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Protein

Histone H2B 1

Gene

his-11

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B 1
Gene namesi
Name:his-11
ORF Names:ZK131.5
AND
Name:his-15
ORF Names:ZK131.9
AND
Name:his-29
ORF Names:F35H10.11
AND
Name:his-34
ORF Names:F17E9.9
AND
Name:his-44
ORF Names:F08G2.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componentsi: Chromosome II, Chromosome IV

Organism-specific databases

WormBaseiF08G2.1; CE07075; WBGene00001918; his-44.
F17E9.9; CE07075; WBGene00001908; his-34.
F35H10.11; CE07075; WBGene00001903; his-29.
ZK131.5; CE07075; WBGene00001885; his-11.
ZK131.9; CE07075; WBGene00001889; his-15.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: WormBase
  • lipid particle Source: UniProtKB
  • nuclear nucleosome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000718672 – 122Histone H2B 1Add BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109O-linked (GlcNAc)By similarity1
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Monoubiquitination of Lys-117 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.By similarity
GlcNAcylation at Ser-109 promotes monoubiquitination of Lys-117. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP04255.
PaxDbiP04255.
PeptideAtlasiP04255.
PRIDEiP04255.

Expressioni

Gene expression databases

BgeeiWBGene00001885.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

STRINGi6239.ZK131.9.

Structurei

3D structure databases

ProteinModelPortaliP04255.
SMRiP04255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00860000133714.
HOGENOMiHOG000231213.
InParanoidiP04255.
KOiK11252.
OMAiRTHSRKE.
OrthoDBiEOG091G0XGD.
PhylomeDBiP04255.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKPSAKGA KKAAKTVTKP KDGKKRRHAR KESYSVYIYR VLKQVHPDTG
60 70 80 90 100
VSSKAMSIMN SFVNDVFERI AAEASRLAHY NKRSTISSRE IQTAVRLILP
110 120
GELAKHAVSE GTKAVTKYTS SK
Length:122
Mass (Da):13,501
Last modified:January 23, 2007 - v4
Checksum:iC7D161DDEB329401
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 28RH → KK AA sequence (PubMed:3753445).Curated2
Sequence conflicti27 – 28RH → KK AA sequence (PubMed:2583267).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15633 Genomic DNA. Translation: CAA33642.1.
FO081169 Genomic DNA. Translation: CCD69642.1.
Z81495 Genomic DNA. Translation: CAB04061.1.
Z83245 Genomic DNA. Translation: CAB05830.1.
Z83245 Genomic DNA. Translation: CAB05832.1.
FO081018 Genomic DNA. Translation: CCD68530.1.
PIRiD88357.
D88753.
RefSeqiNP_496888.1. NM_064487.1.
NP_496892.1. NM_064491.6.
NP_496897.1. NM_064496.1.
NP_501403.1. NM_069002.1.
NP_501409.1. NM_069008.1.
UniGeneiCel.14856.
Cel.29184.
Cel.32395.
Cel.32675.

Genome annotation databases

EnsemblMetazoaiF08G2.1; F08G2.1; WBGene00001918.
F17E9.9; F17E9.9; WBGene00001908.
F35H10.11; F35H10.11; WBGene00001903.
ZK131.5; ZK131.5; WBGene00001885.
ZK131.9; ZK131.9; WBGene00001889.
GeneIDi175026.
175029.
175033.
185332.
191679.
KEGGicel:CELE_F08G2.1.
cel:CELE_F17E9.9.
cel:CELE_F35H10.11.
cel:CELE_ZK131.5.
cel:CELE_ZK131.9.
UCSCiZK131.9. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15633 Genomic DNA. Translation: CAA33642.1.
FO081169 Genomic DNA. Translation: CCD69642.1.
Z81495 Genomic DNA. Translation: CAB04061.1.
Z83245 Genomic DNA. Translation: CAB05830.1.
Z83245 Genomic DNA. Translation: CAB05832.1.
FO081018 Genomic DNA. Translation: CCD68530.1.
PIRiD88357.
D88753.
RefSeqiNP_496888.1. NM_064487.1.
NP_496892.1. NM_064491.6.
NP_496897.1. NM_064496.1.
NP_501403.1. NM_069002.1.
NP_501409.1. NM_069008.1.
UniGeneiCel.14856.
Cel.29184.
Cel.32395.
Cel.32675.

3D structure databases

ProteinModelPortaliP04255.
SMRiP04255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK131.9.

Proteomic databases

EPDiP04255.
PaxDbiP04255.
PeptideAtlasiP04255.
PRIDEiP04255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF08G2.1; F08G2.1; WBGene00001918.
F17E9.9; F17E9.9; WBGene00001908.
F35H10.11; F35H10.11; WBGene00001903.
ZK131.5; ZK131.5; WBGene00001885.
ZK131.9; ZK131.9; WBGene00001889.
GeneIDi175026.
175029.
175033.
185332.
191679.
KEGGicel:CELE_F08G2.1.
cel:CELE_F17E9.9.
cel:CELE_F35H10.11.
cel:CELE_ZK131.5.
cel:CELE_ZK131.9.
UCSCiZK131.9. c. elegans.

Organism-specific databases

CTDi175026.
175029.
175033.
185332.
191679.
WormBaseiF08G2.1; CE07075; WBGene00001918; his-44.
F17E9.9; CE07075; WBGene00001908; his-34.
F35H10.11; CE07075; WBGene00001903; his-29.
ZK131.5; CE07075; WBGene00001885; his-11.
ZK131.9; CE07075; WBGene00001889; his-15.

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00860000133714.
HOGENOMiHOG000231213.
InParanoidiP04255.
KOiK11252.
OMAiRTHSRKE.
OrthoDBiEOG091G0XGD.
PhylomeDBiP04255.

Miscellaneous databases

PROiP04255.

Gene expression databases

BgeeiWBGene00001885.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2B1_CAEEL
AccessioniPrimary (citable) accession number: P04255
Secondary accession number(s): O02656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 141 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.