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Protein

Keratin, type II cytoskeletal 6B

Gene

KRT6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei414Stutter1

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  • ectoderm development Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 6B
Alternative name(s):
Cytokeratin-6B
Short name:
CK-6B
Keratin-6B
Short name:
K6B
Type-II keratin Kb10
Gene namesi
Name:KRT6B
Synonyms:K6B, KRTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6444. KRT6B.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • keratin filament Source: InterPro

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Involvement in diseasei

Pachyonychia congenita 4 (PC4)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant genodermatosis characterized by hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts.
See also OMIM:615728
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023062472E → K in PC4. 3 PublicationsCorresponds to variant dbSNP:rs60627726Ensembl.1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia, Palmoplantar keratoderma

Organism-specific databases

DisGeNETi3854.
MalaCardsiKRT6B.
MIMi615728. phenotype.
OpenTargetsiENSG00000185479.
Orphaneti2309. Pachyonychia congenita.
PharmGKBiPA30232.

Protein family/group databases

Allergomei415. Hom s 5.

Polymorphism and mutation databases

BioMutaiKRT6B.
DMDMi238054404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000637322 – 564Keratin, type II cytoskeletal 6BAdd BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei60PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP04259.
PaxDbiP04259.
PeptideAtlasiP04259.
PRIDEiP04259.
TopDownProteomicsiP04259.

PTM databases

iPTMnetiP04259.
PhosphoSitePlusiP04259.
SwissPalmiP04259.

Expressioni

Tissue specificityi

Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.

Gene expression databases

BgeeiENSG00000185479.
CleanExiHS_KRT6B.
GenevisibleiP04259. HS.

Organism-specific databases

HPAiCAB000130.
HPA045697.
HPA061168.

Interactioni

Subunit structurei

Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110052. 34 interactors.
IntActiP04259. 25 interactors.
MINTiMINT-1456452.
STRINGi9606.ENSP00000252252.

Structurei

3D structure databases

ProteinModelPortaliP04259.
SMRiP04259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 162HeadAdd BLAST161
Regioni163 – 472RodAdd BLAST310
Regioni163 – 198Coil 1AAdd BLAST36
Regioni199 – 217Linker 1Add BLAST19
Regioni218 – 309Coil 1BAdd BLAST92
Regioni310 – 333Linker 12Add BLAST24
Regioni334 – 472Coil 2Add BLAST139
Regioni473 – 564TailAdd BLAST92

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiP04259.
KOiK07605.
OMAiFASFREC.
OrthoDBiEOG090B0872.
PhylomeDBiP04259.
TreeFamiTF317854.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
PRINTSiPR01276. TYPE2KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04259-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSISVSR SRGSGGLGGA
60 70 80 90 100
CGGAGFGSRS LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF
110 120 130 140 150
GFGGGAGIGF GLGGGAGLAG GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL
160 170 180 190 200
QIDPAIQRVR AEEREQIKTL NNKFASFIDK VRFLEQQNKV LDTKWTLLQE
210 220 230 240 250
QGTKTVRQNL EPLFEQYINN LRRQLDNIVG ERGRLDSELR NMQDLVEDLK
260 270 280 290 300
NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA
310 320 330 340 350
LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA
360 370 380 390 400
EAESWYQTKY EELQITAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK
410 420 430 440 450
QCANLQAAIA DAEQRGEMAL KDAKNKLEGL EDALQKAKQD LARLLKEYQE
460 470 480 490 500
LMNVKLALDV EIATYRKLLE GEECRLNGEG VGQVNISVVQ STVSSGYGGA
510 520 530 540 550
SGVGSGLGLG GGSSYSYGSG LGVGGGFSSS SGRATGGGLS SVGGGSSTIK
560
YTTTSSSSRK SYKH
Length:564
Mass (Da):60,067
Last modified:May 26, 2009 - v5
Checksum:iFFA4C351FBF09F09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89 – 90GS → AG in AAA59466 (PubMed:2410904).Curated2
Sequence conflicti116 – 117AG → PA in AAA59466 (PubMed:2410904).Curated2
Sequence conflicti119 – 121AGG → LC in AAA59466 (PubMed:2410904).Curated3
Sequence conflicti159 – 160VR → IG in AAA59466 (PubMed:2410904).Curated2
Sequence conflicti255D → V in AAA59466 (PubMed:2410904).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02126521N → S2 PublicationsCorresponds to variant dbSNP:rs428894Ensembl.1
Natural variantiVAR_021266227N → S2 PublicationsCorresponds to variant dbSNP:rs652423Ensembl.1
Natural variantiVAR_021267365I → V2 PublicationsCorresponds to variant dbSNP:rs437014Ensembl.1
Natural variantiVAR_023062472E → K in PC4. 3 PublicationsCorresponds to variant dbSNP:rs60627726Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42592
, L42584, L42585, L42586, L42587, L42588, L42589, L42590 Genomic DNA. Translation: AAC41768.1.
L42612 mRNA. Translation: AAC41771.1.
L00205
, M11229, L00198, L00199, L00200, L00201, L00202, L00203, L00204 Genomic DNA. Translation: AAA59466.1.
AC055736 Genomic DNA. No translation available.
BC034535 mRNA. Translation: AAH34535.1.
CCDSiCCDS8828.1.
PIRiI61767. KRHUEB.
I61771.
RefSeqiNP_005546.2. NM_005555.3.
UniGeneiHs.708950.

