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P04272

- ANXA2_BOVIN

UniProt

P04272 - ANXA2_BOVIN

Protein

Annexin A2

Gene

ANXA2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

    GO - Molecular functioni

    1. calcium channel activity Source: AgBase
    2. calcium-dependent phospholipid binding Source: UniProtKB-KW
    3. calcium ion binding Source: InterPro
    4. glycoprotein binding Source: AgBase
    5. phospholipase inhibitor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. biomineral tissue development Source: AgBase
    3. calcium ion import Source: AgBase
    4. calcium ion transmembrane transport Source: GOC
    5. cellular response to acid chemical Source: Ensembl
    6. collagen fibril organization Source: Ensembl
    7. fibrinolysis Source: Ensembl
    8. positive regulation of binding Source: Ensembl
    9. positive regulation of vesicle fusion Source: Ensembl

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A2
    Alternative name(s):
    Annexin II
    Annexin-2
    Calpactin I heavy chain
    Calpactin-1 heavy chain
    Chromobindin-8
    Lipocortin II
    Placental anticoagulant protein IV
    Short name:
    PAP-IV
    Protein I
    p36
    Gene namesi
    Name:ANXA2
    Synonyms:ANX2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 10

    Subcellular locationi

    Secretedextracellular spaceextracellular matrixbasement membrane. Melanosome By similarity
    Note: In the lamina beneath the plasma membrane.

    GO - Cellular componenti

    1. basement membrane Source: UniProtKB-SubCell
    2. early endosome Source: Ensembl
    3. extracellular membrane-bounded organelle Source: AgBase
    4. extracellular vesicular exosome Source: Ensembl
    5. extrinsic component of plasma membrane Source: Ensembl
    6. intracellular membrane-bounded organelle Source: AgBase
    7. lipid particle Source: Ensembl
    8. melanosome Source: UniProtKB-SubCell
    9. membrane-bounded vesicle Source: AgBase
    10. midbody Source: Ensembl
    11. myelin sheath adaxonal region Source: Ensembl
    12. plasma membrane Source: AgBase
    13. sarcolemma Source: Ensembl
    14. Schmidt-Lanterman incisure Source: Ensembl

    Keywords - Cellular componenti

    Basement membrane, Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 339338Annexin A2PRO_0000067469Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei24 – 241Phosphotyrosine; by SRCBy similarity
    Modified residuei26 – 261Phosphoserine; by PKCBy similarity
    Modified residuei49 – 491N6-acetyllysineBy similarity
    Modified residuei152 – 1521N6-acetyllysineBy similarity
    Modified residuei199 – 1991PhosphotyrosineBy similarity
    Modified residuei227 – 2271N6-acetyllysineBy similarity

    Post-translational modificationi

    ISGylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP04272.
    PRIDEiP04272.

    Interactioni

    Subunit structurei

    Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF By similarity. Interacts with COCH By similarity.By similarity

    Protein-protein interaction databases

    IntActiP04272. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP04272.
    SMRiP04272. Positions 21-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 10261Annexin 1Add
    BLAST
    Repeati114 – 17461Annexin 2Add
    BLAST
    Repeati199 – 25961Annexin 3Add
    BLAST
    Repeati274 – 33461Annexin 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 2423S100A10-binding siteSequence AnalysisAdd
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG259189.
    GeneTreeiENSGT00680000099735.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    InParanoidiP04272.
    KOiK17092.
    OMAiFIQQDTK.
    OrthoDBiEOG74XS72.
    TreeFamiTF105452.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view]
    PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04272-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG    50
    VDEVTIVNIL TNRSNEQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL 100
    GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM 150
    YKTDLEKDIV SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD 200
    AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG 250
    DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 300
    LKIRSEFKKK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 339
    Length:339
    Mass (Da):38,612
    Last modified:January 23, 2007 - v2
    Checksum:iAA8E2500F4138B3D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti149 – 1491E → G in AAI02517. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14056 mRNA. Translation: AAA30421.1.
    BT021010 mRNA. Translation: AAX09027.1.
    BC102516 mRNA. Translation: AAI02517.1.
    PIRiA03081. LUBO36.
    RefSeqiNP_777141.1. NM_174716.1.
    UniGeneiBt.4314.

    Genome annotation databases

    EnsembliENSBTAT00000012655; ENSBTAP00000012655; ENSBTAG00000009615.
    GeneIDi282689.
    KEGGibta:282689.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Red velvet - Issue 86 of September 2007

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14056 mRNA. Translation: AAA30421.1 .
    BT021010 mRNA. Translation: AAX09027.1 .
    BC102516 mRNA. Translation: AAI02517.1 .
    PIRi A03081. LUBO36.
    RefSeqi NP_777141.1. NM_174716.1.
    UniGenei Bt.4314.

    3D structure databases

    ProteinModelPortali P04272.
    SMRi P04272. Positions 21-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P04272. 1 interaction.

    Proteomic databases

    PaxDbi P04272.
    PRIDEi P04272.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000012655 ; ENSBTAP00000012655 ; ENSBTAG00000009615 .
    GeneIDi 282689.
    KEGGi bta:282689.

    Organism-specific databases

    CTDi 302.

    Phylogenomic databases

    eggNOGi NOG259189.
    GeneTreei ENSGT00680000099735.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    InParanoidi P04272.
    KOi K17092.
    OMAi FIQQDTK.
    OrthoDBi EOG74XS72.
    TreeFami TF105452.

    Miscellaneous databases

    NextBioi 20806357.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view ]
    PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of bovine calpactin I heavy chain (p36), a major cellular substrate for retroviral protein-tyrosine kinases: homology with the human phospholipase A2 inhibitor lipocortin."
      Kristensen T., Saris C.J.M., Hunter T., Hicks L.J., Noonan D.J., Glenney J.R. Jr., Tack B.F.
      Biochemistry 25:4497-4503(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.
    4. "Association of the S-100-related calpactin I light chain with the NH2-terminal tail of the 36-kDa heavy chain."
      Glenney J.R. Jr., Boudreau M., Galyean R., Hunter T., Tack B.
      J. Biol. Chem. 261:10485-10488(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION AT SER-2.

    Entry informationi

    Entry nameiANXA2_BOVIN
    AccessioniPrimary (citable) accession number: P04272
    Secondary accession number(s): Q3ZCC7, Q5E9B0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3