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P04228

- HA2D_MOUSE

UniProt

P04228 - HA2D_MOUSE

Protein

H-2 class II histocompatibility antigen, A-D alpha chain

Gene

H2-Aa

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (20 Mar 1987)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. peptide antigen binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. antigen processing and presentation Source: MGI
    2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
    3. antigen processing and presentation of peptide antigen Source: MGI
    4. immune response Source: InterPro
    5. positive regulation of T cell differentiation Source: MGI

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    H-2 class II histocompatibility antigen, A-D alpha chain
    Gene namesi
    Name:H2-Aa
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:95895. H2-Aa.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosome Source: MGI
    4. MHC class II protein complex Source: MGI
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane, MHC II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Add
    BLAST
    Chaini24 – 256233H-2 class II histocompatibility antigen, A-D alpha chainPRO_0000018976Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi134 ↔ 190PROSITE-ProRule annotation
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP04228.

    Expressioni

    Gene expression databases

    CleanExiMM_H2-AA.
    GenevestigatoriP04228.

    Interactioni

    Protein-protein interaction databases

    IntActiP04228. 2 interactions.
    MINTiMINT-129609.

    Structurei

    Secondary structure

    1
    256
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 4112
    Turni42 – 454
    Beta strandi46 – 538
    Beta strandi56 – 627
    Turni63 – 664
    Beta strandi67 – 726
    Turni73 – 786
    Helixi79 – 813
    Helixi83 – 10422
    Helixi106 – 1116
    Beta strandi115 – 1228
    Beta strandi130 – 13910
    Beta strandi145 – 1506
    Beta strandi153 – 1553
    Beta strandi157 – 1615
    Beta strandi164 – 1663
    Beta strandi172 – 1809
    Beta strandi182 – 1854
    Beta strandi187 – 1937
    Beta strandi201 – 2055
    Beta strandi212 – 2165

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ES0X-ray2.60A24-205[»]
    1F3JX-ray3.10A/D27-208[»]
    1IAOX-ray2.60A24-209[»]
    B28-216[»]
    2IADX-ray2.40A24-205[»]
    3CUPX-ray3.09A24-205[»]
    3MBEX-ray2.89A/E24-205[»]
    ProteinModelPortaliP04228.
    SMRiP04228. Positions 27-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP04228.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 218195ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini245 – 25612CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei219 – 24426HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini114 – 20693Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 11188Alpha-1Add
    BLAST
    Regioni112 – 20594Alpha-2Add
    BLAST
    Regioni206 – 21813Connecting peptideAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class II family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG006862.
    InParanoidiP04228.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P04228-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPCSRALILG VLALNTMLSL CGGEDDIEAD HVGFYGTTVY QSPGDIGQYT    50
    HEFDGDELFY VDLDKKKTVW RLPEFGQLIL FEPQGGLQNI AAEKHNLGIL 100
    TKRSNFTPAT NEAPQATVFP KSPVLLGQPN TLICFVDNIF PPVINITWLR 150
    NSKSVTDGVY ETSFLVNRDH SFHKLSYLTF IPSDDDIYDC KVEHWGLEEP 200
    VLKHWEPEIP APMSELTETV VCALGLSVGL VGIVVGTIFI IQGLRSGGTS 250
    RHPGPL 256
    Length:256
    Mass (Da):28,243
    Last modified:March 20, 1987 - v1
    Checksum:i085B3FE643B58BBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01923 mRNA. Translation: AAA39615.1.
    PIRiA02219. HLMSA2.
    UniGeneiMm.235338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01923 mRNA. Translation: AAA39615.1 .
    PIRi A02219. HLMSA2.
    UniGenei Mm.235338.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ES0 X-ray 2.60 A 24-205 [» ]
    1F3J X-ray 3.10 A/D 27-208 [» ]
    1IAO X-ray 2.60 A 24-209 [» ]
    B 28-216 [» ]
    2IAD X-ray 2.40 A 24-205 [» ]
    3CUP X-ray 3.09 A 24-205 [» ]
    3MBE X-ray 2.89 A/E 24-205 [» ]
    ProteinModelPortali P04228.
    SMRi P04228. Positions 27-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P04228. 2 interactions.
    MINTi MINT-129609.

    Proteomic databases

    PRIDEi P04228.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:95895. H2-Aa.

    Phylogenomic databases

    HOVERGENi HBG006862.
    InParanoidi P04228.

    Miscellaneous databases

    EvolutionaryTracei P04228.
    PROi P04228.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_H2-AA.
    Genevestigatori P04228.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regions of allelic hypervariability in the murine A alpha immune response gene."
      Benoist C.O., Mathis D.J., Kanter M.R., Williams V.E., McDevitt H.O.
      Cell 34:169-177(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHA2D_MOUSE
    AccessioniPrimary (citable) accession number: P04228
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 1987
    Last sequence update: March 20, 1987
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3