P04258 (CO3A1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-1(III) chain

Gene names

Name:

COL3A1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	1049 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Collagen type III occurs in most soft connective tissues along with type I collagen.
Subunit structure	Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Post-translational modification	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Sequence similarities	Belongs to the fibrillar collagen family.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Collagen Repeat
PTM	Disulfide bond Glycoprotein Hydroxylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW extracellular region Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1049	1049	Collagen alpha-1(III) chain		PRO_0000059398
Regions
	Region	1 – 14	14	Nonhelical region (N-terminal)
	Region	15 – 1040	1026	Triple-helical region
	Region	1041 – 1049	9	Nonhelical region (C-terminal)
Amino acid modifications
	Modified residue	95	1	5-hydroxylysine Ref.1 Ref.6
	Modified residue	107	1	5-hydroxylysine Ref.1 Ref.6
	Modified residue	119	1	5-hydroxylysine Ref.1 Ref.6
	Modified residue	938	1	5-hydroxylysine Ref.1 Ref.6
	Modified residue	950	1	5-hydroxylysine Ref.1 Ref.6
	Glycosylation	107	1	O-linked (Gal...) Ref.1
	Glycosylation	950	1	O-linked (Gal...)
	Disulfide bond	1040		Interchain
	Disulfide bond	1041		Interchain

Sequences

	Sequence		Length	Mass (Da)
	P04258 [UniParc]. Last modified March 20, 1987. Version 1. Checksum: 8EEC33D1C66EC9A3	FASTA	1,049	93,651
	10 20 30 40 50 60 EYEAYDVKSG VAGGGIAGYP GPAGPPGPPG PPGTSGHPGA PGAPGYQGPP GEPGQAGPAG 70 80 90 100 110 120 PPGPPGAIGP SGKDGESGRP GRPGPRGFPG PPGMKGPAGM PGFPGMKGHR GFDGRNGEKG 130 140 150 160 170 180 EPGAPGLKGE NGVPGEDGAP GPMGPRGAPG ERGRPGLPGA AGARGNDGAR GSDGQPGPPG 190 200 210 220 230 240 PPGTAGFPGS PGAKGEVGPA GSPGSSGAPG QRGEPGPQGH AGAPGPPGPP GSDGSPGGKG 250 260 270 280 290 300 EMGPAGIPGA PGLIGARGPP GPPGTNGVPG QRGAAGEPGK NGAKGDPGPR GERGEAGSPG 310 320 330 340 350 360 IAGPKGEDGK DGSPGEPGAN GLPGAAGERG VPGFRGPAGA NGLPGEKGPP GDRGGPGPAG 370 380 390 400 410 420 PRGVAGEPGR NGLPGGPGLR GIPGSPGGPG SNGKPGPPGS QGETGRPGPP GSPGPRGQPG 430 440 450 460 470 480 VMGFPGPKGN DGAPGKNGER GGPGGPGPQG PAGKNGETGP QGPPGPTGPS GDKGDTGPPG 490 500 510 520 530 540 PQGLQGLPGT SGPPGENGKP GEPGPKGEAG APGIPGGKGD SGAPGERGPP GAGGPPGPRG 550 560 570 580 590 600 GAGPPGPEGG KGAAGPPGPP GSAGTPGLQG MPGERGGPGG PGPKGDKGEP GSSGVDGAPG 610 620 630 640 650 660 KDGPRGPTGP IGPPGPAGQP GDKGESGAPG VPGIAGPRGG PGERGEQGPP GPAGFPGAPG 670 680 690 700 710 720 QNGEPGAKGE RGAPGEKGEG GPPGAAGPAG GSGPAGPPGP QGVKGERGSP GGPGAAGFPG 730 740 750 760 770 780 GRGPPGPPGS NGNPGPPGSS GAPGKDGPPG PPGSNGAPGS PGISGPKGDS GPPGERGAPG 790 800 810 820 830 840 PQGPPGAPGP LGIAGLTGAR GLAGPPGMPG ARGSPGPQGI KGENGKPGPS GQNGERGPPG 850 860 870 880 890 900 PQGLPGLAGT AGEPGRDGNP GSDGLPGRDG APGAKGDRGE NGSPGAPGAP GHPGPPGPVG 910 920 930 940 950 960 PAGKSGDRGE TGPAGPSGAP GPAGSRGPPG PQGPRGDKGE TGERGAMGIK GHRGFPGNPG 970 980 990 1000 1010 1020 APGSPGPAGH QGAVGSPGPA GPRGPVGPSG PPGKDGASGH PGPIGPPGPR GNRGERGSEG 1030 1040 SPGHPGQPGP PGPPGAPGPC CGAGGVAAI

References

[1]	"The covalent structure of calf skin type III collagen. I. The amino acid sequence of the amino terminal region of the alpha 1(III) chain (positions 1-222)." Fietzek P.P., Allmann H., Rauterberg J., Henkel W., Wachter E., Kuhn K. Hoppe-Seyler's Z. Physiol. Chem. 360:809-820(1979) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-242.
[2]	"The covalent structure of calf skin type III collagen. II. The amino acid sequence of the cyanogen bromide peptide alpha 1(III)CB1,8,10,2 (positions 223-402)." Dewes H., Fietzek P.P., Kuhn K. Hoppe-Seyler's Z. Physiol. Chem. 360:821-832(1979) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 243-422.
[3]	"The covalent structure of calf skin type III collagen. III. The amino acid sequence of the cyanogen bromide peptide alpha 1(III)CB4 (positions 403-551)." Bentz H., Fietzek P.P., Kuhn K. Hoppe-Seyler's Z. Physiol. Chem. 360:833-840(1979) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 423-571.
[4]	"The covalent structure of calf skin type III collagen. IV. The amino acid sequence of the cyanogen bromide peptide alpha 1(III)CB5 (positions 552-788)." Lang H., Glanville R.W., Fietzek P.P., Kuhn K. Hoppe-Seyler's Z. Physiol. Chem. 360:841-850(1979) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 572-808.
[5]	"The covalent structure of calf skin type III collagen. V. The amino acid sequence of the cyanogen bromide peptide alpha 1(III)CB9A (position 789-927)." Dewes H., Fietzek P.P., Kuhn K. Hoppe-Seyler's Z. Physiol. Chem. 360:851-860(1979) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 809-947.
[6]	"The covalent structure of calf skin type III collagen. VI. The amino acid sequence of the carboxyterminal cyanogen bromide peptide alpha 1(III)CB9B (positions 928-1028)." Allmann H., Fietzek P.P., Glanville R.W., Kuhn K. Hoppe-Seyler's Z. Physiol. Chem. 360:861-868(1979) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 948-1049.

Cross-references

Sequence databases
IPI	IPI00731432.
PIR	CGBO7S. A02862.
UniGene	Bt.64714.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000028617.
Proteomic databases
PaxDb	P04258.
PRIDE	P04258.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000085654.
HOVERGEN	HBG004933.
Family and domain databases
InterPro	IPR008160. Collagen. [Graphical view]
Pfam	PF01391. Collagen. 7 hits. [Graphical view]
PROSITE	PS01208. VWFC_1. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CO3A1_BOVIN

Accession

Primary (citable) accession number: P04258

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	March 20, 1987
Last modified:	May 29, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program