P04247 (MYG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myoglobin

Gene names

Name:

Mb

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Molecular function	Muscle protein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	brown fat cell differentiation Inferred from direct assay PubMed 18492766. Source: MGI enucleate erythrocyte differentiation Inferred from mutant phenotype PubMed 14656764. Source: MGI heart development Inferred from mutant phenotype PubMed 11304494. Source: MGI response to hormone stimulus Inferred from electronic annotation. Source: Compara response to hydrogen peroxide Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from mutant phenotype PubMed 14656764. Source: MGI slow-twitch skeletal muscle fiber contraction Inferred from electronic annotation. Source: Compara
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: Compara oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 154	153	Myoglobin		PRO_0000053319
Sites
	Metal binding	65	1	Iron (heme distal ligand)
	Metal binding	94	1	Iron (heme proximal ligand)
Experimental info
	Sequence conflict	116	1	L → K AA sequence Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P04247 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 8EE1EE3FFEE36AF0	FASTA	154	17,070
	10 20 30 40 50 60 MGLSDGEWQL VLNVWGKVEA DLAGHGQEVL IGLFKTHPET LDKFDKFKNL KSEEDMKGSE 70 80 90 100 110 120 DLKKHGCTVL TALGTILKKK GQHAAEIQPL AQSHATKHKI PVKYLEFISE IIIEVLKKRH 130 140 150 SGDFGADAQG AMSKALELFR NDIAAKYKEL GFQG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The mouse myoglobin gene. Characterisation and sequence comparison with other mammalian myoglobin genes." Blanchetot A., Price M., Jeffreys A.J. Eur. J. Biochem. 159:469-474(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
[3]	"The myoglobin of rodents Proechimys guairae (casiragua) and Mus musculus (house mouse)." Harris D.E., Gurnett A.M., Lehmann H., Joysey K.A. FEBS Lett. 190:288-292(1985) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-154.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC025172 mRNA. Translation: AAH25172.1. X04405, X04417 Genomic DNA. Translation: CAA27994.1.
IPI	IPI00230760.
PIR	MYMS. A25799.
RefSeq	NP_001157519.1. NM_001164047.1. NP_001157520.1. NM_001164048.1. NP_038621.2. NM_013593.3.
UniGene	Mm.404074.
3D structure databases
ProteinModelPortal	P04247.
SMR	P04247. Positions 2-154.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4102659.
STRING	10090.ENSMUSP00000019037.
PTM databases
PhosphoSite	P04247.
2D gel databases
SWISS-2DPAGE	P04247.
Proteomic databases
PaxDb	P04247.
PRIDE	P04247.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000019037; ENSMUSP00000019037; ENSMUSG00000018893. ENSMUST00000166179; ENSMUSP00000128399; ENSMUSG00000018893. ENSMUST00000169226; ENSMUSP00000125995; ENSMUSG00000018893.
GeneID	17189.
KEGG	mmu:17189.
UCSC	uc007wmx.2. mouse.
Organism-specific databases
CTD	4151.
MGI	MGI:96922. Mb.
Phylogenomic databases
eggNOG	NOG276460.
HOGENOM	HOG000070111.
HOVERGEN	HBG107340.
InParanoid	P04247.
OMA	FRNDIAA.
OrthoDB	EOG4Z8XXZ.
Gene expression databases
ArrayExpress	P04247.
Bgee	P04247.
CleanEx	MM_MB.
Genevestigator	P04247.
GermOnline	ENSMUSG00000018893. Mus musculus.
Family and domain databases
Gene3D	1.10.490.10. 1 hit.
InterPro	IPR000971. Globin. IPR009050. Globin-like. IPR012292. Globin_dom. IPR002335. Myoglobin. [Graphical view]
PANTHER	PTHR11442:SF5. PTHR11442:SF5. 1 hit.
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00613. MYOGLOBIN.
SUPFAM	SSF46458. Globin_like. 1 hit.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	291526.
SOURCE	Search...

Entry information

Entry name

MYG_MOUSE

Accession

Primary (citable) accession number: P04247

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 108 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program