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Protein

Myoglobin

Gene

Mb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Iron (heme distal ligand)
Metal bindingi94 – 941Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: Ensembl
  4. oxygen transporter activity Source: UniProtKB-KW

GO - Biological processi

  1. brown fat cell differentiation Source: MGI
  2. enucleate erythrocyte differentiation Source: MGI
  3. heart development Source: MGI
  4. response to hormone Source: Ensembl
  5. response to hydrogen peroxide Source: Ensembl
  6. response to hypoxia Source: MGI
  7. slow-twitch skeletal muscle fiber contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:Mb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:96922. Mb.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 154153MyoglobinPRO_0000053319Add
BLAST

Proteomic databases

MaxQBiP04247.
PaxDbiP04247.
PRIDEiP04247.

2D gel databases

SWISS-2DPAGEP04247.

PTM databases

PhosphoSiteiP04247.

Expressioni

Gene expression databases

BgeeiP04247.
CleanExiMM_MB.
ExpressionAtlasiP04247. baseline and differential.
GenevestigatoriP04247.

Interactioni

Protein-protein interaction databases

IntActiP04247. 2 interactions.
MINTiMINT-4102659.
STRINGi10090.ENSMUSP00000019037.

Structurei

3D structure databases

ProteinModelPortaliP04247.
SMRiP04247. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG276460.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP04247.
OMAiTKHKIPI.
OrthoDBiEOG7KSX9V.
PhylomeDBiP04247.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002335. Myoglobin.
[Graphical view]
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04247-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLSDGEWQL VLNVWGKVEA DLAGHGQEVL IGLFKTHPET LDKFDKFKNL
60 70 80 90 100
KSEEDMKGSE DLKKHGCTVL TALGTILKKK GQHAAEIQPL AQSHATKHKI
110 120 130 140 150
PVKYLEFISE IIIEVLKKRH SGDFGADAQG AMSKALELFR NDIAAKYKEL

GFQG
Length:154
Mass (Da):17,070
Last modified:January 23, 2007 - v3
Checksum:i8EE1EE3FFEE36AF0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161L → K AA sequence (PubMed:4043406)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025172 mRNA. Translation: AAH25172.1.
X04405, X04417 Genomic DNA. Translation: CAA27994.1.
CCDSiCCDS27597.1.
PIRiA25799. MYMS.
RefSeqiNP_001157519.1. NM_001164047.1.
NP_001157520.1. NM_001164048.1.
NP_038621.2. NM_013593.3.
UniGeneiMm.404074.

Genome annotation databases

EnsembliENSMUST00000019037; ENSMUSP00000019037; ENSMUSG00000018893.
ENSMUST00000166179; ENSMUSP00000128399; ENSMUSG00000018893.
ENSMUST00000169226; ENSMUSP00000125995; ENSMUSG00000018893.
GeneIDi17189.
KEGGimmu:17189.
UCSCiuc007wmx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025172 mRNA. Translation: AAH25172.1.
X04405, X04417 Genomic DNA. Translation: CAA27994.1.
CCDSiCCDS27597.1.
PIRiA25799. MYMS.
RefSeqiNP_001157519.1. NM_001164047.1.
NP_001157520.1. NM_001164048.1.
NP_038621.2. NM_013593.3.
UniGeneiMm.404074.

3D structure databases

ProteinModelPortaliP04247.
SMRiP04247. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04247. 2 interactions.
MINTiMINT-4102659.
STRINGi10090.ENSMUSP00000019037.

PTM databases

PhosphoSiteiP04247.

2D gel databases

SWISS-2DPAGEP04247.

Proteomic databases

MaxQBiP04247.
PaxDbiP04247.
PRIDEiP04247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019037; ENSMUSP00000019037; ENSMUSG00000018893.
ENSMUST00000166179; ENSMUSP00000128399; ENSMUSG00000018893.
ENSMUST00000169226; ENSMUSP00000125995; ENSMUSG00000018893.
GeneIDi17189.
KEGGimmu:17189.
UCSCiuc007wmx.2. mouse.

Organism-specific databases

CTDi4151.
MGIiMGI:96922. Mb.

Phylogenomic databases

eggNOGiNOG276460.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP04247.
OMAiTKHKIPI.
OrthoDBiEOG7KSX9V.
PhylomeDBiP04247.
TreeFamiTF332967.

Miscellaneous databases

ChiTaRSiMb. mouse.
NextBioi291526.
PROiP04247.
SOURCEiSearch...

Gene expression databases

BgeeiP04247.
CleanExiMM_MB.
ExpressionAtlasiP04247. baseline and differential.
GenevestigatoriP04247.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002335. Myoglobin.
[Graphical view]
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse myoglobin gene. Characterisation and sequence comparison with other mammalian myoglobin genes."
    Blanchetot A., Price M., Jeffreys A.J.
    Eur. J. Biochem. 159:469-474(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. "The myoglobin of rodents Proechimys guairae (casiragua) and Mus musculus (house mouse)."
    Harris D.E., Gurnett A.M., Lehmann H., Joysey K.A.
    FEBS Lett. 190:288-292(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-154.

Entry informationi

Entry nameiMYG_MOUSE
AccessioniPrimary (citable) accession number: P04247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.