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Protein

Vitamin D-binding protein

Gene

Gc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.By similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • vitamin D binding Source: RGD
  • vitamin transmembrane transporter activity Source: InterPro

GO - Biological processi

  • female pregnancy Source: RGD
  • lactation Source: RGD
  • response to estradiol Source: RGD
  • response to nutrient levels Source: RGD
  • response to steroid hormone Source: RGD

Keywordsi

Molecular functionActin-binding
Biological processTransport
LigandVitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin D-binding protein
Short name:
DBP
Short name:
VDB
Alternative name(s):
Gc-globulin
Group-specific component
Gene namesi
Name:Gc
Synonyms:Dbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2667 Gc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2163

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000000110517 – 476Vitamin D-binding protein1 PublicationAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 75PROSITE-ProRule annotation
Disulfide bondi74 ↔ 83PROSITE-ProRule annotation
Disulfide bondi96 ↔ 112PROSITE-ProRule annotation
Disulfide bondi111 ↔ 122PROSITE-ProRule annotation
Disulfide bondi145 ↔ 190PROSITE-ProRule annotation
Disulfide bondi189 ↔ 198PROSITE-ProRule annotation
Disulfide bondi220 ↔ 266PROSITE-ProRule annotation
Disulfide bondi265 ↔ 273PROSITE-ProRule annotation
Disulfide bondi286 ↔ 300PROSITE-ProRule annotation
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi299 ↔ 311PROSITE-ProRule annotation
Disulfide bondi335 ↔ 376PROSITE-ProRule annotation
Disulfide bondi375 ↔ 384PROSITE-ProRule annotation
Disulfide bondi407 ↔ 453PROSITE-ProRule annotation
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei434PhosphoserineCombined sources1
Disulfide bondi452 ↔ 462PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP04276
PRIDEiP04276

PTM databases

iPTMnetiP04276

Interactioni

Subunit structurei

Associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Interacts with LRP2; the interaction is required for renal uptake of GC in complex with 25-hydroxyvitamin D3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004174

Chemistry databases

BindingDBiP04276

Structurei

3D structure databases

ProteinModelPortaliP04276
SMRiP04276
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 208Albumin 1PROSITE-ProRule annotationAdd BLAST192
Domaini209 – 394Albumin 2PROSITE-ProRule annotationAdd BLAST186
Domaini395 – 476Albumin 3PROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410II89 Eukaryota
ENOG4111PH6 LUCA
HOGENOMiHOG000140946
HOVERGENiHBG009729
InParanoidiP04276
PhylomeDBiP04276

Family and domain databases

CDDicd00015 ALBUMIN, 1 hit
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
IPR000213 VitD-bd
IPR015247 VitD-bind_III
PANTHERiPTHR11385 PTHR11385, 1 hit
PTHR11385:SF11 PTHR11385:SF11, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 2 hits
PF09164 VitD-bind_III, 1 hit
PRINTSiPR00802 SERUMALBUMIN
PR00804 VITAMNDBNDNG
SMARTiView protein in SMART
SM00103 ALBUMIN, 2 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 1 hit
PS51438 ALBUMIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRVLVLLLA LAFGHALERG RDYEKDKVCQ ELSTLGKDDF RSLSLILYSR
60 70 80 90 100
KFPSSTFEQV SQLVKEVVSL TEECCAEGAD PNCYDTRTSE LSIKSCESDA
110 120 130 140 150
PFPVHPGTSE CCTKEGLERK LCMAALSHQP QEFPAYVEPT NDEICEAFRK
160 170 180 190 200
DPKGFADQFL FEYSSNYGQA PLPLLVGYTK SYLSMVGSCC TSAKPTVCFL
210 220 230 240 250
KERLQMKQLL LLTTMSNRVC SQYAAYGKEK SRMSHLIKLA QKVPTANLED
260 270 280 290 300
VLPLAEDLTE ILSRCCKSTS EDCMARELPE HTLKICGNLS KKNSKFEECC
310 320 330 340 350
YETTPMGIFM CSYFMPTAEP LQLPAIKLPT SKDLCGQSAT QAMDQYTFEL
360 370 380 390 400
SRRTQVPEVF LSKVLDTTLK TLRECCDTQD SVSCFSTQSP LMKRQLTSFI
410 420 430 440 450
EKGQEMCADY SENTFTEYKK KLAERLRTKM PNASPEELAD MVAKHSDFAS
460 470
KCCSINSPPR YCSSQIDAEM RDILQS
Length:476
Mass (Da):53,544
Last modified:May 1, 1992 - v3
Checksum:iD3C7729BC44E221E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132E → Q in AAA41082 (PubMed:2480956).Curated1
Sequence conflicti174L → P in AAA41080 (PubMed:2419332).Curated1
Sequence conflicti210L → S in AAA41082 (PubMed:2480956).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12450 mRNA Translation: AAA41080.1
J05148 mRNA Translation: AAA41082.1
M60205
, M60197, M60198, M60199, M60200, M60201, M60202, M60203, M60204 Genomic DNA Translation: AAA41081.1
PIRiA38726 VYRTD
UniGeneiRn.1437

Genome annotation databases

UCSCiRGD:2667 rat

Similar proteinsi

Entry informationi

Entry nameiVTDB_RAT
AccessioniPrimary (citable) accession number: P04276
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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