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P04228 (HA2D_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
H-2 class II histocompatibility antigen, A-D alpha chain
Gene names
Name:H2-Aa
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the MHC class II family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processImmunity
   Cellular componentMembrane
MHC II
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation

Inferred from direct assay PubMed 9432982. Source: MGI

antigen processing and presentation of exogenous peptide antigen via MHC class II

Inferred from direct assay PubMed 11027433PubMed 11069069PubMed 11714799PubMed 7679955PubMed 8598040PubMed 8598041PubMed 9432982PubMed 9492004. Source: MGI

antigen processing and presentation of peptide antigen

Inferred from direct assay PubMed 11069069. Source: MGI

immune response

Inferred from electronic annotation. Source: InterPro

positive regulation of T cell differentiation

Inferred from direct assay PubMed 8598041. Source: MGI

   Cellular_componentMHC class II protein complex

Inferred from direct assay PubMed 11148202PubMed 7679955PubMed 7985028PubMed 8598040PubMed 8598041PubMed 8638109PubMed 9492004. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 11148202PubMed 7679955PubMed 8598040PubMed 8598041PubMed 8638109PubMed 9432982PubMed 9492004. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lysosome

Inferred from direct assay PubMed 11854359. Source: MGI

plasma membrane

Inferred from direct assay PubMed 11854359. Source: MGI

   Molecular_functionpeptide antigen binding

Inferred from direct assay PubMed 11069069PubMed 9432982. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323
Chain24 – 256233H-2 class II histocompatibility antigen, A-D alpha chain
PRO_0000018976

Regions

Topological domain24 – 218195Extracellular Potential
Transmembrane219 – 24426Helical; Potential
Topological domain245 – 25612Cytoplasmic Potential
Domain114 – 20693Ig-like C1-type
Region24 – 11188Alpha-1
Region112 – 20594Alpha-2
Region206 – 21813Connecting peptide

Amino acid modifications

Glycosylation1451N-linked (GlcNAc...) Potential
Disulfide bond134 ↔ 190 By similarity

Secondary structure

..................................... 256
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P04228 [UniParc].

Last modified March 20, 1987. Version 1.
Checksum: 085B3FE643B58BBB

FASTA25628,243
        10         20         30         40         50         60 
MPCSRALILG VLALNTMLSL CGGEDDIEAD HVGFYGTTVY QSPGDIGQYT HEFDGDELFY 

        70         80         90        100        110        120 
VDLDKKKTVW RLPEFGQLIL FEPQGGLQNI AAEKHNLGIL TKRSNFTPAT NEAPQATVFP 

       130        140        150        160        170        180 
KSPVLLGQPN TLICFVDNIF PPVINITWLR NSKSVTDGVY ETSFLVNRDH SFHKLSYLTF 

       190        200        210        220        230        240 
IPSDDDIYDC KVEHWGLEEP VLKHWEPEIP APMSELTETV VCALGLSVGL VGIVVGTIFI 

       250 
IQGLRSGGTS RHPGPL 

« Hide

References

[1]"Regions of allelic hypervariability in the murine A alpha immune response gene."
Benoist C.O., Mathis D.J., Kanter M.R., Williams V.E., McDevitt H.O.
Cell 34:169-177(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K01923 mRNA. Translation: AAA39615.1.
PIRHLMSA2. A02219.
UniGeneMm.235338.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ES0X-ray2.60A24-205[»]
1F3JX-ray3.10A/D27-208[»]
1IAOX-ray2.60A24-209[»]
2IADX-ray2.40A24-205[»]
3CUPX-ray3.09A24-205[»]
3MBEX-ray2.89A/E24-205[»]
ProteinModelPortalP04228.
SMRP04228. Positions 27-205.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP04228. 2 interactions.
MINTMINT-129609.

Proteomic databases

PRIDEP04228.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:95895. H2-Aa.

Phylogenomic databases

HOVERGENHBG006862.
InParanoidP04228.

Gene expression databases

CleanExMM_H2-AA.
GenevestigatorP04228.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP04228.
PROP04228.
SOURCESearch...

Entry information

Entry nameHA2D_MOUSE
AccessionPrimary (citable) accession number: P04228
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot