H2-Eb1

Functionⁱ

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class II
Source: MGI
Inferred from direct assayⁱ
- 11027433
- 11714799
immune response Source: InterPro

Keywordsⁱ

Biological process	Immunity

Biological process

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: H-2 class II histocompatibility antigen, E-B beta chain
Gene namesⁱ	Name:H2-Eb1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:95901. H2-Eb1.

Subcellular locationⁱ

Membrane Curated; Single-pass type I membrane protein Curated

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 225	ExtracellularSequence analysisAdd BLAST	199
Transmembraneⁱ	226 – 246	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	247 – 264	CytoplasmicSequence analysisAdd BLAST	18

GO - Cellular componentⁱ

extracellular exosome Source: MGI
integral component of membrane Source: UniProtKB-KW
late endosome membrane Source: MGI
lysosomal membrane Source: MGI
MHC class II protein complex Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane, MHC II

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Add BLAST		26
ChainⁱPRO_0000019000	27 – 264	H-2 class II histocompatibility antigen, E-B beta chainAdd BLAST		238

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	38 ↔ 106	PROSITE-ProRule annotation
Glycosylationⁱ	46	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	144 ↔ 200	PROSITE-ProRule annotation

Post-translational modificationⁱ

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P04230.
PaxDbⁱ	P04230.
PRIDEⁱ	P04230.

Expressionⁱ

Gene expression databases

CleanExⁱ	MM_H2-EB1.

CleanExⁱ

MM_H2-EB1.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000074143.

STRINGⁱ

10090.ENSMUSP00000074143.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	34 – 46	Combined sources	13
Helixⁱ	47 – 49	Combined sources	3
Beta strandⁱ	50 – 59	Combined sources	10
Beta strandⁱ	62 – 68	Combined sources	7
Turnⁱ	69 – 71	Combined sources	3
Beta strandⁱ	73 – 78	Combined sources	6
Helixⁱ	79 – 81	Combined sources	3
Helixⁱ	82 – 89	Combined sources	8
Helixⁱ	92 – 104	Combined sources	13
Helixⁱ	106 – 116	Combined sources	11
Turnⁱ	117 – 119	Combined sources	3
Beta strandⁱ	125 – 129	Combined sources	5
Beta strandⁱ	142 – 152	Combined sources	11
Beta strandⁱ	155 – 157	Combined sources	3
Beta strandⁱ	167 – 171	Combined sources	5
Beta strandⁱ	178 – 180	Combined sources	3
Beta strandⁱ	182 – 188	Combined sources	7
Beta strandⁱ	201 – 203	Combined sources	3
Beta strandⁱ	211 – 214	Combined sources	4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1KT2	X-ray	2.80	B/D	30-215	[»]
	3QIB	X-ray	2.70	B	30-225	[»]
	3QIU	X-ray	2.70	B	30-225	[»]
	3QIW	X-ray	3.30	B	30-225	[»]
ProteinModelPortalⁱ	P04230.
SMRⁱ	P04230.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P04230.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	124 – 214	Ig-like C1-typeAdd BLAST		91

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	27 – 121	Beta-1Add BLAST		95
Regionⁱ	122 – 225	Beta-2Add BLAST		104

Sequence similaritiesⁱ

Belongs to the MHC class II family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IWG3. Eukaryota. ENOG410YI0S. LUCA.
HOGENOMⁱ	HOG000100909.
HOVERGENⁱ	HBG012730.
InParanoidⁱ	P04230.
PhylomeDBⁱ	P04230.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 1 hit. 3.10.320.10. 1 hit.
InterProⁱ	View protein in InterPro IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654. C1-set. 1 hit. PF00969. MHC_II_beta. 1 hit.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD000328. MHC_II_b_N. 1 hit.
SMARTⁱ	View protein in SMART SM00407. IGc1. 1 hit. SM00921. MHC_II_beta. 1 hit.
SUPFAMⁱ	SSF48726. SSF48726. 1 hit. SSF54452. SSF54452. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P04230-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVWLPRVPCV AAVILLLTVL SPPMALVRDS RPWFLEYCKS ECHFYNGTQR 
        60         70         80         90        100
VRLLERYFYN LEENLRFDSD VGEFHAVTEL GRPDAENWNS QPEFLEQKRA 
       110        120        130        140        150
EVDTVCRHNY EISDKFLVRR RVEPTVTVYP TKTQPLEHHN LLVCSVSDFY 
       160        170        180        190        200
PGNIEVRWFR NGKEEKTGIV STGLVRNGDW TFQTLVMLET VPQSGEVYTC 
       210        220        230        240        250
QVEHPSLTDP VTVEWKAQST SAQNKMLSGV GGFVLGLLFL GAGLFIYFRN 
       260 
QKGQSGLQPT GLLS

Length:264

Mass (Da):30,166

Last modified:March 20, 1987 - v1

Checksum:ⁱBF1264C41AF8D1C0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00623 Genomic DNA. Translation: CAA25257.1. X00701, X00702 Genomic DNA. Translation: CAB51615.2. Sequence problems. M36940 mRNA. Translation: AAA39590.1. L38590 Genomic DNA. Translation: AAA57294.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS37584.1.
PIRⁱ	A02226. HLMSE1.
UniGeneⁱ	Mm.22564.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00623 Genomic DNA. Translation: CAA25257.1. X00701, X00702 Genomic DNA. Translation: CAB51615.2. Sequence problems. M36940 mRNA. Translation: AAA39590.1. L38590 Genomic DNA. Translation: AAA57294.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS37584.1.
PIRⁱ	A02226. HLMSE1.
UniGeneⁱ	Mm.22564.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1KT2	X-ray	2.80	B/D	30-215	[»]
	3QIB	X-ray	2.70	B	30-225	[»]
	3QIU	X-ray	2.70	B	30-225	[»]
	3QIW	X-ray	3.30	B	30-225	[»]
ProteinModelPortalⁱ	P04230.
SMRⁱ	P04230.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000074143.

STRINGⁱ

10090.ENSMUSP00000074143.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P04230.
PaxDbⁱ	P04230.
PRIDEⁱ	P04230.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

MGIⁱ	MGI:95901. H2-Eb1.

Phylogenomic databases

eggNOGⁱ	ENOG410IWG3. Eukaryota. ENOG410YI0S. LUCA.
HOGENOMⁱ	HOG000100909.
HOVERGENⁱ	HBG012730.
InParanoidⁱ	P04230.
PhylomeDBⁱ	P04230.

Miscellaneous databases

EvolutionaryTraceⁱ	P04230.
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_H2-EB1.

CleanExⁱ

MM_H2-EB1.

Family and domain databases

Gene3Dⁱ	2.60.40.10. 1 hit. 3.10.320.10. 1 hit.
InterProⁱ	View protein in InterPro IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654. C1-set. 1 hit. PF00969. MHC_II_beta. 1 hit.
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD000328. MHC_II_b_N. 1 hit.
SMARTⁱ	View protein in SMART SM00407. IGc1. 1 hit. SM00921. MHC_II_beta. 1 hit.
SUPFAMⁱ	SSF48726. SSF48726. 1 hit. SSF54452. SSF54452. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HB21_MOUSE
Accessionⁱ	P04230Primary (citable) accession number: P04230 Secondary accession number(s): O78226
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
	Last sequence update:	March 20, 1987
	Last modified:	May 10, 2017
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P04230 (HB21_MOUSE)

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H-2 class II histocompatibility antigen, E-B beta chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