P04229 (2B11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class II histocompatibility antigen, DRB1-1 beta chain

Alternative name(s):
MHC class II antigen DRB1*1
Short name=DR-1
Short name=DR1

Gene names

Name:

HLA-DRB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.
Subunit structure	Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus › trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Ref.23
Post-translational modification	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II Probable. Ref.23
Polymorphism	The following alleles of DRB1-1 are known: DRB1*01:01; DRB1*01:02; DRB1*01:03; DRB1*01:04; DRB1*01:05; DRB1*01:06; DRB1*01:07; DRB1*01:08; DRB1*01:09; DRB1*01:10; DRB1*01:11; DRB1*01:12; DRB1*01:13; DRB1*01:14; DRB1*01:15; DRB1*01:16; DRB1*01:17; DRB1*01:18; DRB1*01:19; DRB1*01:20 and DRB1*01:21. The sequence shown is that of DRB1*01:01.
Involvement in disease	Sarcoidosis 1 (SS1) [MIM:181000]: An idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.17
Sequence similarities	Belongs to the MHC class II family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Immunity
Cellular component	Cell membrane Endoplasmic reticulum Endosome Golgi apparatus Lysosome MHC II Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Isopeptide bond Ubl conjugation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	T cell costimulation Traceable author statement. Source: Reactome T cell receptor signaling pathway Traceable author statement. Source: Reactome T-helper 1 type immune response Inferred from sequence or structural similarity. Source: UniProtKB antigen processing and presentation of exogenous peptide antigen via MHC class II Traceable author statement. Source: Reactome detection of bacterium Inferred from sequence or structural similarity. Source: UniProtKB humoral immune response mediated by circulating immunoglobulin Inferred from sequence or structural similarity. Source: UniProtKB immunoglobulin production involved in immunoglobulin mediated immune response Inferred from sequence or structural similarity. Source: UniProtKB inflammatory response to antigenic stimulus Inferred from sequence or structural similarity. Source: UniProtKB interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome negative regulation of T cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of interferon-gamma production Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of insulin secretion involved in cellular response to glucose stimulus Inferred from sequence or structural similarity. Source: UniProtKB protein tetramerization Inferred from sequence or structural similarity. Source: UniProtKB regulation of interleukin-10 secretion Inferred from sequence or structural similarity. Source: UniProtKB regulation of interleukin-4 production Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class II protein complex Inferred from electronic annotation. Source: UniProtKB-KW clathrin-coated endocytic vesicle membrane Traceable author statement. Source: Reactome external side of plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome late endosome membrane Inferred from direct assay Ref.23. Source: UniProtKB lysosomal membrane Inferred from direct assay Ref.23. Source: UniProtKB trans-Golgi network membrane Traceable author statement. Source: Reactome
Molecular_function	peptide antigen binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

29

Ref.9

Chain

30 – 266

237

HLA class II histocompatibility antigen, DRB1-1 beta chain

PRO_0000018949

Regions

Topological domain

30 – 227

198

Extracellular Potential

Transmembrane

228 – 250

23

Helical; Potential

Topological domain

251 – 266

16

Cytoplasmic Potential

Domain

126 – 214

89

Ig-like C1-type

Region

30 – 124

95

Beta-1

Region

125 – 227

103

Beta-2

Amino acid modifications

Glycosylation

48

1

N-linked (GlcNAc...) Potential

Disulfide bond

44 ↔ 108

By similarity

Disulfide bond

146 ↔ 202

By similarity

Cross-link

254

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Natural variations

Natural variant

5

1

K → R.
Corresponds to variant rs9270305 [ dbSNP | Ensembl ].

VAR_056527

Natural variant

13

1

T → A.
Corresponds to variant rs1059553 [ dbSNP | Ensembl ].

VAR_033377

Natural variant

29

1

A → S.
Corresponds to variant rs9270299 [ dbSNP | Ensembl ].

VAR_033378

Natural variant

33

1

R → K.
Corresponds to variant rs34716432 [ dbSNP | Ensembl ].

