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P04272

- ANXA2_BOVIN

UniProt

P04272 - ANXA2_BOVIN

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Protein

Annexin A2

Gene

ANXA2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

GO - Molecular functioni

  1. calcium channel activity Source: AgBase
  2. calcium-dependent phospholipid binding Source: UniProtKB-KW
  3. calcium ion binding Source: InterPro
  4. glycoprotein binding Source: AgBase
  5. phospholipase A2 inhibitor activity Source: Ensembl
  6. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. biomineral tissue development Source: AgBase
  3. calcium ion import Source: AgBase
  4. calcium ion transmembrane transport Source: GOC
  5. cellular response to acid chemical Source: Ensembl
  6. collagen fibril organization Source: Ensembl
  7. fibrinolysis Source: Ensembl
  8. membrane budding Source: Ensembl
  9. membrane raft assembly Source: Ensembl
  10. osteoclast development Source: Ensembl
  11. positive regulation of binding Source: Ensembl
  12. positive regulation of vesicle fusion Source: Ensembl
  13. protein heterotetramerization Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A2
Alternative name(s):
Annexin II
Annexin-2
Calpactin I heavy chain
Calpactin-1 heavy chain
Chromobindin-8
Lipocortin II
Placental anticoagulant protein IV
Short name:
PAP-IV
Protein I
p36
Gene namesi
Name:ANXA2
Synonyms:ANX2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 10

Subcellular locationi

Secretedextracellular spaceextracellular matrixbasement membrane. Melanosome By similarity
Note: In the lamina beneath the plasma membrane.

GO - Cellular componenti

  1. basement membrane Source: UniProtKB-KW
  2. cell surface Source: Ensembl
  3. early endosome Source: Ensembl
  4. extracellular membrane-bounded organelle Source: AgBase
  5. extracellular space Source: Ensembl
  6. extracellular vesicular exosome Source: Ensembl
  7. extrinsic component of plasma membrane Source: Ensembl
  8. intracellular membrane-bounded organelle Source: AgBase
  9. late endosome membrane Source: Ensembl
  10. lipid particle Source: Ensembl
  11. lysosomal membrane Source: Ensembl
  12. membrane-bounded vesicle Source: AgBase
  13. membrane raft Source: Ensembl
  14. midbody Source: Ensembl
  15. myelin sheath adaxonal region Source: Ensembl
  16. nucleus Source: Ensembl
  17. plasma membrane Source: AgBase
  18. sarcolemma Source: Ensembl
  19. Schmidt-Lanterman incisure Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 339338Annexin A2PRO_0000067469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei24 – 241Phosphotyrosine; by SRCBy similarity
Modified residuei26 – 261Phosphoserine; by PKCBy similarity
Modified residuei49 – 491N6-acetyllysineBy similarity
Modified residuei152 – 1521N6-acetyllysineBy similarity
Modified residuei199 – 1991PhosphotyrosineBy similarity
Modified residuei227 – 2271N6-acetyllysineBy similarity

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP04272.
PRIDEiP04272.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF (By similarity). Interacts with COCH (By similarity).By similarity

Protein-protein interaction databases

IntActiP04272. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP04272.
SMRiP04272. Positions 21-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 10261Annexin 1Add
BLAST
Repeati114 – 17461Annexin 2Add
BLAST
Repeati199 – 25961Annexin 3Add
BLAST
Repeati274 – 33461Annexin 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 2423S100A10-binding siteSequence AnalysisAdd
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG259189.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP04272.
KOiK17092.
OMAiFIQQDTK.
OrthoDBiEOG74XS72.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04272 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG
60 70 80 90 100
VDEVTIVNIL TNRSNEQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL
110 120 130 140 150
GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM
160 170 180 190 200
YKTDLEKDIV SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD
210 220 230 240 250
AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG
260 270 280 290 300
DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM
310 320 330
LKIRSEFKKK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD
Length:339
Mass (Da):38,612
Last modified:January 23, 2007 - v2
Checksum:iAA8E2500F4138B3D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491E → G in AAI02517. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14056 mRNA. Translation: AAA30421.1.
BT021010 mRNA. Translation: AAX09027.1.
BC102516 mRNA. Translation: AAI02517.1.
PIRiA03081. LUBO36.
RefSeqiNP_777141.1. NM_174716.1.
UniGeneiBt.4314.

Genome annotation databases

EnsembliENSBTAT00000012655; ENSBTAP00000012655; ENSBTAG00000009615.
GeneIDi282689.
KEGGibta:282689.

Cross-referencesi

Web resourcesi

Protein Spotlight

Red velvet - Issue 86 of September 2007

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14056 mRNA. Translation: AAA30421.1 .
BT021010 mRNA. Translation: AAX09027.1 .
BC102516 mRNA. Translation: AAI02517.1 .
PIRi A03081. LUBO36.
RefSeqi NP_777141.1. NM_174716.1.
UniGenei Bt.4314.

3D structure databases

ProteinModelPortali P04272.
SMRi P04272. Positions 21-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P04272. 1 interaction.

Proteomic databases

PaxDbi P04272.
PRIDEi P04272.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000012655 ; ENSBTAP00000012655 ; ENSBTAG00000009615 .
GeneIDi 282689.
KEGGi bta:282689.

Organism-specific databases

CTDi 302.

Phylogenomic databases

eggNOGi NOG259189.
GeneTreei ENSGT00760000118972.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi P04272.
KOi K17092.
OMAi FIQQDTK.
OrthoDBi EOG74XS72.
TreeFami TF105452.

Miscellaneous databases

NextBioi 20806357.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view ]
PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of bovine calpactin I heavy chain (p36), a major cellular substrate for retroviral protein-tyrosine kinases: homology with the human phospholipase A2 inhibitor lipocortin."
    Kristensen T., Saris C.J.M., Hunter T., Hicks L.J., Noonan D.J., Glenney J.R. Jr., Tack B.F.
    Biochemistry 25:4497-4503(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  4. "Association of the S-100-related calpactin I light chain with the NH2-terminal tail of the 36-kDa heavy chain."
    Glenney J.R. Jr., Boudreau M., Galyean R., Hunter T., Tack B.
    J. Biol. Chem. 261:10485-10488(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION AT SER-2.

Entry informationi

Entry nameiANXA2_BOVIN
AccessioniPrimary (citable) accession number: P04272
Secondary accession number(s): Q3ZCC7, Q5E9B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1986
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3