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Protein

Semenogelin-1

Gene

SEMG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.1 Publication
Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.1 Publication

GO - Molecular functioni

GO - Biological processi

  • insemination Source: ProtInc
  • negative regulation of calcium ion import Source: CACAO
  • negative regulation of sperm motility Source: CACAO
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_75925. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Semenogelin-1
Alternative name(s):
Cancer/testis antigen 103
Semenogelin I
Short name:
SGI
Cleaved into the following 3 chains:
Gene namesi
Name:SEMG1
Synonyms:SEMG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:10742. SEMG1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
  • nucleus Source: UniProtKB
  • secretory granule Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi239 – 2391C → G: Abrogates binding to EPPIN and do not inhibit spem motility. 1 Publication

Organism-specific databases

PharmGKBiPA35664.

Polymorphism and mutation databases

BioMutaiSEMG1.
DMDMi134426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 462439Semenogelin-1PRO_0000032351Add
BLAST
Peptidei68 – 15992Alpha-inhibin-92PRO_0000032352Add
BLAST
Peptidei108 – 15952Seminal basic proteinPRO_0000032353Add
BLAST
Peptidei108 – 13831Alpha-inhibin-31PRO_0000032354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidCurated
Disulfide bondi239 – 239Interchain

Post-translational modificationi

Transglutaminase substrate.
Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa.

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP04279.
PaxDbiP04279.
PRIDEiP04279.

PTM databases

PhosphoSiteiP04279.

Miscellaneous databases

PMAP-CutDBP04279.

Expressioni

Tissue specificityi

Seminal vesicle.

Gene expression databases

BgeeiP04279.
CleanExiHS_SEMG1.
GenevisibleiP04279. HS.

Organism-specific databases

HPAiHPA042476.

Interactioni

Subunit structurei

Occurs in disulfide-linked complexes which may also contain two less abundant 71- and 76-kDa semenogelin-related polypeptides. Interacts with EPPIN (via C-terminus); Cys-239 is a critical amino acid for both binding to EPPIN.2 Publications

Protein-protein interaction databases

BioGridi112306. 18 interactions.
IntActiP04279. 3 interactions.
MINTiMINT-2862979.
STRINGi9606.ENSP00000361867.

Structurei

3D structure databases

ProteinModelPortaliP04279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati70 – 129603-1Add
BLAST
Repeati141 – 200602-1Add
BLAST
Repeati201 – 260602-2Add
BLAST
Repeati381 – 439593-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 439370Repeat-rich regionBy similarityAdd
BLAST
Regioni164 – 283120Interaction with EPPINAdd
BLAST
Regioni261 – 3801202 X 60 AA tandem repeats, type 1Add
BLAST

Sequence similaritiesi

Belongs to the semenogelin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG74001.
GeneTreeiENSGT00390000020321.
HOVERGENiHBG054194.
InParanoidiP04279.
OMAiFHVIVIH.
OrthoDBiEOG7J4469.
PhylomeDBiP04279.
TreeFamiTF342360.

Family and domain databases

InterProiIPR008836. Semenogelin.
[Graphical view]
PANTHERiPTHR10547. PTHR10547. 1 hit.
PfamiPF05474. Semenogelin. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P04279-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPNIIFVLS LLLILEKQAA VMGQKGGSKG RLPSEFSQFP HGQKGQHYSG
60 70 80 90 100
QKGKQQTESK GSFSIQYTYH VDANDHDQSR KSQQYDLNAL HKTTKSQRHL
110 120 130 140 150
GGSQQLLHNK QEGRDHDKSK GHFHRVVIHH KGGKAHRGTQ NPSQDQGNSP
160 170 180 190 200
SGKGISSQYS NTEERLWVHG LSKEQTSVSG AQKGRKQGGS QSSYVLQTEE
210 220 230 240 250
LVANKQQRET KNSHQNKGHY QNVVEVREEH SSKVQTSLCP AHQDKLQHGS
260 270 280 290 300
KDIFSTQDEL LVYNKNQHQT KNLNQDQQHG RKANKISYQS SSTEERRLHY
310 320 330 340 350
GENGVQKDVS QSSIYSQTEE KAQGKSQKQI TIPSQEQEHS QKANKISYQS
360 370 380 390 400
SSTEERRLHY GENGVQKDVS QRSIYSQTEK LVAGKSQIQA PNPKQEPWHG
410 420 430 440 450
ENAKGESGQS TNREQDLLSH EQKGRHQHGS HGGLDIVIIE QEDDSDRHLA
460
QHLNNDRNPL FT
Length:462
Mass (Da):52,131
Last modified:January 1, 1990 - v2
Checksum:i760F48EFCF2FA702
GO
Isoform 2 (identifier: P04279-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-371: Missing.

