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Protein

H-2 class II histocompatibility antigen, E-B beta chain

Gene

H2-Eb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, E-B beta chain
Gene namesi
Name:H2-Eb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95901. H2-Eb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 225199ExtracellularSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Topological domaini247 – 26418CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Add
BLAST
Chaini27 – 264238H-2 class II histocompatibility antigen, E-B beta chainPRO_0000019000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 106PROSITE-ProRule annotation
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 200PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP04230.
PaxDbiP04230.
PRIDEiP04230.

Expressioni

Gene expression databases

CleanExiMM_H2-EB1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074143.

Structurei

Secondary structure

1
264
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 4613Combined sources
Helixi47 – 493Combined sources
Beta strandi50 – 5910Combined sources
Beta strandi62 – 687Combined sources
Turni69 – 713Combined sources
Beta strandi73 – 786Combined sources
Helixi79 – 813Combined sources
Helixi82 – 898Combined sources
Helixi92 – 10413Combined sources
Helixi106 – 11611Combined sources
Turni117 – 1193Combined sources
Beta strandi125 – 1295Combined sources
Beta strandi142 – 15211Combined sources
Beta strandi155 – 1573Combined sources
Beta strandi167 – 1715Combined sources
Beta strandi178 – 1803Combined sources
Beta strandi182 – 1887Combined sources
Beta strandi201 – 2033Combined sources
Beta strandi211 – 2144Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KT2X-ray2.80B/D30-215[»]
3QIBX-ray2.70B30-225[»]
3QIUX-ray2.70B30-225[»]
3QIWX-ray3.30B30-225[»]
ProteinModelPortaliP04230.
SMRiP04230. Positions 31-215.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04230.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 21491Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 12195Beta-1Add
BLAST
Regioni122 – 225104Beta-2Add
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
HOGENOMiHOG000100909.
HOVERGENiHBG012730.
InParanoidiP04230.
PhylomeDBiP04230.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWLPRVPCV AAVILLLTVL SPPMALVRDS RPWFLEYCKS ECHFYNGTQR
60 70 80 90 100
VRLLERYFYN LEENLRFDSD VGEFHAVTEL GRPDAENWNS QPEFLEQKRA
110 120 130 140 150
EVDTVCRHNY EISDKFLVRR RVEPTVTVYP TKTQPLEHHN LLVCSVSDFY
160 170 180 190 200
PGNIEVRWFR NGKEEKTGIV STGLVRNGDW TFQTLVMLET VPQSGEVYTC
210 220 230 240 250
QVEHPSLTDP VTVEWKAQST SAQNKMLSGV GGFVLGLLFL GAGLFIYFRN
260
QKGQSGLQPT GLLS
Length:264
Mass (Da):30,166
Last modified:March 20, 1987 - v1
Checksum:iBF1264C41AF8D1C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00623 Genomic DNA. Translation: CAA25257.1.
X00701, X00702 Genomic DNA. Translation: CAB51615.2. Sequence problems.
M36940 mRNA. Translation: AAA39590.1.
L38590 Genomic DNA. Translation: AAA57294.1.
CCDSiCCDS37584.1.
PIRiA02226. HLMSE1.
UniGeneiMm.22564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00623 Genomic DNA. Translation: CAA25257.1.
X00701, X00702 Genomic DNA. Translation: CAB51615.2. Sequence problems.
M36940 mRNA. Translation: AAA39590.1.
L38590 Genomic DNA. Translation: AAA57294.1.
CCDSiCCDS37584.1.
PIRiA02226. HLMSE1.
UniGeneiMm.22564.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KT2X-ray2.80B/D30-215[»]
3QIBX-ray2.70B30-225[»]
3QIUX-ray2.70B30-225[»]
3QIWX-ray3.30B30-225[»]
ProteinModelPortaliP04230.
SMRiP04230. Positions 31-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074143.

Proteomic databases

MaxQBiP04230.
PaxDbiP04230.
PRIDEiP04230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95901. H2-Eb1.

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
HOGENOMiHOG000100909.
HOVERGENiHBG012730.
InParanoidiP04230.
PhylomeDBiP04230.

Miscellaneous databases

EvolutionaryTraceiP04230.
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-EB1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The nucleotide sequence of the murine I-E beta b immune response gene: evidence for gene conversion events in class II genes of the major histocompatibility complex."
    Widera G., Flavell R.A.
    EMBO J. 3:1221-1225(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/10.
  2. "Complete coding region sequence of E beta k cDNA clones: lack of polymorphism in the NH2-terminus between E beta k and E beta b molecules."
    King L.B., Sharma S., Corley R.B.
    J. Immunogenet. 15:209-214(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Nucleotide sequence analysis of class II genes borne by mouse t chromosomes."
    Golubic M., Budimir O., Schoepfer R., Kasahara M., Mayer W.E., Figueroa F., Klein J.
    Genet. Res. 50:137-146(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 113-121.
  4. "Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination."
    van Niel G., Wubbolts R., Ten Broeke T., Buschow S.I., Ossendorp F.A., Melief C.J., Raposo G., van Balkom B.W., Stoorvogel W.
    Immunity 25:885-894(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.
  5. "Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination."
    Shin J.S., Ebersold M., Pypaert M., Delamarre L., Hartley A., Mellman I.
    Nature 444:115-118(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.

Entry informationi

Entry nameiHB21_MOUSE
AccessioniPrimary (citable) accession number: P04230
Secondary accession number(s): O78226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: November 11, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.