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Protein

Basic salivary proline-rich protein 1

Gene

PRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32827-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Basic salivary proline-rich protein 1
Short name:
Salivary proline-rich protein
Cleaved into the following 3 chains:
Gene namesi
Name:PRB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:9337. PRB1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5542.
PharmGKBiPA33699.

Polymorphism and mutation databases

BioMutaiPRB1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000002212917 – 392Basic salivary proline-rich protein 1Add BLAST376
ChainiPRO_000037244117 – 91Proline-rich peptide II-2Add BLAST75
ChainiPRO_0000022130275 – 392Basic peptide IB-6Add BLAST118
ChainiPRO_0000022131337 – 392Peptide P-HAdd BLAST56

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Pyrrolidone carboxylic acid2 Publications1
Modified residuei24PhosphoserineBy similarity1
Modified residuei40Phosphoserine; alternate1 Publication1
Glycosylationi40O-linked (Hex); alternate1 Publication1
Glycosylationi87O-linked (HexNAc...); prevalent in head and neck cancer patients1 Publication1
Modified residuei92Phosphoserine1 Publication1
Modified residuei150Phosphoserine; alternate1 Publication1
Glycosylationi150O-linked (Hex); alternate1 Publication1
Glycosylationi330O-linked (HexNAc...); 5 times prevalence in head and neck cancers1

Post-translational modificationi

O-glycosylated.1 Publication
Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P3 position is mostly lysine. The endoprotease may be of microbial origin.1 Publication
Pyroglutamate formation occurs on terminal Gln residues of cleaved peptides. Besides on the N-terminal of mature PBR1, pyroglutamate formation found on at least Gln-58.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PeptideAtlasiP04280.
PRIDEiP04280.
TopDownProteomicsiP04280.

PTM databases

iPTMnetiP04280.
PhosphoSitePlusiP04280.

Expressioni

Gene expression databases

CleanExiHS_PRB1.

Interactioni

Protein-protein interaction databases

BioGridi111534. 4 interactors.

Structurei

3D structure databases

ProteinModelPortaliP04280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 721Add BLAST20
Repeati73 – 922Add BLAST20
Repeati93 – 1123Add BLAST20
Repeati114 – 1334Add BLAST20
Repeati134 – 1535Add BLAST20
Repeati154 – 1736Add BLAST20
Repeati175 – 1947Add BLAST20
Repeati195 – 2148Add BLAST20
Repeati215 – 2349Add BLAST20
Repeati236 – 25510Add BLAST20
Repeati256 – 27511Add BLAST20
Repeati276 – 29512Add BLAST20
Repeati297 – 31613Add BLAST20
Repeati317 – 33614Add BLAST20
Repeati338 – 35715Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 35715 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]-[NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]-[PSR]Add BLAST305

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

InParanoidiP04280.
KOiK13911.

Family and domain databases

InterProiIPR026086. Pro-rich.
[Graphical view]
PANTHERiPTHR23203. PTHR23203. 1 hit.
PfamiPF15240. Pro-rich. 3 hits.
[Graphical view]
SMARTiSM01412. Pro-rich. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLILLSVAL LALSSAQNLN EDVSQEESPS LIAGNPQGPS PQGGNKPQGP
60 70 80 90 100
PPPPGKPQGP PPQGGNKPQG PPPPGKPQGP PPQGDKSRSP RSPPGKPQGP
110 120 130 140 150
PPQGGNQPQG PPPPPGKPQG PPPQGGNKPQ GPPPPGKPQG PPPQGDKSQS
160 170 180 190 200
PRSPPGKPQG PPPQGGNQPQ GPPPPPGKPQ GPPPQGGNKP QGPPPPGKPQ
210 220 230 240 250
GPPPQGDKSQ SPRSPPGKPQ GPPPQGGNQP QGPPPPPGKP QGPPQQGGNR
260 270 280 290 300
PQGPPPPGKP QGPPPQGDKS RSPQSPPGKP QGPPPQGGNQ PQGPPPPPGK
310 320 330 340 350
PQGPPPQGGN KPQGPPPPGK PQGPPAQGGS KSQSARAPPG KPQGPPQQEG
360 370 380 390
NNPQGPPPPA GGNPQQPQAP PAGQPQGPPR PPQGGRPSRP PQ
Length:392
Mass (Da):38,546
Last modified:September 13, 2004 - v2
Checksum:iB3F4C5A01F335CB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18 – 33NLNED…PSLIA → SCVGFYSVFLFSLCPL in AAA36502 (PubMed:6089212).CuratedAdd BLAST16
Sequence conflicti40S → P in AAA36502 (PubMed:6089212).Curated1
Sequence conflicti85 – 86DK → GKR in AAA36502 (PubMed:6089212).Curated2
Sequence conflicti128K → R in CAA30395 (PubMed:2851479).Curated1
Sequence conflicti216 – 217PG → R in AAA36502 (PubMed:6089212).Curated2
Sequence conflicti271R → Q in AAB27288 (PubMed:8317492).Curated1
Sequence conflicti274Q → R in CAA30395 (PubMed:2851479).Curated1
Sequence conflicti278G → R in CAA30395 (PubMed:2851479).Curated1
Sequence conflicti307Q → T in AAA36503 (PubMed:6089212).Curated1
Sequence conflicti326A → P in AAB27289 (PubMed:8317492).Curated1
Sequence conflicti330S → C in AAA36503 (PubMed:6089212).Curated1
Sequence conflicti337A → S in AAA13341 (PubMed:8422499).Curated1
Sequence conflicti337A → S in CAA30395 (PubMed:2851479).Curated1
Sequence conflicti337A → S AA sequence (PubMed:6671974).Curated1
Sequence conflicti385 – 386GR → DK in AAA36503 (PubMed:6089212).Curated2