Note: No experimental confirmation available.
Show »
Length:402
Mass (Da):45,322
Checksum:i4D7F264E7C7FC15D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001L → Q in AAP82463 (PubMed:14629036).Curated
Sequence conflicti235 – 2373QTS → LRT in AAO20112 (PubMed:14562960).Curated
Sequence conflicti235 – 2373QTS → LRT in AAO20113 (PubMed:14562960).Curated
Sequence conflicti321 – 3211K → L AA sequence (PubMed:2757795).Curated
Sequence conflicti423 – 4231K → N in CAA87636 (PubMed:1517240).Curated
Sequence conflicti423 – 4231K → N in AAA18168 (PubMed:1517240).Curated
Sequence conflicti457 – 4571R → Q (Ref. 4) Curated
Sequence conflicti457 – 4571R → Q (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581E → G.
Corresponds to variant rs11559137 [ dbSNP | Ensembl ].
VAR_053650
Natural varianti79 – 791S → T Less common genetic variant. 2 Publications
Corresponds to variant rs2301366 [ dbSNP | Ensembl ].
VAR_005610
Natural varianti108 – 1081H → R.
Corresponds to variant rs2233884 [ dbSNP | Ensembl ].
VAR_053651
Natural varianti372 – 3721R → L.1 Publication
Corresponds to variant rs2233887 [ dbSNP | Ensembl ].
VAR_022679

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei312 – 37160Missing in isoform 2. 2 PublicationsVSP_004385Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04440 mRNA. Translation: AAB59506.1.
Z47556 Genomic DNA. Translation: CAA87636.1.
M81650 Genomic DNA. Translation: AAA18168.1.
AY256465 Genomic DNA. Translation: AAP82462.1.
AY256466 Genomic DNA. Translation: AAP82463.1.
AY256467 Genomic DNA. Translation: AAP82464.1.
AY256468 Genomic DNA. Translation: AAP82465.1.
AY256469 Genomic DNA. Translation: AAP82466.1.
BT007177 mRNA. Translation: AAP35841.1.
AL049767 Genomic DNA. Translation: CAB53523.1.
CH471077 Genomic DNA. Translation: EAW75871.1.
BC007096 mRNA. Translation: AAH07096.1.
BC055416 mRNA. Translation: AAH55416.1.
AY174423 Genomic DNA. Translation: AAO20112.1.
AY174424 Genomic DNA. Translation: AAO20113.1.
AY174437 Genomic DNA. Translation: AAO20126.1.
CCDSiCCDS13345.1. [P04279-1]
PIRiB43412. WTHUB.
RefSeqiNP_002998.1. NM_003007.3. [P04279-1]
UniGeneiHs.1968.

Genome annotation databases

EnsembliENST00000372781; ENSP00000361867; ENSG00000124233.
GeneIDi6406.
KEGGihsa:6406.
UCSCiuc002xni.2. human. [P04279-1]
uc002xnj.2. human. [P04279-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Shackled sperm - Issue 62 of September 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04440 mRNA. Translation: AAB59506.1.
Z47556 Genomic DNA. Translation: CAA87636.1.
M81650 Genomic DNA. Translation: AAA18168.1.
AY256465 Genomic DNA. Translation: AAP82462.1.
AY256466 Genomic DNA. Translation: AAP82463.1.
AY256467 Genomic DNA. Translation: AAP82464.1.
AY256468 Genomic DNA. Translation: AAP82465.1.
AY256469 Genomic DNA. Translation: AAP82466.1.
BT007177 mRNA. Translation: AAP35841.1.
AL049767 Genomic DNA. Translation: CAB53523.1.
CH471077 Genomic DNA. Translation: EAW75871.1.
BC007096 mRNA. Translation: AAH07096.1.
BC055416 mRNA. Translation: AAH55416.1.
AY174423 Genomic DNA. Translation: AAO20112.1.
AY174424 Genomic DNA. Translation: AAO20113.1.
AY174437 Genomic DNA. Translation: AAO20126.1.
CCDSiCCDS13345.1. [P04279-1]
PIRiB43412. WTHUB.
RefSeqiNP_002998.1. NM_003007.3. [P04279-1]
UniGeneiHs.1968.

3D structure databases

ProteinModelPortaliP04279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112306. 18 interactions.
IntActiP04279. 3 interactions.
MINTiMINT-2862979.
STRINGi9606.ENSP00000361867.

PTM databases

PhosphoSiteiP04279.

Polymorphism and mutation databases

BioMutaiSEMG1.
DMDMi134426.

Proteomic databases

MaxQBiP04279.
PaxDbiP04279.
PRIDEiP04279.

