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Protein

Pathogenesis-related leaf protein 6

Gene

PR1B1

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the defense reaction of plants against pathogens. Has antifungal activity.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Fungicide, Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Pathogenesis-related leaf protein 6
Short name:
P6
Alternative name(s):
Ethylene-induced protein P1
P14
P14A
PR protein
Gene namesi
Name:PR1B1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 159135Pathogenesis-related leaf protein 6PRO_0000006309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Pyrrolidone carboxylic acid
Disulfide bondi68 ↔ 136
Disulfide bondi109 ↔ 115
Disulfide bondi131 ↔ 145

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP04284.

Expressioni

Developmental stagei

Maximum expression found during days 4 to 8 and days 8 to 12 after inoculation with an avirulent and a virulent pathogen respectively.

Inductioni

Upon infection by virulent and avirulent races of pathogens, for example fungal pathogen C.fulvum. Also induced by ethylene.

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc00g174340.1.1.

Structurei

Secondary structure

1
159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi28 – 4114Combined sources
Helixi52 – 6413Combined sources
Turni65 – 673Combined sources
Beta strandi74 – 774Combined sources
Beta strandi83 – 853Combined sources
Helixi88 – 969Combined sources
Helixi97 – 1015Combined sources
Helixi104 – 1063Combined sources
Beta strandi111 – 1133Combined sources
Helixi118 – 1225Combined sources
Beta strandi128 – 1358Combined sources
Beta strandi139 – 1468Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CFENMR-A25-159[»]
ProteinModelPortaliP04284.
SMRiP04284. Positions 25-159.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04284.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 147116SCPAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
InParanoidiP04284.
KOiK13449.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLFNISLLL TCLMVLAIFH SCEAQNSPQD YLAVHNDARA QVGVGPMSWD
60 70 80 90 100
ANLASRAQNY ANSRAGDCNL IHSGAGENLA KGGGDFTGRA AVQLWVSERP
110 120 130 140 150
SYNYATNQCV GGKKCRHYTQ VVWRNSVRLG CGRARCNNGW WFISCNYDPV

GNWIGQRPY
Length:159
Mass (Da):17,520
Last modified:June 1, 1994 - v2
Checksum:iEA35A6C3AC0EF3F4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1275Missing AA sequence (PubMed:16453639).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69248 mRNA. Translation: AAA03616.1.
X68738 mRNA. Translation: CAA48672.1.
Y08804 mRNA. Translation: CAA70042.1.
PIRiS26239. VCTO14.
RefSeqiNP_001234314.1. NM_001247385.2.
UniGeneiLes.3626.

Genome annotation databases

GeneIDi544123.
KEGGisly:544123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69248 mRNA. Translation: AAA03616.1.
X68738 mRNA. Translation: CAA48672.1.
Y08804 mRNA. Translation: CAA70042.1.
PIRiS26239. VCTO14.
RefSeqiNP_001234314.1. NM_001247385.2.
UniGeneiLes.3626.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CFENMR-A25-159[»]
ProteinModelPortaliP04284.
SMRiP04284. Positions 25-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc00g174340.1.1.

Proteomic databases

PaxDbiP04284.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi544123.
KEGGisly:544123.

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
InParanoidiP04284.
KOiK13449.

Miscellaneous databases

EvolutionaryTraceiP04284.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differential accumulation of mRNAs encoding extracellular and intracellular PR proteins in tomato induced by virulent and avirulent races of Cladosporium fulvum."
    van Kan J.A.L., Joosten M.H.A.J., Wagemakers C.A.M., van den Berg-Velthuis G.C.M., de Wit P.J.G.M.
    Plant Mol. Biol. 20:513-527(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: cv. Moneymaker.
    Tissue: Leaf.
  2. "Nucleotide sequence of a cDNA encoding a pathogenesis-related protein, p1-p14, from tomato (Lycopersicon esculentum)."
    Tornero P., Rodrigo T., Conejero V., Vera P.
    Plant Physiol. 102:325-325(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leaf.
  3. "Two PR-1 genes from tomato are differentially regulated and reveal a novel mode of expression for a pathogenesis-related gene during the hypersensitive response and development."
    Tornero P., Gadea J., Conejero V., Vera P.
    Mol. Plant Microbe Interact. 10:624-634(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. VFN8.
    Tissue: Leaf.
  4. "Amino acid sequence of the 'pathogenesis-related' leaf protein p14 from viroid-infected tomato reveals a new type of structurally unfamiliar proteins."
    Lucas J., Camacho-Henriquez A., Lottspeich F., Henschen A., Sanger H.L.
    EMBO J. 4:2745-2749(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-159.
    Strain: cv. Rutgers.
  5. "NMR solution structure of the pathogenesis-related protein P14a."
    Fernandez C., Szyperski T., Bruyere T., Ramage P., Moesinger E., Wuethrich K.
    J. Mol. Biol. 266:576-593(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiPR06_SOLLC
AccessioniPrimary (citable) accession number: P04284
Secondary accession number(s): Q04109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: June 1, 1994
Last modified: January 20, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.