Polymorphismi

The number of repeats is polymorphic and varies among different alleles. The sequence shown is that of allele L (long). There are allele M (medium) and allele S (short) which contain 12 and 9 approximate tandem repeats repectively.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01969393 – 153Missing in allele M. Add BLAST61
Natural variantiVAR_005562106 – 319Missing .1 PublicationAdd BLAST214
Natural variantiVAR_005561106 – 299Missing .Add BLAST194
Natural variantiVAR_019694134 – 255Missing in allele S. Add BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03204 mRNA. Translation: AAA60185.1.
K03205 mRNA. Translation: AAA60186.1.
K03206 mRNA. Translation: AAA60187.1.
S52986 Genomic DNA. Translation: AAA13341.2.
M97220 Genomic DNA. Translation: AAB05816.1.
K02575 Genomic DNA. Translation: AAA36502.1.
K02576 Genomic DNA. Translation: AAA36503.1.
X07516 Genomic DNA. Translation: CAA30394.2.
X07517 Genomic DNA. Translation: CAA30395.2.
S62928 Genomic DNA. Translation: AAB27288.2.
S62941 Genomic DNA. Translation: AAB27289.1.
PIRiB40750. PIHUB6.
C38355.
D40750.
RefSeqiNP_005030.2. NM_005039.3.
NP_955385.1. NM_199353.2.
NP_955386.1. NM_199354.2.
UniGeneiHs.631726.

Genome annotation databases

GeneIDi5542.
KEGGihsa:5542.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03204 mRNA. Translation: AAA60185.1.
K03205 mRNA. Translation: AAA60186.1.
K03206 mRNA. Translation: AAA60187.1.
S52986 Genomic DNA. Translation: AAA13341.2.
M97220 Genomic DNA. Translation: AAB05816.1.
K02575 Genomic DNA. Translation: AAA36502.1.
K02576 Genomic DNA. Translation: AAA36503.1.
X07516 Genomic DNA. Translation: CAA30394.2.
X07517 Genomic DNA. Translation: CAA30395.2.
S62928 Genomic DNA. Translation: AAB27288.2.
S62941 Genomic DNA. Translation: AAB27289.1.
PIRiB40750. PIHUB6.
C38355.
D40750.
RefSeqiNP_005030.2. NM_005039.3.
NP_955385.1. NM_199353.2.
NP_955386.1. NM_199354.2.
UniGeneiHs.631726.

3D structure databases

ProteinModelPortaliP04280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111534. 4 interactors.

PTM databases

iPTMnetiP04280.
PhosphoSitePlusiP04280.

Polymorphism and mutation databases

BioMutaiPRB1.

Proteomic databases

PeptideAtlasiP04280.
PRIDEiP04280.
TopDownProteomicsiP04280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5542.
KEGGihsa:5542.

Organism-specific databases

CTDi5542.
DisGeNETi5542.
GeneCardsiPRB1.
HGNCiHGNC:9337. PRB1.
MIMi180989. gene.
neXtProtiNX_P04280.
PharmGKBiPA33699.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiP04280.
KOiK13911.

Enzyme and pathway databases

BioCyciZFISH:G66-32827-MONOMER.

Miscellaneous databases

GeneWikiiPRB1.
GenomeRNAii5542.
PROiP04280.
SOURCEiSearch...

Gene expression databases

CleanExiHS_PRB1.

Family and domain databases

InterProiIPR026086. Pro-rich.
[Graphical view]
PANTHERiPTHR23203. PTHR23203. 1 hit.
PfamiPF15240. Pro-rich. 3 hits.
[Graphical view]
SMARTiSM01412. Pro-rich. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRP1_HUMAN
AccessioniPrimary (citable) accession number: P04280
Secondary accession number(s): Q08805
, Q15186, Q15187, Q15214, Q15215, Q16038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.