VAR_033379

Natural variant

33

1

R → Q.
Corresponds to variant rs34716432 [ dbSNP | Ensembl ].

VAR_033380

Natural variant

39

1

Q → E in allele DRB1*01:07.

VAR_016740

Natural variant

66

1

S → Y.
Corresponds to variant rs16822820 [ dbSNP | Ensembl ].

VAR_033381

Natural variant

74

1

G → R in allele DRB1*01:05.

VAR_016741

Natural variant

76

1

Y → F.
Corresponds to variant rs1060346 [ dbSNP | Ensembl ].

VAR_033382

Natural variant

89

1

Y → S.
Corresponds to variant rs36074728 [ dbSNP | Ensembl ].

VAR_033383

Natural variant

96

1

L → I in allele DRB1*01:03.

VAR_016710

Natural variant

99

1

Q → D in allele DRB1*01:03; requires 2 nucleotide substitutions.

VAR_016711

Natural variant

99

1

Q → E.
Corresponds to variant rs17881965 [ dbSNP | Ensembl ].

VAR_033384

Natural variant

99

1

Q → H.
Corresponds to variant rs17879599 [ dbSNP | Ensembl ].

VAR_033385

Natural variant

100

1

R → A in allele DRB1*01:06; requires 2 nucleotide substitutions.

VAR_016742

Natural variant

100

1

R → E in allele DRB1*01:03; requires 2 nucleotide substitutions.

VAR_016712

Natural variant

102

1

A → G.
Corresponds to variant rs17878857 [ dbSNP | Ensembl ].

VAR_033386

Natural variant

103

1

A → E.
Corresponds to variant rs16822805 [ dbSNP | Ensembl ].

VAR_033387

Natural variant

106

1

T → N in allele DRB1*01:04.
Corresponds to variant rs16822752 [ dbSNP | Ensembl ].

VAR_016713

Natural variant

107

1

Y → H.
Corresponds to variant rs16822512 [ dbSNP | Ensembl ].

VAR_033388

Natural variant

114

1

V → A in allele DRB1*01:02.
Corresponds to variant rs17424145 [ dbSNP | Ensembl ].

VAR_016714

Natural variant

115

1

G → V in allele DRB1*01:02, allele DRB1*01:04 and allele DRB1*01:06.
Corresponds to variant rs2230810 [ dbSNP | Ensembl ].

VAR_016715

Natural variant

164

1

G → D.
Corresponds to variant rs1059633 [ dbSNP | Ensembl ].

VAR_033389

Natural variant

169

1

A → T.
Corresponds to variant rs2308768 [ dbSNP | Ensembl ].

VAR_033390

Natural variant

171

1

V → M.
Corresponds to variant rs701829 [ dbSNP | Ensembl ].

VAR_033391

Natural variant

178

1

Q → H.
Corresponds to variant rs701830 [ dbSNP | Ensembl ].

VAR_033392

Natural variant

195

1

R → Q.
Corresponds to variant rs3205588 [ dbSNP | Ensembl ].

VAR_033393

Natural variant

210

1

T → I.
Corresponds to variant rs17423930 [ dbSNP | Ensembl ].

VAR_033394

Natural variant

236

1

V → M.
Corresponds to variant rs2230816 [ dbSNP | Ensembl ].

VAR_033395

Natural variant

253

1

Q → E in allele DRB1*01:02.

VAR_016716

Natural variant

262

1

T → R. Ref.5
Corresponds to variant rs9269744 [ dbSNP | Ensembl ].

VAR_056528

Experimental info

Sequence conflict

25

1

P → R in AAA59781. Ref.2

Sequence conflict

36

1

F → S AA sequence Ref.9

Sequence conflict

58 – 59

2

RC → LF AA sequence Ref.9

Sequence conflict

80

1

T → E in AAA59781. Ref.2

Sequence conflict

100 – 103

4

RRAA → KRGQ in AAA59781. Ref.2

Sequence conflict

192

1

T → I in AAA59781. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

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.

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.

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.

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.

.

.

.

266

Helix Strand Turn

Details...

