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P04233

- HG2A_HUMAN

UniProt

P04233 - HG2A_HUMAN

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Protein

HLA class II histocompatibility antigen gamma chain

Gene
CD74, DHLAG
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei208 – 2092Breakpoint for translocation to form a CD74-ROS1 fusion protein

GO - Molecular functioni

  1. beta-amyloid binding Source: BHF-UCL
  2. cytokine binding Source: UniProtKB
  3. cytokine receptor activity Source: BHF-UCL
  4. identical protein binding Source: UniProtKB
  5. macrophage migration inhibitory factor binding Source: BHF-UCL
  6. MHC class II protein binding Source: UniProtKB
  7. MHC class II protein binding, via antigen binding groove Source: UniProt
  8. MHC class II protein complex binding Source: UniProt
  9. protein binding Source: IntAct
  10. protein binding involved in protein folding Source: UniProt

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. antigen processing and presentation of endogenous antigen Source: UniProtKB
  3. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  4. cell proliferation Source: UniProtKB
  5. chaperone mediated protein folding requiring cofactor Source: Ensembl
  6. defense response Source: Ensembl
  7. immunoglobulin mediated immune response Source: UniProtKB
  8. intracellular protein transport Source: UniProtKB
  9. macrophage migration inhibitory factor signaling pathway Source: Ensembl
  10. negative regulation of apoptotic process Source: UniProtKB
  11. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
  12. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
  13. negative regulation of mature B cell apoptotic process Source: Ensembl
  14. negative regulation of peptide secretion Source: BHF-UCL
  15. negative regulation of T cell differentiation Source: Ensembl
  16. negative thymic T cell selection Source: Ensembl
  17. positive regulation of B cell proliferation Source: BHF-UCL
  18. positive regulation of chemokine (C-X-C motif) ligand 2 production Source: BHF-UCL
  19. positive regulation of cytokine-mediated signaling pathway Source: BHF-UCL
  20. positive regulation of dendritic cell antigen processing and presentation Source: Ensembl
  21. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  22. positive regulation of fibroblast proliferation Source: BHF-UCL
  23. positive regulation of macrophage cytokine production Source: BHF-UCL
  24. positive regulation of neutrophil chemotaxis Source: BHF-UCL
  25. positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  26. positive regulation of T cell differentiation Source: Ensembl
  27. positive regulation of type 2 immune response Source: Ensembl
  28. positive thymic T cell selection Source: Ensembl
  29. prostaglandin biosynthetic process Source: UniProtKB
  30. protein complex assembly Source: UniProtKB
  31. regulation of macrophage activation Source: UniProtKB
  32. signal transduction Source: UniProtKB
  33. T cell selection Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.

Protein family/group databases

MEROPSiI31.002.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen gamma chain
Alternative name(s):
HLA-DR antigens-associated invariant chain
Ia antigen-associated invariant chain
Short name:
Ii
p33
CD_antigen: CD74
Gene namesi
Name:CD74
Synonyms:DHLAG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:1697. CD74.

Subcellular locationi

Cell membrane; Single-pass type II membrane protein Reviewed prediction. Endoplasmic reticulum membrane. Golgi apparatustrans-Golgi network. Endosome. Lysosome
Note: Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei47 – 7226Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini73 – 296224Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. clathrin-coated endocytic vesicle membrane Source: Reactome
  3. endocytic vesicle membrane Source: Reactome
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. external side of plasma membrane Source: Ensembl
  6. extracellular vesicular exosome Source: UniProt
  7. Golgi membrane Source: Reactome
  8. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  9. integral component of membrane Source: BHF-UCL
  10. intracellular Source: UniProtKB
  11. lysosomal lumen Source: Reactome
  12. lysosomal membrane Source: Reactome
  13. macrophage migration inhibitory factor receptor complex Source: BHF-UCL
  14. MHC class II protein complex Source: Ensembl
  15. multivesicular body Source: Ensembl
  16. NOS2-CD74 complex Source: Ensembl
  17. plasma membrane Source: Reactome
  18. trans-Golgi network membrane Source: Reactome
  19. transport vesicle membrane Source: Reactome
  20. vacuole Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein.1 Publication

Organism-specific databases

PharmGKBiPA26236.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296HLA class II histocompatibility antigen gamma chainPRO_0000067954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Phosphoserine By similarity
Glycosylationi130 – 1301N-linked (GlcNAc...)
Glycosylationi136 – 1361N-linked (GlcNAc...)1 Publication
Glycosylationi203 – 2031O-linked (GalNAc...)2 Publications
Disulfide bondi213 ↔ 2321 Publication
Disulfide bondi243 ↔ 2501 Publication
Disulfide bondi252 ↔ 2711 Publication
Glycosylationi256 – 2561N-linked (GlcNAc...)1 Publication
Glycosylationi281 – 2811O-linked (GalNAc...)1 Publication

Post-translational modificationi

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiP04233.
PaxDbiP04233.
PRIDEiP04233.

