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Protein

Histone H2B 1

Gene

his-11

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B 1
Gene namesi
Name:his-11
ORF Names:ZK131.5
AND
Name:his-15
ORF Names:ZK131.9
AND
Name:his-29
ORF Names:F35H10.11
AND
Name:his-34
ORF Names:F17E9.9
AND
Name:his-44
ORF Names:F08G2.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componentsi: Chromosome II, Chromosome IV

Organism-specific databases

WormBaseiF08G2.1; CE07075; WBGene00001918; his-44.
F17E9.9; CE07075; WBGene00001908; his-34.
F35H10.11; CE07075; WBGene00001903; his-29.
ZK131.5; CE07075; WBGene00001885; his-11.
ZK131.9; CE07075; WBGene00001889; his-15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000718672 – 122Histone H2B 1Add BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109O-linked (GlcNAc) serineBy similarity1
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Monoubiquitination of Lys-117 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.By similarity
GlcNAcylation at Ser-109 promotes monoubiquitination of Lys-117. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP04255.
PaxDbiP04255.
PeptideAtlasiP04255.
PRIDEiP04255.

Expressioni

Gene expression databases

BgeeiWBGene00001885.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.ZK131.9.

Structurei

3D structure databases

ProteinModelPortaliP04255.
SMRiP04255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00760000118976.
HOGENOMiHOG000231213.
InParanoidiP04255.
KOiK11252.
OMAiDCIVEPE.
OrthoDBiEOG091G0XGD.
PhylomeDBiP04255.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00621. HISTONEH2B.
SMARTiView protein in SMART
SM00427. H2B. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00357. HISTONE_H2B. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKPSAKGA KKAAKTVTKP KDGKKRRHAR KESYSVYIYR VLKQVHPDTG
60 70 80 90 100
VSSKAMSIMN SFVNDVFERI AAEASRLAHY NKRSTISSRE IQTAVRLILP
110 120
GELAKHAVSE GTKAVTKYTS SK
Length:122
Mass (Da):13,501
Last modified:January 23, 2007 - v4
Checksum:iC7D161DDEB329401
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 28RH → KK AA sequence (PubMed:3753445).Curated2
Sequence conflicti27 – 28RH → KK AA sequence (PubMed:2583267).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15633 Genomic DNA. Translation: CAA33642.1.
FO081169 Genomic DNA. Translation: CCD69642.1.
Z81495 Genomic DNA. Translation: CAB04061.1.
Z83245 Genomic DNA. Translation: CAB05830.1.
Z83245 Genomic DNA. Translation: CAB05832.1.
FO081018 Genomic DNA. Translation: CCD68530.1.
PIRiD88357.
D88753.
RefSeqiNP_496888.1. NM_064487.1.
NP_496892.1. NM_064491.6.
NP_496897.1. NM_064496.1.
NP_501403.1. NM_069002.1.
NP_501409.1. NM_069008.1.
UniGeneiCel.14856.
Cel.29184.
Cel.32395.
Cel.32675.

Genome annotation databases

EnsemblMetazoaiF08G2.1; F08G2.1; WBGene00001918.
F17E9.9; F17E9.9; WBGene00001908.
F35H10.11; F35H10.11; WBGene00001903.
ZK131.5; ZK131.5; WBGene00001885.
ZK131.9; ZK131.9; WBGene00001889.
GeneIDi175026.
175029.
175033.
185332.
191679.
KEGGicel:CELE_F08G2.1.
cel:CELE_F17E9.9.
cel:CELE_F35H10.11.
cel:CELE_ZK131.5.
cel:CELE_ZK131.9.
UCSCiZK131.9. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiH2B1_CAEEL
AccessioniPrimary (citable) accession number: P04255
Secondary accession number(s): O02656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 148 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families