Beta strand

36 – 47

12

Turn

48 – 51

4

Beta strand

52 – 63

12

Beta strand

65 – 70

6

Turn

71 – 73

3

Beta strand

75 – 80

6

Helix

81 – 83

3

Helix

84 – 91

8

Helix

94 – 106

13

Helix

108 – 115

8

Helix

116 – 118

3

Turn

119 – 121

3

Beta strand

127 – 132

6

Beta strand

135 – 139

5

Beta strand

142 – 154

13

Beta strand

157 – 162

6

Beta strand

165 – 167

3

Beta strand

169 – 173

5

Beta strand

180 – 182

3

Beta strand

184 – 192

9

Beta strand

199 – 205

7

Beta strand

213 – 218

6

Sequences

	Sequence		Length	Mass (Da)
	P04229 [UniParc]. Last modified August 29, 2003. Version 2. Checksum: CC9CC7E2D0DD036C	FASTA	266	29,914
	10 20 30 40 50 60 MVCLKLPGGS CMTALTVTLM VLSSPLALAG DTRPRFLWQL KFECHFFNGT ERVRLLERCI 70 80 90 100 110 120 YNQEESVRFD SDVGEYRAVT ELGRPDAEYW NSQKDLLEQR RAAVDTYCRH NYGVGESFTV 130 140 150 160 170 180 QRRVEPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG 190 200 210 220 230 240 DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 250 260 FLGAGLFIYF RNQKGHSGLQ PTGFLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression." Tonnelle C., Demars R., Long E.O. EMBO J. 4:2839-2847(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*01:01).
[2]	"DNA sequence and characterization of human class II major histocompatibility complex beta chains from the DR1 haplotype." Bell J.I., Estess P., St John T., Saiki R., Watling D.L., Erlich H.A., McDevitt H.O. Proc. Natl. Acad. Sci. U.S.A. 82:3405-3409(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*01:01).
[3]	"Evolution of the HLA-DR1 gene family. Structural and functional analysis of the new allele 'DR-BON'." Coppin H.L., Avoustin P., Fabron J., Huchenq A., Garnier J.-M., Thomsen M., De Preval C. J. Immunol. 144:984-989(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*01:03).
[4]	"Ancient haplotypes of the HLA Class II region." Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S., Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V. Genome Res. 15:1250-1257(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles." von Salome J., Gyllensten U., Bergstroem T.F. Immunogenetics 59:261-271(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DRB1*01:01), VARIANT ARG-262.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[7]	"Polymorphism in the regulatory region of HLA-DRB genes correlating with haplotype evolution." Louis P., Eliaou J.F., Kerlan-Candon S., Pinet V., Vincent R., Clot J. Immunogenetics 38:21-26(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29. Tissue: B-cell.
[8]	Middleton D., Versluis L.F., Tilanus M.G.J. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB1*01:04).
[9]	"N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens." Walker L.E., Hewick R., Hunkapiller M.W., Hood L.E., Dreyer W.J., Reisfeld R.A. Biochemistry 22:185-188(1983) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 30-64. Tissue: B-cell.
[10]	"Identification of a novel DRB1-allele (DRB1*0106) by sequence-based typing." Palou E., Mongay L., Arias M.T., Isart F., Suarez B., Masso M., Fabregat V., Martorell J., Gaya A. Tissue Antigens 53:308-310(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*01:06).
[11]	"Identification of three new DRB1 alleles, DRB1*0107, *0425 and *13012 and confirmation of DRB4*01033." Voorter C.E.M., Hepkema B.G., Lems S.P.M., van den Berg-Loonen E.M. Tissue Antigens 61:398-402(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*01:07).
[12]	"HLA-DRB1 new alleles." Kashiwase K., Akaza T., Juji T. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*01:05).
[13]	"A new HLA-DRB1*01 allele." Dormoy A., Froelich N., Leisenbach R., Tongio M.M. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB1*01:07).
[14]	"Identification and sequencing of a novel DRB1*01 allele." Hashemi S., Couture C., Cole R., Buyse I. Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB1*01:02). Tissue: Blood.
[15]	"Polymorphism of the HLA-DR1 haplotype in American blacks. Identification of a DR1 beta-chain determinant recognized in the mixed lymphocyte reaction." Hurley C.K., Ziff B.L., Silver J., Gregersen P.K., Hartzman R., Johnson A.H. J. Immunol. 140:4019-4023(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-266 (ALLELE DRB1*01:02).
[16]	"HLA class II polymorphism." Arnaiz-Villena A. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-115 (ALLELES DRB1*01:01 AND DRB1*01:02). Tissue: Blood.
[17]	"HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites." Rossman M.D., Thompson B., Frederick M., Maliarik M., Iannuzzi M.C., Rybicki B.A., Pandey J.P., Newman L.S., Magira E., Beznik-Cizman B., Monos D. Am. J. Hum. Genet. 73:720-735(2003) [PubMed] [Europe PMC] [Abstract] Cited for: DISEASE.
[18]	"Invariant chain structure and MHC class II function." Cresswell P. Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[19]	"Presentation of antigens by MHC class II molecules: getting the most out of them." Villadangos J.A. Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[20]	"Autophagy in MHC class II presentation: sampling from within." Menendez-Benito V., Neefjes J. Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[21]	"MHC class II molecules on the move for successful antigen presentation." Rocha N., Neefjes J. EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[22]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[23]	"MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E. Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
[24]	"MHC class II transport at a glance." Berger A.C., Roche P.A. J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[25]	"CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract." Beswick E.J., Reyes V.E. World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[26]	"Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1." Brown J.H., Jardetzky T.S., Gorga J.C., Stern L.J., Urban R.G., Strominger J.L., Wiley D.C. Nature 364:33-39(1993) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 32-219.
[27]	"Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide." Stern L.J., Brown J.H., Jardetzky T.J., Gorga J.C., Urban R.G., Strominger J.L., Wiley D.C. Nature 368:215-221(1994) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 32-219.
[28]	"Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen." Jardetzky T.S., Brown J.H., Gorga J.C., Stern L.J., Urban R.G., Chi Y.I., Stauffacher C., Strominger J.L., Wiley D.C. Nature 368:711-718(1994) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF COMPLEX WITH SEB.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X03069 mRNA. Translation: CAA26873.1.
M11161 mRNA. Translation: AAA59781.1.
M33600 mRNA. Translation: AAA59782.1.
AY663400 Genomic DNA. Translation: AAU87993.1.
AM419948 Genomic DNA. Translation: CAL99240.1.
AK289463 mRNA. Translation: BAF82152.1.
X64547 Genomic DNA. Translation: CAA45845.1.
X99896 mRNA. Translation: CAA68171.1.
AF089723 Genomic DNA. Translation: AAD51131.1.
AJ276206 Genomic DNA. Translation: CAC27123.1.
AB015184 Genomic DNA. Translation: BAA28761.1.
AJ303118 Genomic DNA. Translation: CAC19693.1.
Z50871 Genomic DNA. No translation available.
M21008 mRNA. Translation: AAA59780.1.
AF029288 Genomic DNA. Translation: AAF65497.1.
AF029293 Genomic DNA. Translation: AAF65502.1.