PTM databases

PhosphoSiteiP04233.

Miscellaneous databases

PMAP-CutDBP04233.

Expressioni

Gene expression databases

ArrayExpressiP04233.
BgeeiP04233.
CleanExiHS_CD74.
GenevestigatoriP04233.

Organism-specific databases

HPAiCAB002506.
HPA010592.

Interactioni

Subunit structurei

Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CXCR4P610734EBI-2622890,EBI-489411

Protein-protein interaction databases

BioGridi107410. 5 interactions.
IntActiP04233. 54 interactions.
MINTiMINT-1488574.
STRINGi9606.ENSP00000009530.

Structurei

Secondary structure

1
296
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi139 – 14911
Helixi162 – 17211
Helixi175 – 19420
Helixi212 – 2176
Beta strandi236 – 2383
Beta strandi240 – 2445
Turni245 – 2484
Beta strandi249 – 2535
Beta strandi265 – 2673

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A6AX-ray2.75C103-117[»]
1ICFX-ray2.00I/J210-274[»]
1IIENMR-A/B/C134-208[»]
1L3HNMR-A210-274[»]
1MUJX-ray2.15C97-121[»]
3PDOX-ray1.95C102-120[»]
3PGCX-ray2.66C/F106-120[»]
3PGDX-ray2.72C/F106-120[»]
3QXAX-ray2.71C/F103-117[»]
3QXDX-ray2.30C/F103-117[»]
4AENX-ray2.20C106-120[»]
4AH2X-ray2.36B106-120[»]
ProteinModelPortaliP04233.
SMRiP04233. Positions 134-208, 210-274.

Miscellaneous databases

EvolutionaryTraceiP04233.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini210 – 27162Thyroglobulin type-1Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni103 – 11715CLIPAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG248215.
HOVERGENiHBG004444.
InParanoidiP04233.
KOiK06505.
OrthoDBiEOG793B8J.
PhylomeDBiP04233.
TreeFamiTF317779.

Family and domain databases

Gene3Di1.10.870.10. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR015386. MHC_II-assoc_invar/CLIP_MHC-bd.
IPR022339. MHC_II-assoc_invar_chain.
IPR011988. MHC_II-assoc_invariant_trimer.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR14093. PTHR14093. 1 hit.
PfamiPF09307. MHC2-interact. 1 hit.
PF08831. MHCassoc_trimer. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001992. CD74_antigen. 1 hit.
PRINTSiPR01990. CD74ANTIGEN.
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF48305. SSF48305. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P04233-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY    50
TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP 100
PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD 150
PLKVYPPLKG SFPENLRHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ 200
KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC 250
WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM 296
Length:296
Mass (Da):33,516
Last modified:April 16, 2002 - v3
Checksum:i27A13F252D5FB91D
GO
Isoform 2 (identifier: P04233-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     209-272: Missing.

Show »
Length:232
Mass (Da):26,399
Checksum:i5144439D0FD27C99
GO
Isoform 3 (identifier: P04233-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-160: NADPLKVYPPLKG → SHWNWRTRLLGWV
     161-296: Missing.

