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P04247

- MYG_MOUSE

UniProt

P04247 - MYG_MOUSE

Protein

Myoglobin

Gene

Mb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi65 – 651Iron (heme distal ligand)
    Metal bindingi94 – 941Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: Ensembl
    4. oxygen transporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. brown fat cell differentiation Source: MGI
    2. enucleate erythrocyte differentiation Source: MGI
    3. heart development Source: MGI
    4. response to hormone Source: Ensembl
    5. response to hydrogen peroxide Source: Ensembl
    6. response to hypoxia Source: MGI
    7. slow-twitch skeletal muscle fiber contraction Source: Ensembl

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myoglobin
    Gene namesi
    Name:Mb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:96922. Mb.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 154153MyoglobinPRO_0000053319Add
    BLAST

    Proteomic databases

    MaxQBiP04247.
    PaxDbiP04247.
    PRIDEiP04247.

    2D gel databases

    SWISS-2DPAGEP04247.

    PTM databases

    PhosphoSiteiP04247.

    Expressioni

    Gene expression databases

    ArrayExpressiP04247.
    BgeeiP04247.
    CleanExiMM_MB.
    GenevestigatoriP04247.

    Interactioni

    Protein-protein interaction databases

    IntActiP04247. 2 interactions.
    MINTiMINT-4102659.
    STRINGi10090.ENSMUSP00000019037.

    Structurei

    3D structure databases

    ProteinModelPortaliP04247.
    SMRiP04247. Positions 2-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG276460.
    HOGENOMiHOG000070111.
    HOVERGENiHBG107340.
    InParanoidiP04247.
    OMAiDAQGAMN.
    OrthoDBiEOG7KSX9V.
    PhylomeDBiP04247.
    TreeFamiTF332967.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002335. Myoglobin.
    [Graphical view]
    PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00613. MYOGLOBIN.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04247-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLSDGEWQL VLNVWGKVEA DLAGHGQEVL IGLFKTHPET LDKFDKFKNL    50
    KSEEDMKGSE DLKKHGCTVL TALGTILKKK GQHAAEIQPL AQSHATKHKI 100
    PVKYLEFISE IIIEVLKKRH SGDFGADAQG AMSKALELFR NDIAAKYKEL 150
    GFQG 154
    Length:154
    Mass (Da):17,070
    Last modified:January 23, 2007 - v3
    Checksum:i8EE1EE3FFEE36AF0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1161L → K AA sequence (PubMed:4043406)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC025172 mRNA. Translation: AAH25172.1.
    X04405, X04417 Genomic DNA. Translation: CAA27994.1.
    CCDSiCCDS27597.1.
    PIRiA25799. MYMS.
    RefSeqiNP_001157519.1. NM_001164047.1.
    NP_001157520.1. NM_001164048.1.
    NP_038621.2. NM_013593.3.
    UniGeneiMm.404074.

    Genome annotation databases

    EnsembliENSMUST00000019037; ENSMUSP00000019037; ENSMUSG00000018893.
    ENSMUST00000166179; ENSMUSP00000128399; ENSMUSG00000018893.
    ENSMUST00000169226; ENSMUSP00000125995; ENSMUSG00000018893.
    GeneIDi17189.
    KEGGimmu:17189.
    UCSCiuc007wmx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC025172 mRNA. Translation: AAH25172.1 .
    X04405 , X04417 Genomic DNA. Translation: CAA27994.1 .
    CCDSi CCDS27597.1.
    PIRi A25799. MYMS.
    RefSeqi NP_001157519.1. NM_001164047.1.
    NP_001157520.1. NM_001164048.1.
    NP_038621.2. NM_013593.3.
    UniGenei Mm.404074.

    3D structure databases

    ProteinModelPortali P04247.
    SMRi P04247. Positions 2-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P04247. 2 interactions.
    MINTi MINT-4102659.
    STRINGi 10090.ENSMUSP00000019037.

    PTM databases

    PhosphoSitei P04247.

    2D gel databases

    SWISS-2DPAGE P04247.

    Proteomic databases

    MaxQBi P04247.
    PaxDbi P04247.
    PRIDEi P04247.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019037 ; ENSMUSP00000019037 ; ENSMUSG00000018893 .
    ENSMUST00000166179 ; ENSMUSP00000128399 ; ENSMUSG00000018893 .
    ENSMUST00000169226 ; ENSMUSP00000125995 ; ENSMUSG00000018893 .
    GeneIDi 17189.
    KEGGi mmu:17189.
    UCSCi uc007wmx.2. mouse.

    Organism-specific databases

    CTDi 4151.
    MGIi MGI:96922. Mb.

    Phylogenomic databases

    eggNOGi NOG276460.
    HOGENOMi HOG000070111.
    HOVERGENi HBG107340.
    InParanoidi P04247.
    OMAi DAQGAMN.
    OrthoDBi EOG7KSX9V.
    PhylomeDBi P04247.
    TreeFami TF332967.

    Miscellaneous databases

    NextBioi 291526.
    PROi P04247.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P04247.
    Bgeei P04247.
    CleanExi MM_MB.
    Genevestigatori P04247.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002335. Myoglobin.
    [Graphical view ]
    PANTHERi PTHR11442:SF5. PTHR11442:SF5. 1 hit.
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00613. MYOGLOBIN.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse myoglobin gene. Characterisation and sequence comparison with other mammalian myoglobin genes."
      Blanchetot A., Price M., Jeffreys A.J.
      Eur. J. Biochem. 159:469-474(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    3. "The myoglobin of rodents Proechimys guairae (casiragua) and Mus musculus (house mouse)."
      Harris D.E., Gurnett A.M., Lehmann H., Joysey K.A.
      FEBS Lett. 190:288-292(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-154.

    Entry informationi

    Entry nameiMYG_MOUSE
    AccessioniPrimary (citable) accession number: P04247
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3