ALLLGVFLCT ADAAVSLNTI AAFNFNFSAP 250
    GMLICLTVLF AILVVSLLLV VEGVLCHYVR VLVGPHLGAV AATGIVGLAC 300
    EHYYTNGYYV VETQWPGAQT GVRVALALVA AFALGMAVLR CTRAYLYHRR 350
    HHTKFFMRMR DTRHRAHSAL KRVRSSMRGS RDGRHRPAPG SPPGIPEYAE 400
    DPYAISYGGQ LDRYGDSDGE PIYDEVADDQ TDVLYAKIQH PRHLPDDDPI 450
    YDTVGGYDPE PAEDPVYSTV RRW 473
    Length:473
    Mass (Da):51,393
    Last modified:March 20, 1987 - v1
    Checksum:iE08FD792409A81E6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771R → C in strain: Nonneuroinvasive mutant HF10.
    Natural varianti105 – 1051V → A in strain: Nonneuroinvasive mutant HF10.
    Natural varianti279 – 2791V → M in STRAIN: 17 syn+.
    Natural varianti448 – 4481D → E in strain: Nonneuroinvasive mutant HF10.
    Natural varianti462 – 4621A → T in strain: Nonneuroinvasive mutant HF10.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32346.1.
    X03839 Genomic DNA. Translation: CAA27451.1.
    DQ889502 Genomic DNA. Translation: ABI63472.1.
    FJ593289 Genomic DNA. Translation: ACM62232.1.
    M19120 Genomic DNA. Translation: AAA45821.2.
    PIRiA03736. WMBE51.
    RefSeqiNP_044611.1. NC_001806.1.

    Genome annotation databases

    GeneIDi2703379.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14112 Genomic DNA. Translation: CAA32346.1 .
    X03839 Genomic DNA. Translation: CAA27451.1 .
    DQ889502 Genomic DNA. Translation: ABI63472.1 .
    FJ593289 Genomic DNA. Translation: ACM62232.1 .
    M19120 Genomic DNA. Translation: AAA45821.2 .
    PIRi A03736. WMBE51.
    RefSeqi NP_044611.1. NC_001806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2364696.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2703379.

    Family and domain databases

    InterProi IPR000785. Herpes_glycop.
    [Graphical view ]
    Pfami PF01528. Herpes_glycop. 1 hit.
    [Graphical view ]
    PRINTSi PR00333. HSVINTEGRLMP.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."
      McGeoch D.J., Dolan A., Frame M.C.
      Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
      McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
      J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
      Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
      Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nonneuroinvasive mutant HF10.
    4. "Herpes simplex virus type 1 bacterial artificial chromosome."
      Cunningham C., Davison A.J.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17 syn+.
    5. "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
      McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
      J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98.
    6. "Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane."
      Baines J.D., Wills E., Jacob R.J., Pennington J., Roizman B.
      J. Virol. 81:800-812(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.
    7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
      Loret S., Guay G., Lippe R.
      J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.
    8. "The U(L)31 and U(L)34 gene products of herpes simplex virus 1 are required for optimal localization of viral glycoproteins D and M to the inner nuclear membranes of infected cells."
      Wills E., Mou F., Baines J.D.
      J. Virol. 83:4800-4809(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
      Strain: F.

    Entry informationi

    Entry nameiGM_HHV11
    AccessioniPrimary (citable) accession number: P04288
    Secondary accession number(s): B9VQD7, Q09IC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: March 20, 1987
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3