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Protein

H-2 class II histocompatibility antigen, E-K alpha chain

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, E-K alpha chain
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 216ExtracellularSequence analysisAdd BLAST191
Transmembranei217 – 242HelicalSequence analysisAdd BLAST26
Topological domaini243 – 255CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000001897926 – 255H-2 class II histocompatibility antigen, E-K alpha chainAdd BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi132 ↔ 188PROSITE-ProRule annotation
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP04224

Interactioni

Protein-protein interaction databases

IntActiP04224, 1 interactor

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 40Combined sources11
Turni41 – 43Combined sources3
Beta strandi44 – 51Combined sources8
Beta strandi54 – 60Combined sources7
Turni61 – 64Combined sources4
Beta strandi65 – 70Combined sources6
Helixi71 – 75Combined sources5
Helixi81 – 101Combined sources21
Turni102 – 104Combined sources3
Beta strandi113 – 120Combined sources8
Beta strandi128 – 140Combined sources13
Beta strandi143 – 148Combined sources6
Beta strandi151 – 153Combined sources3
Beta strandi155 – 159Combined sources5
Beta strandi166 – 168Combined sources3
Beta strandi170 – 178Combined sources9
Beta strandi186 – 191Combined sources6
Beta strandi193 – 197Combined sources5
Beta strandi199 – 203Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FNEX-ray1.90A/C26-217[»]
1FNGX-ray1.90A/C26-217[»]
1I3RX-ray2.40A/C/E/G26-217[»]
1R5VX-ray2.50A/C28-207[»]
1R5WX-ray2.90A/C28-207[»]
3QIBX-ray2.70A26-216[»]
3QIUX-ray2.70A28-206[»]
3QIWX-ray3.30A26-217[»]
4P2OX-ray2.60A26-216[»]
4P2QX-ray3.30A/F/K/P26-216[»]
4P2RX-ray3.30A/F/K/P26-216[»]
ProteinModelPortaliP04224
SMRiP04224
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04224

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 204Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 109Alpha-1Add BLAST84
Regioni110 – 203Alpha-2Add BLAST94
Regioni204 – 216Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006862

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIGALVLR FFFIAVLMSS QKSWAIKEEH TIIQAEFYLL PDKRGEFMFD
60 70 80 90 100
FDGDEIFHVD IEKSETIWRL EEFAKFASFE AQGALANIAV DKANLDVMKE
110 120 130 140 150
RSNNTPDANV APEVTVLSRS PVNLGEPNIL ICFIDKFSPP VVNVTWLRNG
160 170 180 190 200
RPVTEGVSET VFLPRDDHLF RKFHYLTFLP STDDFYDCEV DHWGLEEPLR
210 220 230 240 250
KHWEFEEKTL LPETKENVVC ALGLFVGLVG IVVGIILIMK GIKKRNVVER

RQGAL
Length:255
Mass (Da):29,121
Last modified:March 20, 1987 - v1
Checksum:i144EEA3AB1EF3724
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00833, V00834 Genomic DNA Translation: CAA24216.2
PIRiA21938 HLMSEA
B91743 HLMSED
UniGeneiMm.15680

Genome annotation databases

UCSCiuc008cck.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHA22_MOUSE
AccessioniPrimary (citable) accession number: P04224
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health