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Protein

T-cell surface glycoprotein CD3 delta chain

Gene

Cd3d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

The CD3 complex mediates signal transduction.

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • positive thymic T cell selection Source: UniProtKB
  • protein complex assembly Source: UniProtKB
  • T cell activation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-202424. Downstream TCR signaling.
R-MMU-202427. Phosphorylation of CD3 and TCR zeta chains.
R-MMU-202430. Translocation of ZAP-70 to Immunological synapse.
R-MMU-202433. Generation of second messenger molecules.
R-MMU-389948. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD3 delta chain
Alternative name(s):
T-cell receptor T3 delta chain
CD_antigen: CD3d
Gene namesi
Name:Cd3d
Synonyms:T3d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88331. Cd3d.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 10584ExtracellularSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 17347CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • alpha-beta T cell receptor complex Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • T cell receptor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 173152T-cell surface glycoprotein CD3 delta chainPRO_0000016489Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 73By similarity
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Modified residuei149 – 1491PhosphotyrosinePROSITE-ProRule annotationBy similarity
Modified residuei160 – 1601PhosphotyrosinePROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP04235.
PaxDbiP04235.
PRIDEiP04235.

PTM databases

iPTMnetiP04235.
PhosphoSiteiP04235.
SwissPalmiP04235.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032094.
CleanExiMM_CD3D.
ExpressionAtlasiP04235. baseline and differential.
GenevisibleiP04235. MM.

Interactioni

Subunit structurei

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034602.

Structurei

3D structure databases

ProteinModelPortaliP04235.
SMRiP04235. Positions 23-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 16629ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWAX. Eukaryota.
ENOG410Y2TD. LUCA.
HOGENOMiHOG000015287.
HOVERGENiHBG005278.
InParanoidiP04235.
KOiK06450.
OMAiMCQSCVE.
OrthoDBiEOG091G0U7X.
PhylomeDBiP04235.
TreeFamiTF335892.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR015485. CD3D.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR032052. Ig_4.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PTHR10570:SF5. PTHR10570:SF5. 1 hit.
PfamiPF16680. Ig_4. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHSGILASL ILIAVLPQGS PFKIQVTEYE DKVFVTCNTS VMHLDGTVEG
60 70 80 90 100
WFAKNKTLNL GKGVLDPRGI YLCNGTEQLA KVVSSVQVHY RMCQNCVELD
110 120 130 140 150
SGTMAGVIFI DLIATLLLAL GVYCFAGHET GRPSGAAEVQ ALLKNEQLYQ
160 170
PLRDREDTQY SRLGGNWPRN KKS
Length:173
Mass (Da):19,032
Last modified:March 20, 1987 - v1
Checksum:iEEEC182BDF2AFB6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12729, M12728 Genomic DNA. Translation: AAA37268.1.
M18222 Genomic DNA. Translation: AAA37399.1.
CCDSiCCDS23124.1.
PIRiA02246. RWMSD2.
RefSeqiNP_038515.3. NM_013487.3.
UniGeneiMm.4527.

Genome annotation databases

EnsembliENSMUST00000034602; ENSMUSP00000034602; ENSMUSG00000032094.
GeneIDi12500.
KEGGimmu:12500.
UCSCiuc009pey.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12729, M12728 Genomic DNA. Translation: AAA37268.1.
M18222 Genomic DNA. Translation: AAA37399.1.
CCDSiCCDS23124.1.
PIRiA02246. RWMSD2.
RefSeqiNP_038515.3. NM_013487.3.
UniGeneiMm.4527.

3D structure databases

ProteinModelPortaliP04235.
SMRiP04235. Positions 23-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034602.

PTM databases

iPTMnetiP04235.
PhosphoSiteiP04235.
SwissPalmiP04235.

Proteomic databases

EPDiP04235.
PaxDbiP04235.
PRIDEiP04235.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034602; ENSMUSP00000034602; ENSMUSG00000032094.
GeneIDi12500.
KEGGimmu:12500.
UCSCiuc009pey.2. mouse.

Organism-specific databases

CTDi915.
MGIiMGI:88331. Cd3d.

Phylogenomic databases

eggNOGiENOG410IWAX. Eukaryota.
ENOG410Y2TD. LUCA.
HOGENOMiHOG000015287.
HOVERGENiHBG005278.
InParanoidiP04235.
KOiK06450.
OMAiMCQSCVE.
OrthoDBiEOG091G0U7X.
PhylomeDBiP04235.
TreeFamiTF335892.

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-202424. Downstream TCR signaling.
R-MMU-202427. Phosphorylation of CD3 and TCR zeta chains.
R-MMU-202430. Translocation of ZAP-70 to Immunological synapse.
R-MMU-202433. Generation of second messenger molecules.
R-MMU-389948. PD-1 signaling.

Miscellaneous databases

PROiP04235.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032094.
CleanExiMM_CD3D.
ExpressionAtlasiP04235. baseline and differential.
GenevisibleiP04235. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR015485. CD3D.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR032052. Ig_4.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PTHR10570:SF5. PTHR10570:SF5. 1 hit.
PfamiPF16680. Ig_4. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD3D_MOUSE
AccessioniPrimary (citable) accession number: P04235
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: September 7, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.