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P04272 (ANXA2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Annexin A2
Alternative name(s):
Annexin II
Annexin-2
Calpactin I heavy chain
Calpactin-1 heavy chain
Chromobindin-8
Lipocortin II
Placental anticoagulant protein IV
Short name=PAP-IV
Protein I
p36
Gene names
Name:ANXA2
Synonyms:ANX2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

Subunit structure

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF By similarity. Interacts with COCH By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrixbasement membrane. Melanosome By similarity. Note: In the lamina beneath the plasma membrane.

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Post-translational modification

ISGylated By similarity.

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Sequence similarities

Belongs to the annexin family.

Contains 4 annexin repeats.

Ontologies

Keywords
   Cellular componentBasement membrane
Extracellular matrix
Secreted
   DomainAnnexin
Repeat
   LigandCalcium
Calcium/phospholipid-binding
   PTMAcetylation
Phosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from electronic annotation. Source: Ensembl

biomineral tissue development

Inferred from direct assay PubMed 18597635. Source: AgBase

calcium ion import

Inferred from mutant phenotype PubMed 18597635. Source: AgBase

cellular response to acid

Inferred from electronic annotation. Source: Ensembl

collagen fibril organization

Inferred from electronic annotation. Source: Ensembl

fibrinolysis

Inferred from electronic annotation. Source: Ensembl

positive regulation of binding

Inferred from electronic annotation. Source: Ensembl

positive regulation of vesicle fusion

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentSchmidt-Lanterman incisure

Inferred from electronic annotation. Source: Ensembl

basement membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

early endosome

Inferred from electronic annotation. Source: Ensembl

extracellular membrane-bounded organelle

Inferred from direct assay PubMed 18597635. Source: AgBase

extracellular vesicular exosome

Inferred from electronic annotation. Source: Ensembl

extrinsic component of plasma membrane

Inferred from electronic annotation. Source: Ensembl

intracellular membrane-bounded organelle

Inferred from direct assay PubMed 18597635. Source: AgBase

lipid particle

Inferred from electronic annotation. Source: Ensembl

melanosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane-bounded vesicle

Inferred from direct assay PubMed 18597635. Source: AgBase

midbody

Inferred from electronic annotation. Source: Ensembl

myelin sheath adaxonal region

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement PubMed 18597635. Source: AgBase

sarcolemma

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncalcium channel activity

Inferred from mutant phenotype PubMed 18597635. Source: AgBase

calcium ion binding

Inferred from electronic annotation. Source: InterPro

calcium-dependent phospholipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycoprotein binding

Traceable author statement PubMed 18597635. Source: AgBase

phospholipase inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 339338Annexin A2
PRO_0000067469

Regions

Repeat42 – 10261Annexin 1
Repeat114 – 17461Annexin 2
Repeat199 – 25961Annexin 3
Repeat274 – 33461Annexin 4
Region2 – 2423S100A10-binding site Potential

Amino acid modifications

Modified residue21N-acetylserine Ref.4
Modified residue241Phosphotyrosine; by SRC By similarity
Modified residue261Phosphoserine; by PKC By similarity
Modified residue491N6-acetyllysine By similarity
Modified residue1521N6-acetyllysine By similarity
Modified residue1991Phosphotyrosine By similarity
Modified residue2271N6-acetyllysine By similarity

Experimental info

Sequence conflict1491E → G in AAI02517. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P04272 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: AA8E2500F4138B3D

FASTA33938,612
        10         20         30         40         50         60 
MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG VDEVTIVNIL 

        70         80         90        100        110        120 
TNRSNEQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG 

       130        140        150        160        170        180 
LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDIV SDTSGDFRKL MVALAKGRRA 

       190        200        210        220        230        240 
EDGSVIDYEL IDQDARDLYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM 

       250        260        270        280        290        300 
LESIKKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 

       310        320        330 
LKIRSEFKKK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure of bovine calpactin I heavy chain (p36), a major cellular substrate for retroviral protein-tyrosine kinases: homology with the human phospholipase A2 inhibitor lipocortin."
Kristensen T., Saris C.J.M., Hunter T., Hicks L.J., Noonan D.J., Glenney J.R. Jr., Tack B.F.
Biochemistry 25:4497-4503(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[2]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.
[4]"Association of the S-100-related calpactin I light chain with the NH2-terminal tail of the 36-kDa heavy chain."
Glenney J.R. Jr., Boudreau M., Galyean R., Hunter T., Tack B.
J. Biol. Chem. 261:10485-10488(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION AT SER-2.

Web resources

Protein Spotlight

Red velvet - Issue 86 of September 2007

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M14056 mRNA. Translation: AAA30421.1.
BT021010 mRNA. Translation: AAX09027.1.
BC102516 mRNA. Translation: AAI02517.1.
PIRLUBO36. A03081.
RefSeqNP_777141.1. NM_174716.1.
UniGeneBt.4314.

3D structure databases

ProteinModelPortalP04272.
SMRP04272. Positions 21-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP04272. 1 interaction.

Proteomic databases

PaxDbP04272.
PRIDEP04272.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000012655; ENSBTAP00000012655; ENSBTAG00000009615.
GeneID282689.
KEGGbta:282689.

Organism-specific databases

CTD302.

Phylogenomic databases

eggNOGNOG259189.
GeneTreeENSGT00680000099735.
HOGENOMHOG000158803.
HOVERGENHBG061815.
InParanoidP04272.
KOK17092.
OMAFIQQDTK.
OrthoDBEOG74XS72.
TreeFamTF105452.

Family and domain databases

Gene3D1.10.220.10. 4 hits.
InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTSM00335. ANX. 4 hits.
[Graphical view]
PROSITEPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806357.

Entry information

Entry nameANXA2_BOVIN
AccessionPrimary (citable) accession number: P04272
Secondary accession number(s): Q3ZCC7, Q5E9B0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries