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Protein

H-2 class II histocompatibility antigen, E-K alpha chain

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, E-K alpha chain
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 216191ExtracellularSequence analysisAdd
BLAST
Transmembranei217 – 24226HelicalSequence analysisAdd
BLAST
Topological domaini243 – 25513CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 255230H-2 class II histocompatibility antigen, E-K alpha chainPRO_0000018979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi132 ↔ 188PROSITE-ProRule annotation
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP04224.

Interactioni

Protein-protein interaction databases

IntActiP04224. 1 interaction.

Structurei

Secondary structure

1
255
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 4011Combined sources
Turni41 – 433Combined sources
Beta strandi44 – 518Combined sources
Beta strandi54 – 607Combined sources
Turni61 – 644Combined sources
Beta strandi65 – 706Combined sources
Helixi71 – 755Combined sources
Helixi81 – 10121Combined sources
Turni102 – 1043Combined sources
Beta strandi113 – 1208Combined sources
Beta strandi128 – 14013Combined sources
Beta strandi143 – 1486Combined sources
Beta strandi151 – 1533Combined sources
Beta strandi155 – 1595Combined sources
Beta strandi166 – 1683Combined sources
Beta strandi170 – 1789Combined sources
Beta strandi186 – 1916Combined sources
Beta strandi193 – 1975Combined sources
Beta strandi199 – 2035Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FNEX-ray1.90A/C26-217[»]
1FNGX-ray1.90A/C26-217[»]
1I3RX-ray2.40A/C/E/G26-217[»]
1R5VX-ray2.50A/C28-207[»]
1R5WX-ray2.90A/C28-207[»]
3QIBX-ray2.70A26-216[»]
3QIUX-ray2.70A28-206[»]
3QIWX-ray3.30A26-217[»]
4P2OX-ray2.60A26-216[»]
4P2QX-ray3.30A/F/K/P26-216[»]
4P2RX-ray3.30A/F/K/P26-216[»]
ProteinModelPortaliP04224.
SMRiP04224. Positions 26-207.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP04224.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 20493Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 10984Alpha-1Add
BLAST
Regioni110 – 20394Alpha-2Add
BLAST
Regioni204 – 21613Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006862.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P04224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIGALVLR FFFIAVLMSS QKSWAIKEEH TIIQAEFYLL PDKRGEFMFD
60 70 80 90 100
FDGDEIFHVD IEKSETIWRL EEFAKFASFE AQGALANIAV DKANLDVMKE
110 120 130 140 150
RSNNTPDANV APEVTVLSRS PVNLGEPNIL ICFIDKFSPP VVNVTWLRNG
160 170 180 190 200
RPVTEGVSET VFLPRDDHLF RKFHYLTFLP STDDFYDCEV DHWGLEEPLR
210 220 230 240 250
KHWEFEEKTL LPETKENVVC ALGLFVGLVG IVVGIILIMK GIKKRNVVER

RQGAL
Length:255
Mass (Da):29,121
Last modified:March 20, 1987 - v1
Checksum:i144EEA3AB1EF3724
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00833, V00834 Genomic DNA. Translation: CAA24216.2.
PIRiA21938. HLMSEA.
B91743. HLMSED.
UniGeneiMm.15680.

Genome annotation databases

UCSCiuc008cck.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00833, V00834 Genomic DNA. Translation: CAA24216.2.
PIRiA21938. HLMSEA.
B91743. HLMSED.
UniGeneiMm.15680.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FNEX-ray1.90A/C26-217[»]
1FNGX-ray1.90A/C26-217[»]
1I3RX-ray2.40A/C/E/G26-217[»]
1R5VX-ray2.50A/C28-207[»]
1R5WX-ray2.90A/C28-207[»]
3QIBX-ray2.70A26-216[»]
3QIUX-ray2.70A28-206[»]
3QIWX-ray3.30A26-217[»]
4P2OX-ray2.60A26-216[»]
4P2QX-ray3.30A/F/K/P26-216[»]
4P2RX-ray3.30A/F/K/P26-216[»]
ProteinModelPortaliP04224.
SMRiP04224. Positions 26-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP04224. 1 interaction.

Proteomic databases

MaxQBiP04224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc008cck.1. mouse.

Phylogenomic databases

HOVERGENiHBG006862.

Miscellaneous databases

EvolutionaryTraceiP04224.
PROiP04224.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology."
    Benoist C.O., Mathis D.J., Kanter M.R., Williams V.E., McDevitt H.O.
    Proc. Natl. Acad. Sci. U.S.A. 80:534-538(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A/J.

Entry informationi

Entry nameiHA22_MOUSE
AccessioniPrimary (citable) accession number: P04224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: January 20, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.