Show »
Length:160
Mass (Da):18,328
Checksum:i95CB3D7226497DE8
GO

Sequence cautioni

The sequence AAA36304.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei148 – 16013NADPL…PPLKG → SHWNWRTRLLGWV in isoform 3. VSP_037869Add
BLAST
Alternative sequencei161 – 296136Missing in isoform 3. VSP_037870Add
BLAST
Alternative sequencei209 – 27264Missing in isoform 2. VSP_005331Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671R → T in CAA27047. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01144 mRNA. Translation: AAA36304.1. Different initiation.
X00497 mRNA. Translation: CAA25192.1.
X00497 mRNA. Translation: CAA25193.1.
X03339 Genomic DNA. Translation: CAA27046.1.
X03340 Genomic DNA. Translation: CAA27047.1.
M13560
, M13555, M13556, M13558, M13559 Genomic DNA. Translation: AAA36033.1.
BT019505 mRNA. Translation: AAV38312.1.
AK292076 mRNA. Translation: BAF84765.1.
AK297889 mRNA. Translation: BAG60210.1.
AC011372 Genomic DNA. No translation available.
AC011388 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61727.1.
CH471062 Genomic DNA. Translation: EAW61728.1.
CH471062 Genomic DNA. Translation: EAW61729.1.
CH471062 Genomic DNA. Translation: EAW61730.1.
CH471062 Genomic DNA. Translation: EAW61731.1.
BC018726 mRNA. Translation: AAH18726.1.
BC024272 mRNA. Translation: AAH24272.1.
CCDSiCCDS34276.1. [P04233-3]
CCDS47308.1. [P04233-2]
CCDS47309.1. [P04233-1]
PIRiA93981. HLHUG.
RefSeqiNP_001020329.1. NM_001025158.2. [P04233-3]
NP_001020330.1. NM_001025159.2. [P04233-1]
NP_004346.1. NM_004355.3. [P04233-2]
UniGeneiHs.436568.

Genome annotation databases

EnsembliENST00000009530; ENSP00000009530; ENSG00000019582. [P04233-1]
ENST00000353334; ENSP00000230685; ENSG00000019582. [P04233-2]
ENST00000377795; ENSP00000367026; ENSG00000019582. [P04233-3]
GeneIDi972.
KEGGihsa:972.
UCSCiuc003lsc.3. human. [P04233-1]
uc003lsd.3. human. [P04233-2]
uc003lse.3. human. [P04233-3]

Polymorphism databases

DMDMi20178292.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01144 mRNA. Translation: AAA36304.1 . Different initiation.
X00497 mRNA. Translation: CAA25192.1 .
X00497 mRNA. Translation: CAA25193.1 .
X03339 Genomic DNA. Translation: CAA27046.1 .
X03340 Genomic DNA. Translation: CAA27047.1 .
M13560
, M13555 , M13556 , M13558 , M13559 Genomic DNA. Translation: AAA36033.1 .
BT019505 mRNA. Translation: AAV38312.1 .
AK292076 mRNA. Translation: BAF84765.1 .
AK297889 mRNA. Translation: BAG60210.1 .
AC011372 Genomic DNA. No translation available.
AC011388 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61727.1 .
CH471062 Genomic DNA. Translation: EAW61728.1 .
CH471062 Genomic DNA. Translation: EAW61729.1 .
CH471062 Genomic DNA. Translation: EAW61730.1 .
CH471062 Genomic DNA. Translation: EAW61731.1 .
BC018726 mRNA. Translation: AAH18726.1 .
BC024272 mRNA. Translation: AAH24272.1 .
CCDSi CCDS34276.1. [P04233-3 ]
CCDS47308.1. [P04233-2 ]
CCDS47309.1. [P04233-1 ]
PIRi A93981. HLHUG.
RefSeqi NP_001020329.1. NM_001025158.2. [P04233-3 ]
NP_001020330.1. NM_001025159.2. [P04233-1 ]
NP_004346.1. NM_004355.3. [P04233-2 ]
UniGenei Hs.436568.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A6A X-ray 2.75 C 103-117 [» ]
1ICF X-ray 2.00 I/J 210-274 [» ]
1IIE NMR - A/B/C 134-208 [» ]
1L3H NMR - A 210-274 [» ]
1MUJ X-ray 2.15 C 97-121 [» ]
3PDO X-ray 1.95 C 102-120 [» ]
3PGC X-ray 2.66 C/F 106-120 [» ]
3PGD X-ray 2.72 C/F 106-120 [» ]
3QXA X-ray 2.71 C/F 103-117 [» ]
3QXD X-ray 2.30 C/F 103-117 [» ]
4AEN X-ray 2.20 C 106-120 [» ]
4AH2 X-ray 2.36 B 106-120 [» ]
ProteinModelPortali P04233.
SMRi P04233. Positions 134-208, 210-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107410. 5 interactions.
IntActi P04233. 54 interactions.
MINTi MINT-1488574.
STRINGi 9606.ENSP00000009530.

Chemistry

BindingDBi P04233.
ChEMBLi CHEMBL2111430.

Protein family/group databases

MEROPSi I31.002.

PTM databases

PhosphoSitei P04233.

Polymorphism databases

DMDMi 20178292.

Proteomic databases

MaxQBi P04233.
PaxDbi P04233.
PRIDEi P04233.

Protocols and materials databases

DNASUi 972.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000009530 ; ENSP00000009530 ; ENSG00000019582 . [P04233-1 ]
ENST00000353334 ; ENSP00000230685 ; ENSG00000019582 . [P04233-2 ]
ENST00000377795 ; ENSP00000367026 ; ENSG00000019582 . [P04233-3 ]
GeneIDi 972.
KEGGi hsa:972.
UCSCi uc003lsc.3. human. [P04233-1 ]
uc003lsd.3. human. [P04233-2 ]
uc003lse.3. human. [P04233-3 ]

Organism-specific databases

CTDi 972.
GeneCardsi GC05M149753.
HGNCi HGNC:1697. CD74.
HPAi CAB002506.
HPA010592.
MIMi 142790. gene.
neXtProti NX_P04233.
PharmGKBi PA26236.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248215.
HOVERGENi HBG004444.
InParanoidi P04233.
KOi K06505.
OrthoDBi EOG793B8J.
PhylomeDBi P04233.
TreeFami TF317779.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.

Miscellaneous databases

ChiTaRSi CD74. human.
EvolutionaryTracei P04233.
GeneWikii CD74.
GenomeRNAii 972.
NextBioi 4068.
PMAP-CutDB P04233.
PROi P04233.
SOURCEi Search...

Gene expression databases

ArrayExpressi P04233.
Bgeei P04233.
CleanExi HS_CD74.
Genevestigatori P04233.

Family and domain databases

Gene3Di 1.10.870.10. 1 hit.
4.10.800.10. 1 hit.
InterProi IPR015386. MHC_II-assoc_invar/CLIP_MHC-bd.
IPR022339. MHC_II-assoc_invar_chain.
IPR011988. MHC_II-assoc_invariant_trimer.
IPR000716. Thyroglobulin_1.
[Graphical view ]
PANTHERi PTHR14093. PTHR14093. 1 hit.
Pfami PF09307. MHC2-interact. 1 hit.
PF08831. MHCassoc_trimer. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001992. CD74_antigen. 1 hit.
PRINTSi PR01990. CD74ANTIGEN.
SMARTi SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF48305. SSF48305. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEi PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure."
    Claesson L., Larhammar D., Rask L., Peterson P.A.
    Proc. Natl. Acad. Sci. U.S.A. 80:7395-7399(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity."
    Strubin M., Mach B., Long E.O.
    EMBO J. 3:869-872(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens."
    Kudo J., Chao L.-Y., Narni F., Saunders G.F.
    Nucleic Acids Res. 13:8827-8841(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
  4. "Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes."
    O'Sullivan D.M., Larhammar D., Wilson M.C., Peterson P.A., Quaranta V.
    Proc. Natl. Acad. Sci. U.S.A. 83:4484-4488(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
    Tissue: Liver.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Heart and Synovium.
  7. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: B-cell and Tonsil.
  10. Bienvenut W.V.
    Submitted (JUN-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 22-35; 81-94; 171-179 AND 273-288, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  11. "HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides."
    Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P.
    Nature 360:474-477(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 97-120.
  12. "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)."
    Charest A., Lane K., McMahon K., Park J., Preisinger E., Conroy H., Housman D.
    Genes Chromosomes Cancer 37:58-71(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISEASE, CHROMOSOMAL TRANSLOCATION WITH ROS1.
  13. Cited for: INTERACTION WITH MIF.
  14. "MHC class II transport at a glance."
    Berger A.C., Roche P.A.
    J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  15. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-136.
    Tissue: Liver.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
    Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT THR-203, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
  18. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
    Halim A., Ruetschi U., Larson G., Nilsson J.
    J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT THR-203 AND SER-281, IDENTIFICATION BY MASS SPECTROMETRY.
  19. "The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3."
    Ghosh P., Amaya M., Mellins E., Wiley D.C.
    Nature 378:457-462(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 103-117 (CLIP) IN COMPLEX WITH HLA-DRA/HLA-DRB1 HETERODIMER.
  20. "Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii."
    Jasanoff A., Wagner G., Wiley D.C.
    EMBO J. 17:6812-6818(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 134-208.
  21. "Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S."
    Guncar G., Pungercic G., Klemencic I., Turk V., Turk D.
    EMBO J. 18:793-803(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 210-274, GLYCOSYLATION AT ASN-256, DISULFIDE BONDS.

Entry informationi

Entry nameiHG2A_HUMAN
AccessioniPrimary (citable) accession number: P04233
Secondary accession number(s): A8K7R1
, B4DNE8, D3DQG3, D3DQG4, Q14597, Q29832, Q5U0J8, Q8SNA0, Q8WLP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: April 16, 2002
Last modified: September 3, 2014
This is version 170 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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