IPI

IPI00738107.

PIR

A19197.
HLHU1B. D24669.
I56072.
PH0147.

UniGene

Hs.534322.
Hs.696211.
Hs.736560.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1AQD	X-ray	2.45	B/E/H/K	30-227	[»]
1DLH	X-ray	2.80	B/E	32-219	[»]
1FYT	X-ray	2.60	B	30-221	[»]
1HXY	X-ray	2.60	B	30-219	[»]
1JWM	X-ray	2.70	B	30-219	[»]
1JWS	X-ray	2.60	B	30-219	[»]
1JWU	X-ray	2.30	B	30-219	[»]
1KG0	X-ray	2.65	B	32-219	[»]
1KLG	X-ray	2.40	B	30-219	[»]
1KLU	X-ray	1.93	B	30-219	[»]
1LO5	X-ray	3.20	B	30-219	[»]
1PYW	X-ray	2.10	B	30-219	[»]
1R5I	X-ray	2.60	B/F	30-219	[»]
1SEB	X-ray	2.70	B/F	30-221	[»]
1SJE	X-ray	2.45	B	30-219	[»]
1SJH	X-ray	2.25	B	30-219	[»]
1T5W	X-ray	2.40	B/E	30-219	[»]
1T5X	X-ray	2.50	B	30-219	[»]
2FSE	X-ray	3.10	B/D	33-217	[»]
2G9H	X-ray	2.00	B	30-219	[»]
2IAM	X-ray	2.80	B	30-219	[»]
2IAN	X-ray	2.80	B/G/L/Q	30-219	[»]
2ICW	X-ray	2.41	B/E	30-219	[»]
2IPK	X-ray	2.30	B	30-219	[»]
2OJE	X-ray	3.00	B/F	30-219	[»]
2XN9	X-ray	2.30	E	30-219	[»]
3L6F	X-ray	2.10	B	30-221	[»]
3PDO	X-ray	1.95	B	30-227	[»]
3PGC	X-ray	2.66	B/E	30-227	[»]
3PGD	X-ray	2.72	B/E	30-227	[»]
3QXA	X-ray	2.71	B/E	30-219	[»]
3QXD	X-ray	2.30	B/E	30-219	[»]
3S4S	X-ray	2.40	B/E	30-221	[»]
3S5L	X-ray	2.10	B/E	30-221	[»]
4AEN	X-ray	2.20	B	30-227	[»]
4AH2	X-ray	2.36	B	30-227	[»]
4E41	X-ray	2.60	B/G	30-219	[»]
4FQX	X-ray	2.60	B	30-221	[»]
4GBX	X-ray	3.00	B	30-221	[»]

ProteinModelPortal

P04229.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-6143N.

IntAct

P04229. 1 interaction.

MINT

MINT-203282.

PTM databases

PhosphoSite

P04229.

Polymorphism databases

DMDM

34395916.

Proteomic databases

PaxDb

P04229.

PRIDE

P04229.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000360004; ENSP00000353099; ENSG00000196126.

Organism-specific databases

GeneCards

GC06M032546.

HGNC

HGNC:4948. HLA-DRB1.

HPA

CAB015400.
CAB034021.

MIM

142857. gene.
181000. phenotype.

neXtProt

NX_P04229.

Orphanet

243377. Diabetes mellitus type 1.
220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
220407. Limited systemic sclerosis.
802. Multiple sclerosis.
2073. Narcolepsy-cataplexy.
93567. Pediatric systemic sclerosis.
284130. Rheumatoid arthritis.
797. Sarcoidosis.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG68200.

HOVERGEN

HBG012730.

InParanoid

P04229.

OrthoDB

EOG461454.

Enzyme and pathway databases

Pathway_Interaction_DB

il12_stat4pathway. IL12 signaling mediated by STAT4.
il12_2pathway. IL12-mediated signaling events.
tcrpathway. TCR signaling in naive CD4+ T cells.

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P04229.

Bgee

P04229.

CleanEx

HS_HLA-DRB1.

Genevestigator

P04229.

GermOnline

ENSG00000196126. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.10.320.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]

ProDom

PD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P04229.

ChEMBL

CHEMBL1943.

ChiTaRS

HLA-DRB1. human.

DrugBank

DB05259. Glatiramer Acetate.

EvolutionaryTrace

P04229.

SOURCE

Search...

Entry information

Entry name

2B11_HUMAN

Accession

Primary (citable) accession number: P04229
Secondary accession number(s): A4F5N0 , A8K098, O62869, P13758, Q06662, Q30116, Q30117, Q5Y7E9, Q7M2H4, Q95461, Q9BCL7, Q9GIK5, Q9MXZ0, Q9MXZ5, Q9TQ91

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 1987
Last sequence update:	August 29, 2003
Last modified:	May 1, 2013
This is version 132 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.