Genome annotation databases

EnsembliENST00000252252; ENSP00000252252; ENSG00000185479.
GeneIDi3854.
KEGGihsa:3854.
UCSCiuc001sak.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42592
, L42584, L42585, L42586, L42587, L42588, L42589, L42590 Genomic DNA. Translation: AAC41768.1.
L42612 mRNA. Translation: AAC41771.1.
L00205
, M11229, L00198, L00199, L00200, L00201, L00202, L00203, L00204 Genomic DNA. Translation: AAA59466.1.
AC055736 Genomic DNA. No translation available.
BC034535 mRNA. Translation: AAH34535.1.
CCDSiCCDS8828.1.
PIRiI61767. KRHUEB.
I61771.
RefSeqiNP_005546.2. NM_005555.3.
UniGeneiHs.708950.

3D structure databases

ProteinModelPortaliP04259.
SMRiP04259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110052. 34 interactors.
IntActiP04259. 25 interactors.
MINTiMINT-1456452.
STRINGi9606.ENSP00000252252.

Protein family/group databases

Allergomei415. Hom s 5.

PTM databases

iPTMnetiP04259.
PhosphoSitePlusiP04259.
SwissPalmiP04259.

Polymorphism and mutation databases

BioMutaiKRT6B.
DMDMi238054404.

Proteomic databases

EPDiP04259.
PaxDbiP04259.
PeptideAtlasiP04259.
PRIDEiP04259.
TopDownProteomicsiP04259.

Protocols and materials databases

DNASUi3854.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252252; ENSP00000252252; ENSG00000185479.
GeneIDi3854.
KEGGihsa:3854.
UCSCiuc001sak.3. human.

Organism-specific databases

CTDi3854.
DisGeNETi3854.
GeneCardsiKRT6B.
GeneReviewsiKRT6B.
HGNCiHGNC:6444. KRT6B.
HPAiCAB000130.
HPA045697.
HPA061168.
MalaCardsiKRT6B.
MIMi148042. gene.
615728. phenotype.
neXtProtiNX_P04259.
OpenTargetsiENSG00000185479.
Orphaneti2309. Pachyonychia congenita.
PharmGKBiPA30232.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiP04259.
KOiK07605.
OMAiFASFREC.
OrthoDBiEOG090B0872.
PhylomeDBiP04259.
TreeFamiTF317854.

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GenomeRNAii3854.
PROiP04259.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185479.
CleanExiHS_KRT6B.
GenevisibleiP04259. HS.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
PRINTSiPR01276. TYPE2KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS00226. IF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiK2C6B_HUMAN
AccessioniPrimary (citable) accession number: P04259
Secondary accession number(s): P48669
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: May 26, 2009
Last modified: February 15, 2017
This is version 170 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are at least six isoforms of human type II keratin-6 (K6).
There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.