UniProtKB - P04230 (HB21_MOUSE)
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Protein
H-2 class II histocompatibility antigen, E-B beta chain
Gene
H2-Eb1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
- immune response Source: InterPro
Keywordsi
Biological process | Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: H-2 class II histocompatibility antigen, E-B beta chain |
Gene namesi | Name:H2-Eb1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95901. H2-Eb1. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 225 | ExtracellularSequence analysisAdd BLAST | 199 | |
Transmembranei | 226 – 246 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 247 – 264 | CytoplasmicSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Membrane, MHC IIPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Add BLAST | 26 | |
ChainiPRO_0000019000 | 27 – 264 | H-2 class II histocompatibility antigen, E-B beta chainAdd BLAST | 238 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 38 ↔ 106 | PROSITE-ProRule annotation | ||
Glycosylationi | 46 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 144 ↔ 200 | PROSITE-ProRule annotation |
Post-translational modificationi
Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications
Keywords - PTMi
Disulfide bond, Glycoprotein, Ubl conjugationProteomic databases
MaxQBi | P04230. |
PaxDbi | P04230. |
PRIDEi | P04230. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 34 – 46 | Combined sources | 13 | |
Helixi | 47 – 49 | Combined sources | 3 | |
Beta strandi | 50 – 59 | Combined sources | 10 | |
Beta strandi | 62 – 68 | Combined sources | 7 | |
Turni | 69 – 71 | Combined sources | 3 | |
Beta strandi | 73 – 78 | Combined sources | 6 | |
Helixi | 79 – 81 | Combined sources | 3 | |
Helixi | 82 – 90 | Combined sources | 9 | |
Helixi | 92 – 104 | Combined sources | 13 | |
Helixi | 106 – 113 | Combined sources | 8 | |
Turni | 114 – 116 | Combined sources | 3 | |
Turni | 117 – 119 | Combined sources | 3 | |
Beta strandi | 125 – 130 | Combined sources | 6 | |
Beta strandi | 140 – 152 | Combined sources | 13 | |
Beta strandi | 155 – 160 | Combined sources | 6 | |
Beta strandi | 169 – 171 | Combined sources | 3 | |
Beta strandi | 178 – 180 | Combined sources | 3 | |
Beta strandi | 182 – 190 | Combined sources | 9 | |
Beta strandi | 198 – 203 | Combined sources | 6 | |
Beta strandi | 211 – 215 | Combined sources | 5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1I3R | X-ray | 2.40 | B/D/F/H | 30-225 | [»] | |
1KT2 | X-ray | 2.80 | B/D | 30-215 | [»] | |
1KTD | X-ray | 2.40 | B/D | 30-215 | [»] | |
3QIB | X-ray | 2.70 | B | 30-225 | [»] | |
3QIU | X-ray | 2.70 | B | 30-225 | [»] | |
3QIW | X-ray | 3.30 | B | 30-225 | [»] | |
ProteinModelPortali | P04230. | |||||
SMRi | P04230. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P04230. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 124 – 214 | Ig-like C1-typeAdd BLAST | 91 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 121 | Beta-1Add BLAST | 95 | |
Regioni | 122 – 225 | Beta-2Add BLAST | 104 |
Sequence similaritiesi
Belongs to the MHC class II family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IWG3. Eukaryota. ENOG410YI0S. LUCA. |
HOGENOMi | HOG000100909. |
HOVERGENi | HBG012730. |
InParanoidi | P04230. |
PhylomeDBi | P04230. |
Family and domain databases
Gene3Di | 2.60.40.10. 1 hit. 3.10.320.10. 1 hit. |
InterProi | View protein in InterPro IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N. |
Pfami | View protein in Pfam PF07654. C1-set. 1 hit. PF00969. MHC_II_beta. 1 hit. |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD000328. MHC_II_b_N. 1 hit. |
SMARTi | View protein in SMART SM00407. IGc1. 1 hit. SM00921. MHC_II_beta. 1 hit. |
SUPFAMi | SSF48726. SSF48726. 1 hit. SSF54452. SSF54452. 1 hit. |
PROSITEi | View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P04230-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVWLPRVPCV AAVILLLTVL SPPMALVRDS RPWFLEYCKS ECHFYNGTQR
60 70 80 90 100
VRLLERYFYN LEENLRFDSD VGEFHAVTEL GRPDAENWNS QPEFLEQKRA
110 120 130 140 150
EVDTVCRHNY EISDKFLVRR RVEPTVTVYP TKTQPLEHHN LLVCSVSDFY
160 170 180 190 200
PGNIEVRWFR NGKEEKTGIV STGLVRNGDW TFQTLVMLET VPQSGEVYTC
210 220 230 240 250
QVEHPSLTDP VTVEWKAQST SAQNKMLSGV GGFVLGLLFL GAGLFIYFRN
260
QKGQSGLQPT GLLS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00623 Genomic DNA. Translation: CAA25257.1. X00701, X00702 Genomic DNA. Translation: CAB51615.2. Sequence problems. M36940 mRNA. Translation: AAA39590.1. L38590 Genomic DNA. Translation: AAA57294.1. |
CCDSi | CCDS37584.1. |
PIRi | A02226. HLMSE1. |
UniGenei | Mm.22564. |
Similar proteinsi
Entry informationi
Entry namei | HB21_MOUSE | |
Accessioni | P04230Primary (citable) accession number: P04230 Secondary accession number(s): O78226 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 1987 |
Last sequence update: | March 20, 1987 | |
Last modified: | February 28, 2018 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |