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P04288

- GM_HHV11

UniProt

P04288 - GM_HHV11

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Protein
Envelope glycoprotein M
Gene
gM, UL10
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Envelope glycoprotein important for virion assembly and egress. May be involved in capsid budding through the inner nuclear membrane during egress. Also seems to be important for cell-to-cell spread and/or virus entry By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein M
Short name:
gM
Gene namesi
Name:gM
ORF Names:UL10
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000009294: Genome

Subcellular locationi

Virion membrane; Multi-pass membrane protein By similarity. Host Golgi apparatus membrane; Multi-pass membrane protein Inferred. Host endosome membrane; Multi-pass membrane protein By similarity. Host nucleus inner membrane; Multi-pass membrane protein
Note: gM recruitment to the nucleus inner membrane requires UL31 and UL34. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Intravirion Reviewed prediction
Add
BLAST
Transmembranei33 – 5321Helical; Reviewed prediction
Add
BLAST
Topological domaini54 – 9037Virion surface Reviewed prediction
Add
BLAST
Transmembranei91 – 11121Helical; Reviewed prediction
Add
BLAST
Topological domaini112 – 13726Intravirion Reviewed prediction
Add
BLAST
Transmembranei138 – 15821Helical; Reviewed prediction
Add
BLAST
Topological domaini159 – 1635Virion surface Reviewed prediction
Transmembranei164 – 18421Helical; Reviewed prediction
Add
BLAST
Topological domaini185 – 21632Intravirion Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Reviewed prediction
Add
BLAST
Topological domaini238 – 25013Virion surface Reviewed prediction
Add
BLAST
Transmembranei251 – 27121Helical; Reviewed prediction
Add
BLAST
Topological domaini272 – 2809Intravirion Reviewed prediction
Transmembranei281 – 30121Helical; Reviewed prediction
Add
BLAST
Topological domaini302 – 31817Virion surface Reviewed prediction
Add
BLAST
Transmembranei319 – 33921Helical; Reviewed prediction
Add
BLAST
Topological domaini340 – 473134Intravirion Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endosome membrane Source: UniProtKB-SubCell
  3. host cell nuclear inner membrane Source: UniProtKB-SubCell
  4. integral component of membrane Source: UniProtKB-KW
  5. viral envelope Source: UniProtKB-KW
  6. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endosome, Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Envelope glycoprotein M
PRO_0000115775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi246 – 2461N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with gN By similarity. The gM-gN heterodimer forms the gCII complex By similarity.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR000785. Herpes_glycop.
[Graphical view]
PfamiPF01528. Herpes_glycop. 1 hit.
[Graphical view]
PRINTSiPR00333. HSVINTEGRLMP.

Sequencei

Sequence statusi: Complete.

P04288-1 [UniParc]FASTAAdd to Basket

« Hide

MGRPAPRGSP DSAPPTKGMT GARTAWWVWC VQVATFVVSA VCVTGLLVLA    50
SVFRARFPCF YATASSYAGV NSTAEVRGGV AVPLRLDTQS LVGTYVITAV 100
LLLAVAVYAV VGAVTSRYDR ALDAGRRLAA ARMAMPHATL IAGNVCSWLL 150
QITVLLLAHR ISQLAHLVYV LHFACLVYFA AHFCTRGVLS GTYLRQVHGL 200
MELAPTHHRV VGPARAVLTN ALLLGVFLCT ADAAVSLNTI AAFNFNFSAP 250
GMLICLTVLF AILVVSLLLV VEGVLCHYVR VLVGPHLGAV AATGIVGLAC 300
EHYYTNGYYV VETQWPGAQT GVRVALALVA AFALGMAVLR CTRAYLYHRR 350
HHTKFFMRMR DTRHRAHSAL KRVRSSMRGS RDGRHRPAPG SPPGIPEYAE 400
DPYAISYGGQ LDRYGDSDGE PIYDEVADDQ TDVLYAKIQH PRHLPDDDPI 450
YDTVGGYDPE PAEDPVYSTV RRW 473
Length:473
Mass (Da):51,393
Last modified:March 20, 1987 - v1
Checksum:iE08FD792409A81E6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771R → C in strain: Nonneuroinvasive mutant HF10.
Natural varianti105 – 1051V → A in strain: Nonneuroinvasive mutant HF10.
Natural varianti279 – 2791V → M in STRAIN: 17 syn+.
Natural varianti448 – 4481D → E in strain: Nonneuroinvasive mutant HF10.
Natural varianti462 – 4621A → T in strain: Nonneuroinvasive mutant HF10.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32346.1.
X03839 Genomic DNA. Translation: CAA27451.1.
DQ889502 Genomic DNA. Translation: ABI63472.1.
FJ593289 Genomic DNA. Translation: ACM62232.1.
M19120 Genomic DNA. Translation: AAA45821.2.
PIRiA03736. WMBE51.
RefSeqiNP_044611.1. NC_001806.1.

Genome annotation databases

GeneIDi2703379.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14112 Genomic DNA. Translation: CAA32346.1 .
X03839 Genomic DNA. Translation: CAA27451.1 .
DQ889502 Genomic DNA. Translation: ABI63472.1 .
FJ593289 Genomic DNA. Translation: ACM62232.1 .
M19120 Genomic DNA. Translation: AAA45821.2 .
PIRi A03736. WMBE51.
RefSeqi NP_044611.1. NC_001806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2364696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2703379.

Family and domain databases

InterProi IPR000785. Herpes_glycop.
[Graphical view ]
Pfami PF01528. Herpes_glycop. 1 hit.
[Graphical view ]
PRINTSi PR00333. HSVINTEGRLMP.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes."
    McGeoch D.J., Dolan A., Frame M.C.
    Nucleic Acids Res. 14:3435-3448(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."
    McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.
    J. Gen. Virol. 69:1531-1574(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus."
    Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.
    Microbes Infect. 9:142-149(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Nonneuroinvasive mutant HF10.
  4. "Herpes simplex virus type 1 bacterial artificial chromosome."
    Cunningham C., Davison A.J.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17 syn+.
  5. "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."
    McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.
    J. Virol. 62:444-453(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98.
  6. "Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane."
    Baines J.D., Wills E., Jacob R.J., Pennington J., Roizman B.
    J. Virol. 81:800-812(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  7. "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
    Loret S., Guay G., Lippe R.
    J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.
  8. "The U(L)31 and U(L)34 gene products of herpes simplex virus 1 are required for optimal localization of viral glycoproteins D and M to the inner nuclear membranes of infected cells."
    Wills E., Mou F., Baines J.D.
    J. Virol. 83:4800-4809(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: F.

Entry informationi

Entry nameiGM_HHV11
AccessioniPrimary (citable) accession number: P04288
Secondary accession number(s): B9VQD7, Q09IC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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