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Protein

Histone H2B 1

Gene

his-11

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-212300 PRC2 methylates histones and DNA
R-CEL-2299718 Condensation of Prophase Chromosomes
R-CEL-2559580 Oxidative Stress Induced Senescence
R-CEL-3214815 HDACs deacetylate histones
R-CEL-427359 SIRT1 negatively regulates rRNA expression
R-CEL-5578749 Transcriptional regulation by small RNAs
R-CEL-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-CEL-5689880 Ub-specific processing proteases
R-CEL-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-CEL-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B 1
Gene namesi
Name:his-11
ORF Names:ZK131.5
AND
Name:his-15
ORF Names:ZK131.9
AND
Name:his-29
ORF Names:F35H10.11
AND
Name:his-34
ORF Names:F17E9.9
AND
Name:his-44
ORF Names:F08G2.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componentsi: Chromosome II, Chromosome IV

Organism-specific databases

WormBaseiF08G2.1 ; CE07075 ; WBGene00001918 ; his-44
F17E9.9 ; CE07075 ; WBGene00001908 ; his-34
F35H10.11 ; CE07075 ; WBGene00001903 ; his-29
ZK131.5 ; CE07075 ; WBGene00001885 ; his-11
ZK131.9 ; CE07075 ; WBGene00001889 ; his-15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000718672 – 122Histone H2B 1Add BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109O-linked (GlcNAc) serineBy similarity1
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Monoubiquitination of Lys-117 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.By similarity
GlcNAcylation at Ser-109 promotes monoubiquitination of Lys-117. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP04255
PaxDbiP04255
PeptideAtlasiP04255
PRIDEiP04255

Expressioni

Gene expression databases

BgeeiWBGene00001885

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.ZK131.9

Structurei

3D structure databases

ProteinModelPortaliP04255
SMRiP04255
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744 Eukaryota
ENOG4111NV5 LUCA
GeneTreeiENSGT00760000118976
HOGENOMiHOG000231213
InParanoidiP04255
KOiK11252
OMAiRINKKFT
OrthoDBiEOG091G0XGD
PhylomeDBiP04255

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357 HISTONE_H2B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKPSAKGA KKAAKTVTKP KDGKKRRHAR KESYSVYIYR VLKQVHPDTG
60 70 80 90 100
VSSKAMSIMN SFVNDVFERI AAEASRLAHY NKRSTISSRE IQTAVRLILP
110 120
GELAKHAVSE GTKAVTKYTS SK
Length:122
Mass (Da):13,501
Last modified:January 23, 2007 - v4
Checksum:iC7D161DDEB329401
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 28RH → KK AA sequence (PubMed:3753445).Curated2
Sequence conflicti27 – 28RH → KK AA sequence (PubMed:2583267).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15633 Genomic DNA Translation: CAA33642.1
FO081169 Genomic DNA Translation: CCD69642.1
Z81495 Genomic DNA Translation: CAB04061.1
Z83245 Genomic DNA Translation: CAB05830.1
Z83245 Genomic DNA Translation: CAB05832.1
FO081018 Genomic DNA Translation: CCD68530.1
PIRiD88357
D88753
RefSeqiNP_496888.1, NM_064487.1
NP_496892.1, NM_064491.6
NP_496897.1, NM_064496.1
NP_501403.1, NM_069002.1
NP_501409.1, NM_069008.1
UniGeneiCel.14856
Cel.29184
Cel.32395
Cel.32675

Genome annotation databases

EnsemblMetazoaiF08G2.1; F08G2.1; WBGene00001918
F17E9.9; F17E9.9; WBGene00001908
F35H10.11; F35H10.11; WBGene00001903
ZK131.5; ZK131.5; WBGene00001885
ZK131.9; ZK131.9; WBGene00001889
GeneIDi175026
175029
175033
185332
191679
KEGGicel:CELE_F08G2.1
cel:CELE_F17E9.9
cel:CELE_F35H10.11
cel:CELE_ZK131.5
cel:CELE_ZK131.9
UCSCiZK131.9 c. elegans

Similar proteinsi

Entry informationi

Entry nameiH2B1_CAEEL
AccessioniPrimary (citable) accession number: P04255
Secondary accession number(s): O02656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 152 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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