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Protein

Myoglobin

Gene

Mb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Iron (heme distal ligand)1
Metal bindingi94Iron (heme proximal ligand)1

GO - Molecular functioni

GO - Biological processi

  • brown fat cell differentiation Source: MGI
  • enucleate erythrocyte differentiation Source: MGI
  • heart development Source: MGI
  • response to hormone Source: Ensembl
  • response to hydrogen peroxide Source: Ensembl
  • response to hypoxia Source: MGI
  • slow-twitch skeletal muscle fiber contraction Source: Ensembl

Keywordsi

Molecular functionMuscle protein
Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:Mb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96922. Mb.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000533192 – 154MyoglobinAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei68PhosphothreonineCombined sources1
Modified residuei75PhosphothreonineCombined sources1
Modified residuei121PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP04247.
PeptideAtlasiP04247.
PRIDEiP04247.

2D gel databases

SWISS-2DPAGEiP04247.

PTM databases

iPTMnetiP04247.
PhosphoSitePlusiP04247.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018893.
CleanExiMM_MB.
ExpressionAtlasiP04247. baseline and differential.
GenevisibleiP04247. MM.

Interactioni

Protein-protein interaction databases

IntActiP04247. 3 interactors.
MINTiMINT-4102659.
STRINGi10090.ENSMUSP00000019037.

Structurei

3D structure databases

ProteinModelPortaliP04247.
SMRiP04247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP04247.
OMAiLFRNDIA.
OrthoDBiEOG091G0OAO.
PhylomeDBiP04247.
TreeFamiTF332967.

Family and domain databases

InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002335. Myoglobin.
PANTHERiPTHR11442:SF57. PTHR11442:SF57. 1 hit.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSDGEWQL VLNVWGKVEA DLAGHGQEVL IGLFKTHPET LDKFDKFKNL
60 70 80 90 100
KSEEDMKGSE DLKKHGCTVL TALGTILKKK GQHAAEIQPL AQSHATKHKI
110 120 130 140 150
PVKYLEFISE IIIEVLKKRH SGDFGADAQG AMSKALELFR NDIAAKYKEL

GFQG
Length:154
Mass (Da):17,070
Last modified:January 23, 2007 - v3
Checksum:i8EE1EE3FFEE36AF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116L → K AA sequence (PubMed:4043406).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025172 mRNA. Translation: AAH25172.1.
X04405, X04417 Genomic DNA. Translation: CAA27994.1.
CCDSiCCDS27597.1.
PIRiA25799. MYMS.
RefSeqiNP_001157519.1. NM_001164047.1.
NP_001157520.1. NM_001164048.1.
NP_038621.2. NM_013593.3.
UniGeneiMm.404074.

Genome annotation databases

EnsembliENSMUST00000019037; ENSMUSP00000019037; ENSMUSG00000018893.
ENSMUST00000166179; ENSMUSP00000128399; ENSMUSG00000018893.
ENSMUST00000169226; ENSMUSP00000125995; ENSMUSG00000018893.
GeneIDi17189.
KEGGimmu:17189.
UCSCiuc007wmx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC025172 mRNA. Translation: AAH25172.1.
X04405, X04417 Genomic DNA. Translation: CAA27994.1.
CCDSiCCDS27597.1.
PIRiA25799. MYMS.
RefSeqiNP_001157519.1. NM_001164047.1.
NP_001157520.1. NM_001164048.1.
NP_038621.2. NM_013593.3.
UniGeneiMm.404074.

3D structure databases

ProteinModelPortaliP04247.
SMRiP04247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04247. 3 interactors.
MINTiMINT-4102659.
STRINGi10090.ENSMUSP00000019037.

PTM databases

iPTMnetiP04247.
PhosphoSitePlusiP04247.

2D gel databases

SWISS-2DPAGEiP04247.

Proteomic databases

PaxDbiP04247.
PeptideAtlasiP04247.
PRIDEiP04247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019037; ENSMUSP00000019037; ENSMUSG00000018893.
ENSMUST00000166179; ENSMUSP00000128399; ENSMUSG00000018893.
ENSMUST00000169226; ENSMUSP00000125995; ENSMUSG00000018893.
GeneIDi17189.
KEGGimmu:17189.
UCSCiuc007wmx.2. mouse.

Organism-specific databases

CTDi4151.
MGIiMGI:96922. Mb.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP04247.
OMAiLFRNDIA.
OrthoDBiEOG091G0OAO.
PhylomeDBiP04247.
TreeFamiTF332967.

Miscellaneous databases

ChiTaRSiMb. mouse.
PROiPR:P04247.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018893.
CleanExiMM_MB.
ExpressionAtlasiP04247. baseline and differential.
GenevisibleiP04247. MM.

Family and domain databases

InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002335. Myoglobin.
PANTHERiPTHR11442:SF57. PTHR11442:SF57. 1 hit.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMYG_MOUSE
AccessioniPrimary (citable) accession number: P04247
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.