Protocols and materials databases

DNASUi6406.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372781; ENSP00000361867; ENSG00000124233.
GeneIDi6406.
KEGGihsa:6406.
UCSCiuc002xni.2. human. [P04279-1]
uc002xnj.2. human. [P04279-2]

Organism-specific databases

CTDi6406.
GeneCardsiGC20P043835.
HGNCiHGNC:10742. SEMG1.
HPAiHPA042476.
MIMi182140. gene.
neXtProtiNX_P04279.
PharmGKBiPA35664.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG74001.
GeneTreeiENSGT00390000020321.
HOVERGENiHBG054194.
InParanoidiP04279.
OMAiFHVIVIH.
OrthoDBiEOG7J4469.
PhylomeDBiP04279.
TreeFamiTF342360.

Enzyme and pathway databases

ReactomeiREACT_75925. Amyloids.

Miscellaneous databases

GeneWikiiSemenogelin_I.
GenomeRNAii6406.
NextBioi24890.
PMAP-CutDBP04279.
PROiP04279.
SOURCEiSearch...

Gene expression databases

BgeeiP04279.
CleanExiHS_SEMG1.
GenevisibleiP04279. HS.

Family and domain databases

InterProiIPR008836. Semenogelin.
[Graphical view]
PANTHERiPTHR10547. PTHR10547. 1 hit.
PfamiPF05474. Semenogelin. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa."
    Lilja H., Abrahamsson P.-A., Lundwall A.
    J. Biol. Chem. 264:1894-1900(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20."
    Ulvsbaeck M., Lazure C., Lilja H., Spurr N.K., Rao V.V., Loeffler C., Hansmann I., Lundwall A.
    J. Biol. Chem. 267:18080-18084(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  3. "Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen."
    Jensen-Seaman M.I., Li W.-H.
    J. Mol. Evol. 57:261-270(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-79 AND LEU-372.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Prostate.
  8. "Reduced polymorphism in the chimpanzee semen coagulating protein, semenogelin I."
    Kingan S.B., Tatar M., Rand D.M.
    J. Mol. Evol. 57:159-169(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 62-237 AND 241-449, VARIANT THR-79.
  9. "Amino acid sequence of the predominant basic protein in human seminal plasma."
    Lilja H., Jeppsson J.-O.
    FEBS Lett. 182:181-184(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 108-159.
  10. "Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity."
    Seidah N.G., Ramasharma K., Sairam M.R., Chretien M.
    FEBS Lett. 167:98-102(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 108-138.
  11. "Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity."
    Ramasharma K., Sairam M.R., Seidah N.G., Chretien M., Manjunath P., Schiller P.W., Yamashiro D., Li C.H.
    Science 223:1199-1202(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 108-138.
  12. "Isolation and structure determination of two peptides occurring in human seminal plasma."
    Schneider K., Kausler W., Tripier D., Jouvenal K., Spiteller G.
    Biol. Chem. Hoppe-Seyler 370:353-356(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 316-344.
  13. "Isolation and identification of N-terminally extended forms of 5-oxoprolylglutamylprolinamide (Glp-Glu-Pro-NH2), a thyrotropin-releasing-hormone (TRH)-like peptide present in human semen."
    Khan Z., Smyth D.G.
    Eur. J. Biochem. 212:35-40(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 373-397.
  14. "Human seminal alpha inhibins: isolation, characterization, and structure."
    Li C.H., Hammonds R.G., Ramasharma K., Chung D.
    Proc. Natl. Acad. Sci. U.S.A. 82:4041-4044(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 68-159.
  15. "Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein."
    Robert M., Gagnon C.
    Cell. Mol. Life Sci. 55:944-960(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  16. "Association of eppin with semenogelin on human spermatozoa."
    Wang Z., Widgren E.E., Sivashanmugam P., O'Rand M.G., Richardson R.T.
    Biol. Reprod. 72:1064-1070(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EPPIN.
  17. "Characterization of an eppin protein complex from human semen and spermatozoa."
    Wang Z., Widgren E.E., Richardson R.T., O'Rand M.G.
    Biol. Reprod. 77:476-484(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH LTF; CLU AND EPPIN.
  18. "Analysis of recombinant human semenogelin as an inhibitor of human sperm motility."
    Mitra A., Richardson R.T., O'Rand M.G.
    Biol. Reprod. 82:489-496(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF CYS-239.

Entry informationi

Entry nameiSEMG1_HUMAN
AccessioniPrimary (citable) accession number: P04279
Secondary accession number(s): Q53ZV0
, Q53ZV1, Q53ZV2, Q6X4I9, Q6Y809, Q6Y822, Q6Y823, Q86U64, Q96QM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 1, 1990
Last modified: July 22, 2015
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.