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Protein

H-2 class II histocompatibility antigen, A-D alpha chain

Gene

H2-Aa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. peptide antigen binding Source: MGI

GO - Biological processi

  1. antigen processing and presentation Source: MGI
  2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
  3. antigen processing and presentation of peptide antigen Source: MGI
  4. immune response Source: InterPro
  5. positive regulation of T cell differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-D alpha chain
Gene namesi
Name:H2-Aa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:95895. H2-Aa.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 218195ExtracellularSequence AnalysisAdd
BLAST
Transmembranei219 – 24426HelicalSequence AnalysisAdd
BLAST
Topological domaini245 – 25612CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosome Source: MGI
  4. membrane Source: MGI
  5. MHC class II protein complex Source: MGI
  6. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 256233H-2 class II histocompatibility antigen, A-D alpha chainPRO_0000018976Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi134 ↔ 190PROSITE-ProRule annotation
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP04228.

Expressioni

Gene expression databases

CleanExiMM_H2-AA.
GenevestigatoriP04228.

Interactioni

Protein-protein interaction databases

IntActiP04228. 2 interactions.
MINTiMINT-129609.

Structurei

Secondary structure

1
256
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 4112Combined sources
Turni42 – 454Combined sources
Beta strandi46 – 538Combined sources
Beta strandi56 – 627Combined sources
Turni63 – 664Combined sources
Beta strandi67 – 726Combined sources
Turni73 – 786Combined sources
Beta strandi79 – 813Combined sources
Helixi83 – 10422Combined sources
Beta strandi115 – 1228Combined sources
Beta strandi130 – 13910Combined sources
Beta strandi145 – 1506Combined sources
Beta strandi153 – 1553Combined sources
Beta strandi157 – 1615Combined sources
Beta strandi172 – 1809Combined sources
Beta strandi182 – 1854Combined sources
Beta strandi187 – 1937Combined sources
Beta strandi201 – 2055Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ES0X-ray2.60A24-205[»]
1F3JX-ray3.10A/D27-208[»]
1IAOX-ray2.60A24-209[»]
B28-216[»]
2IADX-ray2.40A24-205[»]
3CUPX-ray3.09A24-205[»]
3MBEX-ray2.89A/E24-205[»]
ProteinModelPortaliP04228.
SMRiP04228. Positions 27-205.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04228.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 20693Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 11188Alpha-1Add
BLAST
Regioni112 – 20594Alpha-2Add
BLAST
Regioni206 – 21813Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006862.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04228-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPCSRALILG VLALNTMLSL CGGEDDIEAD HVGFYGTTVY QSPGDIGQYT
60 70 80 90 100
HEFDGDELFY VDLDKKKTVW RLPEFGQLIL FEPQGGLQNI AAEKHNLGIL
110 120 130 140 150
TKRSNFTPAT NEAPQATVFP KSPVLLGQPN TLICFVDNIF PPVINITWLR
160 170 180 190 200
NSKSVTDGVY ETSFLVNRDH SFHKLSYLTF IPSDDDIYDC KVEHWGLEEP
210 220 230 240 250
VLKHWEPEIP APMSELTETV VCALGLSVGL VGIVVGTIFI IQGLRSGGTS

RHPGPL
Length:256
Mass (Da):28,243
Last modified:March 20, 1987 - v1
Checksum:i085B3FE643B58BBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01923 mRNA. Translation: AAA39615.1.
PIRiA02219. HLMSA2.
UniGeneiMm.235338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01923 mRNA. Translation: AAA39615.1.
PIRiA02219. HLMSA2.
UniGeneiMm.235338.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ES0X-ray2.60A24-205[»]
1F3JX-ray3.10A/D27-208[»]
1IAOX-ray2.60A24-209[»]
B28-216[»]
2IADX-ray2.40A24-205[»]
3CUPX-ray3.09A24-205[»]
3MBEX-ray2.89A/E24-205[»]
ProteinModelPortaliP04228.
SMRiP04228. Positions 27-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04228. 2 interactions.
MINTiMINT-129609.

Proteomic databases

PRIDEiP04228.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95895. H2-Aa.

Phylogenomic databases

HOVERGENiHBG006862.

Miscellaneous databases

EvolutionaryTraceiP04228.
PROiP04228.
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-AA.
GenevestigatoriP04228.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Regions of allelic hypervariability in the murine A alpha immune response gene."
    Benoist C.O., Mathis D.J., Kanter M.R., Williams V.E., McDevitt H.O.
    Cell 34:169-177(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHA2D_MOUSE
AccessioniPrimary (citable) accession number: P04228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: